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Aliases for SPATA21 Gene

Aliases for SPATA21 Gene

  • Spermatogenesis Associated 21 2 3 5
  • Spergen-2 3
  • Spergen2 3

External Ids for SPATA21 Gene

Previous GeneCards Identifiers for SPATA21 Gene

  • GC01M016471
  • GC01M016597
  • GC01M016714
  • GC01M015242

Summaries for SPATA21 Gene

GeneCards Summary for SPATA21 Gene

SPATA21 (Spermatogenesis Associated 21) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is EFCAB3.

UniProtKB/Swiss-Prot for SPATA21 Gene

  • Involved in the differentiation of haploid spermatids.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATA21 Gene

Genomics for SPATA21 Gene

Regulatory Elements for SPATA21 Gene

Enhancers for SPATA21 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SPATA21 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPATA21 Gene

16,387,117 bp from pter
16,437,842 bp from pter
50,726 bases
Minus strand

Genomic View for SPATA21 Gene

Genes around SPATA21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATA21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATA21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA21 Gene

Proteins for SPATA21 Gene

  • Protein details for SPATA21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Spermatogenesis-associated protein 21
    Protein Accession:
    Secondary Accessions:
    • B9EK40
    • F5GXP5

    Protein attributes for SPATA21 Gene

    469 amino acids
    Molecular mass:
    52207 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPATA21 Gene


neXtProt entry for SPATA21 Gene

Proteomics data for SPATA21 Gene at MOPED

Post-translational modifications for SPATA21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPATA21 Gene

No data available for DME Specific Peptides for SPATA21 Gene

Domains & Families for SPATA21 Gene

Gene Families for SPATA21 Gene

Protein Domains for SPATA21 Gene

Suggested Antigen Peptide Sequences for SPATA21 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 EF-hand domain.
  • Contains 1 EF-hand domain.
genes like me logo Genes that share domains with SPATA21: view

Function for SPATA21 Gene

Molecular function for SPATA21 Gene

UniProtKB/Swiss-Prot Function:
Involved in the differentiation of haploid spermatids.
genes like me logo Genes that share phenotypes with SPATA21: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPATA21 Gene

Localization for SPATA21 Gene

Subcellular locations from

Jensen Localization Image for SPATA21 Gene COMPARTMENTS Subcellular localization image for SPATA21 gene
Compartment Confidence
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPATA21 Gene

Pathways & Interactions for SPATA21 Gene

SuperPathways for SPATA21 Gene

No Data Available

Interacting Proteins for SPATA21 Gene

Gene Ontology (GO) - Biological Process for SPATA21 Gene


No data available for Pathways by source and SIGNOR curated interactions for SPATA21 Gene

Drugs & Compounds for SPATA21 Gene

No Compound Related Data Available

Transcripts for SPATA21 Gene

Unigene Clusters for SPATA21 Gene

Spermatogenesis associated 21:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA21 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - - - - -
SP2: - -
SP3: - - - - - -

Relevant External Links for SPATA21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPATA21 Gene

mRNA expression in normal human tissues for SPATA21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPATA21 Gene

This gene is overexpressed in Testis (x28.2), Liver (x4.7), Brain - Cerebellum (x4.2), and Brain - Cerebellar Hemisphere (x4.0).

Protein differential expression in normal tissues from HIPED for SPATA21 Gene

This gene is overexpressed in Plasma (33.5), Monocytes (20.1), and Tlymphocyte (15.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPATA21 Gene

SOURCE GeneReport for Unigene cluster for SPATA21 Gene Hs.705501

genes like me logo Genes that share expression patterns with SPATA21: view

Protein tissue co-expression partners for SPATA21 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SPATA21 Gene

Orthologs for SPATA21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPATA21 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SPATA21 35
  • 76.33 (n)
  • 63.01 (a)
SPATA21 36
  • 42 (a)
(Canis familiaris)
Mammalia SPATA21 35
  • 78.65 (n)
  • 70.77 (a)
SPATA21 36
  • 47 (a)
(Mus musculus)
Mammalia Spata21 35
  • 75.13 (n)
  • 67.77 (a)
Spata21 16
Spata21 36
  • 45 (a)
(Pan troglodytes)
Mammalia SPATA21 35
  • 99.19 (n)
  • 98.53 (a)
SPATA21 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Spata21 35
  • 76.5 (n)
  • 68.51 (a)
(Monodelphis domestica)
Mammalia SPATA21 36
  • 17 (a)
(Ornithorhynchus anatinus)
Mammalia SPATA21 36
  • 27 (a)
(Gallus gallus)
Aves -- 36
  • 16 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 18 (a)
Species with no ortholog for SPATA21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPATA21 Gene

Gene Tree for SPATA21 (if available)
Gene Tree for SPATA21 (if available)

Paralogs for SPATA21 Gene

Paralogs for SPATA21 Gene

genes like me logo Genes that share paralogs with SPATA21: view

Variants for SPATA21 Gene

Sequence variations from dbSNP and Humsavar for SPATA21 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_042711 A breast cancer sample
rs12087671 - 16,410,031(+) TCCAA(C/G/T)GTCCC intron-variant, nc-transcript-variant, reference, missense
rs4661746 - 16,409,637(+) TGCTC(C/T)GGTGC intron-variant, nc-transcript-variant, reference, missense
rs525409 - 16,405,015(+) CGTCA(C/G)AGAGA nc-transcript-variant, reference, missense
rs12133574 - 16,400,724(+) CCATA(G/T)TTCTG nc-transcript-variant, downstream-variant-500B, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SPATA21 Gene

Variant ID Type Subtype PubMed ID
nsv829581 CNV Loss 20364138
esv2675247 CNV Deletion 23128226
esv1035588 CNV Insertion 17803354
esv2674598 CNV Deletion 23128226
dgv19n67 CNV Loss 20364138
esv2744408 CNV Deletion 23290073

Variation tolerance for SPATA21 Gene

Residual Variation Intolerance Score: 98.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.39; 81.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPATA21 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATA21 Gene

Disorders for SPATA21 Gene

Relevant External Links for SPATA21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SPATA21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPATA21 Gene

Publications for SPATA21 Gene

  1. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SPATA21 Gene

Sources for SPATA21 Gene