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Aliases for SPATC1 Gene

Aliases for SPATC1 Gene

  • Spermatogenesis And Centriole Associated 1 2 3
  • Spermatogenesis And Centriole-Associated Protein 1 3 4
  • Spermatogenic Cell-Specific Cdc20-Binding Protein 3 4
  • Spermatogenesis-Associated Protein 15 3 4
  • SPATA15 3 4
  • SPRN 4

External Ids for SPATC1 Gene

Previous GeneCards Identifiers for SPATC1 Gene

  • GC08P145159
  • GC08P145086

Summaries for SPATC1 Gene

GeneCards Summary for SPATC1 Gene

SPATC1 (Spermatogenesis And Centriole Associated 1) is a Protein Coding gene. GO annotations related to this gene include gamma-tubulin binding. An important paralog of this gene is SPATC1L.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATC1 Gene

Genomics for SPATC1 Gene

Regulatory Elements for SPATC1 Gene

Genomic Location for SPATC1 Gene

144,010,993 bp from pter
144,047,114 bp from pter
36,122 bases
Plus strand

Genomic View for SPATC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPATC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATC1 Gene

Proteins for SPATC1 Gene

  • Protein details for SPATC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B4DWW9
    • Q5U5I8
    • Q7Z6L7

    Protein attributes for SPATC1 Gene

    591 amino acids
    Molecular mass:
    62399 Da
    Quaternary structure:
    • Found in a complex with CDC20, CDC27 and TUBG1. Interacts with CDC20 (By similarity).
    • Sequence=AAH50390.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH53547.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SPATC1 Gene


neXtProt entry for SPATC1 Gene

Proteomics data for SPATC1 Gene at MOPED

Post-translational modifications for SPATC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPATC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPATC1 Gene

Domains & Families for SPATC1 Gene

Protein Domains for SPATC1 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the speriolin family.
  • Belongs to the speriolin family.
genes like me logo Genes that share domains with SPATC1: view

No data available for Gene Families for SPATC1 Gene

Function for SPATC1 Gene

Phenotypes for SPATC1 Gene

genes like me logo Genes that share phenotypes with SPATC1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPATC1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPATC1 Gene

Localization for SPATC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPATC1 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with the centrosomal pericentrin protein PCNT1 (By similarity). Located in the connecting piece of sperm. {ECO:0000250, ECO:0000269 PubMed:20542897}.

Subcellular locations from

Jensen Localization Image for SPATC1 Gene COMPARTMENTS Subcellular localization image for SPATC1 gene
Compartment Confidence
cytoskeleton 5

Gene Ontology (GO) - Cellular Components for SPATC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 20542897
genes like me logo Genes that share ontologies with SPATC1: view

Pathways & Interactions for SPATC1 Gene

SuperPathways for SPATC1 Gene

No Data Available

Interacting Proteins for SPATC1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q76KD6-SPERI_HUMAN ENSP00000366690 for SPATC1 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for SPATC1 Gene


No data available for Pathways by source and SIGNOR curated interactions for SPATC1 Gene

Drugs & Compounds for SPATC1 Gene

No Compound Related Data Available

Transcripts for SPATC1 Gene

mRNA/cDNA for SPATC1 Gene

(7) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPATC1 Gene

Spermatogenesis and centriole associated 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPATC1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPATC1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP2: -

Relevant External Links for SPATC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPATC1 Gene

mRNA expression in normal human tissues for SPATC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPATC1 Gene

This gene is overexpressed in Testis (x32.6) and Whole Blood (x8.6).

Protein differential expression in normal tissues from HIPED for SPATC1 Gene

This gene is overexpressed in Lung (39.8) and Testis (29.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPATC1 Gene

SOURCE GeneReport for Unigene cluster for SPATC1 Gene Hs.97726

mRNA Expression by UniProt/SwissProt for SPATC1 Gene

Tissue specificity: Detected only in testis.
genes like me logo Genes that share expression patterns with SPATC1: view

Protein tissue co-expression partners for SPATC1 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for SPATC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPATC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SPATC1 35
  • 81.84 (n)
  • 75.43 (a)
  • 75 (a)
(Mus musculus)
Mammalia Spatc1 35
  • 77.83 (n)
  • 72.81 (a)
Spatc1 16
Spatc1 36
  • 67 (a)
(Pan troglodytes)
Mammalia SPATC1 35
  • 96.64 (n)
  • 94.23 (a)
  • 96 (a)
(Rattus norvegicus)
Mammalia Spatc1 35
  • 72.29 (n)
  • 70.2 (a)
(Canis familiaris)
Mammalia SPATC1 36
  • 55 (a)
(Monodelphis domestica)
Mammalia SPATC1 36
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia SPATC1 36
  • 45 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 54 (a)
-- 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
Species with no ortholog for SPATC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPATC1 Gene

Gene Tree for SPATC1 (if available)
Gene Tree for SPATC1 (if available)

Paralogs for SPATC1 Gene

Paralogs for SPATC1 Gene

(1) SIMAP similar genes for SPATC1 Gene using alignment to 1 proteins: Pseudogenes for SPATC1 Gene

genes like me logo Genes that share paralogs with SPATC1: view

Variants for SPATC1 Gene

Sequence variations from dbSNP and Humsavar for SPATC1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs4977178 -- 144,010,046(-) GGGCC(C/T)AGGTT upstream-variant-2KB
rs6985603 -- 144,012,260(+) TTGGC(A/C/G)AGACA upstream-variant-2KB, intron-variant
rs7832427 -- 144,042,340(+) ttgag(A/T)tggtg intron-variant
rs7835415 -- 144,038,503(+) ctgtc(A/G)cccag intron-variant
rs7835568 -- 144,038,611(+) ctggg(A/G)ctaca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPATC1 Gene

Variant ID Type Subtype PubMed ID
dgv7935n71 CNV Loss 21882294
dgv7940n71 CNV Loss 21882294
nsv891766 CNV Loss 21882294
dgv906n27 CNV Loss 19166990
nsv470249 CNV Loss 18288195
dgv7948n71 CNV Loss 21882294
dgv7949n71 CNV Loss 21882294
dgv7950n71 CNV Loss 21882294
nsv891787 CNV Gain+Loss 21882294
nsv515809 CNV Gain+Loss 19592680
nsv470250 CNV Gain 18288195
esv21567 CNV Gain 19812545
dgv7954n71 CNV Loss 21882294
nsv466014 CNV Loss 19166990
dgv7955n71 CNV Loss 21882294
nsv891807 CNV Loss 21882294
nsv6446 CNV Insertion 18451855
esv1010431 CNV Insertion 20482838
nsv428208 CNV Gain 18775914
nsv891809 CNV Loss 21882294
nsv824801 CNV Gain 20364138

Variation tolerance for SPATC1 Gene

Residual Variation Intolerance Score: 95.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.14; 61.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPATC1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATC1 Gene

Disorders for SPATC1 Gene

Relevant External Links for SPATC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SPATC1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPATC1 Gene

Publications for SPATC1 Gene

  1. Speriolin is a novel spermatogenic cell-specific centrosomal protein associated with the seventh WD motif of Cdc20. (PMID: 15280373) Goto M. … Eddy E.M. (J. Biol. Chem. 2004) 2 67
  2. Speriolin is a novel human and mouse sperm centrosome protein. (PMID: 20542897) Goto M. … Eddy E.M. (Hum. Reprod. 2010) 67
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67
  4. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for SPATC1 Gene

Sources for SPATC1 Gene

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