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Aliases for SPATA2L Gene

Aliases for SPATA2L Gene

  • Spermatogenesis Associated 2 Like 2 3 5
  • SPATA2-Like Protein 3 4
  • C16orf76 3 4
  • Spermatogenesis-Associated Protein 2-Like Protein 3
  • Chromosome 16 Open Reading Frame 76 2
  • Tamo 3

External Ids for SPATA2L Gene

Previous HGNC Symbols for SPATA2L Gene

  • C16orf76

Previous GeneCards Identifiers for SPATA2L Gene

  • GC16M088292
  • GC16M089762
  • GC16M075458

Summaries for SPATA2L Gene

GeneCards Summary for SPATA2L Gene

SPATA2L (Spermatogenesis Associated 2 Like) is a Protein Coding gene. An important paralog of this gene is SPATA2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATA2L Gene

Genomics for SPATA2L Gene

Regulatory Elements for SPATA2L Gene

Enhancers for SPATA2L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SPATA2L on UCSC Golden Path with GeneCards custom track

Promoters for SPATA2L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SPATA2L on UCSC Golden Path with GeneCards custom track

Genomic Location for SPATA2L Gene

89,696,343 bp from pter
89,701,713 bp from pter
5,371 bases
Minus strand

Genomic View for SPATA2L Gene

Genes around SPATA2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATA2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATA2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA2L Gene

Proteins for SPATA2L Gene

  • Protein details for SPATA2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Spermatogenesis-associated protein 2-like protein
    Protein Accession:
    Secondary Accessions:
    • D3DX85
    • Q8NHV3

    Protein attributes for SPATA2L Gene

    424 amino acids
    Molecular mass:
    46179 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPATA2L Gene


neXtProt entry for SPATA2L Gene

Post-translational modifications for SPATA2L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPATA2L Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SPATA2L Gene

Domains & Families for SPATA2L Gene

Protein Domains for SPATA2L Gene


Suggested Antigen Peptide Sequences for SPATA2L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPATA2 family.
  • Belongs to the SPATA2 family.
genes like me logo Genes that share domains with SPATA2L: view

No data available for Gene Families for SPATA2L Gene

Function for SPATA2L Gene

genes like me logo Genes that share phenotypes with SPATA2L: view

Animal Model Products

CRISPR Products

miRNA for SPATA2L Gene

miRTarBase miRNAs that target SPATA2L

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPATA2L Gene

Localization for SPATA2L Gene

Subcellular locations from

Jensen Localization Image for SPATA2L Gene COMPARTMENTS Subcellular localization image for SPATA2L gene
Compartment Confidence
cytosol 3
nucleus 3
mitochondrion 2
plasma membrane 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPATA2L Gene

Pathways & Interactions for SPATA2L Gene

SuperPathways for SPATA2L Gene

No Data Available

Interacting Proteins for SPATA2L Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000289805 Q8IUW3-SPA2L_HUMAN for SPATA2L Gene via STRING IID

Gene Ontology (GO) - Biological Process for SPATA2L Gene


No data available for Pathways by source and SIGNOR curated interactions for SPATA2L Gene

Drugs & Compounds for SPATA2L Gene

No Compound Related Data Available

Transcripts for SPATA2L Gene

mRNA/cDNA for SPATA2L Gene

Unigene Clusters for SPATA2L Gene

Spermatogenesis associated 2-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA2L Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1: - -
SP2: -

Relevant External Links for SPATA2L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPATA2L Gene

mRNA expression in normal human tissues for SPATA2L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SPATA2L Gene

This gene is overexpressed in Heart (45.4) and Peripheral blood mononuclear cells (18.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPATA2L Gene

Protein tissue co-expression partners for SPATA2L Gene

NURSA nuclear receptor signaling pathways regulating expression of SPATA2L Gene:


SOURCE GeneReport for Unigene cluster for SPATA2L Gene:

genes like me logo Genes that share expression patterns with SPATA2L: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPATA2L Gene

Orthologs for SPATA2L Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPATA2L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SPATA2L 34
  • 82.52 (n)
  • 83.09 (a)
  • 81 (a)
(Canis familiaris)
Mammalia SPATA2L 34
  • 82.78 (n)
  • 83.25 (a)
  • 76 (a)
(Mus musculus)
Mammalia Spata2l 34
  • 81.4 (n)
  • 86.05 (a)
Spata2l 16
Spata2l 35
  • 84 (a)
(Pan troglodytes)
Mammalia SPATA2L 34
  • 99.06 (n)
  • 99.76 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Spata2L 34
  • 82.82 (n)
  • 86.76 (a)
(Monodelphis domestica)
Mammalia SPATA2L 35
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia SPATA2L 35
  • 56 (a)
(Gallus gallus)
Aves SPATA2L 35
  • 41 (a)
(Anolis carolinensis)
Reptilia SPATA2L 35
  • 38 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia spata2l 34
  • 43.77 (n)
  • 36.58 (a)
(Danio rerio)
Actinopterygii spata2l 35
  • 13 (a)
Species where no ortholog for SPATA2L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPATA2L Gene

Gene Tree for SPATA2L (if available)
Gene Tree for SPATA2L (if available)

Paralogs for SPATA2L Gene

Paralogs for SPATA2L Gene

genes like me logo Genes that share paralogs with SPATA2L: view

Variants for SPATA2L Gene

Sequence variations from dbSNP and Humsavar for SPATA2L Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs3751695 -- 89,698,141(-) TGCTT(C/T)GCCCT reference, synonymous-codon
rs3751696 -- 89,697,211(-) GGGGG(A/T)TGGAG utr-variant-3-prime
rs3803690 -- 89,696,951(-) CAGGA(C/G)TTGGG utr-variant-3-prime
rs9972861 -- 89,698,574(+) TCTGC(C/G)TCCCA intron-variant
rs9972864 -- 89,698,789(+) gccTA(A/G)AAttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPATA2L Gene

Variant ID Type Subtype PubMed ID
esv2762221 CNV gain+loss 21179565
nsv1057351 CNV loss 25217958
nsv428331 CNV gain+loss 18775914
nsv457623 CNV gain 19166990
nsv482951 CNV loss 15286789
nsv509639 CNV insertion 20534489
nsv516241 CNV loss 19592680
nsv573739 CNV gain 21841781
nsv573743 CNV gain 21841781
nsv833330 CNV loss 17160897
nsv952079 CNV deletion 24416366

Variation tolerance for SPATA2L Gene

Residual Variation Intolerance Score: 37.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.91; 35.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPATA2L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATA2L Gene

Disorders for SPATA2L Gene

Relevant External Links for SPATA2L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SPATA2L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPATA2L Gene

Publications for SPATA2L Gene

  1. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3 65
  2. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 65
  3. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3 65
  4. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3 65
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 65

Products for SPATA2L Gene

Sources for SPATA2L Gene