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Aliases for SPATA25 Gene

Aliases for SPATA25 Gene

  • Spermatogenesis Associated 25 2 3 5
  • Testis-Specific Gene 23 Protein 3 4
  • C20orf165 3 4
  • TSG23 3 4
  • Chromosome 20 Open Reading Frame 165 2
  • DJ337O18.8 3

External Ids for SPATA25 Gene

Previous HGNC Symbols for SPATA25 Gene

  • C20orf165

Previous GeneCards Identifiers for SPATA25 Gene

  • GC20M044516

Summaries for SPATA25 Gene

GeneCards Summary for SPATA25 Gene

SPATA25 (Spermatogenesis Associated 25) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SPATA25 Gene

  • May play a role in spermatogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATA25 Gene

Genomics for SPATA25 Gene

Genomic Location for SPATA25 Gene

45,886,486 bp from pter
45,888,653 bp from pter
2,168 bases
Minus strand

Genomic View for SPATA25 Gene

Genes around SPATA25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATA25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATA25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA25 Gene

No data available for Regulatory Elements for SPATA25 Gene

Proteins for SPATA25 Gene

  • Protein details for SPATA25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Spermatogenesis-associated protein 25
    Protein Accession:

    Protein attributes for SPATA25 Gene

    227 amino acids
    Molecular mass:
    23834 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPATA25 Gene

Proteomics data for SPATA25 Gene at MOPED

Post-translational modifications for SPATA25 Gene

No Post-translational modifications

Other Protein References for SPATA25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPATA25 Gene

Domains & Families for SPATA25 Gene

Protein Domains for SPATA25 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPATA25 family.
  • Belongs to the SPATA25 family.
genes like me logo Genes that share domains with SPATA25: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for SPATA25 Gene

Function for SPATA25 Gene

Molecular function for SPATA25 Gene

UniProtKB/Swiss-Prot Function:
May play a role in spermatogenesis.

Phenotypes for SPATA25 Gene

genes like me logo Genes that share phenotypes with SPATA25: view

Animal Models for SPATA25 Gene

MGI Knock Outs for SPATA25:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SPATA25 Gene

Localization for SPATA25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPATA25 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SPATA25 Gene COMPARTMENTS Subcellular localization image for SPATA25 gene
Compartment Confidence
extracellular 3
mitochondrion 2
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for SPATA25 Gene

Pathways & Interactions for SPATA25 Gene

SuperPathways for SPATA25 Gene

No Data Available

Interacting Proteins for SPATA25 Gene

Gene Ontology (GO) - Biological Process for SPATA25 Gene


No data available for Pathways by source and SIGNOR curated interactions for SPATA25 Gene

Drugs & Compounds for SPATA25 Gene

No Compound Related Data Available

Transcripts for SPATA25 Gene

mRNA/cDNA for SPATA25 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPATA25 Gene

Spermatogenesis associated 25:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA25 Gene

No ASD Table

Relevant External Links for SPATA25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPATA25 Gene

mRNA expression in normal human tissues for SPATA25 Gene

mRNA differential expression in normal tissues according to GTEx for SPATA25 Gene

This gene is overexpressed in Testis (x7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPATA25 Gene

SOURCE GeneReport for Unigene cluster for SPATA25 Gene Hs.128235

mRNA Expression by UniProt/SwissProt for SPATA25 Gene

Tissue specificity: Expressed predominantly in testis (at protein level). Expression is lower in patients with obstructive azoospermia than in fertile controls and is not detected in patients with non-obstructive azoospermia.
genes like me logo Genes that share expression patterns with SPATA25: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Protein tissue co-expression partners for SPATA25 Gene

Orthologs for SPATA25 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPATA25 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SPATA25 35
  • 84.25 (n)
  • 75.23 (a)
SPATA25 36
  • 75 (a)
(Canis familiaris)
Mammalia SPATA25 35
  • 88.84 (n)
  • 81.5 (a)
SPATA25 36
  • 82 (a)
(Mus musculus)
Mammalia Spata25 35
  • 84.75 (n)
  • 80.72 (a)
Spata25 16
Spata25 36
  • 80 (a)
(Pan troglodytes)
Mammalia SPATA25 35
  • 98.38 (n)
  • 97.36 (a)
SPATA25 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Spata25 35
  • 86.1 (n)
  • 82.51 (a)
(Monodelphis domestica)
Mammalia SPATA25 36
  • 70 (a)
Species with no ortholog for SPATA25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPATA25 Gene

Gene Tree for SPATA25 (if available)
Gene Tree for SPATA25 (if available)

Paralogs for SPATA25 Gene

No data available for Paralogs for SPATA25 Gene

Variants for SPATA25 Gene

Sequence variations from dbSNP and Humsavar for SPATA25 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs3827040 - 45,886,920(+) CATGC(A/G)GGAAT reference, missense
rs6032576 -- 45,887,456(+) AGAAC(C/T)GCCAC intron-variant
rs6104387 -- 45,886,137(+) CTTGA(C/G)CCCAG downstream-variant-500B
rs6104388 -- 45,887,758(+) GAGGT(G/T)AAAAG intron-variant, upstream-variant-2KB
rs57456861 -- 45,886,046(+) AACCC(C/T)TTCTG downstream-variant-500B

Variation tolerance for SPATA25 Gene

Residual Variation Intolerance Score: 60.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.91; 59.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPATA25 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SPATA25 Gene

Disorders for SPATA25 Gene

Relevant External Links for SPATA25

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SPATA25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPATA25 Gene

Publications for SPATA25 Gene

  1. Developmental expression pattern of a novel gene, TSG23/Tsg23, suggests a role in spermatogenesis. (PMID: 19240080) Zhou Y. … Gui Y. (Mol. Hum. Reprod. 2009) 2 3 4 67
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3

Products for SPATA25 Gene

Sources for SPATA25 Gene

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