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Aliases for SPATA5 Gene

Aliases for SPATA5 Gene

  • Spermatogenesis Associated 5 2 3
  • Spermatogenesis-Associated Factor Protein 3 4
  • ATPase Family Protein 2 Homolog 3 4
  • AFG2 3 4
  • SPAF 3 4
  • ATPase Family Gene 2 Homolog (S. Cerevisiae) 2
  • Spermatogenesis Associated Factor SPAF 3
  • ATPase Family Gene 2 Homolog 3
  • EHLMRS 3

External Ids for SPATA5 Gene

Previous GeneCards Identifiers for SPATA5 Gene

  • GC00U991164
  • GC04P124123
  • GC04P124237
  • GC04P124303
  • GC04P124201
  • GC04P123844
  • GC04P119570

Summaries for SPATA5 Gene

GeneCards Summary for SPATA5 Gene

SPATA5 (Spermatogenesis Associated 5) is a Protein Coding gene. Diseases associated with SPATA5 include epilepsy, hearing loss, and mental retardation syndrome and intracranial embolism. Among its related pathways are Ribosome biogenesis in eukaryotes. GO annotations related to this gene include four-way junction helicase activity. An important paralog of this gene is SPATA5L1.

UniProtKB/Swiss-Prot for SPATA5 Gene

  • May be involved in morphological and functional mitochondrial transformations during spermatogenesis.

Gene Wiki entry for SPATA5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATA5 Gene

Genomics for SPATA5 Gene

Regulatory Elements for SPATA5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SPATA5 Gene

Chromosome:
4
Start:
122,923,070 bp from pter
End:
123,319,450 bp from pter
Size:
396,381 bases
Orientation:
Plus strand

Genomic View for SPATA5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPATA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA5 Gene

Proteins for SPATA5 Gene

  • Protein details for SPATA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NB90-SPAT5_HUMAN
    Recommended name:
    Spermatogenesis-associated protein 5
    Protein Accession:
    Q8NB90
    Secondary Accessions:
    • C9JT97
    • Q86XW1
    • Q8NI20
    • Q8TDL7

    Protein attributes for SPATA5 Gene

    Size:
    893 amino acids
    Molecular mass:
    97904 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPATA5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPATA5 Gene

Proteomics data for SPATA5 Gene at MOPED

Post-translational modifications for SPATA5 Gene

  • Ubiquitination at Lys 189, Lys 311, Lys 374, Lys 380, Lys 461, Lys 693, and Lys 887
  • Modification sites at PhosphoSitePlus

Other Protein References for SPATA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SPATA5 Gene

Domains & Families for SPATA5 Gene

Suggested Antigen Peptide Sequences for SPATA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NB90

UniProtKB/Swiss-Prot:

SPAT5_HUMAN :
  • Belongs to the AAA ATPase family. AFG2 subfamily.
Family:
  • Belongs to the AAA ATPase family. AFG2 subfamily.
genes like me logo Genes that share domains with SPATA5: view

Function for SPATA5 Gene

Molecular function for SPATA5 Gene

UniProtKB/Swiss-Prot Function:
May be involved in morphological and functional mitochondrial transformations during spermatogenesis.

Gene Ontology (GO) - Molecular Function for SPATA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with SPATA5: view

Phenotypes for SPATA5 Gene

GenomeRNAi human phenotypes for SPATA5:
genes like me logo Genes that share phenotypes with SPATA5: view

Animal Model Products

miRNA for SPATA5 Gene

miRTarBase miRNAs that target SPATA5

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPATA5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SPATA5 Gene

Localization for SPATA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPATA5 Gene

Cytoplasm. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPATA5 Gene COMPARTMENTS Subcellular localization image for SPATA5 gene
Compartment Confidence
mitochondrion 3
cytosol 2

Gene Ontology (GO) - Cellular Components for SPATA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with SPATA5: view

Pathways & Interactions for SPATA5 Gene

genes like me logo Genes that share pathways with SPATA5: view

Pathways by source for SPATA5 Gene

1 KEGG pathway for SPATA5 Gene

Gene Ontology (GO) - Biological Process for SPATA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with SPATA5: view

No data available for SIGNOR curated interactions for SPATA5 Gene

Drugs & Compounds for SPATA5 Gene

No Compound Related Data Available

Transcripts for SPATA5 Gene

Unigene Clusters for SPATA5 Gene

Spermatogenesis associated 5:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPATA5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - -
SP2: -
SP3:

Relevant External Links for SPATA5 Gene

GeneLoc Exon Structure for
SPATA5
ECgene alternative splicing isoforms for
SPATA5

Expression for SPATA5 Gene

mRNA expression in normal human tissues for SPATA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SPATA5 Gene

This gene is overexpressed in Serum (40.2) and Lung (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPATA5 Gene



SOURCE GeneReport for Unigene cluster for SPATA5 Gene Hs.709648

genes like me logo Genes that share expression patterns with SPATA5: view

Protein tissue co-expression partners for SPATA5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPATA5 Gene

Orthologs for SPATA5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SPATA5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SPATA5 35
  • 88.1 (n)
  • 86.39 (a)
SPATA5 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPATA5 35
  • 88.15 (n)
  • 86.55 (a)
SPATA5 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spata5 35
  • 85.35 (n)
  • 85.2 (a)
Spata5 16
Spata5 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SPATA5 35
  • 99.51 (n)
  • 99.33 (a)
SPATA5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spata5 35
  • 85.03 (n)
  • 84.71 (a)
oppossum
(Monodelphis domestica)
Mammalia SPATA5 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPATA5 36
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPATA5 35
  • 69.68 (n)
  • 70 (a)
SPRY1 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPATA5 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spata5 35
  • 66.63 (n)
  • 66.47 (a)
Str.17777 35
zebrafish
(Danio rerio)
Actinopterygii LOC100332622 35
  • 61.4 (n)
  • 66.61 (a)
CABZ01085878.1 36
  • 56 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012655 35
  • 50.43 (n)
  • 47.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5776 35
  • 53.68 (n)
  • 49.91 (a)
CG5776 36
  • 37 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cdc-48.3 36
  • 35 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER065C 35
  • 50.06 (n)
  • 45.83 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AFG2 36
  • 40 (a)
OneToMany
AFG2 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9577 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToOne
Species with no ortholog for SPATA5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPATA5 Gene

ENSEMBL:
Gene Tree for SPATA5 (if available)
TreeFam:
Gene Tree for SPATA5 (if available)

Paralogs for SPATA5 Gene

Paralogs for SPATA5 Gene

(13) SIMAP similar genes for SPATA5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPATA5: view

Variants for SPATA5 Gene

Sequence variations from dbSNP and Humsavar for SPATA5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_042703 -
VAR_042704 -

Structural Variations from Database of Genomic Variants (DGV) for SPATA5 Gene

Variant ID Type Subtype PubMed ID
nsv879867 CNV Gain 21882294
dgv5703n71 CNV Gain 21882294
esv275520 CNV Gain+Loss 21479260
nsv879870 CNV Loss 21882294
esv2673720 CNV Deletion 23128226
esv2543745 CNV Deletion 19546169
dgv973e199 CNV Deletion 23128226
nsv830046 CNV Gain 17160897
esv268542 CNV Insertion 20981092
esv273916 CNV Insertion 20981092
nsv4497 CNV Loss 18451855
esv275210 CNV Loss 21479260
nsv508310 CNV Loss 20534489
nsv507197 CNV Insertion 20534489
dgv1669e1 CNV Complex 17122850

Variation tolerance for SPATA5 Gene

Residual Variation Intolerance Score: 7.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.73; 66.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPATA5 Gene

HapMap Linkage Disequilibrium report
SPATA5
Human Gene Mutation Database (HGMD)
SPATA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATA5 Gene

Disorders for SPATA5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SPATA5 Gene - From: OMIM, ClinVar, and DISEASES

Disorder Aliases PubMed IDs
epilepsy, hearing loss, and mental retardation syndrome
  • ehlmrs
intracranial embolism
  • cerebral embolism
rheumatic congestive heart failure
  • rheumatic heart failure
- elite association

Relevant External Links for SPATA5

Genetic Association Database (GAD)
SPATA5
Human Genome Epidemiology (HuGE) Navigator
SPATA5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPATA5
genes like me logo Genes that share disorders with SPATA5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPATA5 Gene

Publications for SPATA5 Gene

  1. FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells. (PMID: 16465403) Katoh Y. … Katoh M. (Int. J. Mol. Med. 2006) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  4. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 67
  5. Genome-wide association study identifies two novel genomic regions in irritable bowel syndrome. (PMID: 24797007) Holliday E.G. … Talley N.J. (Am. J. Gastroenterol. 2014) 67

Products for SPATA5 Gene

Sources for SPATA5 Gene

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