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Aliases for SPATA12 Gene

Aliases for SPATA12 Gene

  • Spermatogenesis Associated 12 2 3 5
  • Spermatogenesis-Related Protein 5 3 4
  • SRG5 3 4
  • Spermatogenesis-Associated Protein 12 3
  • Testicular Tissue Protein Li 184 3

External Ids for SPATA12 Gene

Previous GeneCards Identifiers for SPATA12 Gene

  • GC03P057051

Summaries for SPATA12 Gene

Entrez Gene Summary for SPATA12 Gene

  • This gene is expressed primarily in testis and may play a role in testicular development and spermatogenesis. The encoded protein may be upregulated in response to ultraviolet-C radiation. [provided by RefSeq, Dec 2015]

GeneCards Summary for SPATA12 Gene

SPATA12 (Spermatogenesis Associated 12) is a Protein Coding gene.

Additional gene information for SPATA12 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATA12 Gene

Genomics for SPATA12 Gene

Regulatory Elements for SPATA12 Gene

Enhancers for SPATA12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H057016 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.6 -43.2 -43155 1 PKNOX1 NFRKB ZSCAN4 TCF12 FOS RCOR1 ETV6 RUNX3 CREM ZBTB2 FLNB APPL1 PDE12 SPATA12 ARHGEF3 CCDC66 ARHGEF3-AS1
GH03H057003 1.4 Ensembl ENCODE dbSUPER 12.2 -53.6 -53575 6 TBP SIN3A RAD21 HSF1 FOS RCOR1 SMARCB1 ZNF217 MAFF SMARCA4 ARHGEF3 SPATA12 ARHGEF3-AS1
GH03H056980 1.2 Ensembl ENCODE dbSUPER 10.8 -79.1 -79113 1 MXI1 JUN MAX CEBPG RAD21 FOSL1 POLR2A FOS MAFK CEBPB SPATA12 ARHGEF3 DENND6A ARHGEF3-AS1
GH03H057100 0.9 ENCODE 11.7 +39.8 39847 0 ELF3 RB1 ZSCAN4 ARID4B ZSCAN9 RAD21 RFX5 SIRT6 ZNF143 MIXL1 ARHGEF3 SPATA12 IL17RD HESX1 APPL1 PIR43010 RPL19P2
GH03H056995 0.7 ENCODE 12.3 -64.8 -64824 0 CTCF ZNF384 RAD21 RFX5 YY1 ZNF366 SMC3 ZNF143 GATAD2A ZNF654 APPL1 SPATA12 PDE12 ARHGEF3 CCDC66 ARHGEF3-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPATA12 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPATA12 Gene

Chromosome:
3
Start:
57,060,441 bp from pter
End:
57,076,068 bp from pter
Size:
15,628 bases
Orientation:
Plus strand

Genomic View for SPATA12 Gene

Genes around SPATA12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATA12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATA12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA12 Gene

Proteins for SPATA12 Gene

  • Protein details for SPATA12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6I5-SPT12_HUMAN
    Recommended name:
    Spermatogenesis-associated protein 12
    Protein Accession:
    Q7Z6I5
    Secondary Accessions:
    • A0AVA8
    • B2RMW1

    Protein attributes for SPATA12 Gene

    Size:
    190 amino acids
    Molecular mass:
    20418 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPATA12 Gene

Post-translational modifications for SPATA12 Gene

No Post-translational modifications

Other Protein References for SPATA12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPATA12 Gene

Domains & Families for SPATA12 Gene

Gene Families for SPATA12 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPATA12 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for SPATA12 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPATA12: view

No data available for UniProtKB/Swiss-Prot for SPATA12 Gene

Function for SPATA12 Gene

Phenotypes for SPATA12 Gene

genes like me logo Genes that share phenotypes with SPATA12: view

Animal Model Products

CRISPR Products

miRNA for SPATA12 Gene

miRTarBase miRNAs that target SPATA12

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SPATA12
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPATA12 Gene

Localization for SPATA12 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPATA12 gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 2
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPATA12 Gene

Pathways & Interactions for SPATA12 Gene

SuperPathways for SPATA12 Gene

No Data Available

Interacting Proteins for SPATA12 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000335392%0d%0a9606.ENSP00000216487%0d%0a9606.ENSP00000319756%0d%0a
Selected Interacting proteins: Q7Z6I5-SPT12_HUMAN ENSP00000335392 for SPATA12 Gene via IID STRING UniProtKB

Gene Ontology (GO) - Biological Process for SPATA12 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPATA12 Gene

Drugs & Compounds for SPATA12 Gene

No Compound Related Data Available

Transcripts for SPATA12 Gene

mRNA/cDNA for SPATA12 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPATA12 Gene

Spermatogenesis associated 12:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SPATA12
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA12 Gene

No ASD Table

Relevant External Links for SPATA12 Gene

GeneLoc Exon Structure for
SPATA12
ECgene alternative splicing isoforms for
SPATA12

Expression for SPATA12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPATA12 Gene

mRNA differential expression in normal tissues according to GTEx for SPATA12 Gene

This gene is overexpressed in Testis (x46.2).

NURSA nuclear receptor signaling pathways regulating expression of SPATA12 Gene:

SPATA12

SOURCE GeneReport for Unigene cluster for SPATA12 Gene:

Hs.129794

mRNA Expression by UniProt/SwissProt for SPATA12 Gene:

Q7Z6I5-SPT12_HUMAN
Tissue specificity: Expressed in testis.
genes like me logo Genes that share expression patterns with SPATA12: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPATA12 Gene

Orthologs for SPATA12 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SPATA12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPATA12 33 34
  • 98.6 (n)
Species where no ortholog for SPATA12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPATA12 Gene

ENSEMBL:
Gene Tree for SPATA12 (if available)
TreeFam:
Gene Tree for SPATA12 (if available)

Paralogs for SPATA12 Gene

No data available for Paralogs for SPATA12 Gene

Variants for SPATA12 Gene

Sequence variations from dbSNP and Humsavar for SPATA12 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000228611 -- 57,058,528(+) GAAAA(C/T)TTTTA intron-variant, upstream-variant-2KB
rs1000850072 -- 57,074,522(+) CTTAG(A/C)CCCCG intron-variant, utr-variant-3-prime
rs1000887899 -- 57,069,097(+) TTTGT(A/G)TTTTT intron-variant
rs1000945770 -- 57,062,837(+) CAAAC(-/T)TTTCT intron-variant
rs1001106387 -- 57,076,115(+) GGGTT(A/G)CTTTA intron-variant, downstream-variant-500B

Variation tolerance for SPATA12 Gene

Residual Variation Intolerance Score: 67.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPATA12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPATA12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SPATA12 Gene

Disorders for SPATA12 Gene

Relevant External Links for SPATA12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPATA12

No disorders were found for SPATA12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPATA12 Gene

Publications for SPATA12 Gene

  1. Identification and expression of a novel human testis-specific gene by digital differential display. (PMID: 15603706) Li D … Lu GX (Chinese medical journal 2004) 3 4 22 60
  2. Transcriptional regulation of human novel gene SPATA12 promoter by AP-1 and HSF. (PMID: 22981541) Li D … Liu X (Gene 2012) 2 3 60
  3. Expression and possible functions of a novel gene SPATA12 in human testis. (PMID: 17251597) Dan L … Guangxiu L (Journal of andrology 2007) 2 3 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. [Molecular cloning and expression analysis of a novel human testis-specific gene]. (PMID: 15490870) Li D … Liu G (Yi chuan xue bao = Acta genetica Sinica 2004) 3 4 60

Products for SPATA12 Gene

Sources for SPATA12 Gene

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