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Aliases for SPATA5L1 Gene

Aliases for SPATA5L1 Gene

  • Spermatogenesis Associated 5-Like 1 2 3
  • EC 63
  • EC 3.4.24 63

External Ids for SPATA5L1 Gene

Summaries for SPATA5L1 Gene

GeneCards Summary for SPATA5L1 Gene

SPATA5L1 (Spermatogenesis Associated 5-Like 1) is a Protein Coding gene. GO annotations related to this gene include nucleoside-triphosphatase activity and polyubiquitin binding. An important paralog of this gene is SPATA5.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATA5L1 Gene

Genomics for SPATA5L1 Gene

Genomic Location for SPATA5L1 Gene

45,402,321 bp from pter
45,421,419 bp from pter
19,099 bases
Plus strand

Genomic View for SPATA5L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPATA5L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA5L1 Gene

Regulatory Elements for SPATA5L1 Gene

Proteins for SPATA5L1 Gene

  • Protein details for SPATA5L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Spermatogenesis-associated protein 5-like protein 1
    Protein Accession:
    Secondary Accessions:
    • C9JHR5
    • Q9H8W7
    • Q9HA41

    Protein attributes for SPATA5L1 Gene

    753 amino acids
    Molecular mass:
    80710 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPATA5L1 Gene


neXtProt entry for SPATA5L1 Gene

Proteomics data for SPATA5L1 Gene at MOPED

Selected DME Specific Peptides for SPATA5L1 Gene

Post-translational modifications for SPATA5L1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys48, Lys247, Lys372, Lys485, Lys499, Lys511, Lys577, and Lys600

Other Protein References for SPATA5L1 Gene

Domains for SPATA5L1 Gene

Gene Families for SPATA5L1 Gene

  • AATP :ATPases / AAA-type

Protein Domains for SPATA5L1 Gene

Suggested Antigen Peptide Sequences for SPATA5L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AAA ATPase family. AFG2 subfamily.:
    • Q9BVQ7
genes like me logo Genes that share domains with SPATA5L1: view

Function for SPATA5L1 Gene

Enzyme Numbers (IUBMB) for SPATA5L1 Gene

Gene Ontology (GO) - Molecular Function for SPATA5L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0009378 four-way junction helicase activity --
GO:0016887 ATPase activity --
genes like me logo Genes that share ontologies with SPATA5L1: view

Phenotypes for SPATA5L1 Gene

GenomeRNAi human phenotypes for SPATA5L1:
genes like me logo Genes that share phenotypes with SPATA5L1: view

No data available for Molecular function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SPATA5L1 Gene

Localization for SPATA5L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPATA5L1 Gene


Subcellular locations from

Jensen Localization Image for SPATA5L1 Gene COMPARTMENTS Subcellular localization image for SPATA5L1 gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for SPATA5L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SPATA5L1: view

Pathways for SPATA5L1 Gene

SuperPathways for SPATA5L1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPATA5L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair --
GO:0006310 DNA recombination --
genes like me logo Genes that share ontologies with SPATA5L1: view

No data available for Pathways by source for SPATA5L1 Gene

Transcripts for SPATA5L1 Gene

Unigene Clusters for SPATA5L1 Gene

Spermatogenesis associated 5-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA5L1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP2: -
SP3: - -
SP4: - - -
SP6: - -

Relevant External Links for SPATA5L1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPATA5L1 Gene

mRNA expression in normal human tissues for SPATA5L1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPATA5L1 Gene

SOURCE GeneReport for Unigene cluster for SPATA5L1 Gene Hs.369657

genes like me logo Genes that share expressions with SPATA5L1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPATA5L1 Gene

Orthologs for SPATA5L1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SPATA5L1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPATA5L1 35
  • 96.72 (n)
  • 94.69 (a)
  • 96 (a)
(Bos Taurus)
Mammalia SPATA5L1 35
  • 86.63 (n)
  • 84.86 (a)
  • 83 (a)
(Canis familiaris)
Mammalia SPATA5L1 35
  • 87.43 (n)
  • 88.18 (a)
  • 84 (a)
(Mus musculus)
Mammalia Spata5l1 35
  • 81.97 (n)
  • 80.89 (a)
Spata5l1 16
(Monodelphis domestica)
Mammalia SPATA5L1 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia SPATA5L1 36
  • 61 (a)
(Rattus norvegicus)
Mammalia Spata5l1 35
  • 80.93 (n)
  • 80.35 (a)
(Gallus gallus)
Aves SPATA5L1 35
  • 66.8 (n)
  • 64.28 (a)
  • 60 (a)
(Anolis carolinensis)
Reptilia SPATA5L1 36
  • 56 (a)
(Danio rerio)
Actinopterygii spata5l1 35
  • 56.59 (n)
  • 54.29 (a)
spata5l1 36
  • 51 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12010 36
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AFG2 36
  • 32 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons CDC48B 35
  • 50.26 (n)
  • 45.02 (a)
(Oryza sativa)
Liliopsida Os05g0376200 35
  • 51.35 (n)
  • 47.11 (a)
Species with no ortholog for SPATA5L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPATA5L1 Gene

Gene Tree for SPATA5L1 (if available)
Gene Tree for SPATA5L1 (if available)

Paralogs for SPATA5L1 Gene

Paralogs for SPATA5L1 Gene

Selected SIMAP similar genes for SPATA5L1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SPATA5L1: view

Variants for SPATA5L1 Gene

Sequence variations from dbSNP and Humsavar for SPATA5L1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1145072 -- 45,416,287(-) ccttt(A/G)ttttt intron-variant
rs1145073 -- 45,413,373(+) acccc(A/G)gggat intron-variant
rs1145074 -- 45,411,626(-) aaaaa(A/T)ttttt intron-variant
rs1145075 -- 45,407,854(+) TAACA(A/G)AAAAA intron-variant
rs1153847 -- 45,404,692(-) tagct(A/G)gaact intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPATA5L1 Gene

Variant ID Type Subtype PubMed ID
nsv469721 CNV Complex 16826518

Relevant External Links for SPATA5L1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATA5L1 Gene

Disorders for SPATA5L1 Gene

Relevant External Links for SPATA5L1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SPATA5L1: view

No data available for UniProtKB/Swiss-Prot for SPATA5L1 Gene

Publications for SPATA5L1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Multiple loci associated with indices of renal function and chronic kidney disease. (PMID: 19430482) KAPttgen A. … Fox C.S. (Nat. Genet. 2009) 3 48
  4. New loci associated with kidney function and chronic kidney disease. (PMID: 20383146) KAPttgen A. … Fox C.S. (Nat. Genet. 2010) 3
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3

Products for SPATA5L1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate SPATA5L1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for SPATA5L1
  • Block miRNA regulation of SPATA5L1 using miScript Target Protectors

Sources for SPATA5L1 Gene

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