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Aliases for SPATA25 Gene

Aliases for SPATA25 Gene

  • Spermatogenesis Associated 25 2 3 5
  • Testis-Specific Gene 23 Protein 3 4
  • C20orf165 3 4
  • TSG23 3 4
  • Spermatogenesis-Associated Protein 25 3
  • Chromosome 20 Open Reading Frame 165 2
  • DJ337O18.8 3

External Ids for SPATA25 Gene

Previous HGNC Symbols for SPATA25 Gene

  • C20orf165

Previous GeneCards Identifiers for SPATA25 Gene

  • GC20M044516

Summaries for SPATA25 Gene

GeneCards Summary for SPATA25 Gene

SPATA25 (Spermatogenesis Associated 25) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SPATA25 Gene

  • May play a role in spermatogenesis.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATA25 Gene

Genomics for SPATA25 Gene

Regulatory Elements for SPATA25 Gene

Enhancers for SPATA25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G045334 2 FANTOM5 Ensembl ENCODE dbSUPER 14.3 +546.6 546573 14.4 MLX ZFP64 DMAP1 YY1 ZNF143 SP3 NFYC SSRP1 GLIS1 RCOR2 NCOA5 PCIF1 ZNF335 ZSWIM1 CD40 SPATA25 DBNDD2 SYS1-DBNDD2 SYS1 PIGT
GH20G044909 1.5 FANTOM5 ENCODE 14.3 +977.9 977909 2.9 HDGF CREB3L1 ARNT AGO1 ZFP64 SIN3A ARID4B DMAP1 YY1 SLC30A9 YWHAB SPATA25 PABPC1L TOMM34 STK4-AS1 STK4 DBNDD2 PIR52220
GH20G045433 1.3 FANTOM5 ENCODE dbSUPER 14.3 +455.2 455155 0.8 ZFP64 ZNF140 ZNF384 ZNF697 ZNF316 NFE2 ZNF680 ZBTB11 ZNF426 REST SPATA25 DBNDD2 NCOA5 SYS1 SYS1-DBNDD2 WFDC11 KCNS1 WFDC6 LOC105372631 GC20P045440
GH20G046107 1.6 FANTOM5 ENCODE dbSUPER 11.6 -219.9 -219870 1.3 ATF1 CREB3L1 WRNIP1 ARID4B DMAP1 SLC30A9 ZNF143 ZMIZ1 SP3 NFYC CD40 SPATA25 SLC12A5 SLC12A5-AS1 WFDC3 RPL13P2 SLC35C2 ZNF335 GC20P046113
GH20G045917 1.5 Ensembl ENCODE dbSUPER 11.6 -30.6 -30575 4.0 FOXA2 ARNT ARID4B FEZF1 ZNF48 GATA2 FOS MIER2 KAT8 MIER3 WFDC3 NEURL2 CTSA SPATA25 PLTP ACOT8 ZSWIM3 SNX21 TNNC2 UBE2C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPATA25 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPATA25 Gene

Chromosome:
20
Start:
45,886,486 bp from pter
End:
45,888,653 bp from pter
Size:
2,168 bases
Orientation:
Minus strand

Genomic View for SPATA25 Gene

Genes around SPATA25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATA25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATA25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA25 Gene

Proteins for SPATA25 Gene

  • Protein details for SPATA25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BR10-SPT25_HUMAN
    Recommended name:
    Spermatogenesis-associated protein 25
    Protein Accession:
    Q9BR10

    Protein attributes for SPATA25 Gene

    Size:
    227 amino acids
    Molecular mass:
    23834 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPATA25 Gene

Post-translational modifications for SPATA25 Gene

No Post-translational modifications

Other Protein References for SPATA25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPATA25 Gene

Domains & Families for SPATA25 Gene

Protein Domains for SPATA25 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9BR10

UniProtKB/Swiss-Prot:

SPT25_HUMAN :
  • Belongs to the SPATA25 family.
Family:
  • Belongs to the SPATA25 family.
genes like me logo Genes that share domains with SPATA25: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for SPATA25 Gene

Function for SPATA25 Gene

Molecular function for SPATA25 Gene

UniProtKB/Swiss-Prot Function:
May play a role in spermatogenesis.

Gene Ontology (GO) - Molecular Function for SPATA25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SPATA25: view

Phenotypes for SPATA25 Gene

genes like me logo Genes that share phenotypes with SPATA25: view

Animal Models for SPATA25 Gene

MGI Knock Outs for SPATA25:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SPATA25 Gene

Localization for SPATA25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPATA25 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPATA25 gene
Compartment Confidence
extracellular 3
mitochondrion 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SPATA25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SPATA25: view

Pathways & Interactions for SPATA25 Gene

SuperPathways for SPATA25 Gene

No Data Available

Interacting Proteins for SPATA25 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000361597%0d%0a9606.ENSP00000302564%0d%0a9606.ENSP00000293288%0d%0a
Selected Interacting proteins: ENSP00000361597 for SPATA25 Gene via STRING

Gene Ontology (GO) - Biological Process for SPATA25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis IEP 19240080
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with SPATA25: view

No data available for Pathways by source and SIGNOR curated interactions for SPATA25 Gene

Drugs & Compounds for SPATA25 Gene

No Compound Related Data Available

Transcripts for SPATA25 Gene

mRNA/cDNA for SPATA25 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPATA25 Gene

Spermatogenesis associated 25:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA25 Gene

No ASD Table

Relevant External Links for SPATA25 Gene

GeneLoc Exon Structure for
SPATA25
ECgene alternative splicing isoforms for
SPATA25

Expression for SPATA25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPATA25 Gene

mRNA differential expression in normal tissues according to GTEx for SPATA25 Gene

This gene is overexpressed in Testis (x7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPATA25 Gene



NURSA nuclear receptor signaling pathways regulating expression of SPATA25 Gene:

SPATA25

SOURCE GeneReport for Unigene cluster for SPATA25 Gene:

Hs.128235

mRNA Expression by UniProt/SwissProt for SPATA25 Gene:

Q9BR10-SPT25_HUMAN
Tissue specificity: Expressed predominantly in testis (at protein level). Expression is lower in patients with obstructive azoospermia than in fertile controls and is not detected in patients with non-obstructive azoospermia.

Evidence on tissue expression from TISSUES for SPATA25 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with SPATA25: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPATA25 Gene

Orthologs for SPATA25 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPATA25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPATA25 34 35
  • 98.38 (n)
dog
(Canis familiaris)
Mammalia SPATA25 34 35
  • 88.84 (n)
rat
(Rattus norvegicus)
Mammalia Spata25 34
  • 86.1 (n)
mouse
(Mus musculus)
Mammalia Spata25 34 16 35
  • 84.75 (n)
cow
(Bos Taurus)
Mammalia SPATA25 34 35
  • 84.25 (n)
oppossum
(Monodelphis domestica)
Mammalia SPATA25 35
  • 70 (a)
OneToOne
Species where no ortholog for SPATA25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPATA25 Gene

ENSEMBL:
Gene Tree for SPATA25 (if available)
TreeFam:
Gene Tree for SPATA25 (if available)

Paralogs for SPATA25 Gene

No data available for Paralogs for SPATA25 Gene

Variants for SPATA25 Gene

Sequence variations from dbSNP and Humsavar for SPATA25 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000460046 -- 45,889,581(+) TAGCT(A/T)GCTTG intron-variant, upstream-variant-2KB
rs1003060294 -- 45,889,154(+) GCAAC(G/T)GAAGC intron-variant, upstream-variant-2KB
rs1003266283 -- 45,887,913(+) GAGAT(A/C)ATTTG upstream-variant-2KB
rs1003334266 -- 45,889,358(+) CTTTC(C/T)TTTTT intron-variant, upstream-variant-2KB
rs1005121712 -- 45,889,434(+) TGCAG(A/C)CTTCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SPATA25 Gene

Variant ID Type Subtype PubMed ID
nsv517296 CNV loss 19592680
nsv833990 CNV loss 17160897
nsv833991 CNV loss 17160897

Variation tolerance for SPATA25 Gene

Residual Variation Intolerance Score: 60.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.91; 59.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPATA25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPATA25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATA25 Gene

Disorders for SPATA25 Gene

Relevant External Links for SPATA25

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPATA25

No disorders were found for SPATA25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPATA25 Gene

Publications for SPATA25 Gene

  1. Developmental expression pattern of a novel gene, TSG23/Tsg23, suggests a role in spermatogenesis. (PMID: 19240080) Zhou Y. … Gui Y. (Mol. Hum. Reprod. 2009) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for SPATA25 Gene

Sources for SPATA25 Gene

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