SPATA25 Gene
protein-coding GIFtS: 34
GCID: GC20M044516
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spermatogenesis associated 25(Previous name: chromosome 20 open reading frame 165 )
(Previous symbol: C20orf165)
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Aliases
for SPATA25 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Spermatogenesis Associated 251 2 | | Testis-Specific Gene 23 Protein2 3 | | C20orf1651 2 3 | | Chromosome 20 Open Reading Frame 1651 | | TSG231 2 3 | | Spermatogenesis-Associated Protein 252 | | DJ337O18.81 | | |
Export aliases for SPATA25 gene to outside databases |
Summaries
for SPATA25 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SPT25_HUMAN, Q9BR10Function: May play a role in spermatogenesis
|
Genomic Views
for SPATA25 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for SPATA25
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPATA25
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPATA25 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.12 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q13.12SPATA25 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M044516: view genomic region
(about GC identifiers)
Start:
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44,515,128 bp from pter |
End:
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44,516,274 bp from pter |
Size:
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1,147 bases |
Orientation:
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minus strand |
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Proteins
for SPATA25 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPT25_HUMAN, Q9BR10 (See
protein sequence)Recommended Name: Spermatogenesis-associated protein 25 Size: 227 amino acids; 23834 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Developmental stage: 60-fold stronger expression found in adult than fetal testis. Detected in spermatocytes and roundspermatids of the seminiferous tubuleExplore the universe of human proteins at neXtProt for SPATA25: NX_Q9BR10
SPATA25 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_542175.1
ENSEMBL proteins: ENSP00000361597
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0016021 | integral to membrane |
IEA | -- |
SPATA25 for ontologies About GeneDecksing
SPATA25 Antibody Products:
Assay Products for SPATA25: |
Protein
Domains /
Families
for SPATA25 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9BR10 UniProtKB/Swiss-Prot: SPT25_HUMAN, Q9BR10Similarity: Belongs to the SPATA25 family |
Function
for SPATA25 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SPT25_HUMAN, Q9BR10Function: May play a role in spermatogenesis
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA25 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA25
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for SPATA25 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPATA25 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPATA25 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
SPATA25 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for SPATA25:
|
Pathways & Interactions
for SPATA25 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPATA25
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
SPATA25 for ontologies About GeneDecksing
|
Drugs & Compounds
for SPATA25 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPATA25
Search CenterWatch for drugs/clinical trials and news about SPATA25 / SPT25
|
Transcripts
for SPATA25 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPATA25 gene: NM_080608.3 Unigene Cluster for SPATA25: Spermatogenesis associated 25 Hs.128235 [show with all ESTs]Unigene Representative Sequence: NM_0806081 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000372519(uc002xqf.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA25 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA25
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for SPATA25 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPATA25 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPATA25 |
Additional cDNA sequence: BC039607.1 1 DOTS entry: DT.406295 10 AceView cDNA sequences: NM_080608 BC039607 BX281168 BG720358 AW812529 BI826311 AA897305 AA747847 AA813764 AA972728
GeneLoc Exon Structure
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Expression
for SPATA25 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPATA25 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCACACAGC
About this image
See SPATA25 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPATA25
SOURCE GeneReport for Unigene cluster: Hs.128235
UniProtKB/Swiss-Prot: SPT25_HUMAN, Q9BR10Tissue specificity: Expressed predominantly in testis (at protein level). Expression is lower in patients withobstructive azoospermia than in fertile controls and is not detected in patients with non-obstructive azoospermia
SABiosciences Custom PCR Arrays for SPATA25
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPATA25
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat SPATA25 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPATA25 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPATA25 |
Orthologs
for SPATA25 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for SPATA25 gene from 1/5 species (see all 5) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Spata251 , 5 |
RIKEN cDNA 1700020C07 gene5
spermatogenesis associated 251 |
84.75(n)1
80.72(a)1 |
|
2 (85.27 cM)5
756421 NM_029370.11 NP_083646.11
1648263895 |
ENSEMBL Gene Tree for SPATA25 (if available)
TreeFam Gene Tree for SPATA25 (if available) |
Paralogs
for SPATA25 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SPATA25 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SPATA25 (44515128 - 44516274 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SPATA25: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPATA25 |
|
Disorders
/ Diseases
for SPATA25 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SPATA25 for disorders About GeneDecksing
1  disease for SPATA25: About MalaCardsazoospermia
Export disorders for SPATA25 gene to outside databases
|
Publications
for SPATA25 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPATA25 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SPATA25) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Developmental expression pattern of a novel gene, TSG23/Tsg23, suggests a role in spermatogenesis. (PubMed id 19240080)1, 2, 3 Zhou Y....Gui Y. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for SPATA25 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SPATA25 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPATA25 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPATA25 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPATA25 | Pharmacogenomics, SNPs, Pathways |
|
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About This Section
| Patent Information for SPATA25 gene:
Search GeneIP for patents involving SPATA25
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPATA25 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPATA25 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPATA25 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPATA25 | | | OriGene Protein Over-expression Lysate for SPATA25 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPATA25 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA25 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA25 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SPATA25 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SPATA25 | | OriGene Custom Protein Services for SPATA25 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPATA25 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPATA25 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPATA25 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPATA25 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPATA25 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPATA25 |
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| | | | Search Tocris compounds for SPATA25 |
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 | | | SPATA25 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibodies for SPATA25 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPATA25 |
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