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Aliases for SPATA16 Gene

Aliases for SPATA16 Gene

  • Spermatogenesis Associated 16 2 3 5
  • Testis Development Protein NYD-SP12 3 4
  • Testicular Tissue Protein Li 185 3
  • Testis-Specific Golgi Protein 3
  • NYD-SP12 3
  • SPGF6 3

External Ids for SPATA16 Gene

Previous GeneCards Identifiers for SPATA16 Gene

  • GC03M174090
  • GC03M172607
  • GC03M169978

Summaries for SPATA16 Gene

Entrez Gene Summary for SPATA16 Gene

  • This gene encodes a testis-specific protein that belongs to the tetratricopeptide repeat-like superfamily. The encoded protein localizes to the Golgi apparatus and may play a role in spermatogenesis. [provided by RefSeq, May 2010]

GeneCards Summary for SPATA16 Gene

SPATA16 (Spermatogenesis Associated 16) is a Protein Coding gene. Diseases associated with SPATA16 include spermatogenic failure 6 and male reproductive system disease.

UniProtKB/Swiss-Prot for SPATA16 Gene

  • Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis and sperm-egg fusion.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATA16 Gene

Genomics for SPATA16 Gene

Regulatory Elements for SPATA16 Gene


Genomic Location for SPATA16 Gene

Chromosome:
3
Start:
172,889,357 bp from pter
End:
173,141,268 bp from pter
Size:
251,912 bases
Orientation:
Minus strand

Genomic View for SPATA16 Gene

Genes around SPATA16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATA16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATA16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA16 Gene

Proteins for SPATA16 Gene

  • Protein details for SPATA16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXB7-SPT16_HUMAN
    Recommended name:
    Spermatogenesis-associated protein 16
    Protein Accession:
    Q9BXB7
    Secondary Accessions:
    • Q0R0N4
    • Q0R0S0
    • Q0R0W2
    • Q0R129
    • Q0R131
    • Q0R140
    • Q0R1B8
    • Q0R1G5
    • Q0R1I2
    • Q0R1J6
    • Q0R1S4
    • Q0R202
    • Q0R280
    • Q0R2F8
    • Q0R2N6
    • Q0R2N7
    • Q0R2R0
    • Q0R2R1
    • Q0R2S3
    • Q0R2S4
    • Q0R2S5
    • Q0R2T4
    • Q0R2T7
    • Q0R2U2
    • Q0R2U8
    • Q0R2U9
    • Q0R2V5
    • Q0R2V7
    • Q8NE67

    Protein attributes for SPATA16 Gene

    Size:
    569 amino acids
    Molecular mass:
    65263 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Association analysis reveals significant frequency of a synonymous (Ser-225) sequence polymorphism among clinical groups with different sperm traits: the donor group, which has the highest sperm count and motility level, has a significant higher polymorphism frequency compared to normal and asthenozoopermia groups.

neXtProt entry for SPATA16 Gene

Proteomics data for SPATA16 Gene at MOPED

Post-translational modifications for SPATA16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPATA16 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SPATA16 Gene

Domains & Families for SPATA16 Gene

Protein Domains for SPATA16 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPATA16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BXB7

UniProtKB/Swiss-Prot:

SPT16_HUMAN :
  • Belongs to the SPATA16 family.
Family:
  • Belongs to the SPATA16 family.
genes like me logo Genes that share domains with SPATA16: view

No data available for Gene Families for SPATA16 Gene

Function for SPATA16 Gene

Molecular function for SPATA16 Gene

UniProtKB/Swiss-Prot Function:
Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis and sperm-egg fusion.
genes like me logo Genes that share phenotypes with SPATA16: view

Human Phenotype Ontology for SPATA16 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPATA16 Gene

Localization for SPATA16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPATA16 Gene

Golgi apparatus. Note=Localized to the perinuclear region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPATA16 Gene COMPARTMENTS Subcellular localization image for SPATA16 gene
Compartment Confidence
golgi apparatus 4
nucleus 3
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for SPATA16 Gene

Pathways & Interactions for SPATA16 Gene

SuperPathways for SPATA16 Gene

No Data Available

Interacting Proteins for SPATA16 Gene

Selected Interacting proteins: Q9BXB7-SPT16_HUMAN for SPATA16 Gene via MINT

Symbol External ID(s) Details
--

Gene Ontology (GO) - Biological Process for SPATA16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with SPATA16: view

No data available for Pathways by source and SIGNOR curated interactions for SPATA16 Gene

Drugs & Compounds for SPATA16 Gene

No Compound Related Data Available

Transcripts for SPATA16 Gene

mRNA/cDNA for SPATA16 Gene

Unigene Clusters for SPATA16 Gene

Spermatogenesis associated 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA16 Gene

No ASD Table

Relevant External Links for SPATA16 Gene

GeneLoc Exon Structure for
SPATA16
ECgene alternative splicing isoforms for
SPATA16

Expression for SPATA16 Gene

mRNA expression in normal human tissues for SPATA16 Gene

mRNA differential expression in normal tissues according to GTEx for SPATA16 Gene

This gene is overexpressed in Testis (x52.6).

Protein differential expression in normal tissues from HIPED for SPATA16 Gene

This gene is overexpressed in Plasma (37.0), Platelet (18.6), and Adipocyte (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPATA16 Gene



SOURCE GeneReport for Unigene cluster for SPATA16 Gene Hs.444236

mRNA Expression by UniProt/SwissProt for SPATA16 Gene

Q9BXB7-SPT16_HUMAN
Tissue specificity: Expressed in testis.
genes like me logo Genes that share expression patterns with SPATA16: view

Protein tissue co-expression partners for SPATA16 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SPATA16 Gene

Orthologs for SPATA16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPATA16 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SPATA16 35
  • 90.58 (n)
  • 87.92 (a)
SPATA16 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPATA16 35
  • 90.42 (n)
  • 88.01 (a)
SPATA16 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spata16 35
  • 81.87 (n)
  • 79.23 (a)
Spata16 16
Spata16 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SPATA16 35
  • 98.77 (n)
  • 96.65 (a)
SPATA16 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPATA16 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPATA16 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPATA16 35
  • 69.24 (n)
  • 60.53 (a)
SPATA16 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPATA16 36
  • 75 (a)
OneToOne
Species with no ortholog for SPATA16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPATA16 Gene

ENSEMBL:
Gene Tree for SPATA16 (if available)
TreeFam:
Gene Tree for SPATA16 (if available)

Paralogs for SPATA16 Gene

Pseudogenes.org Pseudogenes for SPATA16 Gene

genes like me logo Genes that share paralogs with SPATA16: view

No data available for Paralogs for SPATA16 Gene

Variants for SPATA16 Gene

Sequence variations from dbSNP and Humsavar for SPATA16 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_038329 -
VAR_038330 -
VAR_038331 -
VAR_038332 -
VAR_038333 -

Structural Variations from Database of Genomic Variants (DGV) for SPATA16 Gene

Variant ID Type Subtype PubMed ID
nsv7356 OTHER Inversion 18451855
nsv829795 CNV Gain 17160897
esv2556969 CNV Deletion 19546169
nsv877992 CNV Loss 21882294
nsv4119 CNV Loss 18451855
nsv519482 CNV Loss 19592680

Variation tolerance for SPATA16 Gene

Residual Variation Intolerance Score: 68.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.11; 97.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPATA16 Gene

HapMap Linkage Disequilibrium report
SPATA16
Human Gene Mutation Database (HGMD)
SPATA16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATA16 Gene

Disorders for SPATA16 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SPATA16 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
spermatogenic failure 6
  • spermatogenic failure 9
male reproductive system disease
  • genital diseases, male
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

SPT16_HUMAN
  • Spermatogenic failure 6 (SPGF6) [MIM:102530]: An infertility disorder caused by spermatogenesis defects. The most prominent feature is the malformation of the acrosome, which can be totally absent in most severe cases. Additional features are an abnormal nuclear shape and abnormal arrangement of the mitochondria of the spermatozoon. {ECO:0000269 PubMed:17847006}. Note=The disease is caused by mutations affecting the gene represented in this entry. An autosomal recessive variation of SPATA16 has been shown to be responsible for the disease in a consanguineous family with members homozygous for the variation.

Relevant External Links for SPATA16

Genetic Association Database (GAD)
SPATA16
Human Genome Epidemiology (HuGE) Navigator
SPATA16
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPATA16
genes like me logo Genes that share disorders with SPATA16: view

No data available for Genatlas for SPATA16 Gene

Publications for SPATA16 Gene

  1. Identification and characterization of a novel human testis-specific Golgi protein, NYD-SP12. (PMID: 12529416) Xu M. … Sha J. (Mol. Hum. Reprod. 2003) 2 3 4 23 67
  2. Homozygous mutation in SPATA16 is associated with male infertility in human globozoospermia. (PMID: 17847006) Dam A.H. … Viville S. (Am. J. Hum. Genet. 2007) 2 3
  3. First successful pregnancy in a globozoospermic patient having homozygous mutation in SPATA16. (PMID: 24825417) Karaca N. … Kervancioglu M.E. (Fertil. Steril. 2014) 3
  4. A genome-wide association meta-analysis of preschool internalizing problems. (PMID: 24839885) Benke K.S. … Middeldorp C.M. (J Am Acad Child Adolesc Psychiatry 2014) 3
  5. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S. … Sun J. (Carcinogenesis 2012) 3

Products for SPATA16 Gene

Sources for SPATA16 Gene

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