Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SPATA5 Gene

protein-coding   GIFtS: 56
GCID: GC04P123844

Spermatogenesis Associated 5

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Spermatogenesis Associated 51 2     ATPase Family Gene 2 Homolog (S. Cerevisiae)1
SPAF2 3 5     ATPase Family Gene 2 Homolog2
Spermatogenesis-Associated Factor Protein2 3     Spermatogenesis Associated Factor SPAF2
AFG22 3     Spermatogenesis-Associated Protein 52
ATPase Family Protein 2 Homolog2 3     

External Ids:    HGNC: 181191   Entrez Gene: 1663782   Ensembl: ENSG000001453757   OMIM: 6139405   UniProtKB: Q8NB903   

Export aliases for SPATA5 gene to outside databases

Previous GC identifers: GC00U991164 GC04P124123 GC04P124237 GC04P124303 GC04P124201 GC04P119570


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for SPATA5 Gene:
SPATA5 (spermatogenesis associated 5) is a protein-coding gene. GO annotations related to this gene include nucleoside-triphosphatase activity. An important paralog of this gene is SPATA5L1.

UniProtKB/Swiss-Prot: SPAT5_HUMAN, Q8NB90
Function: May be involved in morphological and functional mitochondrial transformations during spermatogenesis (By
similarity)

Gene Wiki entry for SPATA5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the SPATA5 gene promoter:
         HOXA3   AP-1   GCNF   STAT3   POU6F1 (c2)   Nkx2-5   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPATA5 promoter sequence
   Search Chromatin IP Primers for SPATA5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPATA5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q28.1   Ensembl cytogenetic band:  4q28.1   HGNC cytogenetic band: 4q28.1

SPATA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPATA5 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P123844:  view genomic region     (about GC identifiers)

Start:
123,844,225 bp from pter      End:
124,240,605 bp from pter
Size:
396,381 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SPAT5_HUMAN, Q8NB90 (See protein sequence)
Recommended Name: Spermatogenesis-associated protein 5  
Size: 893 amino acids; 97904 Da
Secondary accessions: C9JT97 Q86XW1 Q8NI20 Q8TDL7
Alternative splicing: 3 isoforms:  Q8NB90-1   Q8NB90-2   Q8NB90-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SPATA5: NX_Q8NB90

Explore proteomics data for SPATA5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys189, Lys311, Lys374, Lys380, Lys461, Lys693, Lys887
  • Modification sites at PhosphoSitePlus

  • See SPATA5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_660208.2  
    ENSEMBL proteins: 
     ENSP00000274008  

    SPATA5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SPATA5
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SPATA5
    GenScript Custom Purified and Recombinant Proteins Services for SPATA5
    Novus Biologicals SPATA5 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SPATA5

     
    Search eBioscience for Proteins for SPATA5 

     
    antibodies-online proteins for SPATA5 (2 products) 

     
    antibodies-online peptides for SPATA5

    SPATA5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SPATA5
    Novus Biologicals SPATA5 Antibodies
    Abcam antibodies for SPATA5
    Cloud-Clone Corp. Antibodies for SPATA5
    ThermoFisher Antibodies for SPATA5
    antibodies-online antibodies for SPATA5 (3 products) 

    SPATA5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SPATA5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SPATA5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SPATA5
    Cloud-Clone Corp. CLIAs for SPATA5
    Search eBioscience for ELISAs for SPATA5 
    antibodies-online kits for SPATA5 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    AATP: ATPases / AAA-type

    Selected InterPro protein domains (see all 6):
     IPR003959 ATPase_AAA_core
     IPR003960 ATPase_AAA_CS
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase
     IPR009010 Asp_de-COase-like_dom

    Graphical View of Domain Structure for InterPro Entry Q8NB90

    ProtoNet protein and cluster: Q8NB90

    1 Blocks protein domain: IPB003960 AAA-protein subdomain

    UniProtKB/Swiss-Prot: SPAT5_HUMAN, Q8NB90
    Similarity: Belongs to the AAA ATPase family. AFG2 subfamily


    Find genes that share domains with SPATA5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPAT5_HUMAN, Q8NB90
    Function: May be involved in morphological and functional mitochondrial transformations during spermatogenesis (By
    similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005524ATP binding IEA--
    GO:0009378four-way junction helicase activity ----
    GO:0017111nucleoside-triphosphatase activity IEA--
         
    Find genes that share ontologies with SPATA5           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SPATA5

    miRNA
    Products:
        
    miRTarBase miRNAs that target SPATA5:
    hsa-mir-16-5p (MIRT031674)

    Block miRNA regulation of human, mouse, rat SPATA5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SPATA5 (see all 38):
    hsa-miR-3164 hsa-miR-106a hsa-miR-578 hsa-miR-3653 hsa-miR-519a hsa-miR-29b-1* hsa-miR-10b* hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidSPATA5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SPATA5
    Predesigned siRNA for gene silencing in human, mouse, rat SPATA5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SPATA5

    Clone
    Products:
         
    OriGene clones in human, mouse for SPATA5 (see all 7)
    OriGene ORF clones in mouse, rat for SPATA5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SPATA5 (NM_024063)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPATA5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPATA5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SPATA5
    Browse ESI BIO Cell Lines and PureStem Progenitors for SPATA5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPATA5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SPAT5_HUMAN, Q8NB90: Cytoplasm (By similarity). Mitochondrion (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    mitochondrion2
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--

    Find genes that share ontologies with SPATA5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SPATA5 About    
    See pathways by source

    SuperPathContained pathways About
    1Ribosome biogenesis in eukaryotes
    Ribosome biogenesis in eukaryotes


    Find genes that share SuperPaths with SPATA5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for SPATA5):
        Ribosome biogenesis in eukaryotes

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPATA5
    Interactions:

        Search GeneGlobe Interaction Network for SPATA5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SPATA5 (Q8NB902, 3 ENSP000002740084) via UniProtKB, MINT, STRING, and/or I2D (see all 889)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair ----
    GO:0006310DNA recombination ----
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--
    GO:0030154cell differentiation IEA--

    Find genes that share ontologies with SPATA5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPATA5 (SPAT5)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SPATA5 gene: 
    NM_145207.2  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000274008(uc003iey.3 uc003iez.4) ENST00000422835
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SPATA5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SPATA5 (see all 38):
    hsa-miR-3164 hsa-miR-106a hsa-miR-578 hsa-miR-3653 hsa-miR-519a hsa-miR-29b-1* hsa-miR-10b* hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidSPATA5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SPATA5
    Predesigned siRNA for gene silencing in human, mouse, rat SPATA5
    Clone
    Products:
         
    OriGene clones in human, mouse for SPATA5 (see all 7)
    OriGene ORF clones in mouse, rat for SPATA5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SPATA5 (NM_024063)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPATA5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPATA5
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SPATA5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPATA5
      QuantiTect SYBR Green Assays in human, mouse, rat SPATA5
      QuantiFast Probe-based Assays in human, mouse, rat SPATA5

    Selected AceView cDNA sequences (see all 29):

    CK429228 BC048217 BE552149 CB164025 BQ695055 CB161556 AA922894 BE973941 
    BE550289 AA932752 CD654419 AF479656 BE552314 BX641009 AI791698 AA680133 
    CD637554 CD637558 CD637556 CD696774 CD689480 NM_145207 AX746949 AF361489 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SPATA5    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                                                                                -                       -               
    SP2:                                                                                -                                       
    SP3:                                                                                                                        


    ECgene alternative splicing isoforms for SPATA5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SPATA5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCAAGAAAC
    SPATA5 Expression
    About this image

    SPATA5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPATA5 Protein Expression
        Custom PCR Arrays for SPATA5
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SPATA5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPATA5
    QuantiTect SYBR Green Assays in human, mouse, rat SPATA5
    QuantiFast Probe-based Assays in human, mouse, rat SPATA5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPATA5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SPATA5 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spata51 , 5 spermatogenesis associated 51, 5 85.35(n)1
    85.2(a)1
      3 (18.46 cM)5
    578151  NM_001163511.11  NP_001156983.11 
     374198965 
    chicken
    (Gallus gallus)
    Aves SPATA51 spermatogenesis associated 5 69.68(n)
    70(a)
      422665  XM_004941204.1  XP_004941261.1 
    lizard
    (Anolis carolinensis)
    Reptilia SPATA56
    spermatogenesis associated 5
    63(a)
    1 ↔ 1
    5(138352804-138550605)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.177772 Transcribed sequence with weak similarity to protein more 78.34(n)    BX713211.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003326221 spermatogenesis-associated protein 5-like 61.4(n)
    66.61(a)
      100332622  XM_002663196.3  XP_002663242.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG57761 CG5776 53.68(n)
    49.91(a)
      34680  NM_001273491.1  NP_001260420.1 
    worm
    (Caenorhabditis elegans)
    Secernentea cdc-48.36
    Protein CDC-48.3 (cdc-48.3) mRNA, complete cds
    35(a)
    1 ↔ 1
    I(8032862-8035696) WBGene00010562
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AFG2(YLR397C)4 ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms more   --   12(914892-912550) 851113  NP_013501.1 
    Alicante grape
    (Vitis vinifera)
    eudicotyledons CF212856.12   -- 73.37(n)    CF212856.1 


    ENSEMBL Gene Tree for SPATA5 (if available)
    TreeFam Gene Tree for SPATA5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SPATA5 gene
    SPATA5L12  
    13 SIMAP similar genes for SPATA5 using alignment to 1 protein entry:     SPAT5_HUMAN:
    DKFZp434K0126    PSMC1    VCP    SPATA5L1    ATAD1    DKFZp667C165
    PSMC2    DKFZp434E0418    NVL    PSMC3    PSMC4    PSMC5
    PSMC6

    Find genes that share paralogs with SPATA5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SPATA5 (see all 7985)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs709550991,2
    C--119724759(+) TTTTT-/T/TT  
            
    GAGAC
    1 -- int11NA 2
    rs558681911,2
    C--119854784(+) TAACT-/GTACTCA 1 -- int11Minor allele frequency- GT:0.00NA 2
    rs40318561,2
    C--123825074(-) CATAT-/A/AT  
            
    TTATA
    1 -- int11NA 2
    rs1914895571,2
    --123846243(+) ACTCTG/TTTCAG 1 -- int10--------
    rs726749631,2
    C,F--123846246(+) CTGTTC/AAGTTT 1 -- int11Minor allele frequency- A:0.04NA 120
    rs1136519221,2
    F--123846300(+) TCCCCC/GCCATA 1 -- int13Minor allele frequency- G:0.12CSA WA NA 239
    rs1855211861,2
    --123846302(+) CCCCCA/CATATC 1 -- int10--------
    rs788566731,2
    C,F--123846331(+) ACTAAA/CTCATG 1 -- int13Minor allele frequency- C:0.12CSA WA NA 239
    rs738449661,2
    C,F--123846367(+) TCCTCT/ATCTGC 1 -- int12Minor allele frequency- A:0.04WA 120
    rs1432461901,2
    --123846446(+) CTTTTA/GACTGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for SPATA5 (123844225 - 124094225 bp, first 250kb of SPATA5)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SPATA5 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673720CNV Deletion23128226
    dgv973e199CNV Deletion23128226
    esv2543745CNV Deletion19546169
    nsv507197CNV Insertion20534489
    esv268542CNV Insertion20981092
    esv273916CNV Insertion20981092
    nsv4497CNV Loss18451855
    esv275210CNV Loss21479260
    nsv879870CNV Loss21882294
    nsv508310CNV Loss20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SPATA5
    DNA2.0 Custom Variant and Variant Library Synthesis for SPATA5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 613940    OMIM disorders: --

    2 diseases from the University of Copenhagen DISEASES database for SPATA5:
    Cerebrovascular accident     Transient cerebral ischemia

    Find genes that share disorders with SPATA5           About GenesLikeMe

    Genetic Association Database (GAD): SPATA5
    Human Genome Epidemiology (HuGE) Navigator: SPATA5 (1 document)

    Export disorders for SPATA5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SPATA5 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with SPATA5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells. (PubMed id 16465403)1, 3 Katoh Y. and Katoh M. (Int. J. Mol. Med. 2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    6. Genome-wide pooling approach identifies SPATA5 as a new susceptibility locus for alopecia areata. (PubMed id 22027810)1 Forstbauer L.M....Betz R.C. (Eur. J. Hum. Genet. 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Exome sequencing supports a de novo mutational paradigm for schizophrenia. (PubMed id 21822266)1 Xu B....Karayiorgou M. (Nat. Genet. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 166378 HGNC: 18119 AceView: SPATA5 Ensembl:ENSG00000145375 euGenes: HUgn166378
    ECgene: SPATA5 Kegg: 166378 H-InvDB: SPATA5

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SPATA5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SPATA5 gene:
    Search GeneIP for patents involving SPATA5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SPATA5  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SPATA5  
     OriGene qSTAR qPCR primer pairs in human, mouse for SPATA5   OriGene Purified Protein for SPATA5  
     OriGene ORF clones in mouse, rat for SPATA5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SPATA5   OriGene Custom Protein Services for SPATA5  

     
     
     Block miRNA regulation of human, mouse, rat SPATA5 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SPATA5
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPATA5 Predesigned siRNA for gene silencing in human, mouse, rat SPATA5
     QuantiFast Probe-based Assays in human, mouse, rat SPATA5 QuantiTect SYBR Green Assays in human, mouse, rat SPATA5
     Custom PCR Arrays for SPATA5 Search Chromatin IP Primers for SPATA5
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPATA5  Search GeneGlobe Interaction Network for SPATA5
     Regulatory tfbs in SPATA5 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SPATA5 GenScript cDNA clones with any tag delivered in your preferred vector for SPATA5
     GenScript Custom Assay Services for SPATA5 GenScript Custom overexpressing Cell Line Services for SPATA5
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SPATA5 (SPAT5)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SPATA5 antibodies
     SPATA5 proteins
     Antibodies for SPATA5
     See all of Abcam's Antibodies, Kits and Proteins for SPATA5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SPATA5
     Antibodies for SPATA5
     ELISAs for SPATA5
     CLIAs for SPATA5



     Browse ESI BIO Cell Lines and PureStem Progenitors for SPATA5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPATA5
     SwitchGear 3'UTR luciferase reporter plasmids for SPATA5
     SwitchGear Promoter luciferase reporter plasmids for SPATA5
     ThermoFisher Antibodies for SPATA5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPATA5
     Browse compounds at ApexBio
     Search Addgene for plasmids for SPATA5
      Search eBioscience for proteins for SPATA5
      Search eBioscience for elisas for SPATA5
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for SPATA5
     antibodies-online antibodies for SPATA5 (3 products)
     antibodies-online kits for SPATA5 (4 products)
     antibodies-online peptides for SPATA5
     antibodies-online proteins for SPATA5 (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SPATA5 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4