SPATA16 Gene
protein-coding GIFtS: 47
GCID: GC03M172607
|
|
spermatogenesis associated 16
| |
Aliases
for SPATA16 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Spermatogenesis Associated 161 2 | | NYD-SP121 2 | | Testis Development Protein NYD-SP122 3 | | SPGF62 | | Spermatogenesis-Associated Protein 162 | | Testis-Specific Golgi Protein2 |
Export aliases for SPATA16 gene to outside databasesPrevious GC identifers: GC03M174090 GC03M169978 |
Summaries
for SPATA16 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SPATA16:
This gene encodes a testis-specific protein that belongs to the tetratricopeptide repeat-like superfamily. The encodedprotein localizes to the Golgi apparatus and may play a role in spermatogenesis. (provided by RefSeq, May 2010)
UniProtKB/Swiss-Prot: SPT16_HUMAN, Q9BXB7Function: Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis andsperm-egg fusion
|
Genomic Views
for SPATA16 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPATA16 gene promoter:
Pax-6 Bach2 NF-AT C/EBPalpha NF-AT4 NF-AT2 IRF-7A NF-AT3 Pax-4a NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPATA16
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPATA16 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q26.31 Ensembl cytogenetic band: 3q26.31 HGNC cytogenetic band: 3q26.31SPATA16 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M172607: view genomic region
(about GC identifiers)
Start:
|
172,607,147 bp from pter |
End:
|
172,859,058 bp from pter |
Size:
|
251,912 bases |
Orientation:
|
minus strand |
|
Proteins
for SPATA16 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPT16_HUMAN, Q9BXB7 (See
protein sequence)Recommended Name: Spermatogenesis-associated protein 16 Size: 569 amino acids; 65263 Da
Subcellular location: Golgi apparatus. Note=Localized to the perinuclear region
Miscellaneous: Association analysis reveals significant frequency of a synonymous (Ser-225) sequence polymorphism amongclinical groups with different sperm traits: the donor group, which has the highest sperm count and motility level,has a significant higher polymorphism frequency compared to normal and asthenozoopermia groups
Secondary accessions: Q0R0N4 Q0R0S0 Q0R0W2 Q0R129 Q0R131 Q0R140 Q0R1B8 Q0R1G5 Q0R1I2 Q0R1J6 Q0R1S4Q0R202 Q0R280 Q0R2F8 Q0R2N6 Q0R2N7 Q0R2R0 Q0R2R1 Q0R2S3 Q0R2S4 Q0R2S5 Q0R2T4 Q0R2T7 Q0R2U2 Q0R2U8Q0R2U9 Q0R2V5 Q0R2V7 Q8NE67Explore the universe of human proteins at neXtProt for SPATA16: NX_Q9BXB7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BXB7
SPATA16 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_114161.3
ENSEMBL proteins: ENSP00000341765
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005794 | Golgi apparatus |
IEA | -- |
SPATA16 for ontologies About GeneDecksing
SPATA16 Antibody Products:
Assay Products for SPATA16: |
Protein
Domains /
Families
for SPATA16 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPATA16 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BXB7ProtoNet protein and cluster: Q9BXB7 UniProtKB/Swiss-Prot: SPT16_HUMAN, Q9BXB7Similarity: Belongs to the SPATA16 family |
Function
for SPATA16 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SPT16_HUMAN, Q9BXB7Function: Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis andsperm-egg fusion
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA16 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA16
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SPATA16 (NM_031955) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPATA16 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPATA16 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPATA16 |
|
Pathways & Interactions
for SPATA16 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPATA16
1 Interacting protein for SPATA16 (Q9BXB72) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0007283 | spermatogenesis |
IEA | -- | | GO:0030154 | cell differentiation |
IEA | -- |
SPATA16 for ontologies About GeneDecksing
|
Drugs & Compounds
for SPATA16 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPATA16
Search CenterWatch for drugs/clinical trials and news about SPATA16 / SPT16
|
Transcripts
for SPATA16 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPATA16 gene: NM_031955.5 Unigene Cluster for SPATA16: Spermatogenesis associated 16 Hs.444236 [show with all ESTs]Unigene Representative Sequence: NM_0319551 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000351008(uc003fin.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA16 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA16
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPATA16 (NM_031955) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPATA16 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPATA16 |
Additional cDNA sequence: AF345909.2 AF404758.1 AK093041.1 BC034496.2 4 DOTS entries: DT.100017336 DT.100744575 DT.100699380 DT.91924658 24/26 AceView cDNA sequences (see all 26): AA383485 BP370007 AX747878 BC034496 BX281066 AK093041 BG189141 BG722348 NM_031955 BM563232 BI829426 AA902823 AF345909 AF404758 BM563796 BI830435 BG773156 BP370042 AI476510 BQ429605 BE502467 BF061951 CD358192 AI655299
GeneLoc Exon Structure
|
Expression
for SPATA16 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPATA16 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTGAGGAAG
About this image
See SPATA16 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPATA16
SOURCE GeneReport for Unigene cluster: Hs.444236
UniProtKB/Swiss-Prot: SPT16_HUMAN, Q9BXB7Tissue specificity: Expressed in testis
SABiosciences Custom PCR Arrays for SPATA16
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPATA16
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPATA16 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPATA16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPATA16 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPATA16 |
Orthologs
for SPATA16 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SPATA16 gene from 3/9 species (see all 9) About this table
ENSEMBL Gene Tree for SPATA16 (if available)
TreeFam Gene Tree for SPATA16 (if available) |
Paralogs
for SPATA16 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SPATA16 gene
SPATA16 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SPATA16
PGOHUM00000246932
|
Genomic Variants
for SPATA16 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SPATA16 (172607147 - 172857147 bp, first 250kb of SPATA16)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for SPATA16
1 CNV: 98531
6 Indels: 79999 80000 91700 91701 91702 79998
Human Gene Mutation Database (HGMD): SPATA16
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPATA16 |
|
Disorders
/ Diseases
for SPATA16 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SPATA16 for disorders About GeneDecksing
OMIM gene information: 609856
OMIM disorders: 102530
UniProtKB/Swiss-Prot: SPT16_HUMAN, Q9BXB7
Defects in SPATA16 are the cause of spermatogenic failure type 6 (SPGF6) [MIM:102530]; also known asround-headed spermatozoa. An infertility disorder caused by spermatogenesis defects. The most prominent feature is themalformation of the acrosome, which can be totally absent in most severe cases. Additional features are an abnormalnuclear shape and abnormal arrangement of the mitochondria of the spermatozoon. Note=An autosomal recessive variationof SPATA16 has been shown to be responsible for the disease in a consanguineous family with members homozygous for thevariation
4  diseases for SPATA16: About MalaCardssertoli cell-only syndrome globozoospermia male infertility infertility
1 disease from the University of Copenhagen DISEASES database for SPATA16:Male infertility Human Genome Epidemiology (HuGE) Navigator: SPATA16 (1 document)
Export disorders for SPATA16 gene to outside databases
|
Publications
for SPATA16 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPATA16 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with SPATA16) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of a novel human testis-specific Golgi protein, NYD-SP12. (PubMed id 12529416)1, 2, 3, 9 Xu M.... Sha J. (2003)
- Homozygous mutation in SPATA16 is associated with male infertility in human globozoospermia. (PubMed id 17847006)1, 2, 3 Dam A.H.... Viville S. (2007)
- Rapid Evolution, Genetic Variations, and Functional Association of the Human Spermatogenesis-Related Gene NYD-SP12. (PubMed id 17665087)1, 2 Zhang Q.... Su B. (2007)
- A genome-wide search for loci interacting with known p rostate cancer risk-associated genetic variants. (PubMed id 22219177)1 Tao S....Sun J. (2012)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
- Gene functional research using polyethylenimine-mediated in vivo gene transfection into mouse spermatogenic cells. (PubMed id 16372119)1 Lu L....Sha J.H. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
|
External Searches for SPATA16 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SPATA16 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPATA16 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPATA16 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPATA16 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SPATA16 gene:
Search GeneIP for patents involving SPATA16
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPATA16 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPATA16 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPATA16 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPATA16 | | | OriGene Protein Over-expression Lysate for SPATA16 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPATA16 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA16 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPATA16 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SPATA16 | | OriGene Custom Protein Services for SPATA16 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPATA16 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPATA16 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPATA16 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPATA16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPATA16 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPATA16 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for SPATA16 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | SPATA16 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPATA16 |
|  |  |  | | | | ThermoFisher Antibodies for SPATA16 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPATA16 |
|
|
|
|
