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SPARCL1 Gene

protein-coding GIFtS: 58
GCID: GC04M088394

SPARC-Like 1 (Hevin)

(Previous names: SPARC-like 1 (mast9, hevin))

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
SPARC-Like 1 (Hevin)¹ ²		hevin²
SPARC-Like 1 (Mast9, Hevin)¹ ²		mast9²
High Endothelial Venule Protein² ³		Proliferation-Inducing Protein 33²
MAST 9² ³		SPARC-Like Protein 1²
PIG33²		Hevin³
SC1²

External Ids:	HGNC: 11220¹	Entrez Gene: 8404²	Ensembl: ENSG00000152583⁷	OMIM: 606041⁵	UniProtKB: Q14515³

Export aliases for SPARCL1 gene to outside databases

Previous GC identifers: GC04M088552 GC04M088696 GC04M088852 GC04M088751 GC04M088613 GC04M084140

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SPARCL1 Gene:

SPARCL1 (SPARC-like 1 (hevin)) is a protein-coding gene. Diseases associated with SPARCL1 include pediatric osteosarcoma, and hepatitis e. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is SPARC.

Gene Wiki entry for SPARCL1 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000004.12 NC_018915.2 NT_016354.20

Regulatory elements:

Regulatory transcription factor binding sites in the SPARCL1 gene promoter:
HFH-3 NF-1 HTF E47 C/EBPalpha GATA-1 FOXI1 FOXO4 HSF2 Chx10
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SPARCL1 promoter sequence

Search Chromatin IP Primers for SPARCL1

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPARCL1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q22.1 Ensembl cytogenetic band: 4q22.1 HGNC cytogenetic band: 4q22-q25

SPARCL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPARCL1 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M088394: view genomic region (about GC identifiers)

Start:	88,394,487 bp from pter	End:	88,452,213 bp from pter
Size:	57,727 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SPRL1_HUMAN, Q14515 (See protein sequence)

Recommended Name: SPARC-like protein 1 precursor

Size: 664 amino acids; 75208 Da

Secondary accessions: Q14800

Explore the universe of human proteins at neXtProt for SPARCL1: NX_Q14515

Explore proteomics data for SPARCL1 at MOPED

Post-translational modifications:

N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan¹

Glycosylation² at Thr31, Thr40, Ser44, Thr116, Asn169, Asn176, Asn196, Asn280, Thr331, Thr398,
Asn412, Asn476

Modification sites at PhosphoSitePlus

See SPARCL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_001121782.1 NP_004675.3

ENSEMBL proteins:

ENSP00000282470 ENSP00000422903 ENSP00000445678 ENSP00000423483 ENSP00000416971

ENSP00000438188 ENSP00000423448 ENSP00000444832 ENSP00000406251 ENSP00000414856

SPARCL1 Human Recombinant Protein Products:

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	OriGene Purified Protein for SPARCL1 OriGene Protein Over-expression Lysate for SPARCL1 OriGene MassSpec for SPARCL1 OriGene Custom Protein Services for SPARCL1
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	Novus Biologicals SPARCL1 Protein Novus Biologicals SPARCL1 Lysates
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	Cloud-Clone Corp. Proteins for SPARCL1

SPARCL1 Antibody Products:

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	Abcam antibodies for SPARCL1
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SPARCL1 Assay Products:

	Browse Kits and Assays available from EMD Millipore
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	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for SPARCL1 Cloud-Clone Corp. CLIAs for SPARCL1

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

EFHAND: EF-hand domain containing

Selected InterPro protein domains (see all 9):

IPR016359 SPARC-like_p1

IPR018247 EF_Hand_1_Ca_BS

IPR002350 Kazal_dom

IPR011992 EF-hand-dom_pair

IPR002048 EF_hand_dom

Graphical View of Domain Structure for InterPro Entry Q14515

ProtoNet protein and cluster: Q14515

2 Blocks protein domains:

IPB001999 Osteonectin-like

IPB003645 Follistatin-like

UniProtKB/Swiss-Prot: SPRL1_HUMAN, Q14515

Similarity: Belongs to the SPARC family

Similarity: Contains 1 EF-hand domain

Similarity: Contains 1 follistatin-like domain

Similarity: Contains 1 Kazal-like domain

SPARCL1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	--	--

SPARCL1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for SPARCL1:

Decreased viability with pacli

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Sparcl1):

nervous system

reproductive system

vision/eye

SPARCL1 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Sparcl1^tm1Pmc for SPARCL1

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPARCL1

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SPARCL1

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPARCL1

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPARCL1

miRNA Products:		miRTarBase miRNAs that target SPARCL1: hsa-mir-98-5p (MIRT027605)

		Block miRNA regulation of human, mouse, rat SPARCL1 using miScript Target Protectors
		7 qRT-PCR Assays for microRNAs that regulate SPARCL1:
		hsa-miR-1290 hsa-miR-511 hsa-miR-448 hsa-miR-4289 hsa-miR-573 hsa-miR-3616-5p hsa-miR-3647-5p
		SwitchGear 3'UTR luciferase reporter plasmid: SPARCL1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for SPARCL1
		Predesigned siRNA for gene silencing in human, mouse, rat SPARCL1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SPARCL1

Clone Products:		OriGene clones in human, mouse for SPARCL1 (see all 12) OriGene ORF clones in mouse, rat for SPARCL1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SPARCL1 (NM_004684)
		Sino Biological Human cDNA Clone for SPARCL1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPARCL1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPARCL1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SPARCL1
		Browse ESI BIO Cell Lines and PureStem Progenitors for SPARCL1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPARCL1

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

SPRL1_HUMAN, Q14515: Secreted, extracellular space, extracellular matrix (By similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
extracellular	2

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Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005578	proteinaceous extracellular matrix	IEA	--
GO:0005615	extracellular space	IEA	--

SPARCL1 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for SPARCL1
Interactions:

GeneGlobe Interaction Network for SPARCL1

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

Selected Interacting proteins for SPARCL1 (Q14515³ ENSP00000282470⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 18)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ENSG00000204490	P01375³	I2D: score=1
ENSG00000206439	P01375³	I2D: score=1
ENSG00000223952	P01375³	I2D: score=1
ENSG00000228321	P01375³	I2D: score=1
ENSG00000228849	P01375³	I2D: score=1

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Gene Ontology (GO): 1 biological process term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	IEA	--

SPARCL1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for SPARCL1 (SPRL1)

1 Novoseek inferred chemical compound relationship for SPARCL1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cysteine	19.5	3	9199668 (1), 15094114 (1)

SPARCL1 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for SPARCL1 gene (2 alternative transcripts):

NM_001128310.1 NM_004684.4

Unigene Cluster for SPARCL1:

SPARC-like 1 (hevin)

Hs.62886 [show with all ESTs]

Unigene Representative Sequence: NM_001128310

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000282470(uc011cdc.2 uc003hqs.4 uc011cdd.2) ENST00000503414

ENST00000541496 ENST00000509407 ENST00000434434 ENST00000535835 ENST00000512317

ENST00000543631 ENST00000458304 ENST00000418378(uc010ikm.3)

miRNA Products:		Block miRNA regulation of human, mouse, rat SPARCL1 using miScript Target Protectors
		7 qRT-PCR Assays for microRNAs that regulate SPARCL1:
		hsa-miR-1290 hsa-miR-511 hsa-miR-448 hsa-miR-4289 hsa-miR-573 hsa-miR-3616-5p hsa-miR-3647-5p
		SwitchGear 3'UTR luciferase reporter plasmid: SPARCL1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for SPARCL1
		Predesigned siRNA for gene silencing in human, mouse, rat SPARCL1

Clone Products:		OriGene clones in human, mouse for SPARCL1 (see all 12) OriGene ORF clones in mouse, rat for SPARCL1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SPARCL1 (NM_004684)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPARCL1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPARCL1

Primer Products:		OriGene qPCR primer pairs and template standards for SPARCL1 OriGene qSTAR qPCR primer pairs in human, mouse for SPARCL1
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat SPARCL1
		QuantiTect SYBR Green Assays in human, mouse, rat SPARCL1
		QuantiFast Probe-based Assays in human, mouse, rat SPARCL1

Additional mRNA sequence:

AK294335.1 AK298039.1 AK300956.1 AK304494.1 AK304628.1 AK316533.1 AL833430.1 AY513278.1

BC010383.1 BC022484.1 BC033721.1 BX647713.1 X82157.1 X86693.1

Selected DOTS entries (see all 46):

DT.97768756 DT.100889450 DT.91847955 DT.121234854 DT.75148986 DT.100889383 DT.99945076 DT.100889456

DT.121234915 DT.97800117 DT.91796716 DT.100889445 DT.95267021 DT.101961716 DT.87017581 DT.95267023

DT.95267025 DT.100805019 DT.100889448 DT.100889453 DT.121234849 DT.121234994 DT.121234863 DT.121234873

Selected AceView cDNA sequences (see all 963):

CB961067 CD677118 AI805956 BM955302 CF528281 BP349186 AI139460 AW845153

BP348896 BP348813 AJ709259 BM128282 BU687407 CB266202 BM971058 T35755

BP348982 CD678843 AI597796 AI692759 CD676582 BF934465 BM955265 CD172090

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for SPARCL1 (see all 7) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16
SP1:
SP2:									-
SP3:									-		-		-		-
SP4:											-
SP5:

ECgene alternative splicing isoforms for SPARCL1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SPARCL1 expression in normal human tissues (normalized intensities) SPARCL1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TGCACTTCAA

About this image

SPARCL1 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 28) fully expand


Brain (Nervous System) fully expand to see all 14 entries
Adult Endothelial Cells Blood Brain Barrier
Cerebral Cortex
Anterior astroglia-like cells

Bone (Muscoskeletal System) fully expand to see all 4 entries
TGFbeta3+BMP7-induced chondrocytes

Cartilage (Muscoskeletal System) fully expand to see all 3 entries
TGFbeta3+BMP7-induced chondrocytes

Peripheral Nervous System (Nervous System) fully expand to see all 2 entries
Pro-myelinating Schwann Cells Peripheral Nerve Domain

Eye (Sensory Organs) fully expand to see all 2 entries
Mature Horizontal Cells Inner Nuclear Layer

SPARCL1 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

SPARCL1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.62886

UniProtKB/Swiss-Prot: SPRL1_HUMAN, Q14515

Tissue specificity: Highly expressed in lymph node, brain, heart, lung, skeletal muscle, ovary, small intestine,

and colon, with lower levels in placenta, pancreas, testis, spleen, and thymus, and no expression in kidney,

liver, and peripheral blood leukocytes

Custom PCR Arrays for SPARCL1

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		Pre-validated RT² qPCR Primer Assay in human, mouse, rat SPARCL1
		QuantiTect SYBR Green Assays in human, mouse, rat SPARCL1
		QuantiFast Probe-based Assays in human, mouse, rat SPARCL1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPARCL1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for SPARCL1 gene from Selected species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Sparcl1^{1 , 5}	SPARC-like 1^{1, 5}	74.35(n)¹ 66.77(a)¹		5 (50.55 cM)⁵ 13602¹ NM_010097.4¹ NP_034227.3¹ 104079111⁵
chicken (Gallus gallus)	Aves	SPARCL1⁶	SPARC-like 1 (hevin)	32(a)	1 ↔ 1	4(45106288-45113208)
zebrafish (Danio rerio)	Actinopterygii	sparcl1⁶	SPARC-like 1	33(a)	1 ↔ 1	1(37241624-37268289) ENSDARG00000074989
fruit fly (Drosophila melanogaster)	Insecta	BM-40-SPARC¹	BM-40-SPARC	47.78(n) 38.42(a)		43230 NM_001276069.1 NP_001262998.1
worm (Caenorhabditis elegans)	Secernentea	ost-1¹	ost-1	53.88(n) 40.78(a)		176931 NM_067638.6 NP_500039.1

ENSEMBL Gene Tree for SPARCL1 (if available)
TreeFam Gene Tree for SPARCL1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for SPARCL1 gene

SPARC²

1 SIMAP similar gene for SPARCL1 using alignment to 10 protein entries: SPRL1_HUMAN (see all proteins):

SPARC

SPARCL1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs9995083^1,2	C,F,A	--	88393987(+)	`GACCTG/ACTGGG`	2	--	int¹		11		NA WA CSA EA	372
rs185935883^1,2		--	88394036(+)	`GGATCA/TCAGGT`	2	--	int¹		0	--	--	--	--
rs75777700^1,2	F	--	88394288(+)	`AATGAG/ACACCT`	2	--	int¹		1		WA	118
rs73839656^1,2	C,F	--	88394348(+)	`TTTTCT/ACAACC`	2	--	int¹		1		WA	2
rs112354047^1,2	C	--	88394352(+)	`TCAACCA/-CACAC`	2	--	int¹		1		CSA	2
rs199951542^1,2	C	--	88394353(+)	`CACAC-/AC/CA TTAAG`	2	--	int¹		0	--	--	--	--
rs116379206^1,2	F	--	88394501(+)	`TTATGG/AACTCT`	2	--	ut3¹		1		WA	118
rs34883460^1,2	C	--	88394759(+)	`TTAAT-/GTTAA ATACCTGGTGCA`	2	--	cds¹		1		CSA	2
rs201276647^1,2	C	--	88394761(+)	`AATGTG/TAAATA`	2	--	ut3¹		0	--	--	--	--
rs201076887^1,2	C	--	88394762(-)	`GTATTG/TAACAT`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SPARCL1 (88394487 - 88452213 bp)

Structural Variations
Database of Genomic Variants (DGV) variations for SPARCL1: --

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing SPARCL1

DNA2.0 Custom Variant and Variant Library Synthesis for SPARCL1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 606041 OMIM disorders: --

Selected diseases for SPARCL1 (see all 25): About MalaCards

pediatric osteosarcoma hepatitis e acute liver failure intracranial aneurysm

endotheliitis tonsillitis prostate adenocarcinoma osteosarcoma

fanconi's anemia pancreatitis hepatitis multiple sclerosis

renal cell carcinoma schizophrenia prostatitis hypertension

atherosclerosis hepatitis b pancreatic cancer colorectal cancer

SPARCL1 for disorders About GeneDecksing

7 Novoseek inferred disease relationships for SPARCL1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pancreatic tumor	41.7	1	17325739 (1)
lung tumor	34.7	1	9485012 (1)
nsclc	30.6	8	11179481 (2), 15375558 (2), 9485012 (1)
tumors	4.74	13	11179481 (3), 15375558 (2), 17325739 (2), 15211566 (1) (see all 7)
inflammation	0	1	17325739 (1)
metastasis	0	1	15211566 (1)
cancer	0	6	10735494 (3), 11179481 (1), 15094114 (1)

Genetic Association Database (GAD): SPARCL1
Human Genome Epidemiology (HuGE) Navigator: SPARCL1 (6 documents)

Export disorders for SPARCL1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SPARCL1 gene, integrated from 10 sources (see all 55):
(articles sorted by number of sources associating them with SPARCL1)

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Cloning from purified high endothelial venule cells of hevin, a close relative of the antiadhesive extracellular matrix protein SPARC. (PubMed id 7600298)^{1, 2, 3, 9} Girard J.-P. and Springer T.A. (Immunity 1995)
Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)^{1, 4} Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
Association analysis of schizophrenia on 18 genes involved in neuronal migration: MDGA1 as a new susceptibility gene. (PubMed id 18384059)^{1, 4} KAohler A.K....Andreassen O.A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
Candidate gene analysis of SPARCL1 gene in patients with multiple sclerosis. (PubMed id 17825989)^{1, 4} Scalabrini D....Galimberti D. (Neurosci. Lett. 2007)
Matricellular hevin regulates decorin production and collagen assembly. (PubMed id 16844696)^{1, 3} Sullivan M.M....Sage E.H. (J. Biol. Chem. 2006)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (J. Proteome Res. 2005)
cDNA subtraction library construction using a magnet-assisted subtraction technique (MAST). (PubMed id 8488563)^{1, 3} Schraml P....Ludwig C.U. (Trends Genet. 1993)
Hevin is down-regulated in many cancers and is a negative regulator of cell growth and proliferation. (PubMed id 10735494)^{1, 9} Claeskens A....Kutoh E. (Br. J. Cancer 2000)
Modulation of endothelial cell adhesion by hevin, an acidic protein associated with high endothelial venules. (PubMed id 8626806)^{1, 9} Girard J.P. and Springer T.A. (J. Biol. Chem. 1996)
SC1/hevin. An extracellular calcium-modulated protein that binds collagen I. (PubMed id 12538579)^{1, 9} Hambrock H.O....Hartmann U. (J. Biol. Chem. 2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8404	HGNC: 11220	AceView: SPARCL1	Ensembl:ENSG00000152583	euGenes: HUgn8404
ECgene: SPARCL1	H-InvDB: SPARCL1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SPARCL1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SPARCL1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for SPARCL1 gene
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Patent Information for SPARCL1 gene:
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SPARCL1 Gene

SPARC-Like 1 (Hevin)

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