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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPATA8 Gene

protein-coding   GIFtS: 38
GCID: GC15P097326

Spermatogenesis Associated 8

  Search for SPATA8
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Spermatogenesis Associated 81 2
Spermatogenesis-Related Protein 82 3
SRG82
Spermatogenesis-Associated Protein 82

External Ids:    HGNC: 286761   Entrez Gene: 1459462   Ensembl: ENSG000001855947   OMIM: 6139485   UniProtKB: Q6RVD63   

Export aliases for SPATA8 gene to outside databases

Previous GC identifers: GC15P095128 GC15P073456


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SPATA8 Gene: 
SPATA8 (spermatogenesis associated 8) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.2  NT_010274.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPATA8 gene promoter:
         Oct-B1   GR   oct-B3   oct-B2   AML1a   GR-beta   HTF   AREB6   POU2F1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPATA8 promoter sequence
   Search SABiosciences Chromatin IP Primers for SPATA8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPATA8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.2   Ensembl cytogenetic band:  15q26.2   HGNC cytogenetic band: 15q26

SPATA8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPATA8 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P097326:  view genomic region     (about GC identifiers)

Start:
97,326,619 bp from pter      End:
97,328,845 bp from pter
Size:
2,227 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPAT8_HUMAN, Q6RVD6 (See protein sequence)
Recommended Name: Spermatogenesis-associated protein 8  
Size: 105 amino acids; 11727 Da
Secondary accessions: Q2KJ07
Alternative splicing: 2 isoforms:  Q6RVD6-1   Q6RVD6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SPATA8: NX_Q6RVD6

Explore proteomics data for SPATA8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6RVD6

  • SPATA8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SPATA8 Protein Expression
    REFSEQ proteins: NP_775770.1  
    ENSEMBL proteins: 
     ENSP00000328149   ENSP00000453026  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q6RVD6


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SPATA8 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPATA8

    1 Interacting protein for SPATA8 (Q6RVD63) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBPMSQ930623I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPATA8 (SPAT8)

    Search CenterWatch for drugs/clinical trials and news about SPATA8 / SPAT8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SPATA8 gene: 
    NM_173499.3  

    Unigene Cluster for SPATA8:

    Spermatogenesis associated 8
    Hs.326528  [show with all ESTs]
    Unigene Representative Sequence: BC112390
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328504(uc002bue.3) ENST00000561002 ENST00000558553 ENST00000560327

    miRNA
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    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPATA8

    Additional mRNA sequence: 

    AY489187.1 BC033979.2 BC066292.1 BC112390.1 

    4 DOTS entries:

    DT.209645  DT.92012669  DT.100748414  DT.100748413 

    24/46 AceView cDNA sequences (see all 46):

    AA399652 BM553033 AW293729 AW274919 BC033979 AI916811 CD243868 AI953138 
    BI831484 AA861167 AI638541 NM_173499 AI190889 AW003840 AI125837 BI827393 
    AA398750 AI336937 BI831201 BC066292 AI014962 BG722505 BI825151 BI825859 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SPATA8    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c
    SP1:                    -                           
    SP2:                                                
    SP3:              -     -                           


    ECgene alternative splicing isoforms for SPATA8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPATA8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTTTTCTG
    SPATA8 Expression
    About this image


    See SPATA8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPATA8

    SOURCE GeneReport for Unigene cluster: Hs.326528

    UniProtKB/Swiss-Prot: SPAT8_HUMAN, Q6RVD6
    Tissue specificity: Expressed at high levels in adult testis, at moderate levels in sperm and at low levels in
    fetal testis. Not detected in other tissues

        SABiosciences Custom PCR Arrays for SPATA8
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPATA8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and chimp.

    Orthologs for SPATA8 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia SPATA81 spermatogenesis associated 8 99.37(n)
    98.1(a)
      736234  XM_001135799.2  XP_001135799.1 


    ENSEMBL Gene Tree for SPATA8 (if available)
    TreeFam Gene Tree for SPATA8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPATA8 gene

    SPATA8 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SPATA8
    PGOHUM00000262114


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/30 SNPs in SPATA8 are shown (see all 30)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1860481391,2
    --97328689(+) AGATTC/TTCTTC 1 -- ut310--------
    rs585246871,2
    C--97328855(+) TTTTT-/T/TTT 
            
    GTTTG
    2 -- int1 cds10--------
    rs2018668541,2
    --97328862(+) TTTTT-/GTTTTT 1 -- int10--------
    rs2004389651,2
    --97328863(+) TTTTT-/GTTTTT 1 -- int10--------
    rs129040271,2
    C,F--97328866(+) TTTTTG/TTTTGT 1 -- int15Minor allele frequency- T:0.22NA CSA 9
    rs1131373071,2
    C--97328866(+) TTTTTG/-TTTGT 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs3690606491,2
    C--97328867(+) TTTTT-/G/GT  
            
    TTGTT
    1 -- int10--------
    rs759915311,2
    --97328870(+) TTTTTG/TTTTGT 1 -- int10--------
    rs1482847701,2
    --97328878(+) TGTTT-/GTTTTT 1 -- int10--------
    rs2018295581,2
    C--97328878(+) TGTTTG/TTTTTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for SPATA8 (97326619 - 97328845 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SPATA8:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv904533CNV Loss21882294
    nsv522924CNV Gain19592680


    Human Gene Mutation Database (HGMD): SPATA8
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for SPATA8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SPATA8 for disorders           About MalaCards
    OMIM gene information: 613948    OMIM disorders: --


    SPATA8 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SPATA8

    Export disorders for SPATA8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPATA8 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SPATA8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PubMed id 18951430)1, 4 Anney R.J....Gill M. (2008)
    2. Molecular cloning and characterization of a novel hum an testis-specific gene by use of digital differential display. (PubMed id 16809841)1, 2 Nie D. and Xiang Y. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    6. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (2007)
    7. Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data. (PubMed id 17052657)4 Fung H.C....Singleton A. (2006)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 145946 HGNC: 28676 AceView: MGC44294 Ensembl:ENSG00000185594 euGenes: HUgn145946
    ECgene: SPATA8 H-InvDB: SPATA8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPATA8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SPATA8 gene:
    Search GeneIP for patents involving SPATA8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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     Regulatory tfbs in SPATA8 promoter
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     SABiosciences Custom PCR Arrays for SPATA8
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
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     Proteins for SPATA8
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPATA8
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SPATA8
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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