Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SPATA24 Gene

Aliases for SPATA24 Gene

  • Spermatogenesis Associated 24 2 3 5
  • Coiled-Coil Domain Containing 161 2 3
  • Testis Protein T6441 Homolog 3 4
  • Spermatogenesis-Associated Protein 24 3
  • CCDC161 3
  • T6441 3

External Ids for SPATA24 Gene

Previous GeneCards Identifiers for SPATA24 Gene

  • GC05M138762
  • GC05M133922
  • GC05M138732

Summaries for SPATA24 Gene

GeneCards Summary for SPATA24 Gene

SPATA24 (Spermatogenesis Associated 24) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity.

UniProtKB/Swiss-Prot for SPATA24 Gene

  • Binds DNA with high affinity but does not bind to TATA boxes. Synergises with GMNN and TBP in activation of TATA box-containing promoters and with GMNN and TBPL1 in activation of the NF1 TATA-less promoter. May play a role in cytoplasm movement and removal during spermiogenesis (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATA24 Gene

Genomics for SPATA24 Gene

Regulatory Elements for SPATA24 Gene

Enhancers for SPATA24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G139402 1.3 Ensembl ENCODE 0.7 +0.2 220 2.7 HDGF PKNOX1 FOXA2 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZBTB7B YY1 DNAJC18 SPATA24 PROB1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPATA24 on UCSC Golden Path with GeneCards custom track

Promoters for SPATA24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000187641 155 801 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZBTB7B YY1 ZNF766

Genomic Location for SPATA24 Gene

Chromosome:
5
Start:
139,395,940 bp from pter
End:
139,404,155 bp from pter
Size:
8,216 bases
Orientation:
Minus strand

Genomic View for SPATA24 Gene

Genes around SPATA24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATA24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATA24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA24 Gene

Proteins for SPATA24 Gene

  • Protein details for SPATA24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86W54-SPA24_HUMAN
    Recommended name:
    Spermatogenesis-associated protein 24
    Protein Accession:
    Q86W54

    Protein attributes for SPATA24 Gene

    Size:
    205 amino acids
    Molecular mass:
    23587 Da
    Quaternary structure:
    • Homodimer. Interacts with CBX3, CBX5, GMNN, GTF2B, TBPL1 and the polycomb proteins PHCF2, RNF2 and SCMH1 but not with CBX1 or PCGF2 (By similarity).

    Alternative splice isoforms for SPATA24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPATA24 Gene

Post-translational modifications for SPATA24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SPATA24 Gene

Domains & Families for SPATA24 Gene

Protein Domains for SPATA24 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPATA24 Gene

Graphical View of Domain Structure for InterPro Entry

Q86W54

UniProtKB/Swiss-Prot:

SPA24_HUMAN :
  • Belongs to the SPATA24 family.
Family:
  • Belongs to the SPATA24 family.
genes like me logo Genes that share domains with SPATA24: view

No data available for Gene Families for SPATA24 Gene

Function for SPATA24 Gene

Molecular function for SPATA24 Gene

UniProtKB/Swiss-Prot Function:
Binds DNA with high affinity but does not bind to TATA boxes. Synergises with GMNN and TBP in activation of TATA box-containing promoters and with GMNN and TBPL1 in activation of the NF1 TATA-less promoter. May play a role in cytoplasm movement and removal during spermiogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for SPATA24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with SPATA24: view

Phenotypes for SPATA24 Gene

genes like me logo Genes that share phenotypes with SPATA24: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPATA24 Gene

Localization for SPATA24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPATA24 Gene

Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Associated with chromatin. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPATA24 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1

Gene Ontology (GO) - Cellular Components for SPATA24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IEA --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with SPATA24: view

Pathways & Interactions for SPATA24 Gene

SuperPathways for SPATA24 Gene

No Data Available

Interacting Proteins for SPATA24 Gene

Gene Ontology (GO) - Biological Process for SPATA24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with SPATA24: view

No data available for Pathways by source and SIGNOR curated interactions for SPATA24 Gene

Transcripts for SPATA24 Gene

Unigene Clusters for SPATA24 Gene

Spermatogenesis associated 24:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA24 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2: - -
SP3:

Relevant External Links for SPATA24 Gene

GeneLoc Exon Structure for
SPATA24
ECgene alternative splicing isoforms for
SPATA24

Expression for SPATA24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPATA24 Gene

mRNA differential expression in normal tissues according to GTEx for SPATA24 Gene

This gene is overexpressed in Testis (x18.2).

Protein differential expression in normal tissues from HIPED for SPATA24 Gene

This gene is overexpressed in Plasma (62.5) and Testis (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPATA24 Gene



Protein tissue co-expression partners for SPATA24 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SPATA24 Gene:

SPATA24

SOURCE GeneReport for Unigene cluster for SPATA24 Gene:

Hs.373612

Evidence on tissue expression from TISSUES for SPATA24 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with SPATA24: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPATA24 Gene

Orthologs for SPATA24 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPATA24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPATA24 34 35
  • 99.84 (n)
cow
(Bos Taurus)
Mammalia SPATA24 34 35
  • 94.31 (n)
dog
(Canis familiaris)
Mammalia SPATA24 34 35
  • 93.17 (n)
mouse
(Mus musculus)
Mammalia Spata24 34 16 35
  • 91.22 (n)
oppossum
(Monodelphis domestica)
Mammalia SPATA24 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPATA24 35
  • 40 (a)
OneToOne
Species where no ortholog for SPATA24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPATA24 Gene

ENSEMBL:
Gene Tree for SPATA24 (if available)
TreeFam:
Gene Tree for SPATA24 (if available)

Paralogs for SPATA24 Gene

No data available for Paralogs for SPATA24 Gene

Variants for SPATA24 Gene

Sequence variations from dbSNP and Humsavar for SPATA24 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000037209 -- 139,395,931(+) TCACA(A/G)GGCCC upstream-variant-2KB, utr-variant-3-prime
rs1000518419 -- 139,394,934(+) TTTCG(C/T)GTCCG downstream-variant-500B, reference, missense
rs1000573454 -- 139,400,279(+) CAGAT(A/G)TTGTG intron-variant
rs1000591429 -- 139,394,856(+) ATTCT(C/G)GGCGC downstream-variant-500B, reference, missense
rs1000799559 -- 139,401,350(+) CCCCC(G/T)GTCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPATA24 Gene

Variant ID Type Subtype PubMed ID
dgv369e215 CNV deletion 23714750
esv1917494 CNV deletion 18987734
esv2568140 CNV deletion 19546169
esv2669016 CNV deletion 23128226
esv2730828 CNV deletion 23290073
esv2762551 CNV gain 21179565
nsv328925 CNV deletion 16902084
nsv519808 CNV loss 19592680
nsv950410 CNV deletion 24416366
nsv956470 CNV deletion 24416366

Variation tolerance for SPATA24 Gene

Gene Damage Index Score: 12.27; 94.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPATA24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPATA24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATA24 Gene

Disorders for SPATA24 Gene

Relevant External Links for SPATA24

Human Genome Epidemiology (HuGE) Navigator
SPATA24
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPATA24

No disorders were found for SPATA24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPATA24 Gene

Publications for SPATA24 Gene

  1. Cloning and characterization of a novel spermiogenesis-related gene, T6441, in rat testis. (PMID: 16146721) Song X.X. … Liu Y.X. (Front. Biosci. 2006) 2 3 64
  2. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3 64
  5. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. (PMID: 21565611) Sang L. … Jackson P.K. (Cell 2011) 3 64

Products for SPATA24 Gene

Sources for SPATA24 Gene

Content
Loading form....