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Aliases for SPATA21 Gene

Aliases for SPATA21 Gene

  • Spermatogenesis Associated 21 2 3 5
  • Spermatogenesis-Associated Protein 21 3
  • Spergen-2 3
  • Spergen2 3

External Ids for SPATA21 Gene

Previous GeneCards Identifiers for SPATA21 Gene

  • GC01M016471
  • GC01M016597
  • GC01M016714
  • GC01M015242

Summaries for SPATA21 Gene

GeneCards Summary for SPATA21 Gene

SPATA21 (Spermatogenesis Associated 21) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is EFCAB3.

UniProtKB/Swiss-Prot for SPATA21 Gene

  • Involved in the differentiation of haploid spermatids.

Additional gene information for SPATA21 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATA21 Gene

Genomics for SPATA21 Gene

Regulatory Elements for SPATA21 Gene

Enhancers for SPATA21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H016115 0.9 FANTOM5 ENCODE 43.7 +321.7 321711 2 BCOR ZMYM3 ZNF384 ZSCAN21 GLIS2 POLR2A GLIS1 CREB1 KDM1A ZBTB33 SPATA21 HSPB7 FAM131C ENSG00000235241 GC01P016103 LOC101927479
GH01H016498 1.6 FANTOM5 ENCODE dbSUPER 11.9 -61.2 -61229 2 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZNF121 GTF3C2 GLIS2 ZNF143 ZNF207 ENSG00000237938 NECAP2 CROCCP3 ARHGEF19 SPATA21 SPEN RPS16P1 ENSG00000224621 DDI2 RCC2
GH01H016384 1.2 Ensembl ENCODE dbSUPER 11.6 +51.4 51434 4 NR2F1 CEBPB ZNF195 EBF1 NFIC JUND POLR2A IKZF1 SCRT2 NBN ARHGEF19 NECAP2 SPATA21 FBXO42 GC01P016389 RPL22P3
GH01H016363 1.1 Ensembl ENCODE 10.9 +74.3 74342 0 RB1 ARNT ARID4B FEZF1 ZNF2 RAD21 RFX5 ZNF143 CREM MIXL1 ARHGEF19 ARHGEF19-AS1 SPATA21 NECAP2 RPL22P3 SZRD1
GH01H016506 0.9 ENCODE 11.6 -68.8 -68829 0 ZNF133 KLF17 GLI4 ZBTB40 ZEB1 RARA ZNF23 CBX5 ZSCAN5C ZNF391 CROCCP3 LINC01772 SPEN CROCC SPATA21 FBXO42 ENSG00000237301 ENSG00000272426 RNU1-1 GC01M016499
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPATA21 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPATA21 Gene

16,387,117 bp from pter
16,437,842 bp from pter
50,726 bases
Minus strand

Genomic View for SPATA21 Gene

Genes around SPATA21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATA21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATA21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA21 Gene

Proteins for SPATA21 Gene

  • Protein details for SPATA21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Spermatogenesis-associated protein 21
    Protein Accession:
    Secondary Accessions:
    • B9EK40
    • F5GXP5

    Protein attributes for SPATA21 Gene

    469 amino acids
    Molecular mass:
    52207 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPATA21 Gene


neXtProt entry for SPATA21 Gene

Post-translational modifications for SPATA21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SPATA21 Gene

Domains & Families for SPATA21 Gene

Gene Families for SPATA21 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPATA21 Gene

Suggested Antigen Peptide Sequences for SPATA21 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPATA21: view

No data available for UniProtKB/Swiss-Prot for SPATA21 Gene

Function for SPATA21 Gene

Molecular function for SPATA21 Gene

UniProtKB/Swiss-Prot Function:
Involved in the differentiation of haploid spermatids.

Gene Ontology (GO) - Molecular Function for SPATA21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SPATA21: view
genes like me logo Genes that share phenotypes with SPATA21: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SPATA21
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPATA21 Gene

Localization for SPATA21 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPATA21 gene
Compartment Confidence
cytosol 3
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPATA21 Gene

Pathways & Interactions for SPATA21 Gene

SuperPathways for SPATA21 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPATA21 Gene


No data available for Pathways by source and SIGNOR curated interactions for SPATA21 Gene

Drugs & Compounds for SPATA21 Gene

No Compound Related Data Available

Transcripts for SPATA21 Gene

Unigene Clusters for SPATA21 Gene

Spermatogenesis associated 21:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SPATA21
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA21 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - - - - -
SP2: - -
SP3: - - - - - -

Relevant External Links for SPATA21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPATA21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPATA21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPATA21 Gene

This gene is overexpressed in Testis (x28.2), Liver (x4.7), Brain - Cerebellum (x4.2), and Brain - Cerebellar Hemisphere (x4.0).

Protein differential expression in normal tissues from HIPED for SPATA21 Gene

This gene is overexpressed in Plasma (33.5), Monocytes (20.1), and Tlymphocyte (15.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPATA21 Gene

Protein tissue co-expression partners for SPATA21 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPATA21 Gene:


SOURCE GeneReport for Unigene cluster for SPATA21 Gene:

genes like me logo Genes that share expression patterns with SPATA21: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPATA21 Gene

Orthologs for SPATA21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPATA21 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPATA21 33 34
  • 99.19 (n)
(Canis familiaris)
Mammalia SPATA21 33 34
  • 78.65 (n)
(Rattus norvegicus)
Mammalia Spata21 33
  • 76.5 (n)
(Bos Taurus)
Mammalia SPATA21 33 34
  • 76.33 (n)
(Mus musculus)
Mammalia Spata21 34 16 33
  • 75.13 (n)
(Ornithorhynchus anatinus)
Mammalia SPATA21 34
  • 27 (a)
(Monodelphis domestica)
Mammalia SPATA21 34
  • 17 (a)
(Gallus gallus)
Aves -- 34
  • 16 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 18 (a)
Species where no ortholog for SPATA21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPATA21 Gene

Gene Tree for SPATA21 (if available)
Gene Tree for SPATA21 (if available)

Paralogs for SPATA21 Gene

Paralogs for SPATA21 Gene

genes like me logo Genes that share paralogs with SPATA21: view

Variants for SPATA21 Gene

Sequence variations from dbSNP and Humsavar for SPATA21 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_042711 A breast cancer sample
rs1000015713 -- 16,411,034(+) CTCAG(A/G)GGGAC intron-variant, utr-variant-5-prime
rs1000107244 -- 16,409,282(+) GGGAG(C/G)CTGCA intron-variant
rs1000171612 -- 16,408,175(+) AAGAG(G/T)GTTGC intron-variant
rs1000178275 -- 16,425,962(+) CAGGC(G/T)GGTCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SPATA21 Gene

Variant ID Type Subtype PubMed ID
dgv19n67 CNV loss 20364138
esv1035588 CNV insertion 17803354
esv2674598 CNV deletion 23128226
esv2675247 CNV deletion 23128226
esv2744408 CNV deletion 23290073
esv3577751 CNV loss 25503493
esv3585337 CNV gain 21293372
esv3585338 CNV loss 21293372
nsv829581 CNV loss 20364138

Variation tolerance for SPATA21 Gene

Residual Variation Intolerance Score: 98.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.39; 81.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPATA21 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATA21 Gene

Disorders for SPATA21 Gene

Relevant External Links for SPATA21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SPATA21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPATA21 Gene

Publications for SPATA21 Gene

  1. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett EJ … Harper JW (Cell 2010) 3 60
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 60
  3. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjöblom T … Velculescu VE (Science (New York, N.Y.) 2006) 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for SPATA21 Gene

Sources for SPATA21 Gene

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