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Aliases for SPATA13 Gene

Aliases for SPATA13 Gene

  • Spermatogenesis Associated 13 2 3
  • ASEF2 3 4 6
  • APC-Stimulated Guanine Nucleotide Exchange Factor 2 3 4
  • Adenomatous Polyposis Coli Stimulated Exchange Factor 2 3
  • Spermatogenesis-Associated Protein 13 3
  • ARHGEF29 3

External Ids for SPATA13 Gene

Previous GeneCards Identifiers for SPATA13 Gene

  • GC13P022532
  • GC13P023632
  • GC13P024734
  • GC13P005546
  • GC13P024554

Summaries for SPATA13 Gene

GeneCards Summary for SPATA13 Gene

SPATA13 (Spermatogenesis Associated 13) is a Protein Coding gene. Diseases associated with SPATA13 include adenomatous polyposis coli. Among its related pathways are G-protein signaling_Regulation of CDC42 activity and Regulation of CDC42 activity. GO annotations related to this gene include phospholipid binding and Rac guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF7.

UniProtKB/Swiss-Prot for SPATA13 Gene

  • Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATA13 Gene

Genomics for SPATA13 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SPATA13 Gene

Start:
23,979,626 bp from pter
End:
24,307,074 bp from pter
Size:
327,449 bases
Orientation:
Plus strand

Genomic View for SPATA13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPATA13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA13 Gene

Proteins for SPATA13 Gene

  • Protein details for SPATA13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96N96-SPT13_HUMAN
    Recommended name:
    Spermatogenesis-associated protein 13
    Protein Accession:
    Q96N96
    Secondary Accessions:
    • A2VEA9
    • A6NF85
    • B4DQB1
    • B4DSZ0
    • B4DVM8
    • J3KPJ7
    • J3KQH2
    • Q5VX68
    • Q6ZML1
    • Q8N873
    • Q8TEK6

    Protein attributes for SPATA13 Gene

    Size:
    652 amino acids
    Molecular mass:
    74820 Da
    Quaternary structure:
    • Interacts (via ABR and SH3 domain) with APC. The binding of APC enhances its GEF activity by relieving it from an autoinhibitory conformation, in which the ABR and SH3 domains are associated with the C-terminal tail. Interacts (via C-terminal tail) with PPP1R9B (via C-terminus). Interacts with RAC1.
    SequenceCaution:
    • Sequence=BAC04977.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SPATA13 Gene

neXtProt entry for SPATA13 Gene

Proteomics data for SPATA13 Gene at MOPED

Post-translational modifications for SPATA13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SPATA13 Gene

Domains for SPATA13 Gene

Gene Families for SPATA13 Gene

HGNC:
  • ARHGEF :Rho guanine nucleotide exchange factors
  • PLEKH :Pleckstrin homology (PH) domain containing

Protein Domains for SPATA13 Gene

Suggested Antigen Peptide Sequences for SPATA13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96N96

UniProtKB/Swiss-Prot:

SPT13_HUMAN :
  • Q96N96
Domain:
  • The C-terminal tail is required for its GEF activity
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 PH domain.
  • Contains 1 SH3 domain.
genes like me logo Genes that share domains with SPATA13: view

Function for SPATA13 Gene

Molecular function for SPATA13 Gene

UniProtKB/Swiss-Prot EnzymeRegulation: Both the ABR and the SH3 domains contribute to maintaining the protein in an inhibited conformation by associating with the C-terminal tail. Binding of these domains to the C-terminal tail inhibits the activity of the protein by blocking a region that is required for its GEF activity.
UniProtKB/Swiss-Prot Function: Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.

Gene Ontology (GO) - Molecular Function for SPATA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IMP 17145773
GO:0005089 Rho guanyl-nucleotide exchange factor activity --
GO:0005515 protein binding IPI 17145773
GO:0030676 Rac guanyl-nucleotide exchange factor activity IMP 17599059
genes like me logo Genes that share ontologies with SPATA13: view

Phenotypes for SPATA13 Gene

GenomeRNAi human phenotypes for SPATA13:
genes like me logo Genes that share phenotypes with SPATA13: view

Animal Model Products

CRISPR Products

miRNA for SPATA13 Gene

miRTarBase miRNAs that target SPATA13

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPATA13

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SPATA13 Gene

Localization for SPATA13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPATA13 Gene

Cytoplasm. Cell projection, filopodium. Cell projection, lamellipodium. Cell projection, ruffle membrane. Note=Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPATA13 Gene COMPARTMENTS Subcellular localization image for SPATA13 gene
Compartment Confidence
plasma membrane 5
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for SPATA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0030027 lamellipodium IDA 17599059
GO:0030175 filopodium IDA 17599059
genes like me logo Genes that share ontologies with SPATA13: view

Pathways for SPATA13 Gene

genes like me logo Genes that share pathways with SPATA13: view

Pathways by source for SPATA13 Gene

2 BioSystems pathways for SPATA13 Gene
1 GeneGo (Thomson Reuters) pathway for SPATA13 Gene

Interacting Proteins for SPATA13 Gene

Gene Ontology (GO) - Biological Process for SPATA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016477 cell migration IMP 17145773
GO:0030032 lamellipodium assembly IMP 17599059
GO:0030334 regulation of cell migration IMP 17599059
GO:0035023 regulation of Rho protein signal transduction --
GO:0043547 positive regulation of GTPase activity IMP 17145773
genes like me logo Genes that share ontologies with SPATA13: view

Transcripts for SPATA13 Gene

Unigene Clusters for SPATA13 Gene

Spermatogenesis associated 13:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPATA13

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SPATA13

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA13 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a ·
SP1: - - - - - - -
SP2: - - - -
SP3: - - - -
SP4: -
SP5:
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11: - - - - - -
SP12:
SP13: - - - -
SP14:
SP15: -
SP16:
SP17:

ExUns: 16b · 16c ^ 17a · 17b ^ 18a · 18b · 18c ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b · 25c · 25d
SP1: - - - - - - - -
SP2: -
SP3:
SP4:
SP5:
SP6: - - -
SP7: -
SP8: - -
SP9: -
SP10:
SP11:
SP12: - - - -
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for SPATA13 Gene

GeneLoc Exon Structure for
SPATA13
ECgene alternative splicing isoforms for
SPATA13

Expression for SPATA13 Gene

mRNA expression in normal human tissues for SPATA13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPATA13 Gene

SOURCE GeneReport for Unigene cluster for SPATA13 Gene Hs.595391

mRNA Expression by UniProt/SwissProt for SPATA13 Gene

Q96N96-SPT13_HUMAN
Tissue specificity: Expressed at high levels in the placenta, spleen and kidney, at moderate levels in lung, small intestine, liver, brain and heart, and at low levels in skeletal muscle. Expression is aberrantly enhanced in most colorectal tumors.
genes like me logo Genes that share expressions with SPATA13: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SPATA13 Gene

Orthologs for SPATA13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPATA13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPATA13 35
  • 99.4 (n)
  • 99.37 (a)
SPATA13 36
  • 100 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 64 (a)
OneToMany
LOC785769 35
  • 74.12 (n)
  • 68.95 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 76 (a)
OneToMany
SPATA13 35
  • 79.18 (n)
  • 75.72 (a)
mouse
(Mus musculus)
Mammalia Spata13 35
  • 76.84 (n)
  • 73.8 (a)
Spata13 16
Spata13 36
  • 73 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Spata13 35
  • 76.24 (n)
  • 73.86 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 65 (a)
OneToMany
SPATA13 35
  • 68.53 (n)
  • 66.69 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 64 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485539 35
  • 63.44 (n)
  • 63.92 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.14043 35
spata13 35
  • 56.89 (n)
  • 54.15 (a)
spata13 36
  • 43 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7470 36
  • 34 (a)
OneToMany
Species with no ortholog for SPATA13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPATA13 Gene

ENSEMBL:
Gene Tree for SPATA13 (if available)
TreeFam:
Gene Tree for SPATA13 (if available)

Paralogs for SPATA13 Gene

Selected SIMAP similar genes for SPATA13 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SPATA13: view

Variants for SPATA13 Gene

Sequence variations from dbSNP and Humsavar for SPATA13 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs6583 -- 24,307,046(-) ATATA(C/T)AAAAC utr-variant-3-prime
rs715921 -- 24,221,351(-) AAAGA(C/T)TACCA intron-variant
rs724932 -- 23,995,972(-) GGTTG(A/T)CTCTC intron-variant
rs727113 -- 24,112,702(-) GTAGA(C/T)GAAGA intron-variant
rs728096 -- 24,220,291(+) TAAAA(C/G)GTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPATA13 Gene

Variant ID Type Subtype PubMed ID
esv2422502 CNV Duplication 17116639
esv2747122 CNV Deletion 23290073
esv5325 CNV Complex 18987735
nsv455837 CNV Gain 19166990
nsv525965 CNV Gain 19592680
dgv1561n71 CNV Gain 21882294
esv2751136 CNV Loss 17911159
nsv899932 CNV Gain 21882294
esv2422202 CNV Duplication 17116639
nsv509499 CNV Insertion 20534489
esv2751137 CNV Gain 17911159
nsv899936 CNV Gain 21882294
nsv899937 CNV Gain 21882294
esv28977 CNV Gain 19812545
esv1144168 CNV Insertion 17803354
esv1137865 CNV Insertion 17803354
nsv899938 CNV Gain 21882294
esv2665633 CNV Deletion 23128226
nsv899939 CNV Loss 21882294
nsv455842 CNV Gain 19166990
nsv899940 CNV Loss 21882294
nsv832567 CNV Loss 17160897

Relevant External Links for SPATA13 Gene

HapMap Linkage Disequilibrium report
SPATA13
Human Gene Mutation Database (HGMD)
SPATA13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATA13 Gene

Disorders for SPATA13 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SPATA13 Gene including...

Search for SPATA13 Gene in MalaCards »

Relevant External Links for SPATA13

Genetic Association Database (GAD)
SPATA13
Human Genome Epidemiology (HuGE) Navigator
SPATA13
genes like me logo Genes that share disorders with SPATA13: view

No data available for UniProtKB/Swiss-Prot for SPATA13 Gene

Publications for SPATA13 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element. (PMID: 17145773) Hamann M.J. … Billadeau D.D. (Mol. Cell. Biol. 2007) 3 4
  5. Identification and characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42. (PMID: 17599059) Kawasaki Y. … Akiyama T. (Oncogene 2007) 3 4

Products for SPATA13 Gene

  • antibodies-online proteins for SPATA13
  • antibodies-online antibodies for SPATA13
  • antibodies-online kits for SPATA13

Sources for SPATA13 Gene

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