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Aliases for SPATA2 Gene

Aliases for SPATA2 Gene

  • Spermatogenesis Associated 2 2 3
  • Spermatogenesis-Associated Protein PD1 3 4
  • KIAA0757 4 6
  • PD1 3 4
  • Protein Phosphatase 1, Regulatory Subunit 145 3
  • Spermatogenesis-Associated Protein 2 3
  • Spermatogenesis Associated PD1 3
  • Regulatory Subunit 145 2
  • Protein Phosphatase 1 2
  • PPP1R145 3
  • Tamo 3

External Ids for SPATA2 Gene

Previous GeneCards Identifiers for SPATA2 Gene

  • GC20M048248
  • GC20M049158
  • GC20M049205
  • GC20M047953
  • GC20M048519
  • GC20M045269

Summaries for SPATA2 Gene

GeneCards Summary for SPATA2 Gene

SPATA2 (Spermatogenesis Associated 2) is a Protein Coding gene. An important paralog of this gene is SPATA2L.

UniProtKB/Swiss-Prot for SPATA2 Gene

  • May have a role in the regulation of spermatogenesis

Gene Wiki entry for SPATA2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATA2 Gene

Genomics for SPATA2 Gene

Regulatory Elements for SPATA2 Gene

Transcription factor binding sites by QIAGEN in the SPATA2 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SPATA2 Gene

49,903,391 bp from pter
49,915,543 bp from pter
12,153 bases
Minus strand

Genomic View for SPATA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPATA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA2 Gene

Proteins for SPATA2 Gene

  • Protein details for SPATA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Spermatogenesis-associated protein 2
    Protein Accession:
    Secondary Accessions:
    • E1P626
    • O94857

    Protein attributes for SPATA2 Gene

    520 amino acids
    Molecular mass:
    58427 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA34477.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SPATA2 Gene

Proteomics data for SPATA2 Gene at MOPED

Post-translational modifications for SPATA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPATA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SPATA2 Gene

Domains for SPATA2 Gene

Gene Families for SPATA2 Gene

Protein Domains for SPATA2 Gene


Suggested Antigen Peptide Sequences for SPATA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPATA2 family.
  • Belongs to the SPATA2 family.
genes like me logo Genes that share domains with SPATA2: view

Function for SPATA2 Gene

Molecular function for SPATA2 Gene

UniProtKB/Swiss-Prot Function:
May have a role in the regulation of spermatogenesis

Gene Ontology (GO) - Molecular Function for SPATA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SPATA2: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPATA2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for SPATA2 Gene

Localization for SPATA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPATA2 Gene

Subcellular locations from

Jensen Localization Image for SPATA2 Gene COMPARTMENTS Subcellular localization image for SPATA2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SPATA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA 10222154
genes like me logo Genes that share ontologies with SPATA2: view

Pathways for SPATA2 Gene

SuperPathways for SPATA2 Gene

No Data Available

PCR Array Products

Gene Ontology (GO) - Biological Process for SPATA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis NAS 10222154
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with SPATA2: view

No data available for Pathways by source for SPATA2 Gene

Transcripts for SPATA2 Gene

Unigene Clusters for SPATA2 Gene

Spermatogenesis associated 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPATA2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA2 Gene

No ASD Table

Relevant External Links for SPATA2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPATA2 Gene

mRNA expression in normal human tissues for SPATA2 Gene

Protein differential expression in normal tissues for SPATA2 Gene

This gene is overexpressed in Brain (48.3) and Frontal cortex (10.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPATA2 Gene

SOURCE GeneReport for Unigene cluster for SPATA2 Gene Hs.48513

mRNA Expression by UniProt/SwissProt for SPATA2 Gene

Tissue specificity: Highly expressed in Sertoli cells, but not detected in spermatogenic cells. Low expression in spleen, thymus and prostate
genes like me logo Genes that share expressions with SPATA2: view

Expression partners for SPATA2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SPATA2 Gene

Orthologs for SPATA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPATA2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SPATA2 35
  • 85.31 (n)
  • 84.66 (a)
  • 84 (a)
(Canis familiaris)
Mammalia SPATA2 35
  • 89.49 (n)
  • 90.19 (a)
  • 90 (a)
(Mus musculus)
Mammalia Spata2 35
  • 85.21 (n)
  • 85.6 (a)
Spata2 16
Spata2 36
  • 85 (a)
(Pan troglodytes)
Mammalia SPATA2 35
  • 99.62 (n)
  • 99.81 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Spata2 35
  • 85.26 (n)
  • 86.69 (a)
(Monodelphis domestica)
Mammalia SPATA2 36
  • 72 (a)
(Gallus gallus)
Aves SPATA2 35
  • 65.88 (n)
  • 66.67 (a)
  • 64 (a)
(Anolis carolinensis)
Reptilia SPATA2 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia spata2 35
  • 64.04 (n)
  • 61.81 (a)
Str.7351 35
African clawed frog
(Xenopus laevis)
Amphibia MGC64409 35
(Danio rerio)
Actinopterygii spata2 35
  • 55.33 (n)
  • 48.39 (a)
spata2 36
  • 37 (a)
Species with no ortholog for SPATA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPATA2 Gene

Gene Tree for SPATA2 (if available)
Gene Tree for SPATA2 (if available)

Paralogs for SPATA2 Gene

Paralogs for SPATA2 Gene Pseudogenes for SPATA2 Gene

genes like me logo Genes that share paralogs with SPATA2: view

Variants for SPATA2 Gene

Sequence variations from dbSNP and Humsavar for SPATA2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs471997 -- 49,903,165(-) TTGCT(C/G)TGTCG downstream-variant-500B
rs492702 -- 49,906,048(-) GAGTC(A/C/G/T)GCCCT synonymous-codon, reference
rs495337 -- 49,905,793(-) TTCTG(C/T)AACCG reference, synonymous-codon
rs571694 -- 49,907,218(-) CTGGG(C/T)GTGTT intron-variant
rs624115 -- 49,907,091(+) AGTCT(C/T)GCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPATA2 Gene

Variant ID Type Subtype PubMed ID
nsv912915 CNV Loss 21882294
esv2722492 CNV Deletion 23290073

Relevant External Links for SPATA2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATA2 Gene

Disorders for SPATA2 Gene

Relevant External Links for SPATA2

Genetic Association Database (GAD)

No disorders were found for SPATA2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SPATA2 Gene

Publications for SPATA2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  2. cDNA cloning and characterization of PD1: a novel human testicular protein with different expressions in various testiculopathies. (PMID: 10222154) Graziotto R. … Onisto M. (Exp. Cell Res. 1999) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene. (PMID: 18364390) Capon F. … Trembath R.C. (Hum. Mol. Genet. 2008) 3 48

Products for SPATA2 Gene

Sources for SPATA2 Gene

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