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Aliases for SPATA5 Gene

Aliases for SPATA5 Gene

  • Spermatogenesis Associated 5 2 3 5
  • Spermatogenesis-Associated Factor Protein 3 4
  • ATPase Family Protein 2 Homolog 3 4
  • AFG2 3 4
  • SPAF 3 4
  • ATPase Family Gene 2 Homolog (S. Cerevisiae) 2
  • Spermatogenesis Associated Factor SPAF 3
  • ATPase Family Gene 2 Homolog 3
  • EHLMRS 3

External Ids for SPATA5 Gene

Previous GeneCards Identifiers for SPATA5 Gene

  • GC00U991164
  • GC04P124123
  • GC04P124237
  • GC04P124303
  • GC04P124201
  • GC04P123844
  • GC04P119570

Summaries for SPATA5 Gene

GeneCards Summary for SPATA5 Gene

SPATA5 (Spermatogenesis Associated 5) is a Protein Coding gene. Diseases associated with SPATA5 include Epilepsy, Hearing Loss, And Mental Retardation Syndrome and Heart Conduction Disease. Among its related pathways are Ribosome biogenesis in eukaryotes. GO annotations related to this gene include four-way junction helicase activity.

UniProtKB/Swiss-Prot for SPATA5 Gene

  • May be involved in morphological and functional mitochondrial transformations during spermatogenesis.

Gene Wiki entry for SPATA5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATA5 Gene

Genomics for SPATA5 Gene

Regulatory Elements for SPATA5 Gene

Enhancers for SPATA5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SPATA5 on UCSC Golden Path with GeneCards custom track

Promoters for SPATA5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SPATA5 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPATA5 Gene

122,923,070 bp from pter
123,319,450 bp from pter
396,381 bases
Plus strand

Genomic View for SPATA5 Gene

Genes around SPATA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA5 Gene

Proteins for SPATA5 Gene

  • Protein details for SPATA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Spermatogenesis-associated protein 5
    Protein Accession:
    Secondary Accessions:
    • C9JT97
    • Q86XW1
    • Q8NI20
    • Q8TDL7

    Protein attributes for SPATA5 Gene

    893 amino acids
    Molecular mass:
    97904 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPATA5 Gene


neXtProt entry for SPATA5 Gene

Proteomics data for SPATA5 Gene at MOPED

Post-translational modifications for SPATA5 Gene

  • Ubiquitination at Lys 189, Lys 311, Lys 374, Lys 380, Lys 461, Lys 693, and Lys 887
  • Modification sites at PhosphoSitePlus

Other Protein References for SPATA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPATA5 Gene

Domains & Families for SPATA5 Gene

Gene Families for SPATA5 Gene

Suggested Antigen Peptide Sequences for SPATA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AAA ATPase family. AFG2 subfamily.
  • Belongs to the AAA ATPase family. AFG2 subfamily.
genes like me logo Genes that share domains with SPATA5: view

Function for SPATA5 Gene

Molecular function for SPATA5 Gene

UniProtKB/Swiss-Prot Function:
May be involved in morphological and functional mitochondrial transformations during spermatogenesis.

Phenotypes for SPATA5 Gene

genes like me logo Genes that share phenotypes with SPATA5: view

Human Phenotype Ontology for SPATA5 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SPATA5 Gene

MGI Knock Outs for SPATA5:

Animal Model Products

miRNA for SPATA5 Gene

miRTarBase miRNAs that target SPATA5

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for SPATA5 Gene

Localization for SPATA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPATA5 Gene

Cytoplasm. Mitochondrion.

Subcellular locations from

Jensen Localization Image for SPATA5 Gene COMPARTMENTS Subcellular localization image for SPATA5 gene
Compartment Confidence
cytosol 4
mitochondrion 4
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for SPATA5 Gene

Pathways & Interactions for SPATA5 Gene

genes like me logo Genes that share pathways with SPATA5: view

Pathways by source for SPATA5 Gene

1 KEGG pathway for SPATA5 Gene

Gene Ontology (GO) - Biological Process for SPATA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with SPATA5: view

No data available for SIGNOR curated interactions for SPATA5 Gene

Drugs & Compounds for SPATA5 Gene

No Compound Related Data Available

Transcripts for SPATA5 Gene

Unigene Clusters for SPATA5 Gene

Spermatogenesis associated 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - -
SP2: -

Relevant External Links for SPATA5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPATA5 Gene

mRNA expression in normal human tissues for SPATA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SPATA5 Gene

This gene is overexpressed in Serum (40.2) and Lung (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPATA5 Gene

SOURCE GeneReport for Unigene cluster for SPATA5 Gene Hs.709648

genes like me logo Genes that share expression patterns with SPATA5: view

Protein tissue co-expression partners for SPATA5 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPATA5 Gene

Orthologs for SPATA5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SPATA5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SPATA5 35
  • 88.1 (n)
  • 86.39 (a)
  • 85 (a)
(Canis familiaris)
Mammalia SPATA5 35
  • 88.15 (n)
  • 86.55 (a)
  • 85 (a)
(Mus musculus)
Mammalia Spata5 35
  • 85.35 (n)
  • 85.2 (a)
Spata5 16
Spata5 36
  • 85 (a)
(Pan troglodytes)
Mammalia SPATA5 35
  • 99.51 (n)
  • 99.33 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Spata5 35
  • 85.03 (n)
  • 84.71 (a)
(Monodelphis domestica)
Mammalia SPATA5 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia SPATA5 36
  • 51 (a)
(Gallus gallus)
Aves SPATA5 35
  • 69.68 (n)
  • 70 (a)
SPRY1 36
  • 63 (a)
(Anolis carolinensis)
Reptilia SPATA5 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia spata5 35
  • 66.63 (n)
  • 66.47 (a)
Str.17777 35
(Danio rerio)
Actinopterygii LOC100332622 35
  • 61.4 (n)
  • 66.61 (a)
CABZ01085878.1 36
  • 56 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012655 35
  • 50.43 (n)
  • 47.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5776 35
  • 53.68 (n)
  • 49.91 (a)
CG5776 36
  • 37 (a)
(Caenorhabditis elegans)
Secernentea cdc-48.3 36
  • 35 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER065C 35
  • 50.06 (n)
  • 45.83 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AFG2 36
  • 40 (a)
AFG2 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9577 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
Species with no ortholog for SPATA5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPATA5 Gene

Gene Tree for SPATA5 (if available)
Gene Tree for SPATA5 (if available)

Paralogs for SPATA5 Gene

(13) SIMAP similar genes for SPATA5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPATA5: view

No data available for Paralogs for SPATA5 Gene

Variants for SPATA5 Gene

Sequence variations from dbSNP and Humsavar for SPATA5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_042703 -
rs35133326 - 123,028,334(-) TTTTA(G/T)AGCAC reference, missense
rs54013 -- 123,179,606(+) CAGTC(C/T)GCCCA intron-variant
rs149240 -- 123,215,223(+) AACCA(A/G)TTAAG intron-variant
rs159989 -- 123,210,053(-) GAAGA(C/T)AAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPATA5 Gene

Variant ID Type Subtype PubMed ID
nsv879867 CNV Gain 21882294
dgv5703n71 CNV Gain 21882294
esv275520 CNV Gain+Loss 21479260
nsv879870 CNV Loss 21882294
esv2673720 CNV Deletion 23128226
esv2543745 CNV Deletion 19546169
dgv973e199 CNV Deletion 23128226
nsv830046 CNV Gain 17160897
esv268542 CNV Insertion 20981092
esv273916 CNV Insertion 20981092
nsv4497 CNV Loss 18451855
esv275210 CNV Loss 21479260
nsv508310 CNV Loss 20534489
nsv507197 CNV Insertion 20534489
dgv1669e1 CNV Complex 17122850

Variation tolerance for SPATA5 Gene

Residual Variation Intolerance Score: 7.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.73; 66.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPATA5 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATA5 Gene

Disorders for SPATA5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SPATA5 Gene - From: OMIM, ClinVar, Swiss-Prot, and DISEASES

Disorder Aliases PubMed IDs
epilepsy, hearing loss, and mental retardation syndrome
  • ehlmrs
heart conduction disease
  • heart rhythm disease
intracranial embolism
  • cerebral embolism
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SPATA5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SPATA5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPATA5 Gene

Publications for SPATA5 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells. (PMID: 16465403) Katoh Y. … Katoh M. (Int. J. Mol. Med. 2006) 2 3
  3. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for SPATA5 Gene

Sources for SPATA5 Gene