SPATA24 Gene
protein-coding GIFtS: 43
GCID: GC05M138762
|
|
spermatogenesis associated 24
| |
Aliases
for SPATA24 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Spermatogenesis Associated 241 2 | | CCDC1611 2 | | T64411 2 | | Testis Protein T6441 Homolog2 3 | | Coiled-Coil Domain Containing 1612 | | Spermatogenesis-Associated Protein 242 |
Export aliases for SPATA24 gene to outside databasesPrevious GC identifer: GC05M133922 |
Summaries
for SPATA24 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SPA24_HUMAN, Q86W54Function: Binds DNA with high affinity but does not bind to TATA boxes. Synergises with GMNN and TBP in activation ofTATA box-containing promoters and with GMNN and TBPL1 in activation of the NF1 TATA-less promoter. May play a role incytoplasm movement and removal during spermiogenesis (By similarity)
|
Genomic Views
for SPATA24 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_034772.6
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for SPATA24
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPATA24
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPATA24 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q31.2 Ensembl cytogenetic band: 5q31.2 HGNC cytogenetic band: 5q31.2SPATA24 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M138762: view genomic region
(about GC identifiers)
Start:
|
138,732,252 bp from pter |
End:
|
138,739,777 bp from pter |
Size:
|
7,526 bases |
Orientation:
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minus strand |
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Proteins
for SPATA24 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPA24_HUMAN, Q86W54 (See
protein sequence)Recommended Name: Spermatogenesis-associated protein 24 Size: 205 amino acids; 23587 Da
Subunit: Homodimer. Interacts with CBX3, CBX5, GMNN, GTF2B, TBPL1 and the polycomb proteins PHCF2, RNF2 and SCMH1 butnot with CBX1 or PCGF2 (By similarity)
Subcellular location: Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Associated with chromatin (Bysimilarity)Alternative splicing: 2 isoforms: Q86W54-1 Q86W54-2 Explore the universe of human proteins at neXtProt for SPATA24: NX_Q86W54
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86W54
SPATA24 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_919272.1
ENSEMBL proteins: ENSP00000302917 ENSP00000414920 ENSP00000426748 ENSP00000423424 ENSP00000424248 ENSP00000400524 ENSP00000423226
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
SPATA24 for ontologies About GeneDecksing
SPATA24 Antibody Products:
Assay Products for SPATA24: |
Protein
Domains /
Families
for SPATA24 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q86W54 UniProtKB/Swiss-Prot: SPA24_HUMAN, Q86W54Similarity: Belongs to the SPATA24 family |
Function
for SPATA24 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SPA24_HUMAN, Q86W54Function: Binds DNA with high affinity but does not bind to TATA boxes. Synergises with GMNN and TBP in activation ofTATA box-containing promoters and with GMNN and TBPL1 in activation of the NF1 TATA-less promoter. May play a role incytoplasm movement and removal during spermiogenesis (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA24 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA24 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for SPATA24 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPATA24 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPATA24 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- | | GO:0042803 | protein homodimerization activity |
IEA | -- |
SPATA24 for ontologies About GeneDecksing
|
Pathways & Interactions
for SPATA24 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPATA24
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/13 Interacting proteins for SPATA24 (Q86W543 ENSP000004149204) via UniProtKB, MINT, STRING, and/or I2D (see all 13)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0007283 | spermatogenesis |
IEA | -- | | GO:0030154 | cell differentiation |
IEA | -- |
SPATA24 for ontologies About GeneDecksing
|
Drugs & Compounds
for SPATA24 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPATA24
Search CenterWatch for drugs/clinical trials and news about SPATA24 / SPA24
|
Transcripts
for SPATA24 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPATA24 gene: NM_194296.1 Unigene Cluster for SPATA24: Spermatogenesis associated 24 Hs.373612 [show with all ESTs]Unigene Representative Sequence: BQ0672927 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000302091(uc003lek.2 uc003lel.4) ENST00000450845 ENST00000512761
ENST00000514983 ENST00000509959 ENST00000451821(uc003lem.2) ENST00000507779
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA24 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA24 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPATA24 (NM_194296) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPATA24 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPATA24 |
Additional cDNA sequence: AK098740.1 BC040037.1 BC050563.1 7 DOTS entries: DT.105704 DT.91692000 DT.206319 DT.120823307 DT.40120641 DT.75116236 DT.426022 24/30 AceView cDNA sequences (see all 30): AW663380 CD674203 AA999881 BC050563 BX089584 AK098740 AW015836 BQ426104 AA758652 AA922602 BC040037 AI671015 BQ067292 AW082238 BE044369 AI650574 BM785501 BI261744 BM746879 AI692888 AI989587 BE743887 BE745685 BP872735
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for SPATA24 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c |
|---|
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| SP1: | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SPATA24
|
Expression
for SPATA24 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPATA24 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAAAACCAA
About this image
See SPATA24 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPATA24
SOURCE GeneReport for Unigene cluster: Hs.373612
SABiosciences Custom PCR Arrays for SPATA24
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPATA24
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPATA24 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPATA24 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPATA24 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPATA24 |
Orthologs
for SPATA24 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for SPATA24 gene from 1/9 species (see all 9) About this table
ENSEMBL Gene Tree for SPATA24 (if available)
TreeFam Gene Tree for SPATA24 (if available) |
Paralogs
for SPATA24 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SPATA24 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SPATA24 (138732252 - 138739777 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for SPATA24
1 CNV: 99309
2 Indels: 12760 46776 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPATA24 |
|
Disorders
/ Diseases
for SPATA24 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SPATA24 for disorders About GeneDecksing
1  disease for SPATA24: About MalaCardsmyelodysplastic syndrome
Human Genome Epidemiology (HuGE) Navigator: SPATA24 (0 documents)
Export disorders for SPATA24 gene to outside databases
|
Publications
for SPATA24 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPATA24 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SPATA24) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and characterization of a novel spermiogenesi s-related gene, T6441, in rat testis. (PubMed id 16146721)1, 3 Song X.X....Liu Y.X. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis. (PubMed id 19240791)1 Graubert T.A....Walter M.J. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
- (PubMed id 19515240)2
|
External Searches for SPATA24 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SPATA24 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPATA24 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPATA24 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPATA24 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SPATA24 gene:
Search GeneIP for patents involving SPATA24
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPATA24 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPATA24 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPATA24 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPATA24 | | | OriGene Protein Over-expression Lysate for SPATA24 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPATA24 | | OriGene 3'-UTR Clone for SPATA24 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA24 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA24 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SPATA24 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SPATA24 | | OriGene Custom Protein Services for SPATA24 | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPATA24 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPATA24 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPATA24 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPATA24 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPATA24 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPATA24 |
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 |  |  |  | |
| | | | Search Tocris compounds for SPATA24 |
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 | | | SPATA24 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPATA24 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPATA24 |
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