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Aliases for SPATA2 Gene

Aliases for SPATA2 Gene

  • Spermatogenesis Associated 2 2 3 5
  • Spermatogenesis-Associated Protein PD1 3 4
  • PD1 3 4
  • Protein Phosphatase 1, Regulatory Subunit 145 3
  • Spermatogenesis Associated PD1 3
  • Regulatory Subunit 145 2
  • Protein Phosphatase 1 2
  • PPP1R145 3
  • KIAA0757 4
  • Tamo 3

External Ids for SPATA2 Gene

Previous GeneCards Identifiers for SPATA2 Gene

  • GC20M048248
  • GC20M049158
  • GC20M049205
  • GC20M047953
  • GC20M048519
  • GC20M045269

Summaries for SPATA2 Gene

GeneCards Summary for SPATA2 Gene

SPATA2 (Spermatogenesis Associated 2) is a Protein Coding gene. An important paralog of this gene is SPATA2L.

UniProtKB/Swiss-Prot for SPATA2 Gene

  • May have a role in the regulation of spermatogenesis.

Gene Wiki entry for SPATA2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATA2 Gene

Genomics for SPATA2 Gene

Regulatory Elements for SPATA2 Gene

Promoters for SPATA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SPATA2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SPATA2 gene promoter:

Genomic Location for SPATA2 Gene

Chromosome:
20
Start:
49,903,391 bp from pter
End:
49,915,543 bp from pter
Size:
12,153 bases
Orientation:
Minus strand

Genomic View for SPATA2 Gene

Genes around SPATA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA2 Gene

Proteins for SPATA2 Gene

  • Protein details for SPATA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UM82-SPAT2_HUMAN
    Recommended name:
    Spermatogenesis-associated protein 2
    Protein Accession:
    Q9UM82
    Secondary Accessions:
    • E1P626
    • O94857

    Protein attributes for SPATA2 Gene

    Size:
    520 amino acids
    Molecular mass:
    58427 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA34477.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SPATA2 Gene

Proteomics data for SPATA2 Gene at MOPED

Post-translational modifications for SPATA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPATA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPATA2 Gene

Domains & Families for SPATA2 Gene

Gene Families for SPATA2 Gene

Protein Domains for SPATA2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPATA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UM82

UniProtKB/Swiss-Prot:

SPAT2_HUMAN :
  • Belongs to the SPATA2 family.
Family:
  • Belongs to the SPATA2 family.
genes like me logo Genes that share domains with SPATA2: view

Function for SPATA2 Gene

Molecular function for SPATA2 Gene

UniProtKB/Swiss-Prot Function:
May have a role in the regulation of spermatogenesis.

Gene Ontology (GO) - Molecular Function for SPATA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SPATA2: view

Phenotypes for SPATA2 Gene

MGI mutant phenotypes for SPATA2:
inferred from 1 alleles
GenomeRNAi human phenotypes for SPATA2:
genes like me logo Genes that share phenotypes with SPATA2: view

Animal Models for SPATA2 Gene

MGI Knock Outs for SPATA2:

Animal Model Products

miRNA for SPATA2 Gene

miRTarBase miRNAs that target SPATA2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPATA2 Gene

Localization for SPATA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPATA2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPATA2 Gene COMPARTMENTS Subcellular localization image for SPATA2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SPATA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 10222154
genes like me logo Genes that share ontologies with SPATA2: view

Pathways & Interactions for SPATA2 Gene

SuperPathways for SPATA2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPATA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with SPATA2: view

No data available for Pathways by source and SIGNOR curated interactions for SPATA2 Gene

Drugs & Compounds for SPATA2 Gene

No Compound Related Data Available

Transcripts for SPATA2 Gene

Unigene Clusters for SPATA2 Gene

Spermatogenesis associated 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA2 Gene

No ASD Table

Relevant External Links for SPATA2 Gene

GeneLoc Exon Structure for
SPATA2
ECgene alternative splicing isoforms for
SPATA2

Expression for SPATA2 Gene

mRNA expression in normal human tissues for SPATA2 Gene

Protein differential expression in normal tissues from HIPED for SPATA2 Gene

This gene is overexpressed in Brain (48.3) and Frontal cortex (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPATA2 Gene



SOURCE GeneReport for Unigene cluster for SPATA2 Gene Hs.48513

mRNA Expression by UniProt/SwissProt for SPATA2 Gene

Q9UM82-SPAT2_HUMAN
Tissue specificity: Highly expressed in Sertoli cells, but not detected in spermatogenic cells. Low expression in spleen, thymus and prostate.
genes like me logo Genes that share expression patterns with SPATA2: view

Protein tissue co-expression partners for SPATA2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SPATA2 Gene

Orthologs for SPATA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPATA2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SPATA2 35
  • 85.31 (n)
  • 84.66 (a)
SPATA2 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPATA2 35
  • 89.49 (n)
  • 90.19 (a)
SPATA2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spata2 35
  • 85.21 (n)
  • 85.6 (a)
Spata2 16
Spata2 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SPATA2 35
  • 99.62 (n)
  • 99.81 (a)
SPATA2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spata2 35
  • 85.26 (n)
  • 86.69 (a)
oppossum
(Monodelphis domestica)
Mammalia SPATA2 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPATA2 35
  • 65.88 (n)
  • 66.67 (a)
SPATA2 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPATA2 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spata2 35
  • 64.04 (n)
  • 61.81 (a)
Str.7351 35
African clawed frog
(Xenopus laevis)
Amphibia MGC64409 35
zebrafish
(Danio rerio)
Actinopterygii spata2 35
  • 55.33 (n)
  • 48.39 (a)
spata2 36
  • 37 (a)
OneToOne
Species with no ortholog for SPATA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPATA2 Gene

ENSEMBL:
Gene Tree for SPATA2 (if available)
TreeFam:
Gene Tree for SPATA2 (if available)

Paralogs for SPATA2 Gene

Paralogs for SPATA2 Gene

Pseudogenes.org Pseudogenes for SPATA2 Gene

genes like me logo Genes that share paralogs with SPATA2: view

Variants for SPATA2 Gene

Sequence variations from dbSNP and Humsavar for SPATA2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs2072985 - 49,905,855(-) ACCGC(C/T)TCCCG reference, missense
rs471997 -- 49,903,165(-) TTGCT(C/G)TGTCG downstream-variant-500B
rs492702 -- 49,906,048(-) GAGTC(A/C/G/T)GCCCT reference, synonymous-codon
rs495337 -- 49,905,793(-) TTCTG(C/T)AACCG reference, synonymous-codon
rs571694 -- 49,907,218(-) CTGGG(C/T)GTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPATA2 Gene

Variant ID Type Subtype PubMed ID
nsv912915 CNV Loss 21882294
esv2722492 CNV Deletion 23290073

Variation tolerance for SPATA2 Gene

Residual Variation Intolerance Score: 29.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.34; 70.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPATA2 Gene

HapMap Linkage Disequilibrium report
SPATA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATA2 Gene

Disorders for SPATA2 Gene

Relevant External Links for SPATA2

Genetic Association Database (GAD)
SPATA2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPATA2

No disorders were found for SPATA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPATA2 Gene

Publications for SPATA2 Gene

  1. Genome-wide association analysis identifies three psoriasis susceptibility loci. (PMID: 20953189) Stuart P.E. … Elder J.T. (Nat. Genet. 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Proximity Interactions among Centrosome Components Identify Regulators of Centriole Duplication. (PMID: 24613305) Firat-Karalar E.N. … Stearns T. (Curr. Biol. 2014) 3
  4. PD-1(+) CD8(+) T cells are exhausted in tumours and functional in draining lymph nodes of colorectal cancer patients. (PMID: 25093496) Wu X. … Wang S. (Br. J. Cancer 2014) 3
  5. Investigating the genetic association of HCP5, SPATA2, TNIP1, TNFAIP3 and COG6 with psoriasis in Chinese population. (PMID: 25264125) Li X.L. … Wu G.S. (Int. J. Immunogenet. 2014) 3

Products for SPATA2 Gene

Sources for SPATA2 Gene

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