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Aliases for SPATA5 Gene

Aliases for SPATA5 Gene

  • Spermatogenesis Associated 5 2 3
  • SPAF 3 4 6
  • Spermatogenesis-Associated Factor Protein 3 4
  • ATPase Family Protein 2 Homolog 3 4
  • AFG2 3 4
  • ATPase Family Gene 2 Homolog (S. Cerevisiae) 2
  • Spermatogenesis Associated Factor SPAF 3
  • Spermatogenesis-Associated Protein 5 3
  • ATPase Family Gene 2 Homolog 3

External Ids for SPATA5 Gene

Previous GeneCards Identifiers for SPATA5 Gene

  • GC00U991164
  • GC04P124123
  • GC04P124237
  • GC04P124303
  • GC04P124201
  • GC04P123844
  • GC04P119570

Summaries for SPATA5 Gene

GeneCards Summary for SPATA5 Gene

SPATA5 (Spermatogenesis Associated 5) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes. GO annotations related to this gene include nucleoside-triphosphatase activity. An important paralog of this gene is SPATA5L1.

UniProtKB/Swiss-Prot for SPATA5 Gene

  • May be involved in morphological and functional mitochondrial transformations during spermatogenesis.

Gene Wiki entry for SPATA5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATA5 Gene

Genomics for SPATA5 Gene

Regulatory Elements for SPATA5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SPATA5 Gene

122,923,070 bp from pter
123,319,450 bp from pter
396,381 bases
Plus strand

Genomic View for SPATA5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPATA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA5 Gene

Proteins for SPATA5 Gene

  • Protein details for SPATA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Spermatogenesis-associated protein 5
    Protein Accession:
    Secondary Accessions:
    • C9JT97
    • Q86XW1
    • Q8NI20
    • Q8TDL7

    Protein attributes for SPATA5 Gene

    893 amino acids
    Molecular mass:
    97904 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPATA5 Gene


neXtProt entry for SPATA5 Gene

Proteomics data for SPATA5 Gene at MOPED

Post-translational modifications for SPATA5 Gene

  • Ubiquitination at Lys189, Lys311, Lys374, Lys380, Lys461, Lys693, and Lys887
  • Modification sites at PhosphoSitePlus

Other Protein References for SPATA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SPATA5 Gene

Domains for SPATA5 Gene

Gene Families for SPATA5 Gene

  • AATP :ATPases / AAA-type

Suggested Antigen Peptide Sequences for SPATA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8NB90
  • Belongs to the AAA ATPase family. AFG2 subfamily.
genes like me logo Genes that share domains with SPATA5: view

Function for SPATA5 Gene

Molecular function for SPATA5 Gene

UniProtKB/Swiss-Prot Function:
May be involved in morphological and functional mitochondrial transformations during spermatogenesis.

Gene Ontology (GO) - Molecular Function for SPATA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0009378 four-way junction helicase activity --
genes like me logo Genes that share ontologies with SPATA5: view

Animal Model Products

miRNA for SPATA5 Gene

miRTarBase miRNAs that target SPATA5

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPATA5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SPATA5 Gene

Localization for SPATA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPATA5 Gene

Cytoplasm. Mitochondrion.

Subcellular locations from

Jensen Localization Image for SPATA5 Gene COMPARTMENTS Subcellular localization image for SPATA5 gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SPATA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with SPATA5: view

Pathways for SPATA5 Gene

genes like me logo Genes that share pathways with SPATA5: view

Pathways by source for SPATA5 Gene

1 KEGG pathway for SPATA5 Gene

Gene Ontology (GO) - Biological Process for SPATA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair --
GO:0006310 DNA recombination --
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with SPATA5: view

Transcripts for SPATA5 Gene

Unigene Clusters for SPATA5 Gene

Spermatogenesis associated 5:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPATA5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - -
SP2: -

Relevant External Links for SPATA5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPATA5 Gene

mRNA expression in normal human tissues for SPATA5 Gene

Protein differential expression in normal tissues for SPATA5 Gene

This gene is overexpressed in Serum (40.2) and Lung (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPATA5 Gene

SOURCE GeneReport for Unigene cluster for SPATA5 Gene Hs.709648

genes like me logo Genes that share expressions with SPATA5: view

Expression partners for SPATA5 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPATA5 Gene

Orthologs for SPATA5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SPATA5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SPATA5 35
  • 88.1 (n)
  • 86.39 (a)
  • 85 (a)
(Canis familiaris)
Mammalia SPATA5 35
  • 88.15 (n)
  • 86.55 (a)
  • 85 (a)
(Mus musculus)
Mammalia Spata5 35
  • 85.35 (n)
  • 85.2 (a)
Spata5 16
Spata5 36
  • 85 (a)
(Pan troglodytes)
Mammalia SPATA5 35
  • 99.51 (n)
  • 99.33 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Spata5 35
  • 85.03 (n)
  • 84.71 (a)
(Monodelphis domestica)
Mammalia SPATA5 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia SPATA5 36
  • 51 (a)
(Gallus gallus)
Aves SPATA5 35
  • 69.68 (n)
  • 70 (a)
SPRY1 36
  • 63 (a)
(Anolis carolinensis)
Reptilia SPATA5 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia spata5 35
  • 66.63 (n)
  • 66.47 (a)
Str.17777 35
(Danio rerio)
Actinopterygii LOC100332622 35
  • 61.4 (n)
  • 66.61 (a)
CABZ01085878.1 36
  • 56 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012655 35
  • 50.43 (n)
  • 47.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5776 35
  • 53.68 (n)
  • 49.91 (a)
CG5776 36
  • 37 (a)
(Caenorhabditis elegans)
Secernentea cdc-48.3 36
  • 35 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER065C 35
  • 50.06 (n)
  • 45.83 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AFG2 36
  • 40 (a)
AFG2 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9577 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
Species with no ortholog for SPATA5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPATA5 Gene

Gene Tree for SPATA5 (if available)
Gene Tree for SPATA5 (if available)

Paralogs for SPATA5 Gene

Paralogs for SPATA5 Gene

Selected SIMAP similar genes for SPATA5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPATA5: view

Variants for SPATA5 Gene

Sequence variations from dbSNP and Humsavar for SPATA5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs54013 -- 123,179,606(+) CAGTC(C/T)GCCCA intron-variant
rs149240 -- 123,215,223(+) AACCA(A/G)TTAAG intron-variant
rs159989 -- 123,210,053(-) GAAGA(C/T)AAATC intron-variant
rs159990 -- 123,213,812(+) GAGAC(G/T)TCCTT intron-variant
rs159991 -- 123,184,887(-) GGCAA(C/G)TTACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPATA5 Gene

Variant ID Type Subtype PubMed ID
nsv879867 CNV Gain 21882294
dgv5703n71 CNV Gain 21882294
esv275520 CNV Gain+Loss 21479260
nsv879870 CNV Loss 21882294
esv2673720 CNV Deletion 23128226
esv2543745 CNV Deletion 19546169
dgv973e199 CNV Deletion 23128226
nsv830046 CNV Gain 17160897
esv268542 CNV Insertion 20981092
esv273916 CNV Insertion 20981092
nsv4497 CNV Loss 18451855
esv275210 CNV Loss 21479260
nsv508310 CNV Loss 20534489
nsv507197 CNV Insertion 20534489
dgv1669e1 CNV Complex 17122850

Relevant External Links for SPATA5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATA5 Gene

Disorders for SPATA5 Gene

(2) University of Copenhagen DISEASES for SPATA5 Gene

Relevant External Links for SPATA5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SPATA5: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for SPATA5 Gene

Publications for SPATA5 Gene

  1. FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells. (PMID: 16465403) Katoh Y. … Katoh M. (Int. J. Mol. Med. 2006) 2 3
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for SPATA5 Gene

Sources for SPATA5 Gene

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