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Aliases for SPATA45 Gene

Aliases for SPATA45 Gene

  • Spermatogenesis Associated 45 2 3 5
  • C1orf227 3 4
  • Spermatogenesis-Associated Protein 45 3
  • Chromosome 1 Open Reading Frame 227 2
  • UPF0732 Protein C1orf227 3

External Ids for SPATA45 Gene

Previous HGNC Symbols for SPATA45 Gene

  • C1orf227

Previous GeneCards Identifiers for SPATA45 Gene

  • GC01M213004

Summaries for SPATA45 Gene

GeneCards Summary for SPATA45 Gene

SPATA45 (Spermatogenesis Associated 45) is a Protein Coding gene.

Additional gene information for SPATA45 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATA45 Gene

Genomics for SPATA45 Gene

GeneHancer (GH) Regulatory Elements for SPATA45 Gene

Promoters and enhancers for SPATA45 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I212847 Promoter 0.6 EPDnew 561.3 0.0 -8 0.1 ZNF384 SPATA45 GC01P212844 GC01P212852 GC01M212767
GH01I212856 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11 -11.4 -11370 4.5 CLOCK FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC FLVCR1-AS1 FLVCR1 ANGEL2 TATDN3 SPATA45 GC01M212767 GC01P212844
GH01I212698 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 9.1 +147.3 147309 2.8 PKNOX1 FOXA2 ZFP64 ARID4B SIN3A FEZF1 ZNF2 ZNF207 ZNF143 KLF13 BATF3 FLVCR1-AS1 SPATA45 VASH2 PIR52879
GH01I212664 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE 9 +180.7 180705 4.2 HDGF ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF213 E2F8 ZNF207 ZNF143 ENSG00000237980 LOC102723761 FAM71A DTL SPATA45 PPP2R5A ATF3 BATF3 ANGEL2 RPS6KC1
GH01I212793 Enhancer 1.2 Ensembl ENCODE 10.8 +53.1 53120 1.4 HDGF PKNOX1 SMAD1 FOXA2 ARNT IRF4 YY1 ZNF766 E2F8 ZNF143 FLVCR1-AS1 TATDN3 FLVCR1 SPATA45 RPS5P4 GC01M212767
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPATA45 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SPATA45 Gene

Genomic Locations for SPATA45 Gene
chr1:212,830,141-212,847,649
(GRCh38/hg38)
Size:
17,509 bases
Orientation:
Minus strand
chr1:213,003,483-213,020,991
(GRCh37/hg19)

Genomic View for SPATA45 Gene

Genes around SPATA45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATA45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATA45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA45 Gene

Proteins for SPATA45 Gene

  • Protein details for SPATA45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q537H7-SPT45_HUMAN
    Recommended name:
    Spermatogenesis-associated protein 45
    Protein Accession:
    Q537H7

    Protein attributes for SPATA45 Gene

    Size:
    98 amino acids
    Molecular mass:
    11356 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPATA45 Gene

Post-translational modifications for SPATA45 Gene

No Post-translational modifications

Other Protein References for SPATA45 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPATA45 Gene

Domains & Families for SPATA45 Gene

Gene Families for SPATA45 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPATA45 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for SPATA45 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q537H7

UniProtKB/Swiss-Prot:

SPT45_HUMAN :
  • Belongs to the SPATA45 family.
Family:
  • Belongs to the SPATA45 family.
genes like me logo Genes that share domains with SPATA45: view

Function for SPATA45 Gene

Phenotypes From GWAS Catalog for SPATA45 Gene

genes like me logo Genes that share phenotypes with SPATA45: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPATA45 Gene

Localization for SPATA45 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPATA45 gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SPATA45 Gene

Pathways & Interactions for SPATA45 Gene

SuperPathways for SPATA45 Gene

No Data Available

Interacting Proteins for SPATA45 Gene

Gene Ontology (GO) - Biological Process for SPATA45 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPATA45 Gene

Drugs & Compounds for SPATA45 Gene

No Compound Related Data Available

Transcripts for SPATA45 Gene

mRNA/cDNA for SPATA45 Gene

(1) REFSEQ mRNAs :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA45 Gene

No ASD Table

Relevant External Links for SPATA45 Gene

GeneLoc Exon Structure for
SPATA45
ECgene alternative splicing isoforms for
SPATA45

Expression for SPATA45 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPATA45 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPATA45 Gene

This gene is overexpressed in Testis (x28.5).

NURSA nuclear receptor signaling pathways regulating expression of SPATA45 Gene:

SPATA45
genes like me logo Genes that share expression patterns with SPATA45: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPATA45 Gene

Orthologs for SPATA45 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPATA45 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPATA45 33
  • 98.98 (n)
-- 34
  • 98 (a)
OneToMany
-- 34
  • 98 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SPATA45 33
  • 83.16 (n)
C16H1orf227 34
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPATA45 33
  • 82.65 (n)
mouse
(Mus musculus)
Mammalia 1700022P22Rik 33 34
  • 73.2 (n)
Spata45 16
rat
(Rattus norvegicus)
Mammalia LOC498316 33
  • 72.16 (n)
Species where no ortholog for SPATA45 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPATA45 Gene

ENSEMBL:
Gene Tree for SPATA45 (if available)
TreeFam:
Gene Tree for SPATA45 (if available)

Paralogs for SPATA45 Gene

No data available for Paralogs for SPATA45 Gene

Variants for SPATA45 Gene

Sequence variations from dbSNP and Humsavar for SPATA45 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000054221 -- 212,847,377(-) T/A intron_variant
rs1000074166 -- 212,840,936(-) T/C intron_variant
rs1000144371 -- 212,840,656(-) C/T intron_variant
rs1000312387 -- 212,834,607(-) C/A/T intron_variant
rs1000603879 -- 212,842,891(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SPATA45 Gene

Variant ID Type Subtype PubMed ID
dgv571n100 CNV gain 25217958
dgv807n54 CNV loss 21841781
dgv808n54 CNV loss 21841781
dgv809n54 CNV loss 21841781
dgv810n54 CNV loss 21841781
dgv811n54 CNV loss 21841781
dgv812n54 CNV loss 21841781
dgv813n54 CNV loss 21841781
dgv814n54 CNV loss 21841781
dgv815n54 CNV loss 21841781
esv2421907 CNV deletion 20811451
esv24713 CNV loss 19812545
esv2672098 CNV deletion 23128226
esv2722506 CNV deletion 23290073
esv2758997 CNV loss 17122850
esv2763825 CNV loss 21179565
esv32562 CNV loss 17666407
esv3546210 CNV deletion 23714750
esv3588756 CNV loss 21293372
esv3891104 CNV loss 25118596
esv3891115 CNV loss 25118596
nsv1160022 CNV deletion 26073780
nsv441735 CNV loss 18776908
nsv508691 CNV deletion 20534489
nsv514041 CNV loss 21397061
nsv549177 CNV loss 21841781
nsv826564 CNV loss 20364138
nsv8791 CNV loss 18304495

Variation tolerance for SPATA45 Gene

Residual Variation Intolerance Score: 60.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.84; 58.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPATA45 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPATA45

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATA45 Gene

Disorders for SPATA45 Gene

Additional Disease Information for SPATA45

No disorders were found for SPATA45 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPATA45 Gene

Publications for SPATA45 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for SPATA45 Gene

Sources for SPATA45 Gene

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