Aliases for SPATA13 Gene
External Ids for SPATA13 Gene
Previous GeneCards Identifiers for SPATA13 Gene
GeneCards Summary for SPATA13 Gene
SPATA13 (Spermatogenesis Associated 13) is a Protein Coding gene. Diseases associated with SPATA13 include adenomatous polyposis coli and dravet syndrome. Among its related pathways are Regulation of RAC1 activity and G-protein signaling_Regulation of CDC42 activity. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and Rac guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF7.
UniProtKB/Swiss-Prot for SPATA13 Gene
Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.