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Aliases for SPATA21 Gene

Aliases for SPATA21 Gene

  • Spermatogenesis Associated 21 2 3 5
  • Spermatogenesis-Associated Protein 21 3
  • Spergen-2 3
  • Spergen2 3

External Ids for SPATA21 Gene

Previous GeneCards Identifiers for SPATA21 Gene

  • GC01M016471
  • GC01M016597
  • GC01M016714
  • GC01M015242

Summaries for SPATA21 Gene

GeneCards Summary for SPATA21 Gene

SPATA21 (Spermatogenesis Associated 21) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is EFCAB3.

UniProtKB/Swiss-Prot for SPATA21 Gene

  • Involved in the differentiation of haploid spermatids.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATA21 Gene

Genomics for SPATA21 Gene

Regulatory Elements for SPATA21 Gene

Enhancers for SPATA21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F016115 1 FANTOM5 ENCODE 43.7 +321.7 321711 2.0 BCOR ZBTB11 ZMYM3 ZNF384 ELF1 ZBTB7A RELA JUND ZNF766 SMARCA4 SPATA21 HSPB7 FAM131C ENSG00000235241 GC01P016103 LOC101927479
GH01F015829 1.8 FANTOM5 Ensembl ENCODE 9.8 +603.8 603842 10.0 CREB3L1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 FAM231A ENSG00000237938 CD24P1 RNU1-1 CLCNKA FLJ37453 SPEN ZBTB17 HSPB7 RPL22P3
GH01F015791 1.8 FANTOM5 Ensembl ENCODE 9.8 +640.3 640340 11.3 CREB3L1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 CLCNKA HSPB7 FAM231A FBLIM1 CD24P1 RNU1-1 ENSG00000233078 FAM131C ARHGEF19-AS1 ENSG00000237301
GH01F016498 1.3 FANTOM5 ENCODE 11.9 -61.2 -61229 2.0 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF121 GTF3C2 GLIS2 ZNF143 ENSG00000237938 NECAP2 CROCCP3 SPATA21 SPEN ENSG00000224621 RPS16P1 DDI2 RCC2 FAM131C
GH01F015507 1.5 FANTOM5 ENCODE 9.8 +929.1 929063 2.1 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ENSG00000237938 AGMAT CASP9 RPS16P1 CD24P1 ZBTB17 FBXO42 SPEN RPL22P3 ENSG00000224621
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPATA21 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPATA21 Gene

Chromosome:
1
Start:
16,387,117 bp from pter
End:
16,437,842 bp from pter
Size:
50,726 bases
Orientation:
Minus strand

Genomic View for SPATA21 Gene

Genes around SPATA21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATA21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATA21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA21 Gene

Proteins for SPATA21 Gene

  • Protein details for SPATA21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z572-SPT21_HUMAN
    Recommended name:
    Spermatogenesis-associated protein 21
    Protein Accession:
    Q7Z572
    Secondary Accessions:
    • B9EK40
    • F5GXP5

    Protein attributes for SPATA21 Gene

    Size:
    469 amino acids
    Molecular mass:
    52207 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPATA21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPATA21 Gene

Post-translational modifications for SPATA21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SPATA21 Gene

Domains & Families for SPATA21 Gene

Gene Families for SPATA21 Gene

Protein Domains for SPATA21 Gene

Suggested Antigen Peptide Sequences for SPATA21 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z572

UniProtKB/Swiss-Prot:

SPT21_HUMAN :
  • Contains 1 EF-hand domain.
Domain:
  • Contains 1 EF-hand domain.
genes like me logo Genes that share domains with SPATA21: view

Function for SPATA21 Gene

Molecular function for SPATA21 Gene

UniProtKB/Swiss-Prot Function:
Involved in the differentiation of haploid spermatids.

Gene Ontology (GO) - Molecular Function for SPATA21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SPATA21: view
genes like me logo Genes that share phenotypes with SPATA21: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPATA21 Gene

Localization for SPATA21 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPATA21 gene
Compartment Confidence
cytosol 3
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPATA21 Gene

Pathways & Interactions for SPATA21 Gene

SuperPathways for SPATA21 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPATA21 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPATA21 Gene

Transcripts for SPATA21 Gene

Unigene Clusters for SPATA21 Gene

Spermatogenesis associated 21:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA21 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - - - - -
SP2: - -
SP3: - - - - - -
SP4:

Relevant External Links for SPATA21 Gene

GeneLoc Exon Structure for
SPATA21
ECgene alternative splicing isoforms for
SPATA21

Expression for SPATA21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPATA21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPATA21 Gene

This gene is overexpressed in Testis (x28.2), Liver (x4.7), Brain - Cerebellum (x4.2), and Brain - Cerebellar Hemisphere (x4.0).

Protein differential expression in normal tissues from HIPED for SPATA21 Gene

This gene is overexpressed in Plasma (33.5), Monocytes (20.1), and Tlymphocyte (15.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPATA21 Gene



Protein tissue co-expression partners for SPATA21 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPATA21 Gene:

SPATA21

SOURCE GeneReport for Unigene cluster for SPATA21 Gene:

Hs.705501
genes like me logo Genes that share expression patterns with SPATA21: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SPATA21 Gene

Orthologs for SPATA21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPATA21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPATA21 34 35
  • 99.19 (n)
dog
(Canis familiaris)
Mammalia SPATA21 34 35
  • 78.65 (n)
rat
(Rattus norvegicus)
Mammalia Spata21 34
  • 76.5 (n)
cow
(Bos Taurus)
Mammalia SPATA21 34 35
  • 76.33 (n)
mouse
(Mus musculus)
Mammalia Spata21 34 16 35
  • 75.13 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SPATA21 35
  • 27 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPATA21 35
  • 17 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 16 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 18 (a)
OneToMany
Species where no ortholog for SPATA21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPATA21 Gene

ENSEMBL:
Gene Tree for SPATA21 (if available)
TreeFam:
Gene Tree for SPATA21 (if available)

Paralogs for SPATA21 Gene

Paralogs for SPATA21 Gene

genes like me logo Genes that share paralogs with SPATA21: view

Variants for SPATA21 Gene

Sequence variations from dbSNP and Humsavar for SPATA21 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_042711 A breast cancer sample
rs10907226 -- 16,410,051(+) GGGGA(C/T)AGGGG intron-variant
rs10907227 -- 16,411,555(+) GGAGG(C/G)CGAGG intron-variant, upstream-variant-2KB
rs10907228 -- 16,429,378(+) ccacc(C/T)atctc intron-variant
rs111275924 -- 16,408,161(+) GGGCC(A/G)CTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPATA21 Gene

Variant ID Type Subtype PubMed ID
nsv829581 CNV loss 20364138
esv3585338 CNV loss 21293372
esv3585337 CNV gain 21293372
esv3577751 CNV loss 25503493
esv2744408 CNV deletion 23290073
esv2675247 CNV deletion 23128226
esv2674598 CNV deletion 23128226
esv1035588 CNV insertion 17803354
dgv19n67 CNV loss 20364138

Variation tolerance for SPATA21 Gene

Residual Variation Intolerance Score: 98.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.39; 81.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPATA21 Gene

Human Gene Mutation Database (HGMD)
SPATA21
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPATA21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATA21 Gene

Disorders for SPATA21 Gene

Relevant External Links for SPATA21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPATA21

No disorders were found for SPATA21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPATA21 Gene

Publications for SPATA21 Gene

  1. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64
  3. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjoeblom T. … Velculescu V.E. (Science 2006) 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for SPATA21 Gene

Sources for SPATA21 Gene

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