SPATA22 Gene
protein-coding GIFtS: 45
GCID: GC17M003343
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|
spermatogenesis associated 22
| |
Aliases
for SPATA22 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Spermatogenesis Associated 221 2 | | NYD-SP201 2 | | Testis Development Protein NYD-SP202 3 | | NYDSP202 | | Spermatogenesis-Associated Protein 222 | | Testes Development-Related NYD-SP202 |
Export aliases for SPATA22 gene to outside databasesPrevious GC identifers: GC17M003291 GC17M003235 |
Summaries
for SPATA22 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SPATA22 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPATA22 gene promoter:
Elk-1 AML1a IRF-1 Cdc5 YY1 Evi-1 POU2F1 FOXC1 POU2F1a LyF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPATA22
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPATA22 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13.3 Ensembl cytogenetic band: 17p13.2 HGNC cytogenetic band: 17p13.3SPATA22 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M003343: view genomic region
(about GC identifiers)
Start:
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3,343,305 bp from pter |
End:
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3,417,146 bp from pter |
Size:
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73,842 bases |
Orientation:
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minus strand |
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Proteins
for SPATA22 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPT22_HUMAN, Q8NHS9 (See
protein sequence)Recommended Name: Spermatogenesis-associated protein 22 Size: 363 amino acids; 41318 Da
Secondary accessions: B4DXB1 D3DTI9 J3KN63 Q969H3 Q96JT4Alternative splicing: 3 isoforms: Q8NHS9-1 Q8NHS9-2 Q8NHS9-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SPATA22: NX_Q8NHS9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NHS9
SPATA22 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (6 alternative transcripts):
NP_001164166.1 NP_001164167.1 NP_001164168.1 NP_001164169.1 NP_001164170.1 NP_115987.2
ENSEMBL proteins: ENSP00000380354 ENSP00000460187 ENSP00000347541 ENSP00000459329 ENSP00000459580 ENSP00000268981 ENSP00000459552 ENSP00000461462 ENSP00000461722 ENSP00000461180 ENSP00000458923 ENSP00000460692 ENSP00000441920
Human Recombinant Protein Products:
SPATA22 Antibody Products:
Assay Products for SPATA22: |
Protein
Domains /
Families
for SPATA22 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q8NHS9 |
Function
for SPATA22 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA22 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA22 (see all 6)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 6): SPATA22 (NM_032598) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPATA22 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPATA22 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPATA22 |
1 GenomeRNAi human phenotype for SPATA22:
Animal Models:
4 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Spata22):
SPATA22 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SPATA22 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPATA22
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for SPATA22 (Q8NHS92, 3 ENSP000002689814) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for SPATA22 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPATA22
Search CenterWatch for drugs/clinical trials and news about SPATA22 / SPT22
|
Transcripts
for SPATA22 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPATA22 gene (6 alternative transcripts): NM_001170695.1 NM_001170696.1 NM_001170697.1 NM_001170698.1 NM_001170699.1 NM_032598.4 Unigene Cluster for SPATA22: Spermatogenesis associated 22 Hs.351068 [show with all ESTs]Unigene Representative Sequence: AK29529913 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000397168(uc002fvm.3 uc010vrf.2) ENST00000572969(uc002fvo.3)
ENST00000355380 ENST00000575375 ENST00000573128(uc002fvn.3 uc002fvp.3 uc010ckf.3)
ENST00000268981 ENST00000571553 ENST00000574051 ENST00000574797 ENST00000572582
ENST00000571607 ENST00000574457 ENST00000541913
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA22 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA22 (see all 6)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 6): SPATA22 (NM_032598) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPATA22 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPATA22 |
Additional cDNA sequence: AF367472.1 AK295299.1 AK301892.1 AY032684.1 AY035867.1 AY035868.1 BC029483.1 8 DOTS entries: DT.95375334 DT.95375336 DT.95375335 DT.95375332 DT.100024224 DT.120974241 DT.91756453 DT.95375333 24/76 AceView cDNA sequences (see all 76): CD557477 BP371122 BF057853 AI651860 BX116166 BF062332 AI200932 BI829128 AI638483 BC029483 AW294422 BQ432609 AA470124 AW072392 BE463744 BI464345 BI826018 BG772114 AA977048 BI825829 BU154564 BI463870 NM_032598 BU176920
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SPATA22 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b |
|---|
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| SP1: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP5: | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SPATA22
|
Expression
for SPATA22 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPATA22 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACAGAAAAC
About this image
See SPATA22 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPATA22
SOURCE GeneReport for Unigene cluster: Hs.351068
UniProtKB/Swiss-Prot: SPT22_HUMAN, Q8NHS9Tissue specificity: Highly expressed in adult testis
SABiosciences Custom PCR Arrays for SPATA22
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPATA22
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPATA22 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPATA22 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPATA22 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPATA22 |
Orthologs
for SPATA22 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SPATA22 gene from 3/12 species (see all 12) About this table
ENSEMBL Gene Tree for SPATA22 (if available)
TreeFam Gene Tree for SPATA22 (if available) |
Paralogs
for SPATA22 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SPATA22 gene
- ENSG000002623142
SPATA22 for paralogs About GeneDecksing
|
Genomic Variants
for SPATA22 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SPATA22 (3343305 - 3417146 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SPATA22
1 Indel: 25824 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPATA22 |
|
Disorders
/ Diseases
for SPATA22 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SPATA22 for disorders About GeneDecksing
1  disease for SPATA22: About MalaCardsazoospermia
Human Genome Epidemiology (HuGE) Navigator: SPATA22 (1 document)
Export disorders for SPATA22 gene to outside databases
|
Publications
for SPATA22 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPATA22 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SPATA22) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Novel development-related alternative splices in human testis identified by cDNA microarrays. (PubMed id 15713825)1, 2 Huang X....Sha J.H. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Evaluation of 172 candidate polymorphisms for associa tion with oligozoospermia or azoospermia in a large cohort of men of European d escent. (PubMed id 20378615)1 Aston K.I....Carrell D.T. (2010)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
|
External Searches for SPATA22 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SPATA22 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPATA22 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPATA22 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPATA22 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SPATA22 gene:
Search GeneIP for patents involving SPATA22
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPATA22 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPATA22 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPATA22 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPATA22 | | | OriGene Protein Over-expression Lysate for SPATA22 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPATA22 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA22 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA22 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SPATA22 | | OriGene Custom Protein Services for SPATA22 | | | OriGene Custom Immunoassay Development | | |
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 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPATA22 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPATA22 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPATA22 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPATA22 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPATA22 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPATA22 |
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| | | | Search Tocris compounds for SPATA22 |
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 | | | SPATA22 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPATA22 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPATA22 |
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