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SPARCL1 Gene

protein-coding   GIFtS: 58
GCID: GC04M088394

SPARC-Like 1 (Hevin)

(Previous names: SPARC-like 1 (mast9, hevin))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SPARC-Like 1 (Hevin)1 2     hevin2
SPARC-Like 1 (Mast9, Hevin)1 2     mast92
High Endothelial Venule Protein2 3     Proliferation-Inducing Protein 332
MAST 92 3     SPARC-Like Protein 12
PIG332     Hevin3
SC12     

External Ids:    HGNC: 112201   Entrez Gene: 84042   Ensembl: ENSG000001525837   OMIM: 6060415   UniProtKB: Q145153   

Export aliases for SPARCL1 gene to outside databases

Previous GC identifers: GC04M088552 GC04M088696 GC04M088852 GC04M088751 GC04M088613 GC04M084140


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SPARCL1 Gene:
SPARCL1 (SPARC-like 1 (hevin)) is a protein-coding gene. Diseases associated with SPARCL1 include pediatric osteosarcoma, and hepatitis e. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is SPARC.

Gene Wiki entry for SPARCL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPARCL1 gene promoter:
         HFH-3   NF-1   HTF   E47   C/EBPalpha   GATA-1   FOXI1   FOXO4   HSF2   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPARCL1 promoter sequence
   Search Chromatin IP Primers for SPARCL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPARCL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q22.1   Ensembl cytogenetic band:  4q22.1   HGNC cytogenetic band: 4q22-q25

SPARCL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPARCL1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M088394:  view genomic region     (about GC identifiers)

Start:
88,394,487 bp from pter      End:
88,452,213 bp from pter
Size:
57,727 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SPRL1_HUMAN, Q14515 (See protein sequence)
Recommended Name: SPARC-like protein 1 precursor  
Size: 664 amino acids; 75208 Da
Secondary accessions: Q14800

Explore the universe of human proteins at neXtProt for SPARCL1: NX_Q14515

Explore proteomics data for SPARCL1 at MOPED

Post-translational modifications: 

  • N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan1
  • Glycosylation2 at Thr31, Thr40, Ser44, Thr116, Asn169, Asn176, Asn196, Asn280, Thr331, Thr398,
                                 Asn412, Asn476
  • Modification sites at PhosphoSitePlus

  • See SPARCL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001121782.1  NP_004675.3  

    ENSEMBL proteins: 
     ENSP00000282470   ENSP00000422903   ENSP00000445678   ENSP00000423483   ENSP00000416971  
     ENSP00000438188   ENSP00000423448   ENSP00000444832   ENSP00000406251   ENSP00000414856  

    SPARCL1 Human Recombinant Protein Products:

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    Novus Biologicals SPARCL1 Protein
    Novus Biologicals SPARCL1 Lysates
    Sino Biological Recombinant Protein for SPARCL1
    Sino Biological Cell Lysate for SPARCL1
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    Cloud-Clone Corp. Proteins for SPARCL1

    SPARCL1 Antibody Products:

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    SPARCL1 Assay Products:

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    Cloud-Clone Corp. CLIAs for SPARCL1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    Selected InterPro protein domains (see all 9):
     IPR016359 SPARC-like_p1
     IPR018247 EF_Hand_1_Ca_BS
     IPR002350 Kazal_dom
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom

    Graphical View of Domain Structure for InterPro Entry Q14515

    ProtoNet protein and cluster: Q14515

    2 Blocks protein domains:
    IPB001999 Osteonectin-like
    IPB003645 Follistatin-like


    UniProtKB/Swiss-Prot: SPRL1_HUMAN, Q14515
    Similarity: Belongs to the SPARC family
    Similarity: Contains 1 EF-hand domain
    Similarity: Contains 1 follistatin-like domain
    Similarity: Contains 1 Kazal-like domain


    SPARCL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    SPARCL1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SPARCL1:
     Decreased viability with pacli 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sparcl1):
     nervous system  reproductive system  vision/eye 

    SPARCL1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sparcl1tm1Pmc for SPARCL1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPARCL1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPARCL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPARCL1

    miRNA
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    miRTarBase miRNAs that target SPARCL1:
    hsa-mir-98-5p (MIRT027605)

    Block miRNA regulation of human, mouse, rat SPARCL1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate SPARCL1:
    hsa-miR-1290 hsa-miR-511 hsa-miR-448 hsa-miR-4289 hsa-miR-573 hsa-miR-3616-5p hsa-miR-3647-5p
    SwitchGear 3'UTR luciferase reporter plasmidSPARCL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SPARCL1
    Predesigned siRNA for gene silencing in human, mouse, rat SPARCL1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): SPARCL1 (NM_004684)
    Sino Biological Human cDNA Clone for SPARCL1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPARCL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPARCL1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for SPARCL1
    Browse ESI BIO Cell Lines and PureStem Progenitors for SPARCL1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPARCL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPRL1_HUMAN, Q14515: Secreted, extracellular space, extracellular matrix (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IEA--

    SPARCL1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPARCL1
    Interactions:

        GeneGlobe Interaction Network for SPARCL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for SPARCL1 (Q145153 ENSP000002824704) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000204490P013753I2D: score=1 
    ENSG00000206439P013753I2D: score=1 
    ENSG00000223952P013753I2D: score=1 
    ENSG00000228321P013753I2D: score=1 
    ENSG00000228849P013753I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction IEA--

    SPARCL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPARCL1 (SPRL1)

    1 Novoseek inferred chemical compound relationship for SPARCL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 19.5 3 9199668 (1), 15094114 (1)



    SPARCL1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SPARCL1 gene (2 alternative transcripts): 
    NM_001128310.1  NM_004684.4  

    Unigene Cluster for SPARCL1:

    SPARC-like 1 (hevin)
    Hs.62886  [show with all ESTs]
    Unigene Representative Sequence: NM_001128310
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000282470(uc011cdc.2 uc003hqs.4 uc011cdd.2) ENST00000503414
    ENST00000541496 ENST00000509407 ENST00000434434 ENST00000535835 ENST00000512317
    ENST00000543631 ENST00000458304 ENST00000418378(uc010ikm.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat SPARCL1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate SPARCL1:
    hsa-miR-1290 hsa-miR-511 hsa-miR-448 hsa-miR-4289 hsa-miR-573 hsa-miR-3616-5p hsa-miR-3647-5p
    SwitchGear 3'UTR luciferase reporter plasmidSPARCL1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SPARCL1
    Predesigned siRNA for gene silencing in human, mouse, rat SPARCL1
    Clone
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    OriGene clones in human, mouse for SPARCL1 (see all 12)
    OriGene ORF clones in mouse, rat for SPARCL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SPARCL1 (NM_004684)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPARCL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPARCL1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SPARCL1
    OriGene qSTAR qPCR primer pairs in human, mouse for SPARCL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPARCL1
      QuantiTect SYBR Green Assays in human, mouse, rat SPARCL1
      QuantiFast Probe-based Assays in human, mouse, rat SPARCL1

    Additional mRNA sequence: 

    AK294335.1 AK298039.1 AK300956.1 AK304494.1 AK304628.1 AK316533.1 AL833430.1 AY513278.1 
    BC010383.1 BC022484.1 BC033721.1 BX647713.1 X82157.1 X86693.1 

    Selected DOTS entries (see all 46):

    DT.97768756  DT.100889450  DT.91847955  DT.121234854  DT.75148986  DT.100889383  DT.99945076  DT.100889456 
    DT.121234915  DT.97800117  DT.91796716  DT.100889445  DT.95267021  DT.101961716  DT.87017581  DT.95267023 
    DT.95267025  DT.100805019  DT.100889448  DT.100889453  DT.121234849  DT.121234994  DT.121234863  DT.121234873 

    Selected AceView cDNA sequences (see all 963):

    CB961067 CD677118 AI805956 BM955302 CF528281 BP349186 AI139460 AW845153 
    BP348896 BP348813 AJ709259 BM128282 BU687407 CB266202 BM971058 T35755 
    BP348982 CD678843 AI597796 AI692759 CD676582 BF934465 BM955265 CD172090 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SPARCL1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                                                                                                              
    SP2:                          -                                                                                                   
    SP3:                          -     -     -     -                                                                                 
    SP4:                                -                                                                                             
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for SPARCL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SPARCL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCACTTCAA
    SPARCL1 Expression
    About this image


    SPARCL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 28) fully expand
     
     Brain (Nervous System)    fully expand to see all 14 entries
             Adult Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
             Anterior astroglia-like cells
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             TGFbeta3+BMP7-induced chondrocytes
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             TGFbeta3+BMP7-induced chondrocytes
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             Pro-myelinating Schwann Cells Peripheral Nerve Domain
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Horizontal Cells Inner Nuclear Layer
    SPARCL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPARCL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.62886

    UniProtKB/Swiss-Prot: SPRL1_HUMAN, Q14515
    Tissue specificity: Highly expressed in lymph node, brain, heart, lung, skeletal muscle, ovary, small intestine,
    and colon, with lower levels in placenta, pancreas, testis, spleen, and thymus, and no expression in kidney,
    liver, and peripheral blood leukocytes

        Custom PCR Arrays for SPARCL1
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    QuantiTect SYBR Green Assays in human, mouse, rat SPARCL1
    QuantiFast Probe-based Assays in human, mouse, rat SPARCL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPARCL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SPARCL1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sparcl11 , 5 SPARC-like 11, 5 74.35(n)1
    66.77(a)1
      5 (50.55 cM)5
    136021  NM_010097.41  NP_034227.31 
     1040791115 
    chicken
    (Gallus gallus)
    Aves SPARCL16
    SPARC-like 1 (hevin)
    32(a)
    1 ↔ 1
    4(45106288-45113208)
    zebrafish
    (Danio rerio)
    Actinopterygii sparcl16
    SPARC-like 1
    33(a)
    1 ↔ 1
    1(37241624-37268289) ENSDARG00000074989
    fruit fly
    (Drosophila melanogaster)
    Insecta BM-40-SPARC1 BM-40-SPARC 47.78(n)
    38.42(a)
      43230  NM_001276069.1  NP_001262998.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ost-11 ost-1 53.88(n)
    40.78(a)
      176931  NM_067638.6  NP_500039.1 


    ENSEMBL Gene Tree for SPARCL1 (if available)
    TreeFam Gene Tree for SPARCL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SPARCL1 gene
    SPARC2  
    1 SIMAP similar gene for SPARCL1 using alignment to 10 protein entries:     SPRL1_HUMAN (see all proteins):
    SPARC

    SPARCL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SPARCL1 (see all 1227)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs99950831,2
    C,F,A--88393987(+) GACCTG/ACTGGG 2 -- int111Minor allele frequency- A:0.47NA WA CSA EA 372
    rs1859358831,2
    --88394036(+) GGATCA/TCAGGT 2 -- int10--------
    rs757777001,2
    F--88394288(+) AATGAG/ACACCT 2 -- int11Minor allele frequency- A:0.07WA 118
    rs738396561,2
    C,F--88394348(+) TTTTCT/ACAACC 2 -- int11Minor allele frequency- A:0.50WA 2
    rs1123540471,2
    C--88394352(+) TCAACCA/-CACAC 2 -- int11Minor allele frequency- -:0.00CSA 2
    rs1999515421,2
    C--88394353(+) CACAC-/AC/CA 
            
    TTAAG
    2 -- int10--------
    rs1163792061,2
    F--88394501(+) TTATGG/AACTCT 2 -- ut311Minor allele frequency- A:0.01WA 118
    rs348834601,2
    C--88394759(+) TTAAT-/GTTAA 
     ATACCTG
    GTGCA
    2 -- cds11Minor allele frequency- GTTAAATACCTG:0.50CSA 2
    rs2012766471,2
    C--88394761(+) AATGTG/TAAATA 2 -- ut310--------
    rs2010768871,2
    C--88394762(-) GTATTG/TAACAT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SPARCL1 (88394487 - 88452213 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SPARCL1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SPARCL1
    DNA2.0 Custom Variant and Variant Library Synthesis for SPARCL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606041    OMIM disorders: --

    Selected diseases for SPARCL1 (see all 25):    
    About MalaCards
    pediatric osteosarcoma    hepatitis e    acute liver failure    intracranial aneurysm
    endotheliitis    tonsillitis    prostate adenocarcinoma    osteosarcoma
    fanconi's anemia    pancreatitis    hepatitis    multiple sclerosis
    renal cell carcinoma    schizophrenia    prostatitis    hypertension
    atherosclerosis    hepatitis b    pancreatic cancer    colorectal cancer


    SPARCL1 for disorders           About GeneDecksing

    7 Novoseek inferred disease relationships for SPARCL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreatic tumor 41.7 1 17325739 (1)
    lung tumor 34.7 1 9485012 (1)
    nsclc 30.6 8 11179481 (2), 15375558 (2), 9485012 (1)
    tumors 4.74 13 11179481 (3), 15375558 (2), 17325739 (2), 15211566 (1) (see all 7)
    inflammation 0 1 17325739 (1)
    metastasis 0 1 15211566 (1)
    cancer 0 6 10735494 (3), 11179481 (1), 15094114 (1)

    Genetic Association Database (GAD): SPARCL1
    Human Genome Epidemiology (HuGE) Navigator: SPARCL1 (6 documents)

    Export disorders for SPARCL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPARCL1 gene, integrated from 10 sources (see all 55):
    (articles sorted by number of sources associating them with SPARCL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning from purified high endothelial venule cells of hevin, a close relative of the antiadhesive extracellular matrix protein SPARC. (PubMed id 7600298)1, 2, 3, 9 Girard J.-P. and Springer T.A. (Immunity 1995)
    2. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
    3. Association analysis of schizophrenia on 18 genes involved in neuronal migration: MDGA1 as a new susceptibility gene. (PubMed id 18384059)1, 4 KAohler A.K....Andreassen O.A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    4. Candidate gene analysis of SPARCL1 gene in patients with multiple sclerosis. (PubMed id 17825989)1, 4 Scalabrini D....Galimberti D. (Neurosci. Lett. 2007)
    5. Matricellular hevin regulates decorin production and collagen assembly. (PubMed id 16844696)1, 3 Sullivan M.M....Sage E.H. (J. Biol. Chem. 2006)
    6. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    7. cDNA subtraction library construction using a magnet-assisted subtraction technique (MAST). (PubMed id 8488563)1, 3 Schraml P....Ludwig C.U. (Trends Genet. 1993)
    8. Hevin is down-regulated in many cancers and is a negative regulator of cell growth and proliferation. (PubMed id 10735494)1, 9 Claeskens A....Kutoh E. (Br. J. Cancer 2000)
    9. Modulation of endothelial cell adhesion by hevin, an acidic protein associated with high endothelial venules. (PubMed id 8626806)1, 9 Girard J.P. and Springer T.A. (J. Biol. Chem. 1996)
    10. SC1/hevin. An extracellular calcium-modulated protein that binds collagen I. (PubMed id 12538579)1, 9 Hambrock H.O....Hartmann U. (J. Biol. Chem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8404 HGNC: 11220 AceView: SPARCL1 Ensembl:ENSG00000152583 euGenes: HUgn8404
    ECgene: SPARCL1 H-InvDB: SPARCL1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SPARCL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SPARCL1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SPARCL1 gene:
    Search GeneIP for patents involving SPARCL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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