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Aliases for SPATC1L Gene

Aliases for SPATC1L Gene

  • Spermatogenesis And Centriole Associated 1 Like 2 3 5
  • Spermatogenesis And Centriole-Associated Protein 1-Like Protein 3 4
  • Speriolin-Like Protein 2 3
  • C21orf56 3 4
  • Spermatogenesis And Centriole Associated 1-Like 2
  • Chromosome 21 Open Reading Frame 56 2

External Ids for SPATC1L Gene

Previous HGNC Symbols for SPATC1L Gene

  • C21orf56

Previous GeneCards Identifiers for SPATC1L Gene

  • GC21M047582
  • GC21M046163
  • GC21M046170
  • GC21M046175
  • GC21M046177
  • GC21M046178
  • GC21M046179

Summaries for SPATC1L Gene

GeneCards Summary for SPATC1L Gene

SPATC1L (Spermatogenesis And Centriole Associated 1 Like) is a Protein Coding gene. An important paralog of this gene is SPATC1.

Gene Wiki entry for SPATC1L Gene

Additional gene information for SPATC1L Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATC1L Gene

Genomics for SPATC1L Gene

Regulatory Elements for SPATC1L Gene

Enhancers for SPATC1L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21H046182 1.5 Ensembl ENCODE dbSUPER 51.2 +1.1 1067 4 HDGF PKNOX1 ATF1 ARNT ARID4B SIN3A ZBTB7B TCF12 ZNF766 ATF7 SPATC1L MCM3AP YBEY MCM3AP-AS1 COL6A2 ENSG00000228404 LOC105372842 ENSG00000228137 FTCD LSS
GH21H046152 1.3 Ensembl ENCODE 27.1 +31.7 31670 2 ATF1 FOXA2 ARID4B DMAP1 YY1 TCF12 ZNF766 GLIS2 ELK1 ZNF143 MCM3AP SPATC1L ENSG00000228137 MCM3AP-AS1 DIP2A POFUT2 FTCD YBEY FTCD-AS1
GH21H046368 1.6 FANTOM5 Ensembl ENCODE dbSUPER 17.9 -183.9 -183931 1 PKNOX1 MAX BACH1 SIN3A EBF1 BATF RELA POLR2A EED ZNF143 SPATC1L MCM3AP YBEY GC21M046493 PIR36884
GH21H046226 1.3 ENCODE dbSUPER 21.9 -43.2 -43246 4 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF143 ZNF207 MCM3AP YBEY SPATC1L MCM3AP-AS1 ENSG00000228137 COL6A1 LSS PIR60990
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPATC1L on UCSC Golden Path with GeneCards custom track

Promoters for SPATC1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SPATC1L Gene

46,161,148 bp from pter
46,185,149 bp from pter
24,002 bases
Minus strand

Genomic View for SPATC1L Gene

Genes around SPATC1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATC1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATC1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATC1L Gene

Proteins for SPATC1L Gene

  • Protein details for SPATC1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Speriolin-like protein
    Protein Accession:
    Secondary Accessions:
    • B4E323
    • Q52LS9
    • Q6FIH5
    • Q6P0L3
    • Q9NSE5

    Protein attributes for SPATC1L Gene

    340 amino acids
    Molecular mass:
    37613 Da
    Quaternary structure:
    No Data Available
    • Highly variable expression among individuals is associated with differential sensitivity to the DNA alkylating agent N-methyl-N-nitro-N-nitrosoguanidine (MNNG), decreased expression being associated with increased sensitivity.
    • Sequence=BAA95497.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SPATC1L Gene


neXtProt entry for SPATC1L Gene

Post-translational modifications for SPATC1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPATC1L Gene

No data available for DME Specific Peptides for SPATC1L Gene

Domains & Families for SPATC1L Gene

Gene Families for SPATC1L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPATC1L Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the speriolin family.
  • Belongs to the speriolin family.
genes like me logo Genes that share domains with SPATC1L: view

No data available for Suggested Antigen Peptide Sequences for SPATC1L Gene

Function for SPATC1L Gene

Phenotypes From GWAS Catalog for SPATC1L Gene

Gene Ontology (GO) - Molecular Function for SPATC1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SPATC1L: view
genes like me logo Genes that share phenotypes with SPATC1L: view

Animal Model Products

CRISPR Products

miRNA for SPATC1L Gene

miRTarBase miRNAs that target SPATC1L

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SPATC1L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPATC1L Gene

Localization for SPATC1L Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPATC1L gene
Compartment Confidence
cytoskeleton 3
nucleus 3
cytosol 3
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SPATC1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005813 centrosome IBA --
genes like me logo Genes that share ontologies with SPATC1L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SPATC1L Gene

Pathways & Interactions for SPATC1L Gene

SuperPathways for SPATC1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPATC1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SPATC1L: view

No data available for Pathways by source and SIGNOR curated interactions for SPATC1L Gene

Drugs & Compounds for SPATC1L Gene

No Compound Related Data Available

Transcripts for SPATC1L Gene

Unigene Clusters for SPATC1L Gene

Spermatogenesis and centriole associated 1-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SPATC1L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SPATC1L Gene

No ASD Table

Relevant External Links for SPATC1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPATC1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPATC1L Gene

mRNA differential expression in normal tissues according to GTEx for SPATC1L Gene

This gene is overexpressed in Testis (x5.0).

Protein differential expression in normal tissues from HIPED for SPATC1L Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPATC1L Gene

Protein tissue co-expression partners for SPATC1L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SPATC1L Gene:


SOURCE GeneReport for Unigene cluster for SPATC1L Gene:


Evidence on tissue expression from TISSUES for SPATC1L Gene

  • Eye(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with SPATC1L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPATC1L Gene

Orthologs for SPATC1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPATC1L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPATC1L 33 34
  • 98.33 (n)
(Canis familiaris)
Mammalia SPATC1L 33 34
  • 85.74 (n)
(Bos Taurus)
Mammalia SPATC1L 33
  • 85.6 (n)
C1H21ORF56 34
  • 84 (a)
(Mus musculus)
Mammalia Spatc1l 33 16 34
  • 82.1 (n)
(Rattus norvegicus)
Mammalia Spatc1l 33
  • 82.07 (n)
(Monodelphis domestica)
Mammalia SPATC1L 34
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia SPATC1L 34
  • 40 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 27 (a)
Species where no ortholog for SPATC1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPATC1L Gene

Gene Tree for SPATC1L (if available)
Gene Tree for SPATC1L (if available)

Paralogs for SPATC1L Gene

Paralogs for SPATC1L Gene

(1) SIMAP similar genes for SPATC1L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPATC1L: view

Variants for SPATC1L Gene

Sequence variations from dbSNP and Humsavar for SPATC1L Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1000205608 -- 46,178,901(+) CAAAC(A/G)AAAAA intron-variant
rs1000245231 -- 46,165,936(+) TTCAG(C/T)GGTGA intron-variant
rs1000907753 -- 46,179,920(+) TGACG(C/G)GGACA intron-variant
rs1000946724 -- 46,177,613(+) ATGCT(A/G)GCAAC intron-variant
rs1001003017 -- 46,161,174(+) ATGAT(G/T)TTAAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SPATC1L Gene

Variant ID Type Subtype PubMed ID
dgv2515e59 CNV duplication 20981092
dgv7922n54 CNV gain 21841781
dgv7923n54 CNV loss 21841781
dgv7924n54 CNV loss 21841781
dgv7925n54 CNV loss 21841781
esv1674225 CNV deletion 17803354
esv2076361 CNV deletion 18987734
esv25247 CNV loss 19812545
esv25460 CNV loss 19812545
esv2723902 CNV deletion 23290073
esv2723903 CNV deletion 23290073
esv3427650 CNV duplication 20981092
esv3647163 CNV loss 21293372
nsv1060978 CNV gain 25217958
nsv1061087 CNV loss 25217958
nsv1073141 CNV deletion 25765185
nsv1125228 CNV insertion 24896259
nsv187209 CNV deletion 16902084
nsv3545 CNV insertion 18451855
nsv470910 CNV gain 18288195
nsv470911 CNV loss 18288195
nsv509804 CNV insertion 20534489
nsv519904 CNV loss 19592680
nsv525728 CNV loss 19592680
nsv587952 CNV loss 21841781
nsv587954 CNV loss 21841781
nsv587956 CNV loss 21841781
nsv587957 CNV gain+loss 21841781
nsv587964 CNV loss 21841781
nsv953658 CNV deletion 24416366

Variation tolerance for SPATC1L Gene

Residual Variation Intolerance Score: 88.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.07; 87.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPATC1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATC1L Gene

Disorders for SPATC1L Gene

Relevant External Links for SPATC1L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SPATC1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPATC1L Gene

Publications for SPATC1L Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  2. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 60
  3. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M … Chromosome 21 mapping and sequencing consortium (Nature 2000) 3 4 60
  4. Identification of EGFLAM, SPATC1L and RNASE13 as novel susceptibility loci for aortic aneurysm in Japanese individuals by exome-wide association studies. (PMID: 28339009) Yamada Y … Tanaka M (International journal of molecular medicine 2017) 3 60
  5. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2016) 3 60

Products for SPATC1L Gene

Sources for SPATC1L Gene

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