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Aliases for SPATA4 Gene

Aliases for SPATA4 Gene

  • Spermatogenesis Associated 4 2 3
  • Testis Spermatocyte Apoptosis-Related Gene 2 Protein 3 4
  • Testis And Spermatogenesis Cell-Related Protein 2 3 4
  • TSARG2 3 4
  • Testis And Spermatogenesis Cell Related Protein 2 3
  • SPEF1B 3

External Ids for SPATA4 Gene

Previous GeneCards Identifiers for SPATA4 Gene

  • GC00U991162
  • GC04M177802
  • GC04M177480
  • GC04M177342
  • GC04M177105
  • GC04M172856

Summaries for SPATA4 Gene

GeneCards Summary for SPATA4 Gene

SPATA4 (Spermatogenesis Associated 4) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATA4 Gene

Genomics for SPATA4 Gene

Regulatory Elements for SPATA4 Gene

Genomic Location for SPATA4 Gene

Chromosome:
4
Start:
176,184,574 bp from pter
End:
176,195,671 bp from pter
Size:
11,098 bases
Orientation:
Minus strand

Genomic View for SPATA4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPATA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA4 Gene

Proteins for SPATA4 Gene

  • Protein details for SPATA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEY3-SPAT4_HUMAN
    Recommended name:
    Spermatogenesis-associated protein 4
    Protein Accession:
    Q8NEY3
    Secondary Accessions:
    • Q8NCS5
    • Q8WW15

    Protein attributes for SPATA4 Gene

    Size:
    305 amino acids
    Molecular mass:
    34751 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPATA4 Gene

Proteomics data for SPATA4 Gene at MOPED

Post-translational modifications for SPATA4 Gene

No Post-translational modifications

Other Protein References for SPATA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SPATA4 Gene

Domains & Families for SPATA4 Gene

Protein Domains for SPATA4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SPATA4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPATA4: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SPATA4 Gene

Function for SPATA4 Gene

Gene Ontology (GO) - Molecular Function for SPATA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SPATA4: view

Phenotypes for SPATA4 Gene

GenomeRNAi human phenotypes for SPATA4:
genes like me logo Genes that share phenotypes with SPATA4: view

Animal Model Products

miRNA for SPATA4 Gene

miRTarBase miRNAs that target SPATA4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPATA4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SPATA4 Gene

Localization for SPATA4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPATA4 Gene COMPARTMENTS Subcellular localization image for SPATA4 gene
Compartment Confidence
nucleus 1

Gene Ontology (GO) - Cellular Components for SPATA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SPATA4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SPATA4 Gene

Pathways & Interactions for SPATA4 Gene

SuperPathways for SPATA4 Gene

No Data Available

Interacting Proteins for SPATA4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000280191%0d%0a9606.ENSP00000349156%0d%0a
Selected Interacting proteins: Q8NEY3-SPAT4_HUMAN ENSP00000280191 for SPATA4 Gene via I2D UniProtKB MINT STRING

Gene Ontology (GO) - Biological Process for SPATA4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPATA4 Gene

Drugs & Compounds for SPATA4 Gene

No Compound Related Data Available

Transcripts for SPATA4 Gene

mRNA/cDNA for SPATA4 Gene

Unigene Clusters for SPATA4 Gene

Spermatogenesis associated 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPATA4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1:
SP2: -

Relevant External Links for SPATA4 Gene

GeneLoc Exon Structure for
SPATA4
ECgene alternative splicing isoforms for
SPATA4

Expression for SPATA4 Gene

mRNA expression in normal human tissues for SPATA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPATA4 Gene

This gene is overexpressed in Testis (x42.3).

Protein differential expression in normal tissues from HIPED for SPATA4 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPATA4 Gene



SOURCE GeneReport for Unigene cluster for SPATA4 Gene Hs.481235

mRNA Expression by UniProt/SwissProt for SPATA4 Gene

Q8NEY3-SPAT4_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with SPATA4: view

Protein tissue co-expression partners for SPATA4 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SPATA4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPATA4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SPATA4 35
  • 83.52 (n)
  • 79.03 (a)
SPATA4 36
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPATA4 35
  • 83.48 (n)
  • 79.91 (a)
SPATA4 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spata4 35
  • 79.02 (n)
  • 73.08 (a)
Spata4 16
Spata4 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SPATA4 35
  • 99.45 (n)
  • 99.02 (a)
SPATA4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spata4 35
  • 79.62 (n)
  • 71.43 (a)
oppossum
(Monodelphis domestica)
Mammalia SPATA4 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPATA4 36
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPATA4 35
  • 53.14 (n)
  • 45.54 (a)
SPATA4 36
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPATA4 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spata4 35
  • 55.06 (n)
  • 48.18 (a)
zebrafish
(Danio rerio)
Actinopterygii spata4 35
  • 55.24 (n)
  • 50 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToOne
Species with no ortholog for SPATA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPATA4 Gene

ENSEMBL:
Gene Tree for SPATA4 (if available)
TreeFam:
Gene Tree for SPATA4 (if available)

Paralogs for SPATA4 Gene

No data available for Paralogs for SPATA4 Gene

Variants for SPATA4 Gene

Sequence variations from dbSNP and Humsavar for SPATA4 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_051369 -

Structural Variations from Database of Genomic Variants (DGV) for SPATA4 Gene

Variant ID Type Subtype PubMed ID
esv2728772 CNV Deletion 23290073
esv34137 CNV Loss 18971310

Variation tolerance for SPATA4 Gene

Residual Variation Intolerance Score: 70.19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.41; 63.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPATA4 Gene

HapMap Linkage Disequilibrium report
SPATA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATA4 Gene

Disorders for SPATA4 Gene

Relevant External Links for SPATA4

Genetic Association Database (GAD)
SPATA4
Human Genome Epidemiology (HuGE) Navigator
SPATA4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPATA4
genes like me logo Genes that share disorders with SPATA4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPATA4 Gene

Publications for SPATA4 Gene

  1. Retinoic acid protects human breast cancer cells against etoposide-induced apoptosis by NF-kappaB-dependent but cIAP2-independent mechanisms. (PMID: 20102612) JimAcnez-Lara A.M. … Gronemeyer H. (Mol. Cancer 2010) 23 67
  2. Cloning and characterization of zebra fish SPATA4 gene and analysis of its gonad specific expression. (PMID: 16038605) Liu S. … Wang Z. (Biochemistry Mosc. 2005) 23 67
  3. Rapid identification of human testis spermatocyte apoptosis-related gene, TSARG2, by nested PCR and draft human genome searching. (PMID: 12019456) Liu S.F. … Lu G.X. (Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 2002) 23 67
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  5. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 67

Products for SPATA4 Gene

Sources for SPATA4 Gene

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