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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPARCL1 Gene

protein-coding   GIFtS: 55
GCID: GC04M088394

SPARC-like 1 (hevin)

(Previous names: SPARC-like 1 (mast9, hevin) )
 Explore 24 diseases affiliated with
SPARCL1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SPARCL1    

Aliases
for SPARCL1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
SPARC-Like 1 (Hevin)1 2     SC12
SPARC-Like 1 (Mast9, Hevin)1 2     Hevin3
High Endothelial Venule Protein2 3     Mast91
MAST 92 3     Proliferation-Inducing Protein 332
MAST91     SPARC-Like Protein 12
PIG332     Hevin3

External Ids:    HGNC: 112201   Entrez Gene: 84042   Ensembl: ENSG000001525837   OMIM: 6060415   UniProtKB: Q145153   

Export aliases for SPARCL1 gene to outside databases

Previous GC identifers: GC04M088552 GC04M088696 GC04M088852 GC04M088751 GC04M088613 GC04M084140


Summaries
for SPARCL1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Gene Wiki entry for SPARCL1


Genomic Views
for SPARCL1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPARCL1 gene promoter:
         HFH-3   NF-1   HTF   E47   C/EBPalpha   GATA-1   FOXI1   FOXO4   HSF2   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SPARCL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SPARCL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPARCL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q22.1   Ensembl cytogenetic band:  4q22.1   HGNC cytogenetic band: 4q22-q25

SPARCL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPARCL1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M088394:  view genomic region     (about GC identifiers)

Start:
 88,394,487 bp from pter      End:
 88,452,213 bp from pter
Size:
 57,727 bases      Orientation:
 minus strand

Proteins
for SPARCL1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SPRL1_HUMAN, Q14515 (See protein sequence)
Recommended Name: SPARC-like protein 1 precursor  
Size: 664 amino acids; 75208 Da
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Secondary accessions: Q14800

Explore the universe of human proteins at neXtProt for SPARCL1: NX_Q14515

Post-translational modifications:

  • N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14515

    • SPARCL1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001121782.1  NP_004675.3  

    ENSEMBL proteins: 
     ENSP00000282470   ENSP00000422903   ENSP00000445678   ENSP00000423483   ENSP00000416971  
     ENSP00000438188   ENSP00000423448   ENSP00000444832   ENSP00000406251   ENSP00000414856  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate (see all 2): SPARCL1
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    Novus Biologicals SPARCL1 Protein
    Novus Biologicals SPARCL1 Lysates
    Sino Biological Recombinant Protein for SPARCL1
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SPARCL1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IEA--


    SPARCL1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for SPARCL1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SPARCL1 for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR016359 SPARC-like_p1
     IPR018247 EF_Hand_1_Ca_BS
     IPR002350 Prot_inh_Kazal
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_Ca-bd

    Graphical View of Domain Structure for InterPro Entry Q14515

    ProtoNet protein and cluster: Q14515

    2 Blocks protein families:
    IPB001999 Osteonectin-like
    IPB003645 Follistatin-like


    UniProtKB/Swiss-Prot: SPRL1_HUMAN, Q14515
    Similarity: Belongs to the SPARC family
    Similarity: Contains 1 EF-hand domain
    Similarity: Contains 1 follistatin-like domain
    Similarity: Contains 1 Kazal-like domain


    Function
    for SPARCL1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): SPARCL1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPARCL1
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate SPARCL1:
    hsa-miR-1290 hsa-miR-511 hsa-miR-448 hsa-miR-4289 hsa-miR-573 hsa-miR-3616-5p hsa-miR-3647-5p
    SwitchGear 3'UTR luciferase reporter plasmid: SPARCL1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPARCL1 (see all 7)
    OriGene shRNA RFP: SPARCL1
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    Gene Editing
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    Clone
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    Sino Biological Human cDNA Clone for SPARCL1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPARCL1 

    Cell Line
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    Search LifeMap BioReagents cell lines for SPARCL1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPARCL1

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--


    SPARCL1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SPARCL1:
     Decreased viability with pacli 

    Animal Models:
         Mouse knock-out Sparcl1tm1Pmc for SPARCL1
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Sparcl1):
     nervous system  reproductive system  vision/eye 

    SPARCL1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SPARCL1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SPARCL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/12 Interacting proteins for SPARCL1 (Q145153 ENSP000002824704) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DISC1Q9NRI53, ENSP000003555964I2D: score=1 STRING: ENSP00000355596
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    EGFRP005333, ENSP000002754934I2D: score=1 STRING: ENSP00000275493
    PRNPP041563I2D: score=3 
    GRB2P629933I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction IEA--


    SPARCL1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SPARCL1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SPARCL1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPARCL1
    1 Novoseek chemical compound relationship for SPARCL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 19.5 3 9199668 (1), 15094114 (1)

    Search CenterWatch for drugs/clinical trials and news about SPARCL1 / SPRL1 

    Transcripts
    for SPARCL1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SPARCL1 gene (2 alternative transcripts): 
    NM_001128310.1  NM_004684.4  

    Unigene Cluster for SPARCL1:

    SPARC-like 1 (hevin)
    Hs.62886  [show with all ESTs]
    Unigene Representative Sequence: NM_001128310
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000282470(uc011cdc.2 uc003hqs.4 uc011cdd.2) ENST00000503414
    ENST00000541496 ENST00000509407 ENST00000434434 ENST00000535835 ENST00000512317
    ENST00000543631 ENST00000458304 ENST00000418378(uc010ikm.3)

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate SPARCL1:
    hsa-miR-1290 hsa-miR-511 hsa-miR-448 hsa-miR-4289 hsa-miR-573 hsa-miR-3616-5p hsa-miR-3647-5p
    SwitchGear 3'UTR luciferase reporter plasmid: SPARCL1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPARCL1 (see all 7)
    OriGene shRNA RFP: SPARCL1
    OriGene siRNA: SPARCL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPARCL1
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SPARCL1 (NM_004684)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPARCL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPARCL1 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPARCL1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPARCL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPARCL1

    Additional cDNA sequence: 

    AK294335.1 AK298039.1 AK300956.1 AK304494.1 AK304628.1 AK316533.1 AL833430.1 AY513278.1 
    BC010383.1 BC022484.1 BC033721.1 BX647713.1 S73397.1 X82157.1 X86693.1 

    24/46 DOTS entries (see all 46):

    DT.97768756  DT.100889450  DT.91847955  DT.121234854  DT.75148986  DT.100889383  DT.99945076  DT.100889456 
    DT.121234915  DT.97800117  DT.91796716  DT.100889445  DT.95267021  DT.87017581  DT.100889448  DT.101961716 
    DT.95267023  DT.95267025  DT.100805019  DT.100889453  DT.121234849  DT.121234994  DT.121234863  DT.121234873 

    24/963 AceView cDNA sequences (see all 963):

    AA297601 CB152250 AI692759 BP349186 T35755 AI140657 AA297782 BM971058 
    AL693820 CR624121 AJ709259 AL048536 BG057955 CB266202 BP350367 BM677242 
    N89782 BX509437 AA349920 AA705752 T33428 CA942087 BM955297 BP350384 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SPARCL1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                                                                                                              
    SP2:                          -                                                                                                   
    SP3:                          -     -     -     -                                                                                 
    SP4:                                -                                                                                             
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for SPARCL1

    Expression
    for SPARCL1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPARCL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCACTTCAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SPARCL1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerMature Horizontal CellsHorizontal, Retina
    SomiteThoracic Ventrolateral Dermomyotome LipMuscle Progenitor CellsSkeletal Muscle
    KidneyS-shaped BodyKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
    HyStem+TGF?3+GDF5-induced 7SMOO32 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage
    HyStem+TGF?3+GDF5-induced 7PEND24 cells (HyStem+TGF?3+GDF5 in...)Bone
    TGF?3+BMP7-induced chondrocytes (Chondrogenic HyStem+...)Bone, Cartilage

    See SPARCL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPARCL1

    SOURCE GeneReport for Unigene cluster: Hs.62886

    UniProtKB/Swiss-Prot: SPRL1_HUMAN, Q14515
    Tissue specificity: Highly expressed in lymph node, brain, heart, lung, skeletal muscle, ovary, small intestine, and
    colon, with lower levels in placenta, pancreas, testis, spleen, and thymus, and no expression in kidney, liver, and
    peripheral blood leukocytes

        SABiosciences Custom PCR Arrays for SPARCL1
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPARCL1

    Orthologs
    for SPARCL1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SPARCL1 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SPARCL11 SPARC-like 1 (hevin) 54.51(n)
    43.52(a)    		   422586  XM_420545.3  XP_420545.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii sparcl11 SPARC-like 1 52.81(n)
    43.33(a)    		   567331  NM_001130605.1  NP_001124077.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta BM-40-SPARC6
    		 BM-40-SPARC
    		 28(a)
    		 1 → many
    		 3R(22694960-22697738)
    worm
    (Caenorhabditis elegans)    		 Secernentea ost-16
    		 SPARC
    		 34(a)
    		 1 → many
    		 IV(1107396-1110860)


    ENSEMBL Gene Tree for SPARCL1 (if available)
    TreeFam Gene Tree for SPARCL1 (if available) 

    Paralogs
    for SPARCL1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPARCL1 gene
    SPARC2  
    1 SIMAP similar gene for SPARCL1 using alignment to 10 protein entries:     SPRL1_HUMAN (see all proteins):
    SPARC

    SPARCL1 for paralogs           About GeneDecksing



    Genomic Variants
    for SPARCL1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPARCL1
    DNA2.0 Custom Variant and Variant Library Synthesis for SPARCL1

    Disorders / Diseases
    for SPARCL1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SPARCL1 for disorders           About GeneDecksing

    OMIM gene information: 606041    OMIM disorders: --

    20/24 diseases for SPARCL1 (see all 24):    About MalaCards
    intracranial aneurysm    pediatric osteosarcoma    acute liver failure    hepatitis e
    fanconi's anemia    renal cell carcinoma    multiple sclerosis    tonsillitis
    hepatitis b    anemia    prostate adenocarcinoma    pancreatitis
    gastric cancer    hepatitis    pancreatic cancer    colorectal cancer
    osteosarcoma    lung cancer    adenocarcinoma    hypertension

    7 Novoseek disease relationships for SPARCL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreatic tumor 41.7 1 17325739 (1)
    lung tumor 34.7 1 9485012 (1)
    nsclc 30.6 8 11179481 (2), 15375558 (2), 9485012 (1)
    tumors 4.74 13 11179481 (3), 15375558 (2), 17325739 (2), 15211566 (1) (see all 7)
    inflammation 0 1 17325739 (1)
    metastasis 0 1 15211566 (1)
    cancer 0 6 10735494 (3), 11179481 (1), 15094114 (1)

    Human Genome Epidemiology (HuGE) Navigator: SPARCL1 (6 documents)

    Export disorders for SPARCL1 gene to outside databases

    Publications
    for SPARCL1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPARCL1 gene, integrated from 9 sources (see all 51):
    (articles sorted by number of sources associating them with SPARCL1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning from purified high endothelial venule cells of hevin, a close relative of the antiadhesive extracellular matrix protein SPARC. (PubMed id 7600298)1, 2, 3, 9 Girard J.-P. and Springer T.A. (1995)
    2. Matricellular hevin regulates decorin production and collagen assembly. (PubMed id 16844696)1, 3 Sullivan M.M....Sage E.H. (2006)
    3. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    4. cDNA subtraction library construction using a magnet-assisted subtraction technique (MAST). (PubMed id 8488563)1, 3 Schraml P....Ludwig C.U. (1993)
    5. Hevin is down-regulated in many cancers and is a negative regulator of cell growth and proliferation. (PubMed id 10735494)1, 9 Claeskens A....Kutoh E. (2000)
    6. Modulation of endothelial cell adhesion by hevin, an acidic protein associated with high endothelial venules. (PubMed id 8626806)1, 9 Girard J.P. and Springer T.A. (1996)
    7. SC1/hevin. An extracellular calcium-modulated protein that binds collagen I. (PubMed id 12538579)1, 9 Hambrock H.O....Hartmann U. (2003)
    8. LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins. (PubMed id 23234360)2 Halim A.... Nilsson J. (2013)
    9. Secreted protein, acidic and rich in cysteine-like 1 ( SPARCL1) is down regulated in aggressive prostate cancers and is prognostic for poor clinical outcome. (PubMed id 22927397)1 Hurley P.J....Schaeffer E.M. (2012)
    10. Down-regulated SPARCL1 is associated with clinical si gnificance in human gastric cancer. (PubMed id 22161898)1 Li P....Wang J. (2012)

    External Searches for SPARCL1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing SPARCL1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8404 HGNC: 11220 AceView: SPARCL1 Ensembl:ENSG00000152583 euGenes: HUgn8404
    ECgene: SPARCL1 H-InvDB: SPARCL1

    Other Databases showing SPARCL1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SPARCL1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPARCL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SPARCL1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SPARCL1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SPARCL1 gene:
    Search GeneIP for patents involving SPARCL1

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