Aliases for SPATA13 Gene
External Ids for SPATA13 Gene
Previous GeneCards Identifiers for SPATA13 Gene
GeneCards Summary for SPATA13 Gene
SPATA13 (Spermatogenesis Associated 13) is a Protein Coding gene. Diseases associated with SPATA13 include Adenomatous Polyposis Coli and Dravet Syndrome. Among its related pathways are Regulation of RAC1 activity and Regulation of CDC42 activity. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and Rac guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF7.
UniProtKB/Swiss-Prot for SPATA13 Gene
Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.