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SPATA31A4 Gene

protein-coding   GIFtS: 20
GCID: GC09M041321

SPATA31 Subfamily A, Member 4

(Previous names: family with sequence similarity 75, member A4)
(Previous symbol: FAM75A4)
  Search for SPATA31A4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SPATA31 Subfamily A, Member 41
FAM75A41 3
Family With Sequence Similarity 75, Member A41
Protein FAM75A43

External Ids:    HGNC: 320041   Ensembl: ENSG000002342147   UniProtKB: Q4VX673   

Export aliases for SPATA31A4 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SPATA31A4 Gene:
SPATA31A4 (SPATA31 subfamily A, member 4) is a protein-coding gene. An important paralog of this gene is SPATA31A1.

UniProtKB/Swiss-Prot: S31A4_HUMAN, Q4VX67
Function: May play a role in spermatogenesis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for SPATA31A4
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPATA31A4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band:  9p12   HGNC cytogenetic band: 9p12

SPATA31A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPATA31A4 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M041321:  view genomic region     (about GC identifiers)

Start:
41,321,107 bp from pter      End:
41,327,397 bp from pter
Size:
6,291 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: S31A4_HUMAN, Q4VX67 (See protein sequence)
Recommended Name: Spermatogenesis-associated protein 31A4  
Size: 1347 amino acids; 148755 Da

Explore the universe of human proteins at neXtProt for SPATA31A4: NX_Q4VX67

Explore proteomics data for SPATA31A4 at MOPED


See SPATA31A4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


ENSEMBL proteins: 
 ENSP00000366731   ENSP00000411237  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR027970 DUF4599

Graphical View of Domain Structure for InterPro Entry Q4VX67

ProtoNet protein and cluster: Q4VX67

UniProtKB/Swiss-Prot: S31A4_HUMAN, Q4VX67
Similarity: Belongs to the SPATA31 family


Find genes that share domains with SPATA31A4           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: S31A4_HUMAN, Q4VX67
Function: May play a role in spermatogenesis (By similarity)

Animal Models:

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
S31A4_HUMAN, Q4VX67: Membrane; Single-pass membrane protein (Potential)

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral component of membrane ----

Find genes that share ontologies with SPATA31A4           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPATA31A4
Interactions:

    Search GeneGlobe Interaction Network for SPATA31A4

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007283spermatogenesis ----
GO:0030154cell differentiation ----

Find genes that share ontologies with SPATA31A4           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000377509 ENST00000603182 ENST00000603746 ENST00000604139 ENST00000603452
ENST00000429767(uc004abt.4)
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

SPATA31A4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SPATA31A4 Protein Expression
    Custom PCR Arrays for SPATA31A4
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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPATA31A4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

ENSEMBL Gene Tree for SPATA31A4 (if available)
TreeFam Gene Tree for SPATA31A4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SPATA31A4 gene
SPATA31A12  SPATA31D12  SPATA31E12  SPATA31A72  SPATA31A62  SPATA31A22  SPATA31A52  SPATA31A32  
11 SIMAP similar genes for SPATA31A4 using alignment to 2 protein entries:     S31A4_HUMAN (see all proteins):
SPATA31A3    SPATA31A5    SPATA31A7    FAM75A2    SPATA31A1    SPATA31A2
SPATA31A6    DKFZp434M131    SPATA31B1    SPATA31C1    SPATA31C2

Find genes that share paralogs with SPATA31A4           About GenesLikeMe


4 Pseudogenes.org Pseudogenes for SPATA31A4
PGOHUM00000236228 PGOHUM00000236244 PGOHUM00000236683 PGOHUM00000236708


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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10 SNPs for SPATA31A4    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1998890361,2
C,F--41323425(+) GTCCCG/AAAGCT 2 /R /W mis11Minor allele frequency- A:0.12EU 495
rs2012070211,2
F--41323464(+) TCCCAG/AGTTGC 2 /L syn11Minor allele frequency- A:0.01EU 351
rs2022075481,2
F--41323469(+) GGTTGC/TCCCAG 2 D G mis11Minor allele frequency- T:0.12EU 292
rs1996564151,2
C--41328237(+) GTTCAC/GCTCCC 1 -- us2k10--------
rs3681449031,2
----41328406(+) TTATCC/TGTCTA 1 -- us2k10--------
rs3724324551,2
----41328544(+) TCTGCC/TCAGCC 1 -- us2k10--------
rs3702074351,2
----41327940(+) TTCAA-/CAAAGG 1 -- us2k10--------
rs2016261341,2
----41323271(+) GTGGGG/TTCTCA 2 N T mis11Minor allele frequency- T:0.00EU 473
rs3746657811,2
----41328377(+) TTCCAC/TGTGTA 1 -- us2k10--------
rs2006183091,2
----41321671(+) ACTGCC/TGTCAT 2 T syn11Minor allele frequency- T:0.01EU 141

HapMap Linkage Disequilibrium report for SPATA31A4 (41321107 - 41327397 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for SPATA31A4: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing SPATA31A4
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SPATA31A4 gene integrated from 10 sources:
(articles sorted by number of sources associating them with SPATA31A4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The testis-specific VAD1.3/AEP1 interacts with I^-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence. (PubMed id 20850414)3 Zuo Y....Lee K.F. (Biochem. Biophys. Res. Commun. 2010)
  2. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (Nature 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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HGNC: 32004 Ensembl:ENSG00000234214 ECgene: SPATA31A4
H-InvDB: SPATA31A4

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SPATA31A4 gene:
Search GeneIP for patents involving SPATA31A4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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