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Aliases for SPATA4 Gene

Aliases for SPATA4 Gene

  • Spermatogenesis Associated 4 2 3 5
  • Testis Spermatocyte Apoptosis-Related Gene 2 Protein 3 4
  • TSARG2 3 4
  • Testis And Spermatogenesis Cell Related Protein 2 3
  • Testis And Spermatogenesis Cell-Related Protein 2 4
  • Spermatogenesis-Associated Protein 4 3
  • SPEF1B 3

External Ids for SPATA4 Gene

Previous GeneCards Identifiers for SPATA4 Gene

  • GC00U991162
  • GC04M177802
  • GC04M177480
  • GC04M177342
  • GC04M177105
  • GC04M172856

Summaries for SPATA4 Gene

GeneCards Summary for SPATA4 Gene

SPATA4 (Spermatogenesis Associated 4) is a Protein Coding gene. Diseases associated with SPATA4 include Visceral Heterotaxy.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATA4 Gene

Genomics for SPATA4 Gene

Regulatory Elements for SPATA4 Gene

Enhancers for SPATA4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F176654 0.3 FANTOM5 40.1 -458.5 -458507 0.0 SPATA4 LOC105377555 GC04P176677
GH04F176184 0.5 ENCODE 12.8 +10.4 10389 1.2 GTF2F1 CEBPB MAX FEZF1 ZEB2 EP300 ZNF518A OSR2 ZNF692 STAT3 SPATA4 WDR17 GC04M176150
GH04F176192 1 ENCODE 0.8 +1.3 1275 3.8 HDGF ATF1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF2 ETS1 YY1 WDR17 SPATA4 GC04M176150
GH04F176186 0.6 Ensembl ENCODE 0.4 +8.6 8589 1.8 CTCF PKNOX1 SMC3 FEZF1 PRDM1 RAD21 MAFK SPATA4 GC04M176150
GH04F176156 0.2 ENCODE 0.3 +39.0 38979 1.0 JUND GPM6A GC04M176150 SPATA4
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SPATA4 on UCSC Golden Path with GeneCards custom track

Promoters for SPATA4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001254759 71 1200 HDGF ATF1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF2 ETS1 YY1

Genomic Location for SPATA4 Gene

Chromosome:
4
Start:
176,184,574 bp from pter
End:
176,195,671 bp from pter
Size:
11,098 bases
Orientation:
Minus strand

Genomic View for SPATA4 Gene

Genes around SPATA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA4 Gene

Proteins for SPATA4 Gene

  • Protein details for SPATA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEY3-SPAT4_HUMAN
    Recommended name:
    Spermatogenesis-associated protein 4
    Protein Accession:
    Q8NEY3
    Secondary Accessions:
    • Q8NCS5
    • Q8WW15

    Protein attributes for SPATA4 Gene

    Size:
    305 amino acids
    Molecular mass:
    34751 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPATA4 Gene

Post-translational modifications for SPATA4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPATA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPATA4 Gene

Domains & Families for SPATA4 Gene

Protein Domains for SPATA4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SPATA4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPATA4: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SPATA4 Gene

Function for SPATA4 Gene

Gene Ontology (GO) - Molecular Function for SPATA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SPATA4: view
genes like me logo Genes that share phenotypes with SPATA4: view

Animal Model Products

miRNA for SPATA4 Gene

miRTarBase miRNAs that target SPATA4

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPATA4 Gene

Localization for SPATA4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPATA4 Gene COMPARTMENTS Subcellular localization image for SPATA4 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for SPATA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SPATA4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SPATA4 Gene

Pathways & Interactions for SPATA4 Gene

SuperPathways for SPATA4 Gene

No Data Available

Interacting Proteins for SPATA4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000280191%0d%0a9606.ENSP00000349156%0d%0a
Selected Interacting proteins: Q8NEY3-SPAT4_HUMAN ENSP00000280191 for SPATA4 Gene via IID UniProtKB STRING

Gene Ontology (GO) - Biological Process for SPATA4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPATA4 Gene

Transcripts for SPATA4 Gene

mRNA/cDNA for SPATA4 Gene

Unigene Clusters for SPATA4 Gene

Spermatogenesis associated 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1:
SP2: -

Relevant External Links for SPATA4 Gene

GeneLoc Exon Structure for
SPATA4
ECgene alternative splicing isoforms for
SPATA4

Expression for SPATA4 Gene

mRNA expression in normal human tissues for SPATA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPATA4 Gene

This gene is overexpressed in Testis (x42.3).

Protein differential expression in normal tissues from HIPED for SPATA4 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPATA4 Gene



Protein tissue co-expression partners for SPATA4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SPATA4 Gene:

SPATA4

SOURCE GeneReport for Unigene cluster for SPATA4 Gene:

Hs.481235

mRNA Expression by UniProt/SwissProt for SPATA4 Gene:

Q8NEY3-SPAT4_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with SPATA4: view

Primer Products

Orthologs for SPATA4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPATA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPATA4 34 35
  • 99.45 (n)
cow
(Bos Taurus)
Mammalia SPATA4 34 35
  • 83.52 (n)
dog
(Canis familiaris)
Mammalia SPATA4 34 35
  • 83.48 (n)
rat
(Rattus norvegicus)
Mammalia Spata4 34
  • 79.62 (n)
mouse
(Mus musculus)
Mammalia Spata4 34 16 35
  • 79.02 (n)
oppossum
(Monodelphis domestica)
Mammalia SPATA4 35
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPATA4 35
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPATA4 34 35
  • 53.14 (n)
lizard
(Anolis carolinensis)
Reptilia SPATA4 35
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spata4 34
  • 55.06 (n)
zebrafish
(Danio rerio)
Actinopterygii spata4 34
  • 55.24 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
OneToOne
Species where no ortholog for SPATA4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPATA4 Gene

ENSEMBL:
Gene Tree for SPATA4 (if available)
TreeFam:
Gene Tree for SPATA4 (if available)

Paralogs for SPATA4 Gene

No data available for Paralogs for SPATA4 Gene

Variants for SPATA4 Gene

Sequence variations from dbSNP and Humsavar for SPATA4 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10000168 -- 176,189,051(+) TGGAA(A/G)GGTTT intron-variant
rs10004325 -- 176,185,138(+) TTTTG(C/G)TGCAT intron-variant
rs10027520 -- 176,185,323(+) CAGTT(C/T)TAATG intron-variant
rs10049746 -- 176,184,462(+) GGAAA(A/G)CATAT downstream-variant-500B
rs10718997 -- 176,196,348(+) TTTTG(-/T)TTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SPATA4 Gene

Variant ID Type Subtype PubMed ID
esv2728772 CNV deletion 23290073
esv34137 CNV loss 18971310
esv3603274 CNV gain 21293372
nsv1017524 CNV gain 25217958
nsv1020249 CNV loss 25217958
nsv596262 CNV gain 21841781

Variation tolerance for SPATA4 Gene

Residual Variation Intolerance Score: 70.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.41; 63.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPATA4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPATA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATA4 Gene

Disorders for SPATA4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SPATA4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
visceral heterotaxy
  • heterotaxia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SPATA4

Genetic Association Database (GAD)
SPATA4
Human Genome Epidemiology (HuGE) Navigator
SPATA4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPATA4
genes like me logo Genes that share disorders with SPATA4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPATA4 Gene

Publications for SPATA4 Gene

  1. Rapid identification of human testis spermatocyte apoptosis-related gene, TSARG2, by nested PCR and draft human genome searching. (PMID: 12019456) Liu S.F. … Lu G.X. (Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 2002) 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. SPATA4 Counteracts Etoposide-Induced Apoptosis via Modulating Bcl-2 Family Proteins in HeLa Cells. (PMID: 26424010) Jiang J. … Wang Z. (Biol. Pharm. Bull. 2015) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for SPATA4 Gene

Sources for SPATA4 Gene

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