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Aliases for SPATA8 Gene

Aliases for SPATA8 Gene

  • Spermatogenesis Associated 8 2 3 5
  • Spermatogenesis-Related Protein 8 3 4
  • Spermatogenesis-Associated Protein 8 3
  • Testicular Secretory Protein Li 52 3
  • SRG8 3

External Ids for SPATA8 Gene

Previous GeneCards Identifiers for SPATA8 Gene

  • GC15P095128
  • GC15P097326
  • GC15P073456

Summaries for SPATA8 Gene

GeneCards Summary for SPATA8 Gene

SPATA8 (Spermatogenesis Associated 8) is a Protein Coding gene.

Additional gene information for SPATA8 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATA8 Gene

Genomics for SPATA8 Gene

GeneHancer (GH) Regulatory Elements for SPATA8 Gene

Promoters and enhancers for SPATA8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I096783 Promoter 0.5 EPDnew 550.8 +0.1 62 0.1 GC15M098985 GC15M098986 GC15M098993 GC15M098997 GC15M098998 GC15M098999 GC15M099007 GC15M099025 GC15M099026 GC15M099037
GH15I096782 Enhancer 0.3 FANTOM5 559.7 -0.8 -794 0.4 ZNF680 SPATA8 GC15M098984 GC15M098985 GC15M098986 GC15M098993 GC15M098997 GC15M098998 GC15M098999 GC15M099007 GC15M099008
GH15I096728 Enhancer 0.6 UCNEbase 11.9 -55.0 -55017 0.5 MAX FEZF1 MYC SPATA8 GC15P096723 PIRC79
GH15I096891 Enhancer 0.7 UCNEbase ENCODE 10.2 +107.9 107947 0.3 EZH2 SPATA8 GC15M099095 RN7SKP181
GH15I096848 Enhancer 0.6 VISTA UCNEbase 11 +65.7 65701 1.4 SPATA8 RN7SKP181 GC15M099095
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPATA8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPATA8 gene promoter:

Genomic Locations for SPATA8 Gene

Genomic Locations for SPATA8 Gene
chr15:96,783,389-96,785,615
(GRCh38/hg38)
Size:
2,227 bases
Orientation:
Plus strand
chr15:97,326,619-97,328,845
(GRCh37/hg19)

Genomic View for SPATA8 Gene

Genes around SPATA8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATA8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATA8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA8 Gene

Proteins for SPATA8 Gene

  • Protein details for SPATA8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6RVD6-SPAT8_HUMAN
    Recommended name:
    Spermatogenesis-associated protein 8
    Protein Accession:
    Q6RVD6
    Secondary Accessions:
    • Q2KJ07

    Protein attributes for SPATA8 Gene

    Size:
    105 amino acids
    Molecular mass:
    11727 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPATA8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPATA8 Gene

Post-translational modifications for SPATA8 Gene

No Post-translational modifications

Other Protein References for SPATA8 Gene

No data available for DME Specific Peptides for SPATA8 Gene

Domains & Families for SPATA8 Gene

Gene Families for SPATA8 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPATA8 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for SPATA8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPATA8: view

No data available for UniProtKB/Swiss-Prot for SPATA8 Gene

Function for SPATA8 Gene

Phenotypes From GWAS Catalog for SPATA8 Gene

Gene Ontology (GO) - Molecular Function for SPATA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with SPATA8: view

Phenotypes for SPATA8 Gene

genes like me logo Genes that share phenotypes with SPATA8: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPATA8 Gene

Localization for SPATA8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPATA8 gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SPATA8 Gene

Pathways & Interactions for SPATA8 Gene

SuperPathways for SPATA8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPATA8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPATA8 Gene

Drugs & Compounds for SPATA8 Gene

No Compound Related Data Available

Transcripts for SPATA8 Gene

Unigene Clusters for SPATA8 Gene

Spermatogenesis associated 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA8 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c
SP1: -
SP2:
SP3: - -

Relevant External Links for SPATA8 Gene

GeneLoc Exon Structure for
SPATA8
ECgene alternative splicing isoforms for
SPATA8

Expression for SPATA8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPATA8 Gene

mRNA differential expression in normal tissues according to GTEx for SPATA8 Gene

This gene is overexpressed in Testis (x52.4).

Protein differential expression in normal tissues from HIPED for SPATA8 Gene

This gene is overexpressed in Colon muscle (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPATA8 Gene



Protein tissue co-expression partners for SPATA8 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPATA8 Gene:

SPATA8

SOURCE GeneReport for Unigene cluster for SPATA8 Gene:

Hs.326528

mRNA Expression by UniProt/SwissProt for SPATA8 Gene:

Q6RVD6-SPAT8_HUMAN
Tissue specificity: Expressed at high levels in adult testis, at moderate levels in sperm and at low levels in fetal testis. Not detected in other tissues.
genes like me logo Genes that share expression patterns with SPATA8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPATA8 Gene

Orthologs for SPATA8 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SPATA8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPATA8 33 34
  • 99.37 (n)
Species where no ortholog for SPATA8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPATA8 Gene

ENSEMBL:
Gene Tree for SPATA8 (if available)
TreeFam:
Gene Tree for SPATA8 (if available)

Paralogs for SPATA8 Gene

No data available for Paralogs for SPATA8 Gene

Variants for SPATA8 Gene

Sequence variations from dbSNP and Humsavar for SPATA8 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1001149879 -- 96,785,489(+) G/C 3_prime_UTR_variant
rs1001571846 -- 96,782,451(+) G/A upstream_transcript_variant
rs1002001250 -- 96,782,194(+) C/T upstream_transcript_variant
rs1003047768 -- 96,783,242(+) C/T upstream_transcript_variant
rs1003163631 -- 96,782,970(+) T/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SPATA8 Gene

Variant ID Type Subtype PubMed ID
esv3892734 CNV loss 25118596
nsv522924 CNV gain 19592680

Variation tolerance for SPATA8 Gene

Residual Variation Intolerance Score: 88.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.46; 54.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPATA8 Gene

Human Gene Mutation Database (HGMD)
SPATA8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPATA8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATA8 Gene

Disorders for SPATA8 Gene

Additional Disease Information for SPATA8

No disorders were found for SPATA8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPATA8 Gene

Publications for SPATA8 Gene

  1. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PMID: 18951430) Anney RJ … Gill M (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 44 58
  2. Molecular cloning and characterization of a novel human testis-specific gene by use of digital differential display. (PMID: 16809841) Nie D … Xiang Y (Journal of genetics 2006) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Association Study of a Proliferation-inducing Ligand, Spermatogenesis Associated 8, Platelet-derived Growth Factor Receptor-alpha, and POLB Polymorphisms with Systemic Lupus Erythematosus in Chinese Han Population. (PMID: 27569236) Li P … Li YZ (Chinese medical journal 2016) 3 58

Products for SPATA8 Gene

Sources for SPATA8 Gene

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