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Aliases for SPATC1L Gene

Aliases for SPATC1L Gene

  • Spermatogenesis And Centriole Associated 1-Like 2 3 5
  • Spermatogenesis And Centriole-Associated Protein 1-Like Protein 3 4
  • C21orf56 3 4
  • Chromosome 21 Open Reading Frame 56 2
  • Speriolin-Like Protein 2

External Ids for SPATC1L Gene

Previous HGNC Symbols for SPATC1L Gene

  • C21orf56

Previous GeneCards Identifiers for SPATC1L Gene

  • GC21M047582
  • GC21M046163
  • GC21M046170

Summaries for SPATC1L Gene

GeneCards Summary for SPATC1L Gene

SPATC1L (Spermatogenesis And Centriole Associated 1-Like) is a Protein Coding gene. An important paralog of this gene is SPATC1.

Gene Wiki entry for SPATC1L Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATC1L Gene

Genomics for SPATC1L Gene

Regulatory Elements for SPATC1L Gene

Enhancers for SPATC1L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SPATC1L on UCSC Golden Path with GeneCards custom track

Promoters for SPATC1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SPATC1L on UCSC Golden Path with GeneCards custom track

Genomic Location for SPATC1L Gene

46,161,148 bp from pter
46,185,149 bp from pter
24,002 bases
Minus strand

Genomic View for SPATC1L Gene

Genes around SPATC1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATC1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATC1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATC1L Gene

Proteins for SPATC1L Gene

  • Protein details for SPATC1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Speriolin-like protein
    Protein Accession:
    Secondary Accessions:
    • B4E323
    • Q52LS9
    • Q6FIH5
    • Q6P0L3
    • Q9NSE5

    Protein attributes for SPATC1L Gene

    340 amino acids
    Molecular mass:
    37613 Da
    Quaternary structure:
    No Data Available
    • Highly variable expression among individuals is associated with differential sensitivity to the DNA alkylating agent N-methyl-N-nitro-N-nitrosoguanidine (MNNG), decreased expression being associated with increased sensitivity.
    • Sequence=BAA95497.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SPATC1L Gene


neXtProt entry for SPATC1L Gene

Proteomics data for SPATC1L Gene at MOPED

Post-translational modifications for SPATC1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPATC1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPATC1L Gene

Domains & Families for SPATC1L Gene

Protein Domains for SPATC1L Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the speriolin family.
  • Belongs to the speriolin family.
genes like me logo Genes that share domains with SPATC1L: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for SPATC1L Gene

Function for SPATC1L Gene

genes like me logo Genes that share phenotypes with SPATC1L: view

Animal Model Products

miRNA for SPATC1L Gene

miRTarBase miRNAs that target SPATC1L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPATC1L Gene

Localization for SPATC1L Gene

Subcellular locations from

Jensen Localization Image for SPATC1L Gene COMPARTMENTS Subcellular localization image for SPATC1L gene
Compartment Confidence
cytosol 3
nucleus 3
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPATC1L Gene

Pathways & Interactions for SPATC1L Gene

SuperPathways for SPATC1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPATC1L Gene


No data available for Pathways by source and SIGNOR curated interactions for SPATC1L Gene

Drugs & Compounds for SPATC1L Gene

No Compound Related Data Available

Transcripts for SPATC1L Gene

Unigene Clusters for SPATC1L Gene

Spermatogenesis and centriole associated 1-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPATC1L Gene

No ASD Table

Relevant External Links for SPATC1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPATC1L Gene

mRNA expression in normal human tissues for SPATC1L Gene

mRNA differential expression in normal tissues according to GTEx for SPATC1L Gene

This gene is overexpressed in Testis (x5.0).

Protein differential expression in normal tissues from HIPED for SPATC1L Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPATC1L Gene

SOURCE GeneReport for Unigene cluster for SPATC1L Gene Hs.381214

genes like me logo Genes that share expression patterns with SPATC1L: view

Protein tissue co-expression partners for SPATC1L Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SPATC1L Gene

Orthologs for SPATC1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPATC1L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SPATC1L 35
  • 85.6 (n)
  • 84.62 (a)
C1H21ORF56 36
  • 84 (a)
(Canis familiaris)
Mammalia SPATC1L 35
  • 85.74 (n)
  • 80.24 (a)
  • 80 (a)
(Mus musculus)
Mammalia Spatc1l 35
  • 82.1 (n)
  • 85.55 (a)
Spatc1l 16
Spatc1l 36
  • 85 (a)
(Pan troglodytes)
Mammalia SPATC1L 35
  • 98.33 (n)
  • 97.35 (a)
  • 97 (a)
(Rattus norvegicus)
Mammalia Spatc1l 35
  • 82.07 (n)
  • 87.73 (a)
(Monodelphis domestica)
Mammalia SPATC1L 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia SPATC1L 36
  • 40 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
Species with no ortholog for SPATC1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPATC1L Gene

Gene Tree for SPATC1L (if available)
Gene Tree for SPATC1L (if available)

Paralogs for SPATC1L Gene

Paralogs for SPATC1L Gene

(1) SIMAP similar genes for SPATC1L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPATC1L: view

Variants for SPATC1L Gene

Sequence variations from dbSNP and Humsavar for SPATC1L Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs884134 - 46,168,514(+) TGAAG(A/G)GTGCC reference, missense, utr-variant-5-prime
rs14378 - 46,161,509(+) GGCTG(C/G/T)TGTGC reference, missense
rs2330398 -- 46,172,099(+) GAGGC(A/C/G)GGAGT intron-variant
rs2330399 -- 46,172,102(+) GCAGG(A/G)GTGCA intron-variant
rs2330400 -- 46,172,119(+) GAGGC(C/G)GGGGA intron-variant

Variation tolerance for SPATC1L Gene

Residual Variation Intolerance Score: 88.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.07; 87.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPATC1L Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SPATC1L Gene

Disorders for SPATC1L Gene

Relevant External Links for SPATC1L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SPATC1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPATC1L Gene

Publications for SPATC1L Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Identification of the human testis protein phosphatase 1 interactome. (PMID: 21382349) Fardilha M. … da Cruz e Silva E.F. (Biochem. Pharmacol. 2011) 3
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3

Products for SPATC1L Gene

Sources for SPATC1L Gene