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Aliases for SPATC1 Gene

Aliases for SPATC1 Gene

  • Spermatogenesis And Centriole Associated 1 2 3 5
  • Spermatogenesis And Centriole-Associated Protein 1 3 4
  • Spermatogenic Cell-Specific Cdc20-Binding Protein 3 4
  • Spermatogenesis-Associated Protein 15 3 4
  • SPATA15 3 4
  • Testicular Tissue Protein Li 181 3
  • Speriolin 3
  • SPRN 4

External Ids for SPATC1 Gene

Previous GeneCards Identifiers for SPATC1 Gene

  • GC08P145159
  • GC08P145086

Summaries for SPATC1 Gene

GeneCards Summary for SPATC1 Gene

SPATC1 (Spermatogenesis And Centriole Associated 1) is a Protein Coding gene. GO annotations related to this gene include gamma-tubulin binding. An important paralog of this gene is SPATC1L.

Additional gene information for SPATC1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATC1 Gene

Genomics for SPATC1 Gene

Regulatory Elements for SPATC1 Gene

Enhancers for SPATC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H144011 1.4 FANTOM5 Ensembl ENCODE 22 +1.5 1544 2.3 HDGF TBL1XR1 RELA FOSL1 ZNF316 POLR2A EED ATF7 ETV6 RUNX3 PLEC SPATC1 ENSG00000255224 GRINA PARP10
GH08H144014 1.5 FANTOM5 Ensembl ENCODE 16.5 +3.9 3879 0.9 ZSCAN4 INSM2 KLF17 SIN3A ZEB1 ZNF155 GLIS2 ZNF366 SCRT2 FOS ZNF7 ZNF250 ZNF623 ZNF251 VPS28 GPAA1 AK3P2 ZNF16 SPATC1 CPSF1
GH08H144073 1.6 FANTOM5 Ensembl ENCODE 15 +63.4 63404 1.2 HDGF PKNOX1 ATF1 ARNT TCF12 ZNF766 ELK1 ATF7 ZNF491 ZNF592 WDR97 ZNF251 ENSG00000254533 TSSK5P SPATC1 ENSG00000255085 CYC1 SHARPIN MAF1 ZNF252P
GH08H143968 1.6 Ensembl ENCODE dbSUPER 12 -36.8 -36754 11 HDGF FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 PLEC ZNF623 ZNF7 ZNF251 LRRC14 ZNF16 CPSF1 GPAA1 WDR97 ZNF707
GH08H144062 1.4 FANTOM5 ENCODE dbSUPER 13.4 +52.5 52509 2.3 ELF3 CTCF TFAP4 ZNF792 SAP130 ARID4B MAX RAD21 YY1 HIC1 WDR97 ENSG00000255224 SPATC1 CYC1 MAF1 SHARPIN PARP10 PLEC OPLAH MIR6846
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPATC1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SPATC1 Gene

Genomic Locations for SPATC1 Gene
chr8:144,010,993-144,047,114
(GRCh38/hg38)
Size:
36,122 bases
Orientation:
Plus strand
chr8:145,086,582-145,102,015
(GRCh37/hg19)

Genomic View for SPATC1 Gene

Genes around SPATC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATC1 Gene

Proteins for SPATC1 Gene

  • Protein details for SPATC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q76KD6-SPERI_HUMAN
    Recommended name:
    Speriolin
    Protein Accession:
    Q76KD6
    Secondary Accessions:
    • B4DWW9
    • Q5U5I8
    • Q7Z6L7

    Protein attributes for SPATC1 Gene

    Size:
    591 amino acids
    Molecular mass:
    62399 Da
    Quaternary structure:
    • Found in a complex with CDC20, CDC27 and TUBG1. Interacts with CDC20 (By similarity).
    SequenceCaution:
    • Sequence=AAH50390.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH53547.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SPATC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPATC1 Gene

Post-translational modifications for SPATC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SPATC1 Gene

Domains & Families for SPATC1 Gene

Gene Families for SPATC1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPATC1 Gene

Graphical View of Domain Structure for InterPro Entry

Q76KD6

UniProtKB/Swiss-Prot:

SPERI_HUMAN :
  • Belongs to the speriolin family.
Family:
  • Belongs to the speriolin family.
genes like me logo Genes that share domains with SPATC1: view

Function for SPATC1 Gene

Phenotypes From GWAS Catalog for SPATC1 Gene

genes like me logo Genes that share phenotypes with SPATC1: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPATC1 Gene

Localization for SPATC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPATC1 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with the centrosomal pericentrin protein PCNT1 (By similarity). Located in the connecting piece of sperm. {ECO:0000250, ECO:0000269 PubMed:20542897}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPATC1 gene
Compartment Confidence
cytoskeleton 5
nucleus 2
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SPATC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 20542897
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with SPATC1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SPATC1 Gene

Pathways & Interactions for SPATC1 Gene

SuperPathways for SPATC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPATC1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPATC1 Gene

Drugs & Compounds for SPATC1 Gene

No Compound Related Data Available

Transcripts for SPATC1 Gene

mRNA/cDNA for SPATC1 Gene

(8) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPATC1 Gene

Spermatogenesis and centriole associated 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPATC1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for SPATC1 Gene

GeneLoc Exon Structure for
SPATC1
ECgene alternative splicing isoforms for
SPATC1

Expression for SPATC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPATC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPATC1 Gene

This gene is overexpressed in Testis (x32.6) and Whole Blood (x8.6).

Protein differential expression in normal tissues from HIPED for SPATC1 Gene

This gene is overexpressed in Lung (39.8) and Testis (29.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPATC1 Gene



Protein tissue co-expression partners for SPATC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPATC1 Gene:

SPATC1

SOURCE GeneReport for Unigene cluster for SPATC1 Gene:

Hs.97726

mRNA Expression by UniProt/SwissProt for SPATC1 Gene:

Q76KD6-SPERI_HUMAN
Tissue specificity: Detected only in testis.

Evidence on tissue expression from TISSUES for SPATC1 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with SPATC1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SPATC1 Gene

Orthologs for SPATC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPATC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPATC1 33 34
  • 96.64 (n)
cow
(Bos Taurus)
Mammalia SPATC1 33 34
  • 81.84 (n)
mouse
(Mus musculus)
Mammalia Spatc1 33 16 34
  • 77.83 (n)
rat
(Rattus norvegicus)
Mammalia Spatc1 33
  • 72.29 (n)
dog
(Canis familiaris)
Mammalia SPATC1 34
  • 55 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPATC1 34
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPATC1 34
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 54 (a)
OneToMany
-- 34
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 27 (a)
OneToMany
Species where no ortholog for SPATC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPATC1 Gene

ENSEMBL:
Gene Tree for SPATC1 (if available)
TreeFam:
Gene Tree for SPATC1 (if available)

Paralogs for SPATC1 Gene

Paralogs for SPATC1 Gene

(1) SIMAP similar genes for SPATC1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPATC1: view

Variants for SPATC1 Gene

Sequence variations from dbSNP and Humsavar for SPATC1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000037876 -- 144,024,288(+) TCCCT(C/T)AAGAC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000043826 -- 144,044,904(+) AGATC(A/G)AACCA intron-variant
rs1000049636 -- 144,031,225(+) CTCAG(C/T)TTTTG intron-variant
rs1000104779 -- 144,031,449(+) TTTTT(C/T)CTTTT intron-variant
rs1000322106 -- 144,024,821(+) CCCTC(C/T)TCCCT intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SPATC1 Gene

Variant ID Type Subtype PubMed ID
nsv950015 CNV deletion 24416366
nsv824801 CNV gain 20364138
nsv6446 CNV insertion 18451855
nsv612917 CNV loss 21841781
nsv612916 CNV loss 21841781
nsv612915 CNV loss 21841781
nsv612914 CNV loss 21841781
nsv612907 CNV gain+loss 21841781
nsv612906 CNV loss 21841781
nsv515809 CNV gain+loss 19592680
nsv470250 CNV gain 18288195
nsv470249 CNV loss 18288195
nsv466014 CNV loss 19166990
nsv428208 CNV gain 18775914
nsv1161815 CNV deletion 26073780
nsv1025071 CNV gain 25217958
esv3423156 CNV duplication 20981092
esv21567 CNV gain 19812545
esv1010431 CNV insertion 20482838
dgv906n27 CNV loss 19166990
dgv12433n54 CNV gain 21841781
dgv12431n54 CNV loss 21841781

Variation tolerance for SPATC1 Gene

Residual Variation Intolerance Score: 95.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.14; 61.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPATC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPATC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATC1 Gene

Disorders for SPATC1 Gene

Relevant External Links for SPATC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPATC1

No disorders were found for SPATC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPATC1 Gene

Publications for SPATC1 Gene

  1. Speriolin is a novel spermatogenic cell-specific centrosomal protein associated with the seventh WD motif of Cdc20. (PMID: 15280373) Goto M … Eddy EM (The Journal of biological chemistry 2004) 2 3 4 60
  2. Speriolin is a novel human and mouse sperm centrosome protein. (PMID: 20542897) Goto M … Eddy EM (Human reproduction (Oxford, England) 2010) 3 4 60
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60
  4. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 4 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 60

Products for SPATC1 Gene

Sources for SPATC1 Gene

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