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Aliases for SPATA32 Gene

Aliases for SPATA32 Gene

  • Spermatogenesis Associated 32 2 3 5
  • Testis-Expressed Protein 34 3 4
  • Acrosome Expressed 2 2 3
  • Testis Expressed 34 2 3
  • C17orf46 3 4
  • TEX34 3 4
  • Spermatogenesis-Associated Protein 32 3
  • Testis-Expressed Sequence 34 Protein 3
  • Chromosome 17 Open Reading Frame 46 2
  • CTD-2020K17.4 3
  • VAD1.2 3
  • AEP2 3

External Ids for SPATA32 Gene

Previous HGNC Symbols for SPATA32 Gene

  • C17orf46
  • TEX34

Previous GeneCards Identifiers for SPATA32 Gene

  • GC17M043333

Summaries for SPATA32 Gene

GeneCards Summary for SPATA32 Gene

SPATA32 (Spermatogenesis Associated 32) is a Protein Coding gene. GO annotations related to this gene include actin binding.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATA32 Gene

Genomics for SPATA32 Gene

Regulatory Elements for SPATA32 Gene

Enhancers for SPATA32 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G045305 2 FANTOM5 Ensembl ENCODE dbSUPER 17.3 -51.6 -51620 17.2 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 FMNL1 LINC02210 SPATA32 ARHGAP27 GPATCH8 DCAKD LRRC37A4P PLEKHM1 DND1P1 MAPK8IP1P1
GH17G045282 1.3 ENCODE dbSUPER 23.4 -21.5 -21545 3.2 HNRNPUL1 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 SPATA32 FMNL1 MAP3K14 LINC02210 ENSG00000262372 DCAKD KANSL1 EFTUD2 ENSG00000233175 ENSG00000233483
GH17G045287 1.4 ENCODE dbSUPER 21.3 -26.8 -26828 3.3 HNRNPUL1 ARNT ARID4B SIN3A ZNF2 SLC30A9 ZNF302 ZNF143 ZNF207 CEBPZ ENSG00000262372 KANSL1 SPATA32 ENSG00000224505 ENSG00000266918 MAP3K14 FMNL1 GPATCH8 EFTUD2 LRRC37A4P
GH17G045404 2 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -148.7 -148691 13.3 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC LINC02210 LRRC37A4P ARHGAP27 FMNL1 SPATA32 ENSG00000262372 GJC1 KANSL1 EFTUD2 LRRC37A
GH17G045345 1.6 Ensembl ENCODE dbSUPER 11.4 -83.9 -83854 1.9 PKNOX1 ARNT FEZF1 ZNF2 ZNF766 REST ZNF592 MEF2D ZNF610 SMARCA4 MAP3K14 SPATA32 FMNL1 EFTUD2 LRRC37A4P MAPK8IP1P2 DND1P1 KANSL1-AS1 GC17M045328 RNA5SP443
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPATA32 on UCSC Golden Path with GeneCards custom track

Promoters for SPATA32 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000094896 112 401 HDGF CTCF AGO1 RBBP5 ZNF2 RAD21 HIC1 ZFHX2 POLR2A SMC3

Genomic Location for SPATA32 Gene

Chromosome:
17
Start:
45,247,274 bp from pter
End:
45,262,112 bp from pter
Size:
14,839 bases
Orientation:
Minus strand

Genomic View for SPATA32 Gene

Genes around SPATA32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATA32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATA32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA32 Gene

Proteins for SPATA32 Gene

  • Protein details for SPATA32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LK8-SPT32_HUMAN
    Recommended name:
    Spermatogenesis-associated protein 32
    Protein Accession:
    Q96LK8
    Secondary Accessions:
    • Q7Z4U1
    • Q8N6V6

    Protein attributes for SPATA32 Gene

    Size:
    384 amino acids
    Molecular mass:
    42325 Da
    Quaternary structure:
    • Interacts with syntaxin-1 and ACTB.

neXtProt entry for SPATA32 Gene

Post-translational modifications for SPATA32 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPATA32 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPATA32 Gene

Domains & Families for SPATA32 Gene

Protein Domains for SPATA32 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPATA32 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPATA32: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SPATA32 Gene

Function for SPATA32 Gene

Gene Ontology (GO) - Molecular Function for SPATA32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IBA --
genes like me logo Genes that share ontologies with SPATA32: view
genes like me logo Genes that share phenotypes with SPATA32: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPATA32 Gene

Localization for SPATA32 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPATA32 gene
Compartment Confidence
nucleus 3
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for SPATA32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048471 perinuclear region of cytoplasm IBA,IEA --
genes like me logo Genes that share ontologies with SPATA32: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SPATA32 Gene

Pathways & Interactions for SPATA32 Gene

SuperPathways for SPATA32 Gene

No Data Available

Interacting Proteins for SPATA32 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000331532%0d%0a9606.ENSP00000308750%0d%0a9606.ENSP00000334922%0d%0a9606.ENSP00000270617%0d%0a
Selected Interacting proteins: ENSP00000331532 for SPATA32 Gene via STRING

Gene Ontology (GO) - Biological Process for SPATA32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis IBA --
genes like me logo Genes that share ontologies with SPATA32: view

No data available for Pathways by source and SIGNOR curated interactions for SPATA32 Gene

Drugs & Compounds for SPATA32 Gene

No Compound Related Data Available

Transcripts for SPATA32 Gene

mRNA/cDNA for SPATA32 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPATA32 Gene

Spermatogenesis associated 32:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA32 Gene

No ASD Table

Relevant External Links for SPATA32 Gene

GeneLoc Exon Structure for
SPATA32
ECgene alternative splicing isoforms for
SPATA32

Expression for SPATA32 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPATA32 Gene

mRNA differential expression in normal tissues according to GTEx for SPATA32 Gene

This gene is overexpressed in Testis (x46.0).

NURSA nuclear receptor signaling pathways regulating expression of SPATA32 Gene:

SPATA32

SOURCE GeneReport for Unigene cluster for SPATA32 Gene:

Hs.412719

mRNA Expression by UniProt/SwissProt for SPATA32 Gene:

Q96LK8-SPT32_HUMAN
Tissue specificity: Detected in testis, and on the acrosomal cap of spermatids.

Evidence on tissue expression from TISSUES for SPATA32 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with SPATA32: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPATA32 Gene

Orthologs for SPATA32 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPATA32 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPATA32 34 35
  • 98.78 (n)
cow
(Bos Taurus)
Mammalia LOC767871 34
  • 65.89 (n)
SPATA32 35
  • 42 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spata32 34 16 35
  • 61.68 (n)
rat
(Rattus norvegicus)
Mammalia Spata32 34
  • 60.96 (n)
dog
(Canis familiaris)
Mammalia SPATA32 35
  • 46 (a)
OneToOne
Species where no ortholog for SPATA32 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPATA32 Gene

ENSEMBL:
Gene Tree for SPATA32 (if available)
TreeFam:
Gene Tree for SPATA32 (if available)

Paralogs for SPATA32 Gene

No data available for Paralogs for SPATA32 Gene

Variants for SPATA32 Gene

Sequence variations from dbSNP and Humsavar for SPATA32 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000251424 -- 45,262,136(+) GGTGC(-/CTGTGATGTCGCCGCCT)CTGTG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1000335712 -- 45,263,553(+) CTCCT(A/G)CAGTG intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1000888056 -- 45,259,066(+) ATTTT(C/G)TACAT intron-variant
rs1000894770 -- 45,255,500(+) GGACA(G/T)GAGGG intron-variant, reference, missense
rs1000968958 -- 45,261,028(+) CTCTC(C/G)ATGAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SPATA32 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159
nsv953904 CNV deletion 24416366

Variation tolerance for SPATA32 Gene

Residual Variation Intolerance Score: 69.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.10; 69.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPATA32 Gene

Human Gene Mutation Database (HGMD)
SPATA32
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPATA32

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATA32 Gene

Disorders for SPATA32 Gene

Relevant External Links for SPATA32

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPATA32

No disorders were found for SPATA32 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPATA32 Gene

Publications for SPATA32 Gene

  1. Characterization of an acrosome protein VAD1.2/AEP2 which is differentially expressed in spermatogenesis. (PMID: 18621766) Lee K.F. … Luk J.M. (Mol. Hum. Reprod. 2008) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. (PMID: 21048031) Casabonne D. … de Sanjose S. (Haematologica 2011) 3 64
  5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4 64

Products for SPATA32 Gene

Sources for SPATA32 Gene

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