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Aliases for SPATC1 Gene

Aliases for SPATC1 Gene

  • Spermatogenesis And Centriole Associated 1 2 3
  • Spermatogenesis And Centriole-Associated Protein 1 3 4
  • Spermatogenic Cell-Specific Cdc20-Binding Protein 3 4
  • Spermatogenesis-Associated Protein 15 3 4
  • SPATA15 3 4
  • Speriolin 3
  • SPRN 4

External Ids for SPATC1 Gene

Summaries for SPATC1 Gene

GeneCards Summary for SPATC1 Gene

SPATC1 (Spermatogenesis And Centriole Associated 1) is a Protein Coding gene. GO annotations related to this gene include gamma-tubulin binding. An important paralog of this gene is SPATC1L.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATC1 Gene

Genomics for SPATC1 Gene

Genomic Location for SPATC1 Gene

Start:
144,012,414 bp from pter
End:
144,047,114 bp from pter
Size:
34,701 bases
Orientation:
Plus strand

Genomic View for SPATC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPATC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATC1 Gene

Regulatory Elements for SPATC1 Gene

Proteins for SPATC1 Gene

  • Protein details for SPATC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q76KD6-SPERI_HUMAN
    Recommended name:
    Speriolin
    Protein Accession:
    Q76KD6
    Secondary Accessions:
    • B4DWW9
    • Q5U5I8
    • Q7Z6L7

    Protein attributes for SPATC1 Gene

    Size:
    591 amino acids
    Molecular mass:
    62399 Da
    Quaternary structure:
    • Found in a complex with CDC20, CDC27 and TUBG1. Interacts with CDC20 (By similarity).
    SequenceCaution:
    • Sequence=AAH50390.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH53547.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SPATC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPATC1 Gene

Proteomics data for SPATC1 Gene at MOPED

Post-translational modifications for SPATC1 Gene

No Post-translational modifications

Other Protein References for SPATC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPATC1 Gene

Domains for SPATC1 Gene

Protein Domains for SPATC1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

SPERI_HUMAN
Family:
  • Belongs to the speriolin family.:
    • Q76KD6
genes like me logo Genes that share domains with SPATC1: view

No data available for Gene Families for SPATC1 Gene

Function for SPATC1 Gene

Gene Ontology (GO) - Molecular Function for SPATC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0043015 gamma-tubulin binding IEA --
genes like me logo Genes that share ontologies with SPATC1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SPATC1 Gene

Localization for SPATC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPATC1 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with the centrosomal pericentrin protein PCNT1 (By similarity). Located in the connecting piece of sperm. {ECO:0000250, ECO:0000269 PubMed:20542897}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPATC1 Gene COMPARTMENTS Subcellular localization image for SPATC1 gene
Compartment Confidence
cytoskeleton 5
cytosol 2
nucleus 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SPATC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 20542897
genes like me logo Genes that share ontologies with SPATC1: view

Pathways for SPATC1 Gene

SuperPathways for SPATC1 Gene

No Data Available

Interacting Proteins for SPATC1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000366690%0d%0a9606.ENSP00000308450%0d%0a9606.ENSP00000251413%0d%0a
Selected Interacting proteins: ENSP00000366690 Q76KD6-SPERI_HUMAN for SPATC1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SPATC1 Gene

None

No data available for Pathways by source for SPATC1 Gene

Transcripts for SPATC1 Gene

mRNA/cDNA for SPATC1 Gene

(7) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPATC1 Gene

Spermatogenesis and centriole associated 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPATC1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for SPATC1 Gene

GeneLoc Exon Structure for
SPATC1
ECgene alternative splicing isoforms for
SPATC1

Expression for SPATC1 Gene

mRNA expression in normal human tissues for SPATC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPATC1 Gene

This gene is overexpressed in Testis (32.6) and Whole Blood (8.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SPATC1 Gene

SOURCE GeneReport for Unigene cluster for SPATC1 Gene Hs.97726

mRNA Expression by UniProt/SwissProt for SPATC1 Gene

Q76KD6-SPERI_HUMAN
Tissue specificity: Detected only in testis.
genes like me logo Genes that share expressions with SPATC1: view

Orthologs for SPATC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPATC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPATC1 36
  • 96.64 (n)
  • 94.23 (a)
SPATC1 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPATC1 36
  • 81.84 (n)
  • 75.43 (a)
SPATC1 37
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPATC1 37
  • 55 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spatc1 36
  • 77.83 (n)
  • 72.81 (a)
Spatc1 16
Spatc1 37
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPATC1 37
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPATC1 37
  • 45 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spatc1 36
  • 72.29 (n)
  • 70.2 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 54 (a)
OneToMany
-- 37
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 27 (a)
OneToMany
Species with no ortholog for SPATC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPATC1 Gene

ENSEMBL:
Gene Tree for SPATC1 (if available)
TreeFam:
Gene Tree for SPATC1 (if available)

Paralogs for SPATC1 Gene

Paralogs for SPATC1 Gene

Selected SIMAP similar genes for SPATC1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SPATC1 Gene

genes like me logo Genes that share paralogs with SPATC1: view

Variants for SPATC1 Gene

Sequence variations from dbSNP and Humsavar for SPATC1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs6985603 -- 144,012,260(+) TTGGC(C/G)AGACA upstream-variant-2KB
rs9785117 -- 144,017,810(+) cctgc(A/C)aatgg intron-variant
rs11994057 -- 144,012,448(+) AGGCC(C/T)GGGGC utr-variant-5-prime
rs12335107 -- 144,014,925(+) TATGA(A/G)TGTGT intron-variant
rs34193472 -- 144,014,982(+) TAGCG(-/T)TTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPATC1 Gene

Variant ID Type Subtype PubMed ID
dgv7935n71 CNV Loss 21882294
dgv7940n71 CNV Loss 21882294
nsv891766 CNV Loss 21882294
dgv906n27 CNV Loss 19166990
nsv470249 CNV Loss 18288195
dgv7948n71 CNV Loss 21882294
dgv7949n71 CNV Loss 21882294
dgv7950n71 CNV Loss 21882294
nsv891787 CNV Gain+Loss 21882294
nsv515809 CNV Gain+Loss 19592680
nsv470250 CNV Gain 18288195
esv21567 CNV Gain 19812545
dgv7954n71 CNV Loss 21882294
nsv466014 CNV Loss 19166990
dgv7955n71 CNV Loss 21882294
nsv891807 CNV Loss 21882294
nsv6446 CNV Insertion 18451855
esv1010431 CNV Insertion 20482838
nsv428208 CNV Gain 18775914
nsv891809 CNV Loss 21882294
nsv824801 CNV Gain 20364138

Relevant External Links for SPATC1 Gene

HapMap Linkage Disequilibrium report
SPATC1

Disorders for SPATC1 Gene

No disorders were found for SPATC1 Gene.

No data available for UniProtKB/Swiss-Prot for SPATC1 Gene

Publications for SPATC1 Gene

  1. Speriolin is a novel spermatogenic cell-specific centrosomal protein associated with the seventh WD motif of Cdc20. (PMID: 15280373) Goto M. … Eddy E.M. (J. Biol. Chem. 2004) 2 3 4
  2. Speriolin is a novel human and mouse sperm centrosome protein. (PMID: 20542897) Goto M. … Eddy E.M. (Hum. Reprod. 2010) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 4

Products for SPATC1 Gene

Sources for SPATC1 Gene

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