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Aliases for SPATA6 Gene

Aliases for SPATA6 Gene

  • Spermatogenesis Associated 6 2 3
  • Spermatogenesis-Related Factor-1 2 3
  • HASH 3 6
  • SRF1 3 6
  • Spermatogenesis-Associated Protein 6 3
  • SRF-1 3

External Ids for SPATA6 Gene

Previous GeneCards Identifiers for SPATA6 Gene

  • GC01M048388
  • GC01M047653
  • GC01M048085
  • GC01M048134
  • GC01M048476
  • GC01M048536
  • GC01M048763
  • GC01M046877

Summaries for SPATA6 Gene

GeneCards Summary for SPATA6 Gene

SPATA6 (Spermatogenesis Associated 6) is a Protein Coding gene. An important paralog of this gene is SPATA6L.

UniProtKB/Swiss-Prot for SPATA6 Gene

  • Required for formation of the sperm connecting piece during spermiogenesis. Sperm connecting piece is essential for linking the developing flagellum to the head during late spermiogenesis. May be involved in myosin-based microfilament transport through interaction with myosin subunits.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATA6 Gene

Genomics for SPATA6 Gene

Regulatory Elements for SPATA6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SPATA6 Gene

Start:
48,260,553 bp from pter
End:
48,472,208 bp from pter
Size:
211,656 bases
Orientation:
Minus strand

Genomic View for SPATA6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPATA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA6 Gene

Proteins for SPATA6 Gene

  • Protein details for SPATA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWH7-SPAT6_HUMAN
    Recommended name:
    Spermatogenesis-associated protein 6
    Protein Accession:
    Q9NWH7
    Secondary Accessions:
    • Q5T3N7
    • Q8WUE6

    Protein attributes for SPATA6 Gene

    Size:
    488 amino acids
    Molecular mass:
    55989 Da
    Quaternary structure:
    • Interacts with MYL6.

    Alternative splice isoforms for SPATA6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPATA6 Gene

Proteomics data for SPATA6 Gene at MOPED

Post-translational modifications for SPATA6 Gene

  • Glycosylation at Asn181
  • Modification sites at PhosphoSitePlus

Other Protein References for SPATA6 Gene

No data available for DME Specific Peptides for SPATA6 Gene

Domains for SPATA6 Gene

Protein Domains for SPATA6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPATA6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NWH7

UniProtKB/Swiss-Prot:

SPAT6_HUMAN :
  • Q9NWH7
Family:
  • Belongs to the SPATA6 family.
genes like me logo Genes that share domains with SPATA6: view

No data available for Gene Families for SPATA6 Gene

Function for SPATA6 Gene

Molecular function for SPATA6 Gene

UniProtKB/Swiss-Prot Function: Required for formation of the sperm connecting piece during spermiogenesis. Sperm connecting piece is essential for linking the developing flagellum to the head during late spermiogenesis. May be involved in myosin-based microfilament transport through interaction with myosin subunits.

Phenotypes for SPATA6 Gene

genes like me logo Genes that share phenotypes with SPATA6: view

Animal Model Products

CRISPR Products

miRNA for SPATA6 Gene

miRTarBase miRNAs that target SPATA6

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for SPATA6 Gene

Localization for SPATA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPATA6 Gene

Secreted. Cell projection, cilium, flagellum. Note=Specifically localizes to the segmented columns and the capitulum of the sperm connecting piece. {ECO:0000250 UniProtKB:Q3U6K5}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPATA6 Gene COMPARTMENTS Subcellular localization image for SPATA6 gene
Compartment Confidence
extracellular 3
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SPATA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0097224 sperm connecting piece ISS --
genes like me logo Genes that share ontologies with SPATA6: view

Pathways for SPATA6 Gene

SuperPathways for SPATA6 Gene

No Data Available

Interacting Proteins for SPATA6 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000360913%0d%0a9606.ENSP00000254108%0d%0a
Selected Interacting proteins: ENSP00000360913 for SPATA6 Gene via STRING

Symbol External ID(s) Details
FUS

Gene Ontology (GO) - Biological Process for SPATA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis ISS --
GO:0030154 cell differentiation IEA --
GO:0044458 motile cilium assembly ISS --
genes like me logo Genes that share ontologies with SPATA6: view

No data available for Pathways by source for SPATA6 Gene

Transcripts for SPATA6 Gene

Unigene Clusters for SPATA6 Gene

Spermatogenesis associated 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPATA6

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SPATA6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA6 Gene

No ASD Table

Relevant External Links for SPATA6 Gene

GeneLoc Exon Structure for
SPATA6
ECgene alternative splicing isoforms for
SPATA6

Expression for SPATA6 Gene

mRNA expression in normal human tissues for SPATA6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPATA6 Gene

This gene is overexpressed in Testis (6.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SPATA6 Gene

SOURCE GeneReport for Unigene cluster for SPATA6 Gene Hs.538103

genes like me logo Genes that share expressions with SPATA6: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SPATA6 Gene

Orthologs for SPATA6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPATA6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPATA6 35
  • 99.65 (n)
  • 99.58 (a)
SPATA6 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPATA6 35
  • 92.62 (n)
  • 92.62 (a)
SPATA6 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPATA6 35
  • 94.66 (n)
  • 93.46 (a)
SPATA6 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spata6 35
  • 90.37 (n)
  • 90.08 (a)
Spata6 16
Spata6 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPATA6 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPATA6 36
  • 32 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spata6 35
  • 90.51 (n)
  • 89.87 (a)
chicken
(Gallus gallus)
Aves SPATA6 35
  • 63.97 (n)
  • 54.05 (a)
SPATA6 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPATA6 36
  • 47 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33502 35
zebrafish
(Danio rerio)
Actinopterygii spata6 35
  • 49.22 (n)
  • 39.84 (a)
spata6 36
  • 37 (a)
OneToOne
Species with no ortholog for SPATA6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPATA6 Gene

ENSEMBL:
Gene Tree for SPATA6 (if available)
TreeFam:
Gene Tree for SPATA6 (if available)

Paralogs for SPATA6 Gene

Paralogs for SPATA6 Gene

Selected SIMAP similar genes for SPATA6 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SPATA6: view

Variants for SPATA6 Gene

Sequence variations from dbSNP and Humsavar for SPATA6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs127724 -- 48,269,176(-) GAATA(C/T)GTATA intron-variant
rs169877 -- 48,261,380(+) CGGAT(A/G)TTCAG utr-variant-3-prime
rs177112 -- 48,267,226(+) tgagg(C/T)gggca intron-variant
rs183326 -- 48,267,548(+) gaagt(C/T)ggccg intron-variant
rs212945 -- 48,262,654(+) TAATG(C/T)TAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPATA6 Gene

Variant ID Type Subtype PubMed ID
nsv871053 CNV Gain 21882294
nsv508182 CNV Loss 20534489
nsv870765 CNV Loss 21882294
esv2566377 CNV Deletion 19546169
nsv461461 CNV Gain 19166990

Relevant External Links for SPATA6 Gene

HapMap Linkage Disequilibrium report
SPATA6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATA6 Gene

Disorders for SPATA6 Gene

No disorders were found for SPATA6 Gene.

No data available for UniProtKB/Swiss-Prot for SPATA6 Gene

Publications for SPATA6 Gene

  1. Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin- containing protein/p97 during capacitation. (PMID: 12509440) Ficarro S. … Visconti P.E. (J. Biol. Chem. 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3

Products for SPATA6 Gene

Sources for SPATA6 Gene

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