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Aliases for SPATA22 Gene

Aliases for SPATA22 Gene

  • Spermatogenesis Associated 22 2 3
  • Testis Development Protein NYD-SP20 3 4
  • Spermatogenesis-Associated Protein 22 3
  • Testes Development-Related NYD-SP20 3
  • NYD-SP20 3
  • NYDSP20 3

External Ids for SPATA22 Gene

Previous GeneCards Identifiers for SPATA22 Gene

  • GC17M003291
  • GC17M003235
  • GC17M003343

Summaries for SPATA22 Gene

GeneCards Summary for SPATA22 Gene

SPATA22 (Spermatogenesis Associated 22) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SPATA22 Gene

  • Meiosis-specific protein required for homologous recombination in meiosis I.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATA22 Gene

Genomics for SPATA22 Gene

Regulatory Elements for SPATA22 Gene

Genomic Location for SPATA22 Gene

3,440,011 bp from pter
3,513,852 bp from pter
73,842 bases
Minus strand

Genomic View for SPATA22 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPATA22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA22 Gene

Proteins for SPATA22 Gene

  • Protein details for SPATA22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Spermatogenesis-associated protein 22
    Protein Accession:
    Secondary Accessions:
    • B4DXB1
    • D3DTI9
    • J3KN63
    • Q969H3
    • Q96JT4

    Protein attributes for SPATA22 Gene

    363 amino acids
    Molecular mass:
    41318 Da
    Quaternary structure:
    • Component of a multiprotein complex with MEIOB and SPATA22.

    Alternative splice isoforms for SPATA22 Gene


neXtProt entry for SPATA22 Gene

Proteomics data for SPATA22 Gene at MOPED

Post-translational modifications for SPATA22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SPATA22

No data available for DME Specific Peptides for SPATA22 Gene

Domains for SPATA22 Gene

Protein Domains for SPATA22 Gene


Suggested Antigen Peptide Sequences for SPATA22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPATA22: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SPATA22 Gene

Function for SPATA22 Gene

Molecular function for SPATA22 Gene

UniProtKB/Swiss-Prot Function:
Meiosis-specific protein required for homologous recombination in meiosis I.

Gene Ontology (GO) - Molecular Function for SPATA22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SPATA22: view

Phenotypes for SPATA22 Gene

genes like me logo Genes that share phenotypes with SPATA22: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SPATA22 Gene

Localization for SPATA22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPATA22 Gene

Chromosome. Note=Localizes on meiotic chromosome axes. Accumulates on resected DNA. Localization is dependent on MEIOB (By similarity). {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for SPATA22 Gene COMPARTMENTS Subcellular localization image for SPATA22 gene
Compartment Confidence
mitochondrion 3
nucleus 2
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for SPATA22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with SPATA22: view

Pathways for SPATA22 Gene

SuperPathways for SPATA22 Gene

No Data Available

Interacting Proteins for SPATA22 Gene

Gene Ontology (GO) - Biological Process for SPATA22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000711 meiotic DNA repair synthesis IEA --
GO:0007129 synapsis IEA --
GO:0007276 gamete generation IEA --
GO:0009566 fertilization IEA --
GO:0051445 regulation of meiotic cell cycle IEA --
genes like me logo Genes that share ontologies with SPATA22: view

No data available for Pathways by source for SPATA22 Gene

Transcripts for SPATA22 Gene

Unigene Clusters for SPATA22 Gene

Spermatogenesis associated 22:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPATA22

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA22 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: - -
SP3: -
SP4: - - - - -
SP5: - - - - -
SP6: - -
SP7: -

Relevant External Links for SPATA22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPATA22 Gene

mRNA expression in normal human tissues for SPATA22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPATA22 Gene

This gene is overexpressed in Testis (46.0).

Protein differential expression in normal tissues for SPATA22 Gene

This gene is overexpressed in Testis (35.7), Ovary (23.9), and Fetal ovary (9.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SPATA22 Gene

SOURCE GeneReport for Unigene cluster for SPATA22 Gene Hs.351068

mRNA Expression by UniProt/SwissProt for SPATA22 Gene

Tissue specificity: Highly expressed in adult testis.
genes like me logo Genes that share expressions with SPATA22: view

Expression partners for SPATA22 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for SPATA22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPATA22 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SPATA22 35
  • 86.59 (n)
  • 78.51 (a)
SPATA22 36
  • 78 (a)
(Mus musculus)
Mammalia Spata22 35
  • 82.35 (n)
  • 72.83 (a)
Spata22 16
Spata22 36
  • 73 (a)
(Pan troglodytes)
Mammalia SPATA22 35
  • 98.99 (n)
  • 97.52 (a)
SPATA22 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Spata22 35
  • 80.74 (n)
  • 70.83 (a)
(Canis familiaris)
Mammalia SPATA22 36
  • 80 (a)
(Monodelphis domestica)
Mammalia SPATA22 36
  • 39 (a)
(Ornithorhynchus anatinus)
Mammalia SPATA22 36
  • 56 (a)
(Gallus gallus)
Aves SPATA22 35
  • 64.89 (n)
  • 54.92 (a)
(Anolis carolinensis)
Reptilia SPATA22 36
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia spata22 35
  • 55.32 (n)
  • 45.9 (a)
(Danio rerio)
Actinopterygii LOC100330730 35
  • 57.28 (n)
  • 49.3 (a)
Species with no ortholog for SPATA22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPATA22 Gene

Gene Tree for SPATA22 (if available)
Gene Tree for SPATA22 (if available)

Paralogs for SPATA22 Gene

No data available for Paralogs for SPATA22 Gene

Variants for SPATA22 Gene

Sequence variations from dbSNP and Humsavar for SPATA22 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs12867 -- 3,503,170(+) GTTTC(A/C)AATGT intron-variant
rs980781 -- 3,447,108(+) AATAA(A/G)TAAAC intron-variant
rs996172 -- 3,449,995(+) CTACA(C/G)GTGAG intron-variant
rs1185100 -- 3,453,977(+) aaccc(C/T)aaaaa intron-variant
rs1488689 - 3,449,000(+) CAGGT(A/G)TTCTT missense, reference

Structural Variations from Database of Genomic Variants (DGV) for SPATA22 Gene

Variant ID Type Subtype PubMed ID
esv2660206 CNV Deletion 23128226
nsv907553 CNV Loss 21882294
nsv833341 CNV Loss 17160897
nsv521277 CNV Gain 19592680
nsv528368 CNV Gain 19592680
esv1173810 CNV Deletion 17803354

Relevant External Links for SPATA22 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATA22 Gene

Disorders for SPATA22 Gene

Relevant External Links for SPATA22

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for SPATA22 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SPATA22 Gene

Publications for SPATA22 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Novel development-related alternative splices in human testis identified by cDNA microarrays. (PMID: 15713825) Huang X. … Sha J.H. (J. Androl. 2005) 3 4
  3. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PMID: 20378615) Aston K.I. … Carrell D.T. (Hum. Reprod. 2010) 3 48
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for SPATA22 Gene

Sources for SPATA22 Gene

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