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SPATA2 Gene

protein-coding   GIFtS: 50
GCID: GC20M048519

Spermatogenesis Associated 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Spermatogenesis Associated 21 2     Spermatogenesis Associated PD12
Spermatogenesis-Associated Protein PD12 3     Spermatogenesis-Associated Protein 22
PD12 3     tamo2
KIAA07573 5     

External Ids:    HGNC: 146811   Entrez Gene: 98252   Ensembl: ENSG000001584807   OMIM: 6076625   UniProtKB: Q9UM823   

Export aliases for SPATA2 gene to outside databases

Previous GC identifers: GC20M048248 GC20M049158 GC20M049205 GC20M047953 GC20M045269


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SPATA2 Gene:
SPATA2 (spermatogenesis associated 2) is a protein-coding gene. An important paralog of this gene is SPATA2L.

UniProtKB/Swiss-Prot: SPAT2_HUMAN, Q9UM82
Function: May have a role in the regulation of spermatogenesis

Gene Wiki entry for SPATA2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPATA2 gene promoter:
         CREB   p53   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPATA2 promoter sequence
   Search Chromatin IP Primers for SPATA2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPATA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.13   Ensembl cytogenetic band:  20q13.13   HGNC cytogenetic band: 20q13.13

SPATA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPATA2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M048519:  view genomic region     (about GC identifiers)

Start:
48,519,928 bp from pter      End:
48,532,080 bp from pter
Size:
12,153 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SPAT2_HUMAN, Q9UM82 (See protein sequence)
Recommended Name: Spermatogenesis-associated protein 2  
Size: 520 amino acids; 58427 Da
Sequence caution: Sequence=BAA34477.2; Type=Erroneous initiation;
Secondary accessions: E1P626 O94857

Explore the universe of human proteins at neXtProt for SPATA2: NX_Q9UM82

Explore proteomics data for SPATA2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SPATA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001129245.1  NP_006029.1  

    ENSEMBL proteins: 
     ENSP00000289431   ENSP00000416799   ENSP00000438855  

    SPATA2 Human Recombinant Protein Products:

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    Novus Biologicals SPATA2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SPATA2

     
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    antibodies-online proteins for SPATA2 (9 products) 

     
    antibodies-online peptides for SPATA2

    SPATA2 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for SPATA2
    antibodies-online antibodies for SPATA2 (239 products) 

    SPATA2 Assay Products:

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    Cloud-Clone Corp. ELISAs for SPATA2
    Cloud-Clone Corp. CLIAs for SPATA2
    Search eBioscience for ELISAs for SPATA2 
    antibodies-online kits for SPATA2 (7 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q9UM82

    UniProtKB/Swiss-Prot: SPAT2_HUMAN, Q9UM82
    Similarity: Belongs to the SPATA2 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPAT2_HUMAN, Q9UM82
    Function: May have a role in the regulation of spermatogenesis

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    Find genes that share ontologies with SPATA2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPATA2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SPATA2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPATA2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPATA2

    miRNA
    Products:
        
    miRTarBase miRNAs that target SPATA2:
    hsa-mir-101-3p (MIRT027331), hsa-mir-19b-3p (MIRT031273), hsa-let-7d-5p (MIRT032133), hsa-mir-16-5p (MIRT031994), hsa-mir-130b-3p (MIRT020308), hsa-mir-196a-5p (MIRT026033), hsa-mir-93-5p (MIRT048858), hsa-mir-7-5p (MIRT025967), hsa-mir-32-5p (MIRT028290)

    Block miRNA regulation of human, mouse, rat SPATA2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SPATA2 (see all 54):
    hsa-let-7d hsa-miR-128 hsa-miR-301a hsa-let-7g hsa-let-7a hsa-miR-3613-3p hsa-miR-34b hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidSPATA2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SPATA2
    Predesigned siRNA for gene silencing in human, mouse, rat SPATA2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): SPATA2 (NM_006038)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPATA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPATA2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPATA2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPAT2_HUMAN, Q9UM82: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA10222154

    Find genes that share ontologies with SPATA2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including SPATA2: 
              Necrosis in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SPATA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SPATA2 (Q9UM822, 3 ENSP000002894314) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CEP72Q9P2092, 3, ENSP000002649354MINT-67691 I2D: score=5 STRING: ENSP00000264935
    DUTP333162, 3, ENSP000003703764MINT-66521 I2D: score=4 STRING: ENSP00000370376
    ENSG00000237335O152123, ENSP000004123194I2D: score=2 STRING: ENSP00000412319
    PFDN6O152123, ENSP000003637344I2D: score=2 STRING: ENSP00000363734
    ENSG00000206283O152123I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis NAS10222154
    GO:0030154cell differentiation IEA--

    Find genes that share ontologies with SPATA2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPATA2 (SPAT2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SPATA2 gene (2 alternative transcripts): 
    NM_001135773.1  NM_006038.3  

    Unigene Cluster for SPATA2:

    Spermatogenesis associated 2
    Hs.48513  [show with all ESTs]
    Unigene Representative Sequence: NM_001135773
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000289431(uc002xuw.3 uc010zyn.2) ENST00000422556(uc010gie.3)
    ENST00000543716
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SPATA2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SPATA2 (see all 54):
    hsa-let-7d hsa-miR-128 hsa-miR-301a hsa-let-7g hsa-let-7a hsa-miR-3613-3p hsa-miR-34b hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidSPATA2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SPATA2
    Predesigned siRNA for gene silencing in human, mouse, rat SPATA2
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SPATA2 (NM_006038)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPATA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPATA2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SPATA2
    OriGene qSTAR qPCR primer pairs in human, mouse for SPATA2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPATA2
      QuantiTect SYBR Green Assays in human, mouse, rat SPATA2
      QuantiFast Probe-based Assays in human, mouse, rat SPATA2

    Additional mRNA sequence: 

    AB018300.1 AK023229.1 AK289644.1 AK295536.1 BC009481.2 U28164.1 

    5 DOTS entries:

    DT.109457  DT.100792074  DT.120832432  DT.101980526  DT.99974656 

    Selected AceView cDNA sequences (see all 112):

    CB243227 BC009481 NM_006038 AB018300 AW206476 AA807420 N62318 BM453046 
    F29636 CR591290 CB160374 CR612212 F07151 AA577209 BM127128 AI918972 
    AW294143 BF062189 CK818847 Z40256 BM701616 BF979463 CB992178 CB994513 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SPATA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCTCTTAC
    SPATA2 Expression
    About this image

    SPATA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPATA2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.48513

    UniProtKB/Swiss-Prot: SPAT2_HUMAN, Q9UM82
    Tissue specificity: Highly expressed in Sertoli cells, but not detected in spermatogenic cells. Low expression in
    spleen, thymus and prostate

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SPATA2: 
              Necrosis in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SPATA2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPATA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SPATA2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spata21 , 5 spermatogenesis associated 21, 5 85.21(n)1
    85.6(a)1
      2 (87.23 cM)5
    2638761  NM_170756.21  NP_739562.11 
     1674811335 
    chicken
    (Gallus gallus)
    Aves SPATA21 spermatogenesis associated 2 65.88(n)
    66.67(a)
      419355  NM_001007873.1  NP_001007874.1 
    lizard
    (Anolis carolinensis)
    Reptilia SPATA26
    spermatogenesis associated 2
    63(a)
    1 ↔ 1
    4(147360605-147370301)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC644092 hypothetical protein MGC64409 73.07(n)    BC054226.1 
    zebrafish
    (Danio rerio)
    Actinopterygii spata21 spermatogenesis associated 2 55.33(n)
    48.39(a)
      568830  NM_001080191.2  NP_001073660.2 


    ENSEMBL Gene Tree for SPATA2 (if available)
    TreeFam Gene Tree for SPATA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SPATA2 gene
    SPATA2L2  

    Find genes that share paralogs with SPATA2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SPATA2
    PGOHUM00000248604


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SPATA2 (see all 408)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs114842501,2
    C--48519434(+) AAAAA-/ACATGG 2 -- int10--------
    rs1383756891,2
    C--48519527(+) GAGATC/GGAGAC 2 -- int10--------
    rs760961421,2
    C,F--48519558(+) AATCCC/TGTCTC 2 -- int11Minor allele frequency- T:0.50WA 2
    rs781810261,2
    C--48519645(+) ACCCAA/GGAGGC 2 -- int10--------
    rs1444427801,2
    C--48519676(+) ATAGCA/GCCACT 2 -- int10--------
    rs1484717401,2
    --48519681(+) GCCACC/TGTGCT 2 -- int10--------
    rs4719971,2
    C,F,A,H--48519702(-) TTGCTG/CTGTCG 2 -- int16Minor allele frequency- C:0.17NA 12
    rs1816226101,2
    --48519783(+) GTATAG/TCACTC 2 -- int10--------
    rs1442086421,2
    C--48519947(+) ACACT-/TTATTA
            
    TTATT
    2 -- cds10--------
    rs1177430951,2
    F--48520127(+) CACAGT/CGCGTC 2 -- ut311Minor allele frequency- C:0.01EA 120

    HapMap Linkage Disequilibrium report for SPATA2 (48519928 - 48532080 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SPATA2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2722492CNV Deletion23290073
    nsv912915CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SPATA2
    DNA2.0 Custom Variant and Variant Library Synthesis for SPATA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607662    OMIM disorders: --


    Find genes that share disorders with SPATA2           About GenesLikeMe

    Genetic Association Database (GAD): SPATA2

    Export disorders for SPATA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPATA2 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with SPATA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association analysis identifies three psoriasis susceptibility loci. (PubMed id 20953189)1, 4 Stuart P.E....Elder J.T. (Nat. Genet. 2010)
    2. Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene. (PubMed id 18364390)1, 4 Capon F.... Trembath R.C. (Hum. Mol. Genet. 2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    5. cDNA cloning and characterization of PD1: a novel human testicular protein with different expressions in various testiculopathies. (PubMed id 10222154)1, 2 Graziotto R.... Onisto M. (Exp. Cell Res. 1999)
    6. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)
    7. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    8. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Tumor-infiltrating NY-ESO-1-specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer. (PubMed id 20385810)1 Matsuzaki J....Odunsi K. (Proc. Natl. Acad. Sci. U.S.A. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9825 HGNC: 14681 AceView: SPATA2 Ensembl:ENSG00000158480 euGenes: HUgn9825
    ECgene: SPATA2 H-InvDB: SPATA2

    (According to HUGE)
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    HUGE: KIAA0757

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SPATA2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SPATA2 gene:
    Search GeneIP for patents involving SPATA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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