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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPARCL1 Gene

protein-coding   GIFtS: 57
GCID: GC04M088394

SPARC-Like 1 (Hevin)

(Previous names: SPARC-like 1 (mast9, hevin))
  25 related diseases
at
MalaCards
 

Aliases
for SPARCL1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
SPARC-Like 1 (Hevin)1 2     hevin2
SPARC-Like 1 (Mast9, Hevin)1 2     mast92
High Endothelial Venule Protein2 3     Proliferation-Inducing Protein 332
MAST 92 3     SPARC-Like Protein 12
PIG332     Hevin3
SC12     

External Ids:    HGNC: 112201   Entrez Gene: 84042   Ensembl: ENSG000001525837   OMIM: 6060415   UniProtKB: Q145153   

Export aliases for SPARCL1 gene to outside databases

Previous GC identifers: GC04M088552 GC04M088696 GC04M088852 GC04M088751 GC04M088613 GC04M084140


Summaries
for SPARCL1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
GeneCards Summary for SPARCL1 Gene: 
SPARCL1 (SPARC-like 1 (hevin)) is a protein-coding gene. Diseases associated with SPARCL1 include pediatric osteosarcoma, and hepatitis e. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is SPARC.

Gene Wiki entry for SPARCL1 Gene


Genomic Views
for SPARCL1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPARCL1 gene promoter:
         HFH-3   NF-1   HTF   E47   C/EBPalpha   GATA-1   FOXI1   FOXO4   HSF2   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SPARCL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SPARCL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPARCL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q22.1   Ensembl cytogenetic band:  4q22.1   HGNC cytogenetic band: 4q22-q25

SPARCL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPARCL1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M088394:  view genomic region     (about GC identifiers)

Start:
 88,394,487 bp from pter      End:
 88,452,213 bp from pter
Size:
 57,727 bases      Orientation:
 minus strand

Proteins
for SPARCL1 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: SPRL1_HUMAN, Q14515 (See protein sequence)
Recommended Name: SPARC-like protein 1 precursor  
Size: 664 amino acids; 75208 Da
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Secondary accessions: Q14800

Explore the universe of human proteins at neXtProt for SPARCL1: NX_Q14515

Explore proteomics data for SPARCL1 at MOPED 

Post-translational modifications:

  • UniProtKB: N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14515

    • SPARCL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SPARCL1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001121782.1  NP_004675.3  

    ENSEMBL proteins: 
     ENSP00000282470   ENSP00000422903   ENSP00000445678   ENSP00000423483   ENSP00000416971  
     ENSP00000438188   ENSP00000423448   ENSP00000444832   ENSP00000406251   ENSP00000414856  

    Human Recombinant Protein Products for SPARCL1: 
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    R&D Systems Recombinant & Natural Proteins for SPARCL1 (SPARC-like 1/SPARCL1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SPARCL1
    OriGene Protein Over-expression Lysate for SPARCL1
    OriGene MassSpec for SPARCL1 
    OriGene Custom Protein Services for SPARCL1
    GenScript Custom Purified and Recombinant Proteins Services for SPARCL1
    Novus Biologicals SPARCL1 Protein
    Novus Biologicals SPARCL1 Lysates
    Sino Biological Recombinant Protein for SPARCL1
    Sino Biological Cell Lysate for SPARCL1 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SPARCL1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IEA--

    SPARCL1 for ontologies           About GeneDecksing



    SPARCL1 Antibody Products: 
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    Abcam antibodies for SPARCL1
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    ThermoFisher Antibodies for SPARCL1
    LSBio Antibodies in human, mouse, rat for SPARCL1 

    Assay Products for SPARCL1: 
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    Cloud-Clone Corp. ELISAs for SPARCL1 
    Cloud-Clone Corp. CLIAs for SPARCL1

    Protein Domains /
    Families
    for SPARCL1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    EFHAND: EF-hand domain containing

    5/9 InterPro protein domains (see all 9):
     IPR016359 SPARC-like_p1
     IPR018247 EF_Hand_1_Ca_BS
     IPR002350 Kazal_dom
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom

    Graphical View of Domain Structure for InterPro Entry Q14515

    ProtoNet protein and cluster: Q14515

    2 Blocks protein domains:
    IPB001999 Osteonectin-like
    IPB003645 Follistatin-like


    UniProtKB/Swiss-Prot: SPRL1_HUMAN, Q14515
    Similarity: Belongs to the SPARC family
    Similarity: Contains 1 EF-hand domain
    Similarity: Contains 1 follistatin-like domain
    Similarity: Contains 1 Kazal-like domain


    SPARCL1 for domains           About GeneDecksing


    Function
    for SPARCL1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    SPARCL1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SPARCL1:
     Decreased viability with pacli 

         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Sparcl1):
     nervous system  reproductive system  vision/eye 

    SPARCL1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Sparcl1tm1Pmc for SPARCL1
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SPARCL1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SPARCL1

    miRNA
    Products:        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPARCL1
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate SPARCL1:
    hsa-miR-1290 hsa-miR-511 hsa-miR-448 hsa-miR-4289 hsa-miR-573 hsa-miR-3616-5p hsa-miR-3647-5p
    SwitchGear 3'UTR luciferase reporter plasmid: SPARCL1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SPARCL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPARCL1
    Sirion Biotech Custom design and validation of potent shRNA sequences against SPARCL1

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of SPARCL1
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    Clone
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    OriGene clones in human, mouse for SPARCL1 (see all 13)
    OriGene ORF clones in mouse, rat for SPARCL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SPARCL1 (NM_004684)
    Sino Biological Human cDNA Clone for SPARCL1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPARCL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPARCL1

    Cell Line
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    Search LifeMap BioReagents cell lines for SPARCL1
    Sirion Biotech Customized stable knockdown cell line services for SPARCL1
                         Customized inducible knockdown cell line services for SPARCL1
                         Customized stable overexpressing cell line services for SPARCL1
                         Customized inducible overexpressing cell line services for SPARCL1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPARCL1


    Pathways & Interactions
    for SPARCL1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SPARCL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/18 Interacting proteins for SPARCL1 (Q145153 ENSP000002824704) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000204490P013753I2D: score=1 
    ENSG00000206439P013753I2D: score=1 
    ENSG00000223952P013753I2D: score=1 
    ENSG00000228321P013753I2D: score=1 
    ENSG00000228849P013753I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction IEA--

    SPARCL1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SPARCL1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SPARCL1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPARCL1 (SPRL1)

    1 Novoseek inferred chemical compound relationship for SPARCL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 19.5 3 9199668 (1), 15094114 (1)

    Search CenterWatch for drugs/clinical trials and news about SPARCL1 / SPRL1

    Transcripts
    for SPARCL1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SPARCL1 gene (2 alternative transcripts): 
    NM_001128310.1  NM_004684.4  

    Unigene Cluster for SPARCL1:

    SPARC-like 1 (hevin)
    Hs.62886  [show with all ESTs]
    Unigene Representative Sequence: NM_001128310
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000282470(uc011cdc.2 uc003hqs.4 uc011cdd.2) ENST00000503414
    ENST00000541496 ENST00000509407 ENST00000434434 ENST00000535835 ENST00000512317
    ENST00000543631 ENST00000458304 ENST00000418378(uc010ikm.3)
    miRNA
    Products:         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPARCL1
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate SPARCL1:
    hsa-miR-1290 hsa-miR-511 hsa-miR-448 hsa-miR-4289 hsa-miR-573 hsa-miR-3616-5p hsa-miR-3647-5p
    SwitchGear 3'UTR luciferase reporter plasmid: SPARCL1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SPARCL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPARCL1
    Sirion Biotech Custom design and validation of potent shRNA sequences against SPARCL1
    Clone
    Products:             		 OriGene clones in human, mouse for SPARCL1 (see all 13)
    OriGene ORF clones in mouse, rat for SPARCL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SPARCL1 (NM_004684)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPARCL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPARCL1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SPARCL1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPARCL1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPARCL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPARCL1

    Additional mRNA sequence: 

    AK294335.1 AK298039.1 AK300956.1 AK304494.1 AK304628.1 AK316533.1 AL833430.1 AY513278.1 
    BC010383.1 BC022484.1 BC033721.1 BX647713.1 X82157.1 X86693.1 

    24/46 DOTS entries (see all 46):

    DT.97768756  DT.100889450  DT.91847955  DT.121234854  DT.75148986  DT.100889383  DT.99945076  DT.100889456 
    DT.121234915  DT.97800117  DT.91796716  DT.100889445  DT.95267021  DT.101961716  DT.87017581  DT.95267023 
    DT.95267025  DT.100805019  DT.100889448  DT.100889453  DT.121234849  DT.121234994  DT.121234863  DT.121234873 

    24/963 AceView cDNA sequences (see all 963):

    CB961067 BP379977 AA679075 CD678843 CD679324 BM955265 CR624121 AA903228 
    AA297782 BU726210 BQ940265 BP349186 CB113603 CD102663 BM128282 BU687407 
    BQ004463 CF528281 T32642 AA600892 R52718 BM955282 AV751574 BF934465 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SPARCL1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                                                                                                              
    SP2:                          -                                                                                                   
    SP3:                          -     -     -     -                                                                                 
    SP4:                                -                                                                                             
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for SPARCL1

    Expression
    for SPARCL1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPARCL1 expression in normal human tissues (normalized intensities)      SPARCL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCACTTCAA
    SPARCL1 Expression
    About this image


    SPARCL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Brain (Nervous System)    fully expand to see all 21 entries
             Adult Endothelial Cells Blood Brain Barrier
             Thalamus
             Dorsal telencephalic astroglia-like cells (Directed differentiation of functional...
             Septum
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             HyStem+TGFbeta3+GDF5-induced 7PEND24 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             HyStem+TGFbeta3+GDF5-induced 7PEND24 cells
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
             S-shaped Body
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
             "PureStem ES-335, Meso-latp Progenitor"

    See SPARCL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPARCL1

    SOURCE GeneReport for Unigene cluster: Hs.62886

    UniProtKB/Swiss-Prot: SPRL1_HUMAN, Q14515
    Tissue specificity: Highly expressed in lymph node, brain, heart, lung, skeletal muscle, ovary, small intestine, and
    colon, with lower levels in placenta, pancreas, testis, spleen, and thymus, and no expression in kidney, liver, and
    peripheral blood leukocytes

        SABiosciences Custom PCR Arrays for SPARCL1
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPARCL1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPARCL1

    Orthologs
    for SPARCL1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SPARCL1 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Sparcl11 , 5 SPARC-like 11, 5 75.18(n)1
    67.87(a)1    		   5 (50.55 cM)5
    136021  NM_010097.41  NP_034227.31 
     1040791115 
    chicken
    (Gallus gallus)    		 Aves SPARCL11 SPARC-like 1 (hevin) 54.51(n)
    43.52(a)    		   422586  XM_420545.3  XP_420545.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii sparcl11 SPARC-like 1 52.81(n)
    43.33(a)    		   567331  NM_001130605.1  NP_001124077.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta BM-40-SPARC6
    		 BM-40-SPARC
    		 29(a)
    		 1 → many
    		 3R(22694960-22697738)
    worm
    (Caenorhabditis elegans)    		 Secernentea ost-16
    		 SPARC
    		 33(a)
    		 1 → many
    		 IV(1107396-1110860)


    ENSEMBL Gene Tree for SPARCL1 (if available)
    TreeFam Gene Tree for SPARCL1 (if available)

    Paralogs
    for SPARCL1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPARCL1 gene
    SPARC2  
    1 SIMAP similar gene for SPARCL1 using alignment to 10 protein entries:     SPRL1_HUMAN (see all proteins):
    SPARC

    SPARCL1 for paralogs           About GeneDecksing



    Genomic Variants
    for SPARCL1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1227 SNPs in SPARCL1 are shown (see all 1227)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 4 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs99950831,2
    		C,F,A--88393987(+) GACCTG/ACTGGG 2 -- int111Minor allele frequency- A:0.47NA WA CSA EA 372
    rs1859358831,2
    		--88394036(+) GGATCA/TCAGGT 2 -- int10--------
    rs757777001,2
    		F--88394288(+) AATGAG/ACACCT 2 -- int11Minor allele frequency- A:0.07WA 118
    rs738396561,2
    		C,F--88394348(+) TTTTCT/ACAACC 2 -- int11Minor allele frequency- A:0.50WA 2
    rs1123540471,2
    		C--88394352(+) TCAACCA/-CACAC 2 -- int11Minor allele frequency- -:0.00CSA 2
    rs1999515421,2
    		C--88394353(+) CACAC-/AC/CA 
                TTAAG     		2 -- int10--------
    rs1163792061,2
    		F--88394501(+) TTATGG/AACTCT 2 -- ut311Minor allele frequency- A:0.01WA 118
    rs348834601,2
    		C--88394759(+) TTAAT-/GTTAA 
     ATACCTG    GTGCA     		2 -- cds11Minor allele frequency- GTTAAATACCTG:0.50CSA 2
    rs2012766471,2
    		C--88394761(+) AATGTG/TAAATA 2 -- ut310--------
    rs2010768871,2
    		C--88394762(-) GTATTG/TAACAT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SPARCL1 (88394487 - 88452213 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SPARCL1: --
    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for SPARCL1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SPARCL1 for disorders           About GeneDecksing

    OMIM gene information: 606041    OMIM disorders: --

    20/25 diseases for SPARCL1 (see all 25):    About MalaCards
    pediatric osteosarcoma    hepatitis e    acute liver failure    intracranial aneurysm
    endotheliitis    tonsillitis    prostate adenocarcinoma    osteosarcoma
    fanconi's anemia    anemia    pancreatitis    multiple sclerosis
    schizophrenia    renal cell carcinoma    hepatitis    hypertension
    pancreatic cancer    hepatitis b    gastric cancer    adenocarcinoma

    7 Novoseek inferred disease relationships for SPARCL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreatic tumor 41.7 1 17325739 (1)
    lung tumor 34.7 1 9485012 (1)
    nsclc 30.6 8 11179481 (2), 15375558 (2), 9485012 (1)
    tumors 4.74 13 11179481 (3), 15375558 (2), 17325739 (2), 15211566 (1) (see all 7)
    inflammation 0 1 17325739 (1)
    metastasis 0 1 15211566 (1)
    cancer 0 6 10735494 (3), 11179481 (1), 15094114 (1)

    Genetic Association Database (GAD): SPARCL1
    Human Genome Epidemiology (HuGE) Navigator: SPARCL1 (6 documents)

    Export disorders for SPARCL1 gene to outside databases

    Publications
    for SPARCL1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPARCL1 gene, integrated from 9 sources (see all 55):
    (articles sorted by number of sources associating them with SPARCL1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning from purified high endothelial venule cells of hevin, a close relative of the antiadhesive extracellular matrix protein SPARC. (PubMed id 7600298)1, 2, 3, 9 Girard J.-P. and Springer T.A. (1995)
    2. Sequential use of transcriptional profiling, expressi on quantitative trait mapping, and gene association implicates MMP20 in human k idney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (2009)
    3. Association analysis of schizophrenia on 18 genes involved in neuronal migration: MDGA1 as a new susceptibility gene. (PubMed id 18384059)1, 4 Kahler A.K....Andreassen O.A. (2008)
    4. Candidate gene analysis of SPARCL1 gene in patients with multiple sclerosis. (PubMed id 17825989)1, 4 Scalabrini D....Galimberti D. (2007)
    5. Matricellular hevin regulates decorin production and collagen assembly. (PubMed id 16844696)1, 3 Sullivan M.M....Sage E.H. (2006)
    6. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    7. cDNA subtraction library construction using a magnet-assisted subtraction technique (MAST). (PubMed id 8488563)1, 3 Schraml P....Ludwig C.U. (1993)
    8. Hevin is down-regulated in many cancers and is a negative regulator of cell growth and proliferation. (PubMed id 10735494)1, 9 Claeskens A....Kutoh E. (2000)
    9. Modulation of endothelial cell adhesion by hevin, an acidic protein associated with high endothelial venules. (PubMed id 8626806)1, 9 Girard J.P. and Springer T.A. (1996)
    10. SC1/hevin. An extracellular calcium-modulated protein that binds collagen I. (PubMed id 12538579)1, 9 Hambrock H.O....Hartmann U. (2003)

    External Searches for SPARCL1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SPARCL1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8404 HGNC: 11220 AceView: SPARCL1 Ensembl:ENSG00000152583 euGenes: HUgn8404
    ECgene: SPARCL1 H-InvDB: SPARCL1

    Other Databases showing SPARCL1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SPARCL1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPARCL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SPARCL1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SPARCL1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SPARCL1 gene:
    Search GeneIP for patents involving SPARCL1

    GeneCards and IP:
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    About This Section

     
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