SPATA5 Gene
protein-coding GIFtS: 55
GCID: GC04P123844
|
|
spermatogenesis associated 5
| |
Aliases for SPATA5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Spermatogenesis Associated 51 2 | | ATPase Family Protein 2 Homolog2 3 | | AFG21 2 3 | | ATPase Family Gene 2 Homolog2 | | SPAF1 2 3 | | Spermatogenesis Associated Factor SPAF2 | | Spermatogenesis-Associated Factor Protein2 3 | | Spermatogenesis-Associated Protein 52 |
Export aliases for SPATA5 gene to outside databasesPrevious GC identifers: GC00U991164 GC04P124123 GC04P124237 GC04P124303 GC04P124201 GC04P119570 |
Summaries for SPATA5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: SPAT5_HUMAN, Q8NB90Function: May be involved in morphological and functional mitochondrial transformations during spermatogenesis (Bysimilarity) Gene Wiki entry for SPATA5
|
Genomic Views for SPATA5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SPATA5 gene promoter: HOXA3 AP-1 GCNF STAT3 POU6F1 (c2) Nkx2-5 ATF Other transcription factors
Search SABiosciences Chromatin IP Primers for SPATA5
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPATA5 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q28.1 Ensembl cytogenetic band: 4q28.1 HGNC cytogenetic band: 4q28.1SPATA5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P123844: view genomic region
(about GC identifiers)
Start:
|
123,844,225 bp from pter |
End:
|
124,240,605 bp from pter |
Size:
|
396,381 bases |
Orientation:
|
plus strand |
|
Proteins for SPATA5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: SPAT5_HUMAN, Q8NB90 (See
protein sequence)Recommended Name: Spermatogenesis-associated protein 5 Size: 893 amino acids; 97904 Da
Subcellular location: Cytoplasm (By similarity). Mitochondrion (By similarity)
Secondary accessions: C9JT97 Q86XW1 Q8NI20 Q8TDL7Alternative splicing: 3 isoforms: Q8NB90-1 Q8NB90-2 Q8NB90-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SPATA5: NX_Q8NB90
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NB90 SPATA5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_660208.2 ENSEMBL proteins: ENSP00000274008 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SPATA5 for ontologies About GeneDecksing
SPATA5 Antibody Products: Assay Products for SPATA5: |
Protein
Domains / Families for SPATA5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPATA5 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NB90ProtoNet protein and cluster: Q8NB90 1 Blocks protein family: IPB003960 AAA-protein subdomain
UniProtKB/Swiss-Prot: SPAT5_HUMAN, Q8NB90Similarity: Belongs to the AAA ATPase family. AFG2 subfamily |
Function for SPATA5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: SPAT5_HUMAN, Q8NB90Function: May be involved in morphological and functional mitochondrial transformations during spermatogenesis (Bysimilarity)
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA5 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA5 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPATA5 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005524 | ATP binding |
IEA | -- | | GO:0017111 | nucleoside-triphosphatase activity |
IEA | -- |
SPATA5 for ontologies About GeneDecksing
|
Pathways & Interactions for SPATA5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ribosome biogenesis in eukaryotes | |
Pathway sources See GeneCards unified pathways Show all pathways
1
Kegg Pathway (Kegg details for SPATA5):
SPATA5 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPATA5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
 5/791 Interacting proteins for SPATA5 (Q8NB902, 3 ENSP000002740084) via UniProtKB, MINT, STRING, and/or I2D (see all 791)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0007283 | spermatogenesis |
IEA | -- | | GO:0030154 | cell differentiation |
IEA | -- |
SPATA5 for ontologies About GeneDecksing
|
Drugs & Compounds for SPATA5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for SPATA5 Search CenterWatch for drugs/clinical trials and news about SPATA5 / SPAT5 
|
Transcripts for SPATA5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for SPATA5 gene: NM_145207.2 Unigene Cluster for SPATA5: Spermatogenesis associated 5 Hs.709648 [show with all ESTs]Unigene Representative Sequence: NM_1452072 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000274008(uc003iey.3 uc003iez.4) ENST00000422835
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA5 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA5 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SPATA5 (NM_024063) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPATA5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPATA5  |
Additional cDNA sequence: AF361489.1 AF479656.1 AK091384.1 AL832175.1 BC048217.1 7 DOTS entries: DT.407316 DT.75181099 DT.100018626 DT.100690397 DT.303551 DT.40126282 DT.40277868 24/29 AceView cDNA sequences (see all 29): CB161556 BC048217 CK429228 BQ695055 CB164025 BE552149 CD654419 AA680133 AA922894 AF479656 AI791698 BE550289 BE973941 CD637554 BE552314 BX641009 AA932752 CD637558 CD637556 CD696774 AX746949 AF361489 CF597467 NM_145207 GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for SPATA5 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for SPATA5
|
Expression for SPATA5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPATA5 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GCCAAGAAAC
About this image See SPATA5 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SPATA5
SOURCE GeneReport for Unigene cluster: Hs.709648 SABiosciences Custom PCR Arrays for SPATA5
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPATA5 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPATA5 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPATA5 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPATA5 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPATA5 |
Orthologs for SPATA5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SPATA5 gene from 8/30 species (see all 30) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
SPATA51 |
spermatogenesis associated 5 |
68.66(n) 68.66(a) |
  |
422665 XM_420619.3 XP_420619.2 |
lizard (Anolis carolinensis) |
Reptilia |
SPATA56 |
-- |
64(a) |
1 ↔ 1 |
5(138491788-138549952) |
tropical clawed frog (Xenopus tropicalis) |
Amphibia |
Str.177772 |
Transcribed sequence with weak similarity to protein more |
78.34(n) |
  |
BX713211.1 |
zebrafish (Danio rerio) |
Actinopterygii |
LOC1003326221 |
spermatogenesis-associated protein 5-like |
61.04(n) 65.83(a) |
  |
100332622 XM_002663196.2 XP_002663242.2 |
fruit fly (Drosophila melanogaster) |
Insecta |
CG57761 |
CG5776 |
53.32(n) 49.47(a) |
  |
34680 NM_135741.2 NP_609585.1 |
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes |
AFG2(YLR397C)4 AFG21 |
ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms more4 Afg2p1 |
54.24(n)1 50.9(a)1 |
  |
12(914892-912550)4 8511131, 4 NP_013501.11, 4 |
thale cress (Arabidopsis thaliana) |
eudicotyledons |
CIP1116 |
Cam interacting protein 111 |
28(a) |
1 ↔ 1 |
3(20993693-20998695) |
rice (Oryza sativa) |
Liliopsida |
-- |
CIP111, putative, expressed |
29(a) |
1 ↔ 1 |
11(6284657-6290913) |
ENSEMBL Gene Tree for SPATA5 (if available) TreeFam Gene Tree for SPATA5 (if available)  |
Paralogs for SPATA5 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for SPATA5 gene
- SPATA5L12 VCP2
13 SIMAP similar genes for SPATA5 using alignment to 1 protein entry: SPAT5_HUMAN:DKFZp434K0126 PSMC1 VCP SPATA5L1 ATAD1 DKFZp667C165 PSMC2 DKFZp434E0418 NVL PSMC3 PSMC4 PSMC5 PSMC6
SPATA5 for paralogs About GeneDecksing
|
Genomic Variants for SPATA5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 4 variations for SPATA5 4 CNVs: 3512 92367 98872 2543 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPATA5 |
|
Disorders
/ Diseases for SPATA5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SPATA5 for disorders About GeneDecksing
OMIM gene information: 613940
OMIM disorders: --
4 diseases for SPATA5: About MalaCardscerebrovascular accident schizophrenia tuberculosis mycobacterium tuberculosis 2 diseases from the University of Copenhagen DISEASES database for SPATA5:Cerebrovascular accident Transient cerebral ischemia Human Genome Epidemiology (HuGE) Navigator: SPATA5 (1 document) Export disorders for SPATA5 gene to outside databases
|
Publications for SPATA5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPATA5 gene, integrated from 9 sources (see all 21): (articles sorted by number of sources associating them with SPATA5) | |  | Utopia: connect your pdf to the dynamic world of online information |
- FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells. (PubMed id 16465403)1, 3 Katoh Y. and Katoh M. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Genome-wide pooling approach identifies SPATA5 as a ne w susceptibility locus for alopecia areata. (PubMed id 22027810)1 Forstbauer L.M....Betz R.C. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Exome sequencing supports a de novo mutational paradi gm for schizophrenia. (PubMed id 21822266)1 Xu B....Karayiorgou M. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
|
External Searches for SPATA5 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing SPATA5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPATA5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPATA5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for SPATA5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SPATA5 gene: Search GeneIP for patents involving SPATA5
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for SPATA5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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| | | Search Tocris compounds for SPATA5 |
| |  |  |  |  | | | | |
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 |
 |
 | | SPATA5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPATA5 |
|  |  |  | | | ThermoFisher Antibodies for SPATA5 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPATA5 |
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