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Aliases for SPATA22 Gene

Aliases for SPATA22 Gene

  • Spermatogenesis Associated 22 2 3 5
  • Testis Development Protein NYD-SP20 3 4
  • Spermatogenesis-Associated Protein 22 3
  • Testicular Tissue Protein Li 186 3
  • NYD-SP20 3
  • NYDSP20 3

External Ids for SPATA22 Gene

Previous GeneCards Identifiers for SPATA22 Gene

  • GC17M003291
  • GC17M003235
  • GC17M003343

Summaries for SPATA22 Gene

GeneCards Summary for SPATA22 Gene

SPATA22 (Spermatogenesis Associated 22) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SPATA22 Gene

  • Meiosis-specific protein required for homologous recombination in meiosis I.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATA22 Gene

Genomics for SPATA22 Gene

Regulatory Elements for SPATA22 Gene

Enhancers for SPATA22 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G003511 1.2 Ensembl ENCODE dbSUPER 11.3 +1.0 1002 2.2 MAX RAD21 RARA YY1 POLR2A STAT1 L3MBTL2 NRF1 PPARG NR2F2 SPATA22 PIR41418
GH17G003386 0.6 FANTOM5 15.2 +127.5 127541 0.4 ATF3 POLR2A CEBPB CEBPG SPATA22 ASPA OR3A3 OR1E2 OR3A1 ENSG00000262670
GH17G003514 0.5 dbSUPER 7.8 -1.1 -1054 1.3 MAFF ZNF316 MAFG EMSY MAFK SPATA22 GC17M003518
GH17G003503 0.2 dbSUPER 9.7 +9.9 9891 1.0 OR1E2 SPATA22 OR1E1 PIR41418 ASPA
GH17G003528 1.7 FANTOM5 Ensembl ENCODE dbSUPER 0.4 -16.6 -16557 3.8 ZFP64 ARID4B DMAP1 RAD21 CHAMP1 HMG20B SP5 MIER1 YY2 REST TRPV3 ASPA OR1E2 CAMKK1 TRPV1 GC17M003518 SPATA22
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPATA22 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPATA22 Gene

Chromosome:
17
Start:
3,440,011 bp from pter
End:
3,513,852 bp from pter
Size:
73,842 bases
Orientation:
Minus strand

Genomic View for SPATA22 Gene

Genes around SPATA22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATA22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATA22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA22 Gene

Proteins for SPATA22 Gene

  • Protein details for SPATA22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHS9-SPT22_HUMAN
    Recommended name:
    Spermatogenesis-associated protein 22
    Protein Accession:
    Q8NHS9
    Secondary Accessions:
    • B4DXB1
    • D3DTI9
    • J3KN63
    • Q969H3
    • Q96JT4

    Protein attributes for SPATA22 Gene

    Size:
    363 amino acids
    Molecular mass:
    41318 Da
    Quaternary structure:
    • Component of a multiprotein complex with MEIOB and SPATA22.

    Alternative splice isoforms for SPATA22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPATA22 Gene

Post-translational modifications for SPATA22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SPATA22 Gene

Domains & Families for SPATA22 Gene

Protein Domains for SPATA22 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPATA22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPATA22: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SPATA22 Gene

Function for SPATA22 Gene

Molecular function for SPATA22 Gene

UniProtKB/Swiss-Prot Function:
Meiosis-specific protein required for homologous recombination in meiosis I.

Gene Ontology (GO) - Molecular Function for SPATA22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SPATA22: view
genes like me logo Genes that share phenotypes with SPATA22: view

Animal Models for SPATA22 Gene

MGI Knock Outs for SPATA22:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SPATA22 Gene

Localization for SPATA22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPATA22 Gene

Chromosome. Note=Localizes on meiotic chromosome axes. Accumulates on resected DNA. Localization is dependent on MEIOB (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPATA22 gene
Compartment Confidence
mitochondrion 3
nucleus 2
extracellular 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SPATA22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with SPATA22: view

Pathways & Interactions for SPATA22 Gene

SuperPathways for SPATA22 Gene

No Data Available

Interacting Proteins for SPATA22 Gene

Gene Ontology (GO) - Biological Process for SPATA22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000711 meiotic DNA repair synthesis IEA --
GO:0007129 synapsis IEA --
GO:0007276 gamete generation IEA --
GO:0051321 meiotic cell cycle IEA --
genes like me logo Genes that share ontologies with SPATA22: view

No data available for Pathways by source and SIGNOR curated interactions for SPATA22 Gene

Drugs & Compounds for SPATA22 Gene

No Compound Related Data Available

Transcripts for SPATA22 Gene

Unigene Clusters for SPATA22 Gene

Spermatogenesis associated 22:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA22 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: - -
SP2:
SP3: -
SP4: - - - - -
SP5: - - - - -
SP6: - -
SP7: -

Relevant External Links for SPATA22 Gene

GeneLoc Exon Structure for
SPATA22
ECgene alternative splicing isoforms for
SPATA22

Expression for SPATA22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPATA22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPATA22 Gene

This gene is overexpressed in Testis (x46.0).

Protein differential expression in normal tissues from HIPED for SPATA22 Gene

This gene is overexpressed in Testis (35.7), Ovary (23.9), and Fetal ovary (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPATA22 Gene



Protein tissue co-expression partners for SPATA22 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SPATA22 Gene:

SPATA22

SOURCE GeneReport for Unigene cluster for SPATA22 Gene:

Hs.351068

mRNA Expression by UniProt/SwissProt for SPATA22 Gene:

Q8NHS9-SPT22_HUMAN
Tissue specificity: Highly expressed in adult testis.
genes like me logo Genes that share expression patterns with SPATA22: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPATA22 Gene

Orthologs for SPATA22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPATA22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPATA22 34 35
  • 98.99 (n)
cow
(Bos Taurus)
Mammalia SPATA22 34 35
  • 86.59 (n)
mouse
(Mus musculus)
Mammalia Spata22 34 16 35
  • 82.35 (n)
rat
(Rattus norvegicus)
Mammalia Spata22 34
  • 80.74 (n)
dog
(Canis familiaris)
Mammalia SPATA22 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPATA22 35
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPATA22 35
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPATA22 34
  • 64.89 (n)
lizard
(Anolis carolinensis)
Reptilia SPATA22 35
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spata22 34
  • 55.32 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100330730 34
  • 57.28 (n)
Species where no ortholog for SPATA22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPATA22 Gene

ENSEMBL:
Gene Tree for SPATA22 (if available)
TreeFam:
Gene Tree for SPATA22 (if available)

Paralogs for SPATA22 Gene

No data available for Paralogs for SPATA22 Gene

Variants for SPATA22 Gene

Sequence variations from dbSNP and Humsavar for SPATA22 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs104894548 Pathogenic 3,483,520(+) TACCC(C/T)GCTAC intron-variant, nc-transcript-variant, reference, missense
rs104894549 Pathogenic 3,494,369(+) CCCTG(A/C/T)GCCAT intron-variant, nc-transcript-variant, reference, synonymous-codon, stop-gained
rs104894550 Pathogenic 3,494,407(+) TGATT(A/G)CCCCC intron-variant, nc-transcript-variant, reference, missense
rs104894551 Pathogenic 3,476,230(+) GAATG(A/G)GCTAA intron-variant, nc-transcript-variant, reference, missense
rs104894553 Pathogenic 3,476,371(+) GAATC(A/G)CATTT intron-variant, nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SPATA22 Gene

Variant ID Type Subtype PubMed ID
esv1173810 CNV deletion 17803354
esv2660206 CNV deletion 23128226
esv3345781 CNV insertion 20981092
esv3892950 CNV loss 25118596
nsv1055740 CNV gain 25217958
nsv1059413 CNV loss 25217958
nsv1060071 CNV loss 25217958
nsv1065489 CNV gain 25217958
nsv521277 CNV gain 19592680
nsv528368 CNV gain 19592680
nsv574232 CNV gain 21841781
nsv574236 CNV gain 21841781
nsv833341 CNV loss 17160897

Variation tolerance for SPATA22 Gene

Residual Variation Intolerance Score: 70.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.67; 65.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPATA22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPATA22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATA22 Gene

Disorders for SPATA22 Gene

Relevant External Links for SPATA22

Genetic Association Database (GAD)
SPATA22
Human Genome Epidemiology (HuGE) Navigator
SPATA22
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPATA22

No disorders were found for SPATA22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPATA22 Gene

Publications for SPATA22 Gene

  1. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PMID: 20378615) Aston K.I. … Carrell D.T. (Hum. Reprod. 2010) 3 46 64
  2. Novel development-related alternative splices in human testis identified by cDNA microarrays. (PMID: 15713825) Huang X. … Sha J.H. (J. Androl. 2005) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64

Products for SPATA22 Gene

Sources for SPATA22 Gene

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