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Aliases for SPATA33 Gene

Aliases for SPATA33 Gene

  • Spermatogenesis Associated 33 2 3 5
  • C16orf55 3 4
  • Spermatogenesis-Associated Protein 33 3
  • Chromosome 16 Open Reading Frame 55 2

External Ids for SPATA33 Gene

Previous HGNC Symbols for SPATA33 Gene

  • C16orf55

Previous GeneCards Identifiers for SPATA33 Gene

  • GC16P089733

Summaries for SPATA33 Gene

GeneCards Summary for SPATA33 Gene

SPATA33 (Spermatogenesis Associated 33) is a Protein Coding gene.

Additional gene information for SPATA33 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATA33 Gene

Genomics for SPATA33 Gene

GeneHancer (GH) Regulatory Elements for SPATA33 Gene

Promoters and enhancers for SPATA33 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I089656 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.0 21 2.6 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SLC30A9 POLR2B E2F8 ZNF143 CHMP1A SPATA33 CDK10 AFG3L1P TCF25 MC1R ENSG00000259877 GAS8-AS1 ACSF3 DBNDD1
GH16I089993 Enhancer 1.5 Ensembl ENCODE dbSUPER 12.2 +337.5 337503 3.5 HDGF PKNOX1 CLOCK FOXA2 ARNT ZFP64 ARID4B SIN3A ZNF2 ZBTB7B PIR44838 ENSG00000259877 AFG3L1P ANKRD11 MC1R ACSF3 TCF25 GAS8 LOC101927863 SNORD68
GH16I090032 Enhancer 0.9 ENCODE 10.6 +374.4 374424 0.2 HDGF HDAC1 ZNF133 INSM2 ZNF76 KLF5 ZEB1 ZNF23 KLF7 ZNF548 ANKRD11 LOC101927863 ENSG00000259877 SNORD68 GAS8 RPL13 AFG3L1P ACSF3 CDK10 ZNF778
GH16I089616 Enhancer 1.1 FANTOM5 Ensembl ENCODE 7 -40.9 -40867 0.9 KLF1 ZBTB6 MAX FEZF1 ZBTB40 ZNF335 ETV6 ZNF600 ZBTB11 ELF1 DBNDD1 GAS8-AS1 RPL13 SPATA33 DPEP1 PIR44959
GH16I090076 Enhancer 1.4 FANTOM5 Ensembl ENCODE 1.1 +420.1 420103 1.9 PKNOX1 CLOCK ARNT SIN3A ZNF2 GLIS2 E2F8 ARID2 ZNF143 FOS CDK10 ZNF778 ENSG00000261172 SPATA2L ZNF276 TCF25 VPS9D1 SPATA33 PRDM7 URAHP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPATA33 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SPATA33 Gene

Genomic Locations for SPATA33 Gene
13,529 bases
Plus strand

Genomic View for SPATA33 Gene

Genes around SPATA33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATA33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATA33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA33 Gene

Proteins for SPATA33 Gene

  • Protein details for SPATA33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Spermatogenesis-associated protein 33
    Protein Accession:
    Secondary Accessions:
    • A8WFL2
    • B4DZN8

    Protein attributes for SPATA33 Gene

    139 amino acids
    Molecular mass:
    15461 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPATA33 Gene


neXtProt entry for SPATA33 Gene

Post-translational modifications for SPATA33 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SPATA33 Gene

Domains & Families for SPATA33 Gene

Gene Families for SPATA33 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPATA33 Gene


Suggested Antigen Peptide Sequences for SPATA33 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPATA33: view

No data available for UniProtKB/Swiss-Prot for SPATA33 Gene

Function for SPATA33 Gene

Phenotypes From GWAS Catalog for SPATA33 Gene

Phenotypes for SPATA33 Gene

GenomeRNAi human phenotypes for SPATA33:
genes like me logo Genes that share phenotypes with SPATA33: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPATA33 Gene

Localization for SPATA33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPATA33 Gene

Cytoplasm, cytosol. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPATA33 gene
Compartment Confidence
nucleus 4
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SPATA33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with SPATA33: view

Pathways & Interactions for SPATA33 Gene

SuperPathways for SPATA33 Gene

No Data Available

Interacting Proteins for SPATA33 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000301031 for SPATA33 Gene via STRING

Gene Ontology (GO) - Biological Process for SPATA33 Gene


No data available for Pathways by source and SIGNOR curated interactions for SPATA33 Gene

Drugs & Compounds for SPATA33 Gene

No Compound Related Data Available

Transcripts for SPATA33 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA33 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - -
SP5: - - -
SP6: - - - - - - -
SP7: - - - - - - -
SP8: - -
SP9: - - - - - -
SP10: - - - - - -

Relevant External Links for SPATA33 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPATA33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPATA33 Gene

mRNA differential expression in normal tissues according to GTEx for SPATA33 Gene

This gene is overexpressed in Testis (x13.8).

Protein differential expression in normal tissues from HIPED for SPATA33 Gene

This gene is overexpressed in Testis (49.3) and Ovary (18.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPATA33 Gene

Protein tissue co-expression partners for SPATA33 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SPATA33 Gene:


Evidence on tissue expression from TISSUES for SPATA33 Gene

  • Spleen(3)
  • Nervous system(3)
  • Lung(2.9)
  • Liver(2.8)
  • Intestine(2.6)
  • Kidney(2.6)
  • Muscle(2.6)
  • Heart(2.4)
genes like me logo Genes that share expression patterns with SPATA33: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPATA33 Gene

Orthologs for SPATA33 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPATA33 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPATA33 33 34
  • 99.05 (n)
(Mus musculus)
Mammalia Spata33 33 16 34
  • 72.47 (n)
(Rattus norvegicus)
Mammalia Spata33 33
  • 70.77 (n)
(Bos Taurus)
Mammalia SPATA33 33
  • 67.65 (n)
(Canis familiaris)
Mammalia SPATA33 34
  • 51 (a)
Species where no ortholog for SPATA33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPATA33 Gene

Gene Tree for SPATA33 (if available)
Gene Tree for SPATA33 (if available)

Paralogs for SPATA33 Gene

(1) SIMAP similar genes for SPATA33 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SPATA33: view

No data available for Paralogs for SPATA33 Gene

Variants for SPATA33 Gene

Sequence variations from dbSNP and Humsavar for SPATA33 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs369307331 likely-benign, not specified 89,657,569(+) C/A upstream_transcript_variant
rs73262948 benign, not specified 89,657,619(+) G/A/C/T upstream_transcript_variant
rs1000034231 -- 89,664,295(+) G/A/T genic_downstream_transcript_variant, intron_variant
rs1000251385 -- 89,662,835(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000335852 -- 89,659,132(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SPATA33 Gene

Variant ID Type Subtype PubMed ID
esv2762221 CNV gain+loss 21179565
nsv1057351 CNV loss 25217958
nsv1063483 CNV gain 25217958
nsv1066382 CNV gain 25217958
nsv428331 CNV gain+loss 18775914
nsv457623 CNV gain 19166990
nsv482951 CNV loss 15286789
nsv509639 CNV insertion 20534489
nsv573739 CNV gain 21841781
nsv573743 CNV gain 21841781

Variation tolerance for SPATA33 Gene

Residual Variation Intolerance Score: 88.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.32; 70.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPATA33 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATA33 Gene

Disorders for SPATA33 Gene

Additional Disease Information for SPATA33

No disorders were found for SPATA33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPATA33 Gene

Publications for SPATA33 Gene

  1. A novel testis-enriched gene Spata33 is expressed during spermatogenesis. (PMID: 23844118) Chen H … Zhou R (PloS one 2013) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Genome-wide association study in Han Chinese identifies three novel loci for human height. (PMID: 23456168) Hao Y … Gu D (Human genetics 2013) 3 58
  5. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y … Sugano S (Genome research 2004) 3 58

Products for SPATA33 Gene

Sources for SPATA33 Gene

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