SPATA2L Gene
protein-coding GIFtS: 41
GCID: GC16M089762
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spermatogenesis associated 2-like(Previous name: chromosome 16 open reading frame 76 )
(Previous symbol: C16orf76)
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Aliases
for SPATA2L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Spermatogenesis Associated 2-Like1 2 | | MGC268851 | | C16orf761 2 3 | | Chromosome 16 Open Reading Frame 761 | | Tamo1 | | Spermatogenesis-Associated Protein 2-Like Protein2 | | SPATA2-Like Protein2 3 | | |
Export aliases for SPATA2L gene to outside databasesPrevious GC identifers: GC16M088292 GC16M075458 |
Summaries
for SPATA2L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SPATA2L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010542.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPATA2L gene promoter:
AhR POU2F1 NRF-2 AML1a CP2 POU2F1a Olf-1 XBP-1 CUTL1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPATA2L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPATA2L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q24.3 Ensembl cytogenetic band: 16q24.3 HGNC cytogenetic band: 16q24.3SPATA2L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M089762: view genomic region
(about GC identifiers)
Start:
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89,762,751 bp from pter |
End:
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89,768,113 bp from pter |
Size:
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5,363 bases |
Orientation:
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minus strand |
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Proteins
for SPATA2L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPA2L_HUMAN, Q8IUW3 (See
protein sequence)Recommended Name: Spermatogenesis-associated protein 2-like protein Size: 424 amino acids; 46179 Da
Secondary accessions: D3DX85 Q8NHV3Alternative splicing: 2 isoforms: Q8IUW3-1 Q8IUW3-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SPATA2L: NX_Q8IUW3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IUW3
SPATA2L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689552.2
ENSEMBL proteins: ENSP00000289805 ENSP00000334006 ENSP00000458083
Human Recombinant Protein Products:
SPATA2L Antibody Products:
Assay Products for SPATA2L: |
Protein
Domains /
Families
for SPATA2L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q8IUW3 UniProtKB/Swiss-Prot: SPA2L_HUMAN, Q8IUW3Similarity: Belongs to the SPATA2 family |
Function
for SPATA2L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA2L (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA2L (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: SPATA2L (NM_152339) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPATA2L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPATA2L |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPATA2L |
3 GenomeRNAi human phenotypes for SPATA2L:
|
Pathways & Interactions
for SPATA2L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPATA2L
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for SPATA2L (Q8IUW33 ENSP000002898054) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for SPATA2L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPATA2L
Search CenterWatch for drugs/clinical trials and news about SPATA2L / SPA2L
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Transcripts
for SPATA2L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPATA2L gene: NM_152339.3 Unigene Cluster for SPATA2L: Spermatogenesis associated 2-like Hs.374556 [show with all ESTs]Unigene Representative Sequence: NM_1523393 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000289805(uc002foj.3) ENST00000335360(uc002fok.3) ENST00000569918
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA2L (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA2L (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPATA2L (NM_152339) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPATA2L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPATA2L |
Additional cDNA sequence: AF070574.1 AK127372.1 BC027606.1 BC039608.1 BC053588.1 6 DOTS entries: DT.100832847 DT.75149153 DT.97769715 DT.100705508 DT.95369535 DT.97847205 24/52 AceView cDNA sequences (see all 52): BX387118 BX353978 CR602544 BU849032 BE793145 BX353977 BG394879 BI820975 BI917333 BM273272 CK819980 BX375464 BC027606 BM973644 BG721575 AK127372 NM_152339 BC053588 BQ072915 BC039608 BM544766 BE875800 AL525023 BM906021
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for SPATA2L About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b |
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| SP1: | | | | | | | - | | | | | | - | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SPATA2L
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Expression
for SPATA2L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPATA2L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCTGGGTAG
About this image
See SPATA2L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPATA2L
SOURCE GeneReport for Unigene cluster: Hs.374556
SABiosciences Custom PCR Arrays for SPATA2L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPATA2L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPATA2L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPATA2L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPATA2L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPATA2L |
Orthologs
for SPATA2L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SPATA2L gene from 3/10 species (see all 10) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LOC1008581371 |
spermatogenesis-associated protein 2-like protein-like |
56.34(n)
43.32(a) |
|
100858137 XM_003641955.1 XP_003642003.1 |
lizard
(Anolis carolinensis) |
Reptilia |
SPATA2L6 |
-- |
38(a) |
1 ↔ 1 |
GL343487.1(634682-636149) |
zebrafish
(Danio rerio) |
Actinopterygii |
CT027744.26 |
-- |
12(a) |
1 ↔ 1 |
7(45582225-45585779) |
ENSEMBL Gene Tree for SPATA2L (if available)
TreeFam Gene Tree for SPATA2L (if available) |
Paralogs
for SPATA2L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SPATA2L gene
- SPATA22
SPATA2L for paralogs About GeneDecksing
|
Genomic Variants
for SPATA2L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SPATA2L (89762751 - 89768113 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SPATA2L
2 CNVs: 49803 4977 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for SPATA2L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for SPATA2L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPATA2L gene integrated from 9 sources:
(articles sorted by number of sources associating them with SPATA2L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (1996)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (1997)
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External Searches for SPATA2L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SPATA2L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPATA2L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPATA2L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPATA2L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SPATA2L gene:
Search GeneIP for patents involving SPATA2L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPATA2L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPATA2L | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPATA2L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPATA2L | | | OriGene Protein Over-expression Lysate for SPATA2L | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPATA2L | | OriGene 3'-UTR Clone for SPATA2L | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA2L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA2L | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SPATA2L | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SPATA2L | | OriGene Custom Protein Services for SPATA2L | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPATA2L | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPATA2L | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPATA2L | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPATA2L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPATA2L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPATA2L |
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| | | | Search Tocris compounds for SPATA2L |
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 | | | SPATA2L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPATA2L |
|  |  |  | | | | ThermoFisher Antibodies for SPATA2L |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPATA2L |
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