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SPARC Gene

protein-coding   GIFtS: 69
GCID: GC05M151021

Secreted Protein, Acidic, Cysteine-Rich (Osteonectin)


(Previous symbol: ON)
  See SPARC-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Secreted Protein, Acidic, Cysteine-Rich (Osteonectin)1 2     Basement-Membrane Protein 402 3
ON1 2 3 5     Secreted Protein Acidic And Rich In Cysteine2 3
Cysteine-Rich Protein1 2     BM-402 3
osteonectin1 2     Osteonectin3

External Ids:    HGNC: 112191   Entrez Gene: 66782   Ensembl: ENSG000001131407   OMIM: 1821205   UniProtKB: P094863   

Export aliases for SPARC gene to outside databases

Previous GC identifers: GC05M151110 GC05M151639 GC05M151025 GC05M151070 GC05M146186


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SPARC Gene:
This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the
collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of
changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated
with metastasis based on changes to cell shape which can promote tumor cell invasion. (provided by RefSeq, Dec
2011)

GeneCards Summary for SPARC Gene:
SPARC (secreted protein, acidic, cysteine-rich (osteonectin)) is a protein-coding gene. Diseases associated with SPARC include lateral cystocele, and chorioangioma. GO annotations related to this gene include extracellular matrix binding and calcium ion binding. An important paralog of this gene is SPARCL1.

UniProtKB/Swiss-Prot: SPRC_HUMAN, P09486
Function: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds
calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two
calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that
binds a Ca(2+) ion with a high affinity

Gene Wiki entry for SPARC (Osteonectin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_029289.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPARC gene promoter:
         AML1a   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPARC promoter sequence
   Search Chromatin IP Primers for SPARC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPARC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.3-q32   Ensembl cytogenetic band:  5q33.1   HGNC cytogenetic band: 5q31-q33

SPARC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPARC gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M151021:  view genomic region     (about GC identifiers)

Start:
151,040,657 bp from pter      End:
151,066,726 bp from pter
Size:
26,070 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SPRC_HUMAN, P09486 (See protein sequence)
Recommended Name: SPARC precursor  
Size: 303 amino acids; 34632 Da
Developmental stage: Expressed at high levels in tissues undergoing morphogenesis, remodeling and wound repair
Sequence caution: Sequence=AAA60993.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of
unknown origin in the C-terminal part;
4 PDB 3D structures from and Proteopedia for SPARC:
1BMO (3D)        1NUB (3D)        1SRA (3D)        2V53 (3D)    
Secondary accessions: D3DQH9 Q6IBK4

Explore the universe of human proteins at neXtProt for SPARC: NX_P09486

Explore proteomics data for SPARC at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn116

  • See SPARC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003109.1  
    ENSEMBL proteins: 
     ENSP00000231061   ENSP00000440127   ENSP00000428119   ENSP00000444998   ENSP00000429152  
    Reactome Protein details: P09486

    SPARC Human Recombinant Protein Products:

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    Novus Biologicals SPARC Protein
    Novus Biologicals SPARC Lysate
    Sino Biological Recombinant Protein for SPARC
    Sino Biological Cell Lysate for SPARC
    ProSpec Recombinant Protein for SPARC
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SPARC 

     
    antibodies-online proteins for SPARC (50 products) 

     
    antibodies-online peptides for SPARC

    SPARC Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SPARC
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    Abcam antibodies for SPARC
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for SPARC
    antibodies-online antibodies for SPARC (117 products) 

    SPARC Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for SPARC         (see all)
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
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    antibodies-online kits for SPARC (43 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR018247 EF_Hand_1_Ca_BS
     IPR002350 Kazal_dom
     IPR011992 EF-hand-dom_pair
     IPR019577 SPARC/Testican_Ca-bd-dom
     IPR001999 Osteonectin_CS

    Graphical View of Domain Structure for InterPro Entry P09486

    ProtoNet protein and cluster: P09486

    2 Blocks protein domains:
    IPB001999 Osteonectin-like
    IPB003645 Follistatin-like


    UniProtKB/Swiss-Prot: SPRC_HUMAN, P09486
    Similarity: Belongs to the SPARC family
    Similarity: Contains 1 EF-hand domain
    Similarity: Contains 1 follistatin-like domain
    Similarity: Contains 1 Kazal-like domain


    Find genes that share domains with SPARC           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPRC_HUMAN, P09486
    Function: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds
    calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two
    calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that
    binds a Ca(2+) ion with a high affinity

         Genatlas biochemistry entry for SPARC:
    glycoprotein,acidic,cysteine rich,into the basement membrane,involved in extracellular matrix
    remodeling,interacting with collagen,thrombospondin,regulator of cell growth (osteonectin/BM40),and of activator
    of MMP2 at the cell surface,contributing to the proteolytic pathway associated with tumor invasion,overexpressed
    in hepatocellular carcinoma

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI18808384
    GO:0005518collagen binding TAS7034958
    GO:0050840extracellular matrix binding IEA--
         
    Find genes that share ontologies with SPARC           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Sparc):
     behavior/neurological  craniofacial  hematopoietic system  homeostasis/metabolism  immune system 
     skeleton  tumorigenesis  vision/eye 

    Find genes that share phenotypes with SPARC           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for SPARC: Sparctm1Anjm Sparctm1Hwe

       genOway: Develop your customized and physiologically relevant rodent model for SPARC

    miRNA
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    miRTarBase miRNAs that target SPARC:
    hsa-mir-29a-3p (MIRT006175), hsa-mir-10a-5p (MIRT047698), hsa-mir-192-5p (MIRT004126), hsa-mir-29c-3p (MIRT001922)

    Block miRNA regulation of human, mouse, rat SPARC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SPARC (see all 25):
    hsa-miR-34b* hsa-miR-495 hsa-miR-4263 hsa-miR-29c hsa-miR-29a hsa-miR-3653 hsa-miR-1205 hsa-miR-204
    SwitchGear 3'UTR luciferase reporter plasmidSPARC 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SPARC
    Predesigned siRNA for gene silencing in human, mouse, rat SPARC

    Gene Editing
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPARC

    Cell Line
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-11122) for SPARC 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPRC_HUMAN, P09486: Secreted, extracellular space, extracellular matrix, basement membrane. Note=In or around
    the basement membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytoskeleton2
    nucleus2
    golgi apparatus1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix TAS7034958
    GO:0005604basement membrane IEA--
    GO:0005615extracellular space IEA--
    GO:0005622intracellular ----

    Find genes that share ontologies with SPARC           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SPARC About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Response to elevated platelet cytosolic Ca2+
    Response to elevated platelet cytosolic Ca2+0.94
    Platelet degranulation0.94
    2Binding and Uptake of Ligands by Scavenger Receptors
    Binding and Uptake of Ligands by Scavenger Receptors0.53
    Scavenging by Class H Receptors0.00
    3Hemostasis
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43
    4Degradation of the extracellular matrix
    Extracellular matrix organization0.34
    5Cell adhesion ECM remodeling
    Cell adhesion ECM remodeling0.31


    Find genes that share SuperPaths with SPARC           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SPARC
        Wnt / Hedgehog / Notch

    1 GeneGo (Thomson Reuters) Pathway for SPARC
        Cell adhesion ECM remodeling

    2 BioSystems Pathways for SPARC
        Senescence and Autophagy
    TGF-beta Receptor Signaling Pathway


    3 Reactome Pathways for SPARC
        Scavenging by Class H Receptors
    ECM proteoglycans
    Platelet degranulation


        Pathway & Disease-focused RT2 Profiler PCR Arrays including SPARC: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Cellular Senescence in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SPARC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SPARC (P094861, 2, 3 ENSP000002310614) via UniProtKB, MINT, STRING, and/or I2D (see all 63)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    XRCC6P129562, 3, ENSP000003522574MINT-8271916 I2D: score=2 STRING: ENSP00000352257
    ZNF579Q8NAF02, 3, ENSP000003201884MINT-8271927 I2D: score=2 STRING: ENSP00000320188
    COL3A1P024613, ENSP000003044084I2D: score=4 STRING: ENSP00000304408
    COL1A1P024523, ENSP000002259644I2D: score=3 STRING: ENSP00000225964
    PDGFAP040853, ENSP000003465084I2D: score=3 STRING: ENSP00000346508
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0002576platelet degranulation TAS--
    GO:0007165signal transduction IEA--
    GO:0007507heart development IEA--
    GO:0007596blood coagulation TAS--

    Find genes that share ontologies with SPARC           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPARC (SPRC)

    2 HMDB Compounds for SPARC    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    CopperCu (see all 2)7440-50-8--

    Selected Novoseek inferred chemical compound relationships for SPARC gene (see all 50)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 72.5 158 15838642 (2), 9008236 (2), 1555584 (1), 8500547 (1) (see all 99)
    hydroxyapatite 63.8 17 8547349 (3), 8443690 (1), 17579299 (1), 17266017 (1) (see all 11)
    alizarin 63.1 2 19642865 (1), 17177849 (1)
    procollagen 46.7 7 8826089 (2), 14722903 (1), 9173088 (1), 12381951 (1) (see all 6)
    titanium 43.6 2 12419636 (1)
    dexamethasone 40.2 14 16934542 (1), 7953977 (1), 15988617 (1), 8275945 (1) (see all 9)
    octacalcium phosphate 33.6 2 8443690 (1)
    thymidine 32.9 7 8419407 (2), 17066632 (1), 7649376 (1), 14765266 (1) (see all 5)
    ascorbic acid 31.1 3 9495521 (1), 16934542 (1)
    calcium 29.2 35 1555584 (5), 7563094 (4), 10446063 (3), 15065403 (2) (see all 18)



    Find genes that share compounds with SPARC           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SPARC gene: 
    NM_003118.3  

    Unigene Cluster for SPARC:

    Secreted protein, acidic, cysteine-rich (osteonectin)
    Hs.111779  [show with all ESTs]
    Unigene Representative Sequence: AK126525
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000231061(uc003lug.3 uc003lui.3) ENST00000520687 ENST00000538026
    ENST00000537849 ENST00000521569 ENST00000524277 ENST00000539687 ENST00000521327
    ENST00000522348
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SPARC (see all 25):
    hsa-miR-34b* hsa-miR-495 hsa-miR-4263 hsa-miR-29c hsa-miR-29a hsa-miR-3653 hsa-miR-1205 hsa-miR-204
    SwitchGear 3'UTR luciferase reporter plasmidSPARC 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: SPARC (NM_003118)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat SPARC
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    Flow Cytometry
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    Additional mRNA sequence: 

    AK096969.1 AK126525.1 AK299441.1 AK315591.1 AY545555.1 BC004974.1 BC008011.1 BC072457.1 
    CR456799.1 J03040.1 Y00755.1 

    Selected DOTS entries (see all 93):

    DT.80101600  DT.100060104  DT.95194845  DT.100060108  DT.101986038  DT.91856216  DT.100702514  DT.100702534 
    DT.95275147  DT.100853342  DT.100702480  DT.100702495  DT.100702491  DT.91782050  DT.100638608  DT.97821055 
    DT.100702493  DT.97777033  DT.100702535  DT.91849618  DT.120857232  DT.100702545  DT.120857190  DT.100767409 

    Selected AceView cDNA sequences (see all 2827):

    AI753028 AI753681 BQ233316 BG537456 BQ719932 CF131481 BU627835 BI905914 
    BG025233 AI754674 BM510534 AA384171 AL540459 CN483158 CA414549 BX446387 
    CA771079 BU855878 BQ638713 AL697637 AA156221 BU615824 AA167278 BG109291 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SPARC    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b · 11c
    SP1:                                                                                                            
    SP2:                                -     -                                                                     
    SP3:                                      -     -     -     -     -                                             
    SP4:                                                                                                            


    ECgene alternative splicing isoforms for SPARC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SPARC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTGAAGAG
    SPARC Expression
    About this image


    SPARC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 30) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 16 entries
             Endochondral Preosteoblasts Caudal Endochondral Bones
             Bone Marrow
     
     Hypoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Parietal Endoderm Cells Hypoblast
             Extraembryonic endoderm-like cells
     
     Tooth (Integumentary System)    fully expand to see all 4 entries
             Stem cells from human exfoliated deciduous teeth (family)
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Hippocampus
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    SPARC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPARC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.111779
        Pathway & Disease-focused RT2 Profiler PCR Arrays including SPARC: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Cellular Senescence in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPARC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SPARC gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sparc1 , 5 secreted acidic cysteine rich glycoprotein1, 5 88.3(n)1
    91.06(a)1
      11 (33.04 cM)5
    206921  NM_009242.41  NP_033268.11 
     553945005 
    chicken
    (Gallus gallus)
    Aves SPARC1 secreted protein, acidic, cysteine-rich (osteonectin) 84.56(n)
    86.24(a)
      386571  NM_204410.1  NP_989741.1 
    lizard
    (Anolis carolinensis)
    Reptilia SPARC6
    secreted protein, acidic, cysteine-rich (osteonect...
    88(a)
    1 ↔ 1
    1(152369324-152401409)
    African clawed frog
    (Xenopus laevis)
    Amphibia BQ884411.12   -- 88.23(n)    BQ884411.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sparc1 secreted acidic cysteine rich glycoprotein 76.86(n)
    78.69(a)
      321357  NM_001001942.1  NP_001001942.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta BM-40-SPARC6
    BM-40-SPARC
    25(a)
    1 → many
    3R(22694960-22697738)
    worm
    (Caenorhabditis elegans)
    Secernentea ost-16
    Protein OST-1 (ost-1) mRNA, complete cds
    33(a)
    1 → many
    IV(1107396-1110860) WBGene00003893


    ENSEMBL Gene Tree for SPARC (if available)
    TreeFam Gene Tree for SPARC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SPARC gene
    SPARCL12  
    2 SIMAP similar genes for SPARC using alignment to 7 protein entries:     SPRC_HUMAN (see all proteins):
    SPARCL1    SMOC2

    Find genes that share paralogs with SPARC           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SPARC (see all 700)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2014228181,2
    C--151040160(+) TAAAA-/TTTTTT 1 -- int10--------
    rs577321451,2
    C--151040166(+) TTTTTG/TTTTTT 1 -- int10--------
    rs757257131,2
    C--151040179(+) TTTTTA/TAAAAA 1 -- int10--------
    rs23471231,2
    C--151040180(+) TTTTTT/AAAAAA 1 -- int11Minor allele frequency- A:0.00NA 2
    rs1407445121,2
    --151040180(+) TTTTT-/AAAAAAAT 1 -- int10--------
    rs23471241,2
    C--151040181(+) TTTTAT/AAAAAA 1 -- int11Minor allele frequency- A:0.00NA 2
    rs1826384071,2
    --151040213(+) GACAGA/GTAGAA 1 -- int10--------
    rs799056971,2
    --151040265(+) AGGGAC/TCCTGT 1 -- int10--------
    rs68988151,2
    C,F,A--151040266(+) GGGACC/GCTGTT 1 -- int111Minor allele frequency- G:0.36NA CSA WA EA 510
    rs1422327571,2
    --151040335(+) CGCCCA/GGGGCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for SPARC (151040657 - 151066726 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SPARC:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5069CNV Insertion18451855
    dgv6360n71CNV Loss21882294
    nsv883038CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SPARC
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 182120    OMIM disorders: --

    7 diseases for SPARC:    
    About MalaCards
    lateral cystocele    chorioangioma    osteoblastoma    clear cell chondrosarcoma
    quebec platelet disorder    osteofibrous dysplasia    gray platelet syndrome

    2 diseases from the University of Copenhagen DISEASES database for SPARC:
    Cancer     Lateral cystocele

    Find genes that share disorders with SPARC           About GenesLikeMe

    Selected Novoseek inferred disease relationships for SPARC gene (see all 74)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteosarcoma 63.3 27 8717113 (5), 1622861 (3), 1637573 (2), 2287591 (2) (see all 14)
    gray platelet syndrome 62.1 2 1796754 (1), 1737102 (1)
    calcification 59.7 25 7649376 (3), 10446063 (3), 16709694 (2), 18422975 (1) (see all 19)
    osteofibrous dysplasia 45.9 5 10667418 (5)
    bone tumor 43.9 7 2287591 (2), 8717113 (1), 1468768 (1), 1997469 (1) (see all 5)
    tumors 36.2 175 12414657 (6), 16596217 (4), 10502421 (4), 18350569 (4) (see all 65)
    chondrosarcoma mesenchymal 33.4 2 8717113 (1), 1997469 (1)
    osteogenesis imperfecta 32.8 1 8725177 (1)
    fibrous dysplasia 30.5 7 10667418 (5), 9403710 (1)
    chondrosarcoma 28.7 16 1997469 (5), 19594492 (3), 8336066 (2), 8717113 (1) (see all 5)

    Genetic Association Database (GAD): SPARC
    Human Genome Epidemiology (HuGE) Navigator: SPARC (19 documents)

    Export disorders for SPARC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPARC gene, integrated from 10 sources (see all 705):
    (articles sorted by number of sources associating them with SPARC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and complete amino acid sequences of human and murine basement membrane protein BM-40 (SPARC, osteonectin). (PubMed id 3410046)1, 2, 3 Lankat-Buttgereit B.... Krieg T. (FEBS Lett. 1988)
    2. Molecular analysis of the cDNA for human SPARC/osteonectin/BM-40: sequence, expression, and localization of the gene to chromosome 5q31- q33. (PubMed id 2838412)1, 2, 3 Swaroop A.... Francke U. (Genomics 1988)
    3. BM-40 (osteonectin, SPARC) is expressed both in the epidermal and in the dermal compartment of adult human skin. (PubMed id 9457905)1, 2, 9 Hunzelmann N.... Nischt R. (J. Invest. Dermatol. 1998)
    4. Association of novel polymorphisms with the expression of SPARC in normal fibroblasts and with susceptibility to scleroderma. (PubMed id 12428242)1, 4, 9 Zhou X....Arnett F.C. (Arthritis Rheum. 2002)
    5. Crystal structure of a pair of follistatin-like and EF-hand calcium- binding domains in BM-40. (PubMed id 9233787)1, 2, 9 Hohenester E.... Timpl R. (EMBO J. 1997)
    6. SPARC gene polymorphism in renal transplant patients with gingival overgrowth. (PubMed id 17970686)1, 4, 9 Drozdzik A....Drozdzik M. (J. Periodontol. 2007)
    7. Gene polymorphisms, bone mineral density and bone mineral content in young children: the Iowa Bone Development Study. (PubMed id 12879219)1, 4, 9 Willing M.C....Levy S.M. (Osteoporos Int 2003)
    8. Evaluation of SPARC as a candidate gene of juvenile-onset primary open-angle glaucoma by mutation and copy number analyses. (PubMed id 21042566)1, 4 Chen L.J....Pang C.P. (Mol. Vis. 2010)
    9. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    10. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6678 HGNC: 11219 AceView: SPARC Ensembl:ENSG00000113140 euGenes: HUgn6678
    ECgene: SPARC H-InvDB: SPARC

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SPARC Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SPARC Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Osteonectin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SPARC gene:
    Search GeneIP for patents involving SPARC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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