SPATA6L Gene
protein-coding GIFtS: 35
GCID: GC09M004553
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spermatogenesis associated 6-like(Previous name: chromosome 9 open reading frame 68 )
(Previous symbol: C9orf68)
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Aliases
for SPATA6L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Spermatogenesis Associated 6-Like1 2 | | C9orf681 2 3 | | FLJ100581 | | Chromosome 9 Open Reading Frame 681 | | BA6J24.21 | | Spermatogenesis Associated 6-Like Protein2 |
Export aliases for SPATA6L gene to outside databases |
Summaries
for SPATA6L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SPATA6L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for SPATA6L
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPATA6L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPATA6L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p24.2 Ensembl cytogenetic band: 9p24.1 HGNC cytogenetic band: 9p24.2SPATA6L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M004553: view genomic region
(about GC identifiers)
Start:
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4,553,386 bp from pter |
End:
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4,666,674 bp from pter |
Size:
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113,289 bases |
Orientation:
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minus strand |
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Proteins
for SPATA6L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPA6L_HUMAN, Q8N4H0 (See
protein sequence)Recommended Name: Spermatogenesis associated 6-like protein Size: 392 amino acids; 45058 Da
Secondary accessions: B4DIY4 Q5JVJ5 Q8IY90Alternative splicing: 3 isoforms: Q8N4H0-1 Q8N4H0-2 Q8N4H0-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SPATA6L: NX_Q8N4H0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N4H0
SPATA6L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001034484.3
ENSEMBL proteins: ENSP00000420003 ENSP00000418458 ENSP00000417965 ENSP00000371314 ENSP00000417063 ENSP00000384342 ENSP00000404277 ENSP00000371319
Human Recombinant Protein Products for SPATA6L:
SPATA6L Antibody Products:
Assay Products for SPATA6L: |
Protein
Domains /
Families
for SPATA6L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPATA6L for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8N4H0ProtoNet protein and cluster: Q8N4H0 UniProtKB/Swiss-Prot: SPA6L_HUMAN, Q8N4H0Similarity: Belongs to the SPATA6 family |
Function
for SPATA6L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
1 GenomeRNAi human phenotype for SPATA6L:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA6L
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA6L
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for SPATA6L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPATA6L |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPATA6L |
|
Pathways & Interactions
for SPATA6L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPATA6L
|
Drugs & Compounds
for SPATA6L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPATA6L
Search CenterWatch for drugs/clinical trials and news about SPATA6L / SPA6L
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Transcripts
for SPATA6L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPATA6L gene (2 alternative transcripts): NM_017985.3 NM_001039395.3 Unigene Cluster for SPATA6L: Spermatogenesis associated 6-like Hs.179615 [show with all ESTs]Unigene Representative Sequence: BX64903015 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000485616(uc003zik.3) ENST00000461761 ENST00000486047(uc003zil.3)
ENST00000381890 ENST00000475086 ENST00000406861 ENST00000223517 ENST00000496798
ENST00000498087 ENST00000451763(uc003zim.3) ENST00000485981 ENST00000471669
ENST00000497383 ENST00000454239(uc011lly.2 uc011llz.2) ENST00000381895
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA6L
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA6L
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for SPATA6L | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPATA6L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPATA6L |
Additional cDNA sequence: AK295831.1 AK301790.1 BX649030.1 11 DOTS entries: DT.202845 DT.95255315 DT.109787 DT.100019583 DT.101976926 DT.75169274 DT.100747449 DT.121143597 DT.121143605 DT.75126405 DT.121143554 24/29 AceView cDNA sequences (see all 29): BI826180 AI354943 BI520328 BX100219 AU117437 BF194854 AL603321 BC034293 AK000920 BC036349 BM982488 AW611804 AA936404 AI695191 BX649030 AW135596 NM_017985 BP369387 BI827091 AW246362 AA609149 AW246578 AI806217 BQ016484
GeneLoc Exon Structure
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Expression
for SPATA6L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPATA6L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGGGGCAAG
About this image
See SPATA6L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPATA6L
SOURCE GeneReport for Unigene cluster: Hs.179615
SABiosciences Custom PCR Arrays for SPATA6L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPATA6L
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat SPATA6L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPATA6L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPATA6L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPATA6L |
Orthologs
for SPATA6L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SPATA6L gene from 2/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.108302 |
Xenopus laevis transcribed sequence with weak similarity more |
75.28(n) |
|
BJ074900.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
BC054618.12 |
-- |
72.7(n) |
|
393384 BC054618.1 |
Species with no ortholog for SPATA6L
ENSEMBL Gene Tree for SPATA6L (if available)
TreeFam Gene Tree for SPATA6L (if available) |
Paralogs
for SPATA6L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SPATA6L gene
- SPATA62
1 SIMAP similar gene for SPATA6L using alignment to 4 protein entries: SPA6L_HUMAN (see all proteins):SPATA6
SPATA6L for paralogs About GeneDecksing
|
Genomic Variants
for SPATA6L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SPATA6L (4553386 - 4666674 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SPATA6L: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPATA6L |
|
Disorders
/ Diseases
for SPATA6L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for SPATA6L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPATA6L gene integrated from 9 sources:
(articles sorted by number of sources associating them with SPATA6L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for SPATA6L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SPATA6L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPATA6L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPATA6L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPATA6L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SPATA6L gene:
Search GeneIP for patents involving SPATA6L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPATA6L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPATA6L | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPATA6L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPATA6L | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPATA6L | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA6L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA6L | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for SPATA6L |
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 | | | SPATA6L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPATA6L |
|  |  |  |  | | | | Search ThermoFisher Antibodies for SPATA6L |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPATA6L |
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