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Aliases for SPATS2 Gene

Aliases for SPATS2 Gene

  • Spermatogenesis Associated, Serine-Rich 2 2 3
  • SPATA10 3 4 6
  • P59SCR 3 4 6
  • SCR59 3 4 6
  • Serine-Rich Spermatocytes And Round Spermatid 59 KDa Protein 3 4
  • Serine-Rich Spermatocytes And Round Spermatid Protein 3
  • Spermatogenesis-Associated Serine-Rich Protein 2 3
  • Putative Protein Product Of Nbla00526 3
  • Nbla00526 3

External Ids for SPATS2 Gene

Previous GeneCards Identifiers for SPATS2 Gene

  • GC12P049477
  • GC12P048047
  • GC12P049760
  • GC12P046791

Summaries for SPATS2 Gene

GeneCards Summary for SPATS2 Gene

SPATS2 (Spermatogenesis Associated, Serine-Rich 2) is a Protein Coding gene. An important paralog of this gene is SPATS2L.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATS2 Gene

Genomics for SPATS2 Gene

Regulatory Elements for SPATS2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SPATS2 Gene

Start:
49,366,584 bp from pter
End:
49,527,424 bp from pter
Size:
160,841 bases
Orientation:
Plus strand

Genomic View for SPATS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPATS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATS2 Gene

Proteins for SPATS2 Gene

  • Protein details for SPATS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XZ4-SPAS2_HUMAN
    Recommended name:
    Spermatogenesis-associated serine-rich protein 2
    Protein Accession:
    Q86XZ4
    Secondary Accessions:
    • A8K8G9
    • Q9H7D4
    • Q9H8Y7
    • Q9H8Z8

    Protein attributes for SPATS2 Gene

    Size:
    545 amino acids
    Molecular mass:
    59545 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14448.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14958.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SPATS2 Gene

Proteomics data for SPATS2 Gene at MOPED

Post-translational modifications for SPATS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SPATS2 Gene

Domains for SPATS2 Gene

Protein Domains for SPATS2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPATS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86XZ4

UniProtKB/Swiss-Prot:

SPAS2_HUMAN :
  • Q86XZ4
Family:
  • Belongs to the SPATS2 family.
genes like me logo Genes that share domains with SPATS2: view

No data available for Gene Families for SPATS2 Gene

Function for SPATS2 Gene

Gene Ontology (GO) - Molecular Function for SPATS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SPATS2: view

Animal Model Products

CRISPR Products

miRNA for SPATS2 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPATS2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SPATS2 Gene

Localization for SPATS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPATS2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPATS2 Gene COMPARTMENTS Subcellular localization image for SPATS2 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for SPATS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SPATS2: view

Pathways for SPATS2 Gene

SuperPathways for SPATS2 Gene

No Data Available

Interacting Proteins for SPATS2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000326841%0d%0a9606.ENSP00000358548%0d%0a9606.ENSP00000362931%0d%0a
Selected Interacting proteins: ENSP00000326841 for SPATS2 Gene via STRING

Gene Ontology (GO) - Biological Process for SPATS2 Gene

None

No data available for Pathways by source for SPATS2 Gene

Transcripts for SPATS2 Gene

Unigene Clusters for SPATS2 Gene

Spermatogenesis associated, serine-rich 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPATS2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SPATS2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPATS2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - -
SP4:
SP5: - - - - - - - - - - - - - - - - - -
SP6: - - - - - -
SP7: - - - - - - - - - - - - - - -
SP8: - - - - - - -
SP9: - - - - - - -
SP10: - - - -
SP11: - - - - - - -
SP12: - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - -
SP14: - - -
SP15: - - - - - -
SP16: - - - - - -
SP17: - - - - - -
SP18:
SP19: - - - -

ExUns: 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b · 25c · 25d
SP1: - -
SP2: - - -
SP3: - -
SP4: -
SP5: -
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: -
SP19:

Relevant External Links for SPATS2 Gene

GeneLoc Exon Structure for
SPATS2
ECgene alternative splicing isoforms for
SPATS2

Expression for SPATS2 Gene

mRNA expression in normal human tissues for SPATS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPATS2 Gene

SOURCE GeneReport for Unigene cluster for SPATS2 Gene Hs.654826

genes like me logo Genes that share expressions with SPATS2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPATS2 Gene

Orthologs for SPATS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPATS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPATS2 35
  • 99.57 (n)
  • 99.08 (a)
SPATS2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 83 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
SPATS2 35
  • 90.03 (n)
  • 88.44 (a)
dog
(Canis familiaris)
Mammalia SPATS2 35
  • 91.93 (n)
  • 91.19 (a)
SPATS2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spats2 35
  • 83.64 (n)
  • 83.82 (a)
Spats2 16
Spats2 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPATS2 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPATS2 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spats2 35
  • 82.9 (n)
  • 82.72 (a)
chicken
(Gallus gallus)
Aves SPATS2 35
  • 69.04 (n)
  • 70.13 (a)
SPATS2 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPATS2 36
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC69117 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75583 35
spats2 35
  • 62.19 (n)
  • 61.63 (a)
zebrafish
(Danio rerio)
Actinopterygii hcrtr2 35
SPATS2 (1 of 2) 36
  • 46 (a)
OneToMany
SPATS2 (2 of 2) 36
  • 42 (a)
OneToMany
zgc:154064 35
  • 57.29 (n)
  • 52.31 (a)
Species with no ortholog for SPATS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPATS2 Gene

ENSEMBL:
Gene Tree for SPATS2 (if available)
TreeFam:
Gene Tree for SPATS2 (if available)

Paralogs for SPATS2 Gene

Paralogs for SPATS2 Gene

genes like me logo Genes that share paralogs with SPATS2: view

Variants for SPATS2 Gene

Sequence variations from dbSNP and Humsavar for SPATS2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1248274 -- 49,450,621(-) ggttg(C/T)agtga intron-variant
rs1270901 -- 49,441,462(-) GAAGA(C/T)AGCCC intron-variant
rs1271407 -- 49,450,629(-) gaggc(A/G)gaggt intron-variant
rs1343752 -- 49,404,679(+) TGCTG(A/T)CTTTG intron-variant
rs2007490 -- 49,487,352(-) CACCA(C/T)GCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPATS2 Gene

Variant ID Type Subtype PubMed ID
dgv1423n71 CNV Loss 21882294
nsv832405 CNV Gain 17160897
nsv899070 CNV Loss 21882294
esv2675557 CNV Deletion 23128226
esv2665539 CNV Deletion 23128226
esv1526240 CNV Deletion 17803354
esv2660035 CNV Deletion 23128226
esv2678939 CNV Deletion 23128226
nsv832406 CNV Loss 17160897
nsv518746 CNV Loss 19592680
esv2674904 CNV Deletion 23128226

Relevant External Links for SPATS2 Gene

HapMap Linkage Disequilibrium report
SPATS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATS2 Gene

Disorders for SPATS2 Gene

Relevant External Links for SPATS2

Genetic Association Database (GAD)
SPATS2
Human Genome Epidemiology (HuGE) Navigator
SPATS2
genes like me logo Genes that share disorders with SPATS2: view

No data available for UniProtKB/Swiss-Prot for SPATS2 Gene

Publications for SPATS2 Gene

  1. Microarray analysis of bisphenol A-induced changes in gene expression in human oral epithelial cells. (PMID: 17989879) Seki K. … Ito K. (Acta Biochim. Biophys. Sin. (Shanghai) 2007) 2 3 23
  2. Identification of a novel protein p59(scr), which is expressed at specific stages of mouse spermatogenesis. (PMID: 11944913) Senoo M. … Habu S. (Biochem. Biophys. Res. Commun. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for SPATS2 Gene

Sources for SPATS2 Gene

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