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Aliases for SPARC Gene

Aliases for SPARC Gene

  • Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) 2 3
  • Osteonectin 2 3 4
  • ON 3 4 6
  • Secreted Protein Acidic And Rich In Cysteine 3 4
  • Basement-Membrane Protein 40 3 4
  • Cysteine-Rich Protein 2 3
  • BM-40 3 4

External Ids for SPARC Gene

Previous HGNC Symbols for SPARC Gene

  • ON

Previous GeneCards Identifiers for SPARC Gene

  • GC05M151110
  • GC05M151025
  • GC05M151070
  • GC05M151021
  • GC05M146186

Summaries for SPARC Gene

Entrez Gene Summary for SPARC Gene

  • This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. [provided by RefSeq, Dec 2011]

GeneCards Summary for SPARC Gene

SPARC (Secreted Protein, Acidic, Cysteine-Rich (Osteonectin)) is a Protein Coding gene. Diseases associated with SPARC include lateral cystocele and chorioangioma. Among its related pathways are Hemostasis and Hemostasis. GO annotations related to this gene include calcium ion binding and extracellular matrix binding. An important paralog of this gene is SPARCL1.

UniProtKB/Swiss-Prot for SPARC Gene

  • Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity

Gene Wiki entry for SPARC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPARC Gene

Genomics for SPARC Gene

Regulatory Elements for SPARC Gene

Transcription factor binding sites by QIAGEN in the SPARC gene promoter:

Genomic Location for SPARC Gene

Start:
151,661,096 bp from pter
End:
151,687,165 bp from pter
Size:
26,070 bases
Orientation:
Minus strand

Genomic View for SPARC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPARC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPARC Gene

Proteins for SPARC Gene

  • Protein details for SPARC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09486-SPRC_HUMAN
    Recommended name:
    SPARC
    Protein Accession:
    P09486
    Secondary Accessions:
    • D3DQH9
    • Q6IBK4

    Protein attributes for SPARC Gene

    Size:
    303 amino acids
    Molecular mass:
    34632 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA60993.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SPARC Gene

neXtProt entry for SPARC Gene

Proteomics data for SPARC Gene at MOPED

Post-translational modifications for SPARC Gene

  • Glycosylation at Asn116
  • Modification sites at PhosphoSitePlus

Other Protein References for SPARC Gene

No data available for DME Specific Peptides for SPARC Gene

Domains for SPARC Gene

Graphical View of Domain Structure for InterPro Entry

P09486

UniProtKB/Swiss-Prot:

SPRC_HUMAN :
  • P09486
Domain:
  • Contains 1 EF-hand domain.
  • Contains 1 follistatin-like domain.
  • Contains 1 Kazal-like domain.
Family:
  • Belongs to the SPARC family.
genes like me logo Genes that share domains with SPARC: view

No data available for Gene Families for SPARC Gene

Function for SPARC Gene

Molecular function for SPARC Gene

GENATLAS Biochemistry: glycoprotein,acidic,cysteine rich,into the basement membrane,involved in extracellular matrix remodeling,interacting with collagen,thrombospondin,regulator of cell growth (osteonectin/BM40),and of activator of MMP2 at the cell surface,contributing to the proteolytic pathway associated with tumor invasion,overexpressed in hepatocellular carcinoma
UniProtKB/Swiss-Prot Function: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity

Gene Ontology (GO) - Molecular Function for SPARC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IDA 7034958
GO:0005515 protein binding IPI 18808384
GO:0005518 collagen binding IDA 7034958
GO:0050840 extracellular matrix binding IEA --
genes like me logo Genes that share ontologies with SPARC: view
genes like me logo Genes that share phenotypes with SPARC: view

Animal Models for SPARC Gene

MGI Knock Outs for SPARC:

miRNA for SPARC Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SPARC Gene

Localization for SPARC Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPARC Gene

Secreted, extracellular space, extracellular matrix, basement membrane. Note=In or around the basement membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPARC Gene COMPARTMENTS Subcellular localization image for SPARC gene
Compartment Confidence
extracellular 5
cytoskeleton 2
nucleus 2
golgi apparatus 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SPARC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix --
GO:0005604 basement membrane IEA --
GO:0005615 extracellular space IEA --
GO:0005622 intracellular --
genes like me logo Genes that share ontologies with SPARC: view

Pathways for SPARC Gene

genes like me logo Genes that share pathways with SPARC: view

Pathways by source for SPARC Gene

1 Cell Signaling Technology pathway for SPARC Gene
2 BioSystems pathways for SPARC Gene

Gene Ontology (GO) - Biological Process for SPARC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0001937 negative regulation of endothelial cell proliferation IDA 12867428
GO:0002576 platelet degranulation TAS --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with SPARC: view

Compounds for SPARC Gene

(2) HMDB Compounds for SPARC Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Copper
  • Cu
7440-50-8

(50) Novoseek inferred chemical compound relationships for SPARC Gene

Compound -log(P) Hits PubMed IDs
cysteine 72.5 101
hydroxyapatite 63.8 13
alizarin 63.1 2
procollagen 46.7 7
titanium 43.6 1
genes like me logo Genes that share compounds with SPARC: view

Transcripts for SPARC Gene

Unigene Clusters for SPARC Gene

Secreted protein, acidic, cysteine-rich (osteonectin):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPARC Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b · 11c
SP1:
SP2: - -
SP3: - - - - -
SP4:

Relevant External Links for SPARC Gene

GeneLoc Exon Structure for
SPARC
ECgene alternative splicing isoforms for
SPARC

Expression for SPARC Gene

mRNA expression in normal human tissues for SPARC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPARC Gene

This gene is overexpressed in Artery - Aorta (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPARC Gene

SOURCE GeneReport for Unigene cluster for SPARC Gene Hs.111779

genes like me logo Genes that share expressions with SPARC: view

No data available for mRNA Expression by UniProt/SwissProt for SPARC Gene

Orthologs for SPARC Gene

This gene was present in the common ancestor of animals.

Orthologs for SPARC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPARC 35
  • 99.34 (n)
  • 100 (a)
SPARC 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPARC 35
  • 92.96 (n)
  • 99.01 (a)
SPARC 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPARC 35
  • 92.63 (n)
  • 97.36 (a)
SPARC 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sparc 35
  • 88.3 (n)
  • 91.06 (a)
Sparc 16
Sparc 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPARC 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPARC 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sparc 35
  • 87.49 (n)
  • 90.37 (a)
chicken
(Gallus gallus)
Aves SPARC 35
  • 84.56 (n)
  • 86.24 (a)
SPARC 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPARC 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76263 35
sparc 35
  • 77 (n)
  • 81.67 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8852 35
zebrafish
(Danio rerio)
Actinopterygii sparc 35
  • 76.86 (n)
  • 78.69 (a)
sparc 36
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta BM-40-SPARC 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ost-1 36
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for SPARC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPARC Gene

ENSEMBL:
Gene Tree for SPARC (if available)
TreeFam:
Gene Tree for SPARC (if available)

Paralogs for SPARC Gene

Paralogs for SPARC Gene

Selected SIMAP similar genes for SPARC Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SPARC: view

Variants for SPARC Gene

Sequence variations from dbSNP and Humsavar for SPARC Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1023 -- 151,661,582(+) TATCT(C/G)TAAGG utr-variant-3-prime
rs3549 -- 151,661,589(+) AAGGG(C/G)AGTCT utr-variant-3-prime
rs707156 -- 151,661,627(+) AACAT(C/G)ATGAA utr-variant-3-prime
rs707157 -- 151,667,547(-) TGCGG(A/G/T)ACTGG missense, reference
rs724662 -- 151,671,432(-) CAGCA(G/T)GAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPARC Gene

Variant ID Type Subtype PubMed ID
dgv6360n71 CNV Loss 21882294
nsv883038 CNV Loss 21882294
nsv5069 CNV Insertion 18451855

Relevant External Links for SPARC Gene

HapMap Linkage Disequilibrium report
SPARC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPARC Gene

Disorders for SPARC Gene

(2) University of Copenhagen DISEASES for SPARC Gene

(74) Novoseek inferred disease relationships for SPARC Gene

Disease -log(P) Hits PubMed IDs
osteosarcoma 63.3 23
gray platelet syndrome 62.1 2
calcification 59.7 24
osteofibrous dysplasia 45.9 5
bone tumor 43.9 6

Relevant External Links for SPARC

Genetic Association Database (GAD)
SPARC
Human Genome Epidemiology (HuGE) Navigator
SPARC
genes like me logo Genes that share disorders with SPARC: view

No data available for UniProtKB/Swiss-Prot for SPARC Gene

Publications for SPARC Gene

  1. Crystal structure of a pair of follistatin-like and EF-hand calcium- binding domains in BM-40. (PMID: 9233787) Hohenester E. … Timpl R. (EMBO J. 1997) 3 4 23
  2. BM-40 (osteonectin, SPARC) is expressed both in the epidermal and in the dermal compartment of adult human skin. (PMID: 9457905) Hunzelmann N. … Nischt R. (J. Invest. Dermatol. 1998) 3 4 23
  3. Association of novel polymorphisms with the expression of SPARC in normal fibroblasts and with susceptibility to scleroderma. (PMID: 12428242) Zhou X. … Arnett F.C. (Arthritis Rheum. 2002) 3 23 48
  4. Gene polymorphisms, bone mineral density and bone mineral content in young children: the Iowa Bone Development Study. (PMID: 12879219) Willing M.C. … Levy S.M. (Osteoporos Int 2003) 3 23 48
  5. SPARC gene polymorphism in renal transplant patients with gingival overgrowth. (PMID: 17970686) Drozdzik A. … Drozdzik M. (J. Periodontol. 2007) 3 23 48

Products for SPARC Gene

Sources for SPARC Gene

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