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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SPARC Gene

protein-coding GIFtS: 69
GCID: GC05M151021

secreted protein, acidic, cysteine-rich (osteonectin)

(Previous symbol: ON)

Explore 107 diseases affiliated with
SPARC via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Secreted Protein, Acidic, Cysteine-Rich (Osteonectin)¹ ²		BM-40² ³
ON¹ ² ³ ⁵		Cysteine-Rich Protein²
Basement-Membrane Protein 40² ³		Osteonectin³
Secreted Protein Acidic And Rich In Cysteine² ³		Osteonectin³

External Ids:	HGNC: 11219¹	Entrez Gene: 6678²	Ensembl: ENSG00000113140⁷	OMIM: 182120⁵	UniProtKB: P09486³

Export aliases for SPARC gene to outside databases

Previous GC identifers: GC05M151110 GC05M151639 GC05M151025 GC05M151070 GC05M146186

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SPARC:

This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in

bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell

shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based

on changes to cell shape which can promote tumor cell invasion. (provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: SPRC_HUMAN, P09486

Function: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds

calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium

binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+)

ion with a high affinity

Gene Wiki entry for SPARC (Osteonectin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_029289.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SPARC gene promoter:
AML1a Nkx2-5
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SPARC promoter sequence

Search SABiosciences Chromatin IP Primers for SPARC

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPARC

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.3-q32 Ensembl cytogenetic band: 5q33.1 HGNC cytogenetic band: 5q31-q33

SPARC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPARC gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M151021: view genomic region (about GC identifiers)

Start:	151,040,657 bp from pter	End:	151,066,726 bp from pter
Size:	26,070 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SPRC_HUMAN, P09486 (See protein sequence)

Recommended Name: SPARC precursor

Size: 303 amino acids; 34632 Da

Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane. Note=In or around the

basement membrane

Developmental stage: Expressed at high levels in tissues undergoing morphogenesis, remodeling and wound repair

Sequence caution: Sequence=AAA60993.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown

origin in the C-terminal part;

4 PDB 3D structures from and Proteopedia for SPARC:

1BMO (3D)

1NUB (3D)

1SRA (3D)

2V53 (3D)

Secondary accessions: D3DQH9 Q6IBK4

Explore the universe of human proteins at neXtProt for SPARC: NX_P09486

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P09486

SPARC Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003109.1

ENSEMBL proteins:

ENSP00000231061 ENSP00000440127 ENSP00000428119 ENSP00000444998 ENSP00000429152

Reactome Protein details: P09486
Human Recombinant Protein Products for SPARC:

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	ProSpec Recombinant Protein for SPARC
	Uscn Proteins for SPARC

Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005578	proteinaceous extracellular matrix	TAS	7034958
GO:0005604	basement membrane	IEA	--
GO:0005615	extracellular space	IEA	--
GO:0005622	intracellular	--	--

SPARC for ontologies About GeneDecksing

SPARC Antibody Products:

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	Uscn Antibodies for SPARC
	ThermoFisher Antibodies for SPARC

Assay Products for SPARC:

	Browse Kits and Assays available from EMD Millipore
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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SPARC

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SPARC for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR018247 EF_Hand_1_Ca_BS

IPR002350 Prot_inh_Kazal

IPR011992 EF-hand-like_dom

IPR019577 SPARC/Testican_Ca-bd-dom

IPR001999 Osteonectin_CS

Graphical View of Domain Structure for InterPro Entry P09486

ProtoNet protein and cluster: P09486

2 Blocks protein families:

IPB001999 Osteonectin-like

IPB003645 Follistatin-like

UniProtKB/Swiss-Prot: SPRC_HUMAN, P09486

Similarity: Belongs to the SPARC family

Similarity: Contains 1 EF-hand domain

Similarity: Contains 1 follistatin-like domain

Similarity: Contains 1 Kazal-like domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SPRC_HUMAN, P09486

Function: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds

calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium

binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+)

ion with a high affinity

Genatlas biochemistry entry for SPARC:

glycoprotein,acidic,cysteine rich,into the basement membrane,involved in extracellular matrix remodeling,interacting

with collagen,thrombospondin,regulator of cell growth (osteonectin/BM40),and of activator of MMP2 at the cell

surface,contributing to the proteolytic pathway associated with tumor invasion,overexpressed in hepatocellular

carcinoma

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	3402455
GO:0005518	collagen binding	TAS	7034958
GO:0050840	extracellular matrix binding	IEA	--

SPARC for ontologies About GeneDecksing

Phenotypes:
8 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Sparc):

behavior/neurological	craniofacial	hematopoietic system	homeostasis/metabolism	immune system
skeleton	tumorigenesis	vision/eye

SPARC for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for SPARC: Sparc^tm1Anjm Sparc^tm1Hwe

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SPARC

miRNA Products:		miRTarBase miRNAs that target SPARC: hsa-mir-192 (MIRT004126), hsa-mir-29c (MIRT001922)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPARC
		8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate SPARC (see all 25):
		hsa-miR-34b* hsa-miR-495 hsa-miR-4263 hsa-miR-29c hsa-miR-29a hsa-miR-3653 hsa-miR-1205 hsa-miR-204

		SwitchGear 3'UTR luciferase reporter plasmid: SPARC 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPARC (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPARC OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SPARC (NM_003118)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SPARC
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPARC

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Platelet activation, signaling and aggregation

Platelet activation, signaling and aggregation

1.00

Hemostasis

0.43

Platelet degranulation

Platelet degranulation

1.00

Response to elevated platelet cytosolic Ca2+

0.94

Cell adhesion_ECM remodeling

Cell adhesion_ECM remodeling

1.00

Cell adhesion ECM remodeling

1.00

Wnt / Hedgehog / Notch

Wnt / Hedgehog / Notch

1.00

Senescence and Autophagy

Senescence and Autophagy

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for SPARC

Cell adhesion ECM remodeling

1 Cell Signaling Technology (CST) Pathway for SPARC

Wnt / Hedgehog / Notch

1 GeneGo (Thomson Reuters) Pathway for SPARC

Cell adhesion ECM remodeling

2 BioSystems Pathways for SPARC

	Senescence and Autophagy
	TGF-beta Receptor Signaling Pathway

4 Reactome Pathways for SPARC

	Hemostasis
	Platelet degranulation
	Platelet activation, signaling and aggregation
	Response to elevated platelet cytosolic Ca2+

SPARC for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SPARC

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/62 Interacting proteins for SPARC (P09486^{1, 2, 3} ENSP00000231061⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 62)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
XRCC6	P12956²^,³, ENSP00000352257⁴	MINT-8271916 I2D: score=2 STRING: ENSP00000352257
ZNF579	Q8NAF0²^,³, ENSP00000320188⁴	MINT-8271927 I2D: score=2 STRING: ENSP00000320188
COL3A1	P02461³, ENSP00000304408⁴	I2D: score=4 STRING: ENSP00000304408
COL1A1	P02452³, ENSP00000225964⁴	I2D: score=3 STRING: ENSP00000225964
PDGFA	P04085³, ENSP00000346508⁴	I2D: score=3 STRING: ENSP00000346508

About this table

Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001503	ossification	IEA	--
GO:0002576	platelet degranulation	TAS	--
GO:0007165	signal transduction	IEA	--
GO:0007507	heart development	IEA	--
GO:0007596	blood coagulation	TAS	--

SPARC for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SPARC for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SPARC

2 HMDB Compounds for SPARC About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Copper	Cu (see all 2)	7440-50-8	--

10/50 Novoseek chemical compound relationships for SPARC gene (see all 50) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cysteine	72.5	158	15838642 (2), 9008236 (2), 1555584 (1), 8500547 (1) (see all 99)
hydroxyapatite	63.8	17	8547349 (3), 8443690 (1), 17579299 (1), 17266017 (1) (see all 11)
alizarin	63.1	2	19642865 (1), 17177849 (1)
procollagen	46.7	7	8826089 (2), 14722903 (1), 9173088 (1), 12381951 (1) (see all 6)
titanium	43.6	2	12419636 (1)
dexamethasone	40.2	14	16934542 (1), 7953977 (1), 15988617 (1), 8275945 (1) (see all 9)
octacalcium phosphate	33.6	2	8443690 (1)
thymidine	32.9	7	8419407 (2), 17066632 (1), 7649376 (1), 14765266 (1) (see all 5)
ascorbic acid	31.1	3	9495521 (1), 16934542 (1)
calcium	29.2	35	1555584 (5), 7563094 (4), 10446063 (3), 15065403 (2) (see all 18)

Search CenterWatch for drugs/clinical trials and news about SPARC / SPRC

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SPARC gene:

NM_003118.3

Unigene Cluster for SPARC:

Secreted protein, acidic, cysteine-rich (osteonectin)

Hs.111779 [show with all ESTs]

Unigene Representative Sequence: AK126525

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000231061(uc003lug.3 uc003lui.3) ENST00000520687 ENST00000538026

ENST00000537849 ENST00000521569 ENST00000524277 ENST00000539687 ENST00000521327

ENST00000522348

miRNA Products:		OriGene 3'-UTR Clone: SPARC Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPARC
		8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate SPARC (see all 25):
		hsa-miR-34b* hsa-miR-495 hsa-miR-4263 hsa-miR-29c hsa-miR-29a hsa-miR-3653 hsa-miR-1205 hsa-miR-204

		SwitchGear 3'UTR luciferase reporter plasmid: SPARC 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector: SPARC (NM_003118)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPARC

Additional cDNA sequence:

AK096969.1 AK126525.1 AK299441.1 AK315591.1 AY545555.1 BC004974.1 BC008011.1 BC072457.1

CR456799.1 J03040.1 Y00755.1

24/93 DOTS entries (see all 93):

DT.80101600 DT.100060104 DT.95194845 DT.100060108 DT.101986038 DT.91856216 DT.100702514 DT.100702534

DT.95275147 DT.100853342 DT.100702480 DT.100702495 DT.100702491 DT.91782050 DT.100638608 DT.97821055

DT.100702493 DT.97777033 DT.100702535 DT.91849618 DT.120857232 DT.100702545 DT.120857190 DT.100767409

24/2827 AceView cDNA sequences (see all 2827):

CA310374 AL542739 CR622084 AL552465 CR604100 BM697232 CA414941 CA425303

AI754674 CN482066 AA398478 AI754420 BU188430 BX343813 AU156504 CD358322

CA437693 BU846056 BQ019665 AA775486 BM698389 BQ278139 CA449133 BM722538

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for SPARC About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	·	5c	^	6	^	7	^	8	^	9a	·	9b	^	10a	·	10b	·	10c	^	11a	·	11b	·	11c
SP1:
SP2:											-		-
SP3:													-		-		-		-		-
SP4:

ECgene alternative splicing isoforms for SPARC

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SPARC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGTGAAGAG

About this image

SPARC expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/18 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 18)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Autopod Periosteum

Endochondral Osteocytes

Selective marker (cell-identifying gene)

Bone

Caudal Endochondral Bones

Endochondral Osteocytes

Bone

Caudal Endochondral Bones

Endochondral Preosteoblasts

Bone

Endochondral Facial Bones

Endochondral Osteocytes

Bone

Endochondral Facial Bones

Endochondral Preosteoblasts

Bone

Membranous Facial Bones

Intramembranous Osteoblasts

Bone

Membranous Facial Bones

Intramembranous Preosteoblasts

Bone

Membranous Facial Bones

Intramembrenous Osteocytes

Bone

Rostral Endochondral Facial Bones

Endochondral Osteocytes

Bone

Rostral Endochondral Facial Bones

Endochondral Preosteoblasts

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

Extra-embryonic endoderm cells (Fetal Stem / Progenitor Cell)

Extraembryonic Tissues

Extraembryonic endoderm-like cells (Generation of extrae...)

Connective tissue progenitor cells (Generation of connec...)

Definitive endoderm-like cells (A scalable, suspensi...)

See SPARC Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPARC

SOURCE GeneReport for Unigene cluster: Hs.111779

SABiosciences Expression via Pathway-Focused PCR Arrays including SPARC:

Extracellular Matrix & Adhesion Molecules in human mouse rat

Cellular Senescence in human mouse rat

Epithelial to Mesenchymal Transition (EMT) in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPARC Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPARC

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPARC

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SPARC gene from 7/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Sparc^{1 , 5}	secreted acidic cysteine rich glycoprotein^{1, 5}	89.51(n)¹ 92.72(a)¹		11 (33.04 cM)⁵ 20692¹ NM_009242.4¹ NP_033268.1¹ 55394500⁵
chicken (Gallus gallus)	Aves	SPARC¹	secreted protein, acidic, cysteine-rich (osteonectin)	84.45(n) 86.58(a)		386571 NM_204410.1 NP_989741.1
lizard (Anolis carolinensis)	Reptilia	SPARC⁶	--	86(a)	1 ↔ 1	1(152373909-152386905)
African clawed frog (Xenopus laevis)	Amphibia	BQ884411.1²	--	88.23(n)		BQ884411.1
zebrafish (Danio rerio)	Actinopterygii	sparc¹	secreted acidic cysteine rich glycoprotein	77.78(n) 80.76(a)		321357 NM_001001942.1 NP_001001942.1
fruit fly (Drosophila melanogaster)	Insecta	BM-40-SPARC⁶	BM-40-SPARC	24(a)	1 → many	3R(22694960-22697738)
worm (Caenorhabditis elegans)	Secernentea	ost-1⁶	SPARC	33(a)	1 → many	IV(1107396-1110860)

ENSEMBL Gene Tree for SPARC (if available)
TreeFam Gene Tree for SPARC (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SPARC gene

SPARCL1²

2 SIMAP similar genes for SPARC using alignment to 7 protein entries: SPRC_HUMAN (see all proteins):

SPARCL1 SMOC2

SPARC for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs201422818^1,2		--	151040160(+)	`TAAAA-/TTTTTT`	1	--	int¹		0	--	--	--	--
rs57732145^1,2	C	--	151040166(+)	`TTTTTG/TTTTTT`	1	--	int¹		0	--	--	--	--
rs75725713^1,2	C	--	151040179(+)	`TTTTTA/TAAAAA`	1	--	int¹		0	--	--	--	--
rs2347123^1,2	C	--	151040180(+)	`TTTTTT/AAAAAA`	1	--	int¹		1		NA	2
rs140744512^1,2		--	151040180(+)	`TTTTT-/AAAAAAAT`	1	--	int¹		0	--	--	--	--
rs2347124^1,2	C	--	151040181(+)	`TTTTAT/AAAAAA`	1	--	int¹		1		NA	2
rs182638407^1,2		--	151040213(+)	`GACAGA/GTAGAA`	1	--	int¹		0	--	--	--	--
rs79905697^1,2		--	151040265(+)	`AGGGAC/TCCTGT`	1	--	int¹		0	--	--	--	--
rs6898815^1,2	C,F,A	--	151040266(+)	`GGGACC/GCTGTT`	1	--	int¹		11		NA CSA WA EA	510
rs142232757^1,2		--	151040335(+)	`CGCCCA/GGGGCC`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SPARC (151040657 - 151066726 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SPARC: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPARC

DNA2.0 Custom Variant and Variant Library Synthesis for SPARC

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SPARC for disorders           About GeneDecksing

OMIM gene information: 182120    OMIM disorders: --

20/107 diseases for SPARC (see all 107):    About MalaCards

angle-closure glaucoma open-angle glaucoma primary angle-closure glaucoma gray platelet syndrome

malignant fibrous histiocytoma fibrous histiocytoma osteogenesis imperfecta diffuse large b-cell lymphoma

primary open angle glaucoma quebec platelet disorder osteofibrous dysplasia spinal stenosis

mccune albright syndrome lateral cystocele osteoblastoma b-cell lymphomas

acute myocardial infarction back pain fibrous dysplasia primitive neuroectodermal tumor

4 diseases from the University of Copenhagen DISEASES database for SPARC:

Parkinson's disease Cancer Lateral cystocele Akinetopsia

10/74 Novoseek disease relationships for SPARC gene (see all 74) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
osteosarcoma	63.3	27	8717113 (5), 1622861 (3), 1637573 (2), 2287591 (2) (see all 14)
gray platelet syndrome	62.1	2	1796754 (1), 1737102 (1)
calcification	59.7	25	7649376 (3), 10446063 (3), 16709694 (2), 18422975 (1) (see all 19)
osteofibrous dysplasia	45.9	5	10667418 (5)
bone tumor	43.9	7	2287591 (2), 8717113 (1), 1468768 (1), 1997469 (1) (see all 5)
tumors	36.2	175	12414657 (6), 16596217 (4), 10502421 (4), 18350569 (4) (see all 65)
chondrosarcoma mesenchymal	33.4	2	8717113 (1), 1997469 (1)
osteogenesis imperfecta	32.8	1	8725177 (1)
fibrous dysplasia	30.5	7	10667418 (5), 9403710 (1)
chondrosarcoma	28.7	16	1997469 (5), 19594492 (3), 8336066 (2), 8717113 (1) (see all 5)

Genetic Association Database (GAD): SPARC
Human Genome Epidemiology (HuGE) Navigator: SPARC (19 documents)

Export disorders for SPARC gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SPARC gene, integrated from 9 sources (see all 683):
(articles sorted by number of sources associating them with SPARC)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and complete amino acid sequences of human and murine basement membrane protein BM-40 (SPARC, osteonectin). (PubMed id 3410046)^{1, 2, 3} Lankat-Buttgereit B.... Krieg T. (1988)
Molecular analysis of the cDNA for human SPARC/osteonectin/BM-40: sequence, expression, and localization of the gene to chromosome 5q31- q33. (PubMed id 2838412)^{1, 2, 3} Swaroop A.... Francke U. (1988)
BM-40 (osteonectin, SPARC) is expressed both in the epidermal and in the dermal compartment of adult human skin. (PubMed id 9457905)^{1, 2, 9} Hunzelmann N.... Nischt R. (1998)
Association of novel polymorphisms with the expression of SPARC in normal fibroblasts and with susceptibility to scleroderma. (PubMed id 12428242)^{1, 4, 9} Zhou X....Arnett F.C. (2002)
Crystal structure of a pair of follistatin-like and EF-hand calcium- binding domains in BM-40. (PubMed id 9233787)^{1, 2, 9} Hohenester E.... Timpl R. (1997)
Gene polymorphisms, bone mineral density and bone mineral content in young children: the Iowa Bone Development Study. (PubMed id 12879219)^{1, 4, 9} Willing M.C....Levy S.M. (2003)
Single-nucleotide polymorphisms in the SPARC gene are not associated with susceptibility to scleroderma. (PubMed id 15546965)^{1, 4} Lagan A.L....Welsh K.I. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Crystal structure and mapping by site-directed mutagenesis of the collagen-binding epitope of an activated form of BM- 40/SPARC/osteonectin. (PubMed id 9501084)^{1, 2} Sasaki T.... Timpl R. (1998)
Structure of a novel extracellular Ca(2+)-binding module in BM-40. (PubMed id 8548457)^{1, 2} Hohenester E....Engel J. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6678	HGNC: 11219	AceView: SPARC	Ensembl:ENSG00000113140	euGenes: HUgn6678
ECgene: SPARC	H-InvDB: SPARC

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SPARC	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SPARC	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Osteonectin

Intellectual Property for SPARC gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SPARC gene:
Search GeneIP for patents involving SPARC

GeneCards and IP:
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SPARC Gene

secreted protein, acidic, cysteine-rich (osteonectin)

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Ossification Heterotopic
OSTEOFIBROUS DYSPLASIA
Retinoblastoma
Acute myocardial infarction
Bone Diseases
malignant fibrous histiocytoma
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SPARC Gene

secreted protein, acidic, cysteine-rich (osteonectin)

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