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SPATA31A2 Gene

protein-coding   GIFtS: 27
GCID: GC09P039884

SPATA31 Subfamily A, Member 2

(Previous names: family with sequence similarity 75, member A2)
(Previous symbol: FAM75A2)
  Search for SPATA31A2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SPATA31 Subfamily A, Member 21 2
FAM75A21 2 3
Family With Sequence Similarity 75, Member A21 2
Protein FAM75A22 3
Spermatogenesis-Associated Protein 31A22

External Ids:    HGNC: 320021   Entrez Gene: 6422652   Ensembl: ENSG000002048487   UniProtKB: Q5RGS23   

Export aliases for SPATA31A2 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SPATA31A2 Gene:
SPATA31A2 (SPATA31 subfamily A, member 2) is a protein-coding gene. An important paralog of this gene is SPATA31A1.

UniProtKB/Swiss-Prot: S31A2_HUMAN, Q5RGS2
Function: May play a role in spermatogenesis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:NC_018920.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SPATA31A2
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPATA31A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.1   Ensembl cytogenetic band:  9p13.1   HGNC cytogenetic band: 9p13.1

SPATA31A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPATA31A2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P039884:  view genomic region     (about GC identifiers)

Start:
39,884,975 bp from pter      End:
39,891,210 bp from pter
Size:
6,236 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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UniProtKB/Swiss-Prot: S31A2_HUMAN, Q5RGS2 (See protein sequence)
Recommended Name: Spermatogenesis-associated protein 31A2  
Size: 1347 amino acids; 148657 Da

Explore the universe of human proteins at neXtProt for SPATA31A2: NX_Q5RGS2

Explore proteomics data for SPATA31A2 at MOPED


See SPATA31A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001035154.1  
ENSEMBL proteins: 
 ENSP00000406957  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR027970 DUF4599

Graphical View of Domain Structure for InterPro Entry Q5RGS2

ProtoNet protein and cluster: Q5RGS2

UniProtKB/Swiss-Prot: S31A2_HUMAN, Q5RGS2
Similarity: Belongs to the SPATA31 family


SPATA31A2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: S31A2_HUMAN, Q5RGS2
Function: May play a role in spermatogenesis (By similarity)

Animal Models:

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
S31A2_HUMAN, Q5RGS2: Membrane; Single-pass membrane protein (Potential)

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral component of membrane IEA--

SPATA31A2 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPATA31A2
Interactions:

    Search GeneGlobe Interaction Network for SPATA31A2

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007283spermatogenesis IEA--
GO:0030154cell differentiation IEA--

SPATA31A2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for SPATA31A2 (S31A2)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for SPATA31A2 gene: 
NM_001040065.1  

Unigene Cluster for SPATA31A2:

SPATA31 subfamily A, member 2
Hs.575677  [show with all ESTs]
Unigene Representative Sequence: NM_001040065
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000456183(uc004abp.3)
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  QuantiFast Probe-based Assays in human, mouse, rat SPATA31A2

Additional mRNA sequence: 

AK302569.1 BC146855.1 

1 DOTS entry:

DT.121164070 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SPATA31A2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
SPATA31A2 Expression
About this image

SPATA31A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SPATA31A2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.575677
    Custom PCR Arrays for SPATA31A2
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPATA31A2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

ENSEMBL Gene Tree for SPATA31A2 (if available)
TreeFam Gene Tree for SPATA31A2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SPATA31A2 gene
SPATA31A12  SPATA31D12  SPATA31E12  SPATA31A72  SPATA31A62  SPATA31A52  SPATA31A32  SPATA31A42  
11 SIMAP similar genes for SPATA31A2 using alignment to 1 protein entry:     S31A2_HUMAN:
FAM75A2    SPATA31A1    SPATA31A3    SPATA31A4    SPATA31A5    SPATA31A6
SPATA31A7    DKFZp434M131    SPATA31C1    SPATA31C2    SPATA31B1

SPATA31A2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SPATA31A2 (see all 38)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs558060251,2
C--39884520(+) GTGTGA/GGAAAG 1 -- us2k10--------
rs2003264351,2
F--39886897(+) GGTGGG/CGCCCA 1 -- int11Minor allele frequency- C:0.01EU 489
rs2021804271,2
F--39886959(+) TGAGAA/TCCCAG 1 -- int11Minor allele frequency- T:0.01EU 547
rs2013499221,2
C--39887043(+) ACTTCG/AGACCT 2 /S syn11Minor allele frequency- A:0.00EU 1319
rs2006932931,2
F--39887302(+) AGCTCG/ATGCCT 1 -- int11Minor allele frequency- A:0.01EU 927
rs1996665891,2
F--39887382(+) CCCCCA/GGGTGA 2 P syn11Minor allele frequency- G:0.00EU 1195
rs2010367981,2
F--39888103(+) CTTTGC/TGGAAT 2 R W mis11Minor allele frequency- T:0.00EU 1135
rs2021752291,2
F--39888121(+) AATCAT/CTGGAT 2 /L syn11Minor allele frequency- C:0.00EU 1240
rs2001866461,2
C--39890213(+) CATGCG/AGCTTC 2 /Q /R mis11Minor allele frequency- A:0.00EU 1323
rs2011784321,2
F--39890304(+) TCATGC/TAAGAG 2 C syn11Minor allele frequency- T:0.00EU 1093

HapMap Linkage Disequilibrium report for SPATA31A2 (39884975 - 39891210 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for SPATA31A2: --
Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing SPATA31A2
DNA2.0 Custom Variant and Variant Library Synthesis for SPATA31A2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SPATA31A2 gene integrated from 10 sources:
(articles sorted by number of sources associating them with SPATA31A2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The testis-specific VAD1.3/AEP1 interacts with I^-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence. (PubMed id 20850414)1, 3 Zuo Y....Lee K.F. (Biochem. Biophys. Res. Commun. 2010)
  2. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (Nature 2004)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 642265 HGNC: 32002 Ensembl:ENSG00000204848 euGenes: HUgn642265 ECgene: SPATA31A2
H-InvDB: SPATA31A2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SPATA31A2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SPATA31A2 gene:
Search GeneIP for patents involving SPATA31A2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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