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Aliases for SPATA19 Gene

Aliases for SPATA19 Gene

  • Spermatogenesis Associated 19 2 3 5
  • Spermatogenic Cell-Specific Gene 1 Protein 3 4
  • Cancer/Testis Antigen 132 2 3
  • Spergen-1 3 4
  • Spergen1 3 4
  • Spermatogenesis-Associated Protein 19, Mitochondrial 3
  • Testis Secretory Sperm-Binding Protein Li 243mP 3
  • Spermatogenic Specific-Gene1 3
  • Spergen 1 2
  • CT132 3
  • SPAS1 3

External Ids for SPATA19 Gene

Previous GeneCards Identifiers for SPATA19 Gene

  • GC11M133216
  • GC11M133710
  • GC11M129665

Summaries for SPATA19 Gene

GeneCards Summary for SPATA19 Gene

SPATA19 (Spermatogenesis Associated 19) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SPATA19 Gene

  • May have a role in spermiogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATA19 Gene

Genomics for SPATA19 Gene

Regulatory Elements for SPATA19 Gene

Enhancers for SPATA19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F134050 1.4 FANTOM5 Ensembl ENCODE 8.9 -205.5 -205492 1.3 ZNF48 ZNF2 RAD21 GLIS2 EGR1 ZNF143 ZNF391 EGR2 ZNF654 REST THYN1 SPATA19 JAM3 B3GAT1 LOC105369582
GH11F133895 0.7 Ensembl ENCODE 10.1 -49.6 -49600 0.3 TEAD4 RELA IGSF9B SPATA19 PIR56503 LOC283172
GH11F133896 0.4 ENCODE 10.1 -49.8 -49823 0.2 RELA IGSF9B SPATA19 PIR56503 LOC283172
GH11F133894 0.2 Ensembl 10.1 -49.2 -49163 0.2 IGSF9B SPATA19 PIR56503 LOC283172
GH11F133835 0.7 ENCODE 0.4 +10.2 10168 0.2 ZNF263 CTCF ZNF654 MAX THRB RAD21 SMC3 ZNF143 MYC RXRB SPATA19 GC11P133812
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPATA19 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPATA19 Gene

Chromosome:
11
Start:
133,835,930 bp from pter
End:
133,845,538 bp from pter
Size:
9,609 bases
Orientation:
Minus strand

Genomic View for SPATA19 Gene

Genes around SPATA19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATA19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATA19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA19 Gene

Proteins for SPATA19 Gene

  • Protein details for SPATA19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5L4-SPT19_HUMAN
    Recommended name:
    Spermatogenesis-associated protein 19, mitochondrial
    Protein Accession:
    Q7Z5L4
    Secondary Accessions:
    • Q8N7A9

    Protein attributes for SPATA19 Gene

    Size:
    167 amino acids
    Molecular mass:
    19186 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPATA19 Gene

Post-translational modifications for SPATA19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPATA19 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for SPATA19
  • Santa Cruz Biotechnology (SCBT) Antibodies for SPATA19

No data available for DME Specific Peptides for SPATA19 Gene

Domains & Families for SPATA19 Gene

Protein Domains for SPATA19 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPATA19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPATA19: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SPATA19 Gene

Function for SPATA19 Gene

Molecular function for SPATA19 Gene

UniProtKB/Swiss-Prot Function:
May have a role in spermiogenesis.

Phenotypes for SPATA19 Gene

GenomeRNAi human phenotypes for SPATA19:
genes like me logo Genes that share phenotypes with SPATA19: view

Animal Model Products

miRNA for SPATA19 Gene

miRTarBase miRNAs that target SPATA19

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPATA19 Gene

Localization for SPATA19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPATA19 Gene

Mitochondrion outer membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPATA19 gene
Compartment Confidence
mitochondrion 4
extracellular 2
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SPATA19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SPATA19: view

Pathways & Interactions for SPATA19 Gene

SuperPathways for SPATA19 Gene

No Data Available

Interacting Proteins for SPATA19 Gene

Gene Ontology (GO) - Biological Process for SPATA19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with SPATA19: view

No data available for Pathways by source and SIGNOR curated interactions for SPATA19 Gene

Transcripts for SPATA19 Gene

mRNA/cDNA for SPATA19 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPATA19 Gene

Spermatogenesis associated 19:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA19 Gene

No ASD Table

Relevant External Links for SPATA19 Gene

GeneLoc Exon Structure for
SPATA19
ECgene alternative splicing isoforms for
SPATA19

Expression for SPATA19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPATA19 Gene

mRNA differential expression in normal tissues according to GTEx for SPATA19 Gene

This gene is overexpressed in Testis (x51.6).

Protein differential expression in normal tissues from HIPED for SPATA19 Gene

This gene is overexpressed in Testis (56.5) and Ovary (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPATA19 Gene



Protein tissue co-expression partners for SPATA19 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SPATA19 Gene:

SPATA19

SOURCE GeneReport for Unigene cluster for SPATA19 Gene:

Hs.97541

mRNA Expression by UniProt/SwissProt for SPATA19 Gene:

Q7Z5L4-SPT19_HUMAN
Tissue specificity: Expressed specifically in testis.
genes like me logo Genes that share expression patterns with SPATA19: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SPATA19 Gene

Orthologs for SPATA19 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPATA19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPATA19 34 35
  • 99 (n)
cow
(Bos Taurus)
Mammalia SPATA19 34 35
  • 81.6 (n)
dog
(Canis familiaris)
Mammalia SPATA19 34 35
  • 81.6 (n)
mouse
(Mus musculus)
Mammalia Spata19 34 16 35
  • 78.35 (n)
rat
(Rattus norvegicus)
Mammalia Spata19 34
  • 76.19 (n)
oppossum
(Monodelphis domestica)
Mammalia SPATA19 35
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPATA19 35
  • 55 (a)
OneToOne
Species where no ortholog for SPATA19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPATA19 Gene

ENSEMBL:
Gene Tree for SPATA19 (if available)
TreeFam:
Gene Tree for SPATA19 (if available)

Paralogs for SPATA19 Gene

No data available for Paralogs for SPATA19 Gene

Variants for SPATA19 Gene

Sequence variations from dbSNP and Humsavar for SPATA19 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10750541 -- 133,843,294(+) TAGCA(A/C)AACCA intron-variant
rs10750542 -- 133,843,541(+) CAACA(C/T)CGATG intron-variant
rs10791325 -- 133,838,812(+) CTACA(A/G)TGAAC intron-variant
rs10791326 -- 133,838,858(+) ATCAA(A/C)AAGTG intron-variant
rs10791327 -- 133,838,914(+) AGCCA(A/T)AAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPATA19 Gene

Variant ID Type Subtype PubMed ID
esv3628157 CNV gain 21293372
esv3628160 CNV gain 21293372
nsv1046273 CNV gain 25217958

Variation tolerance for SPATA19 Gene

Residual Variation Intolerance Score: 65.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.54; 94.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPATA19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPATA19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATA19 Gene

Disorders for SPATA19 Gene

Relevant External Links for SPATA19

Genetic Association Database (GAD)
SPATA19
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPATA19

No disorders were found for SPATA19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPATA19 Gene

Publications for SPATA19 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Isolation and expression analysis of the human testis-specific gene, SPERGEN-1, a spermatogenic cell-specific gene-1. (PMID: 12688595) Miyamoto T. … Ishikawa M. (J. Assist. Reprod. Genet. 2003) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. Elevated expression levels of testis-specific genes TEX101 and SPATA19 in basal cell carcinoma and their correlation with clinical and pathological features. (PMID: 19886887) Ghafouri-Fard S. … Modarressi M.H. (Br. J. Dermatol. 2010) 3 64

Products for SPATA19 Gene

Sources for SPATA19 Gene

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