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SPARC Gene

protein-coding GIFtS: 66

GC05M151021

secreted protein, acidic, cysteine-rich (osteonectin)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ON)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BM-40 ^³
ON ^², ³, ⁵
Osteonectin ^³
osteonectin ^²

Descriptions
Basement-membrane protein 40 ^³
Secreted protein acidic and rich in cysteine ^³
cysteine-rich protein ^²
secreted protein, acidic, cysteine-rich ^²
secreted protein, acidic, cysteine-rich (osteonectin) ^²

External Ids
HGNC: 11219¹
Entrez Gene: 6678²
UniProtKB: P09486³
Ensembl: ENSG00000113140⁷

Search outside databases for aliases for SPARC gene

Previous GC identifers: GC05M151110 GC05M151639 GC05M151025 GC05M151070

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for SPARC:

Secreted protein acidic and rich in cysteine/osteonectin/BM40, or SPARC, is a matrix-associated

protein that elicits changes in cell shape, inhibits cell-cycle progression, and influences the

synthesis of extracellular matrix (ECM) (Bradshaw et al., 2003 [PubMed 12721366]).[supplied by

OMIM]

UniProtKB/Swiss-Prot: SPRC_HUMAN, P09486

Function: Appears to regulate cell growth through interactions with the extracellular matrix and

cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and

cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+)

with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity

Gene Wiki entry for SPARC (Osteonectin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SPARC gene

Entrez Gene cytogenetic band: 5q31.3-q32 Ensembl cytogenetic band: 5q33.1 HGNC cytogenetic band: 5q31-q33

SPARC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M151021: (about GC identifiers)

Start:	151,021,201 bp from pter
End:	151,046,710 bp from pter
Size:	25,510 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000005.8 NT_029289.10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: SPRC_HUMAN, P09486 (See protein sequence)

Recommended Name: SPARC precursor

Size: 303 amino acids; 34632 Da

Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane.

Note=In or around the basement membrane

Developmental stage: Expressed at high levels in tissues undergoing morphogenesis, remodeling and

wound repair

PDB structures from and Proteopedia :

1BMO (3D)

1NUB (3D)

1SRA (3D)

2V53 (3D)

REFSEQ proteins: NP_003109.1

ENSEMBL proteins:

ENSP00000231061

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for SPARC (SPARC/Osteonectin)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (SPARC)
	Human Recombinant Proteins from Abnova (SPARC)

OriGene Purified Recombinant Human Protein: SPARC

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	14718574
GO:0005604	basement membrane	IEA	--
GO:0031093	platelet alpha granule lumen	EXP	1737102

About this table

Antibodies for SPARC:

	Invitrogen Antibodies for SPARC
	Millipore Mono- and Polyclonal Antibodies for the study of SPARC
	Sigma-Aldrich Antibodies for SPARC
	R&D Systems Antibodies for SPARC (SPARC/Osteonectin)
	Antibodies from Abcam (SPARC), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (SPARC)
	Novus Biologicals Antibodies for SPARC

Assays for SPARC:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P09486

ProtoNet protein and cluster: P09486

2 Blocks protein families:

IPB001999 Osteonectin-like

IPB003645 Follistatin-like

UniProtKB/Swiss-Prot: SPRC_HUMAN, P09486

Similarity: Belongs to the SPARC family

Similarity: Contains 1 EF-hand domain

Similarity: Contains 1 follistatin-like domain

Similarity: Contains 1 Kazal-like domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SPARC)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SPARC)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003118

Applied Biosystems Silencer® siRNAs for SPARC

Sigma-Aldrich siRNA for SPARC

Sigma-Aldrich shRNA Panels and shRNA for SPARC

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for SPARC
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003118
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003118
untagged cDNA clone in CMV expression vector: NM_003118

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003118

UniProtKB/Swiss-Prot: SPRC_HUMAN, P09486

Function: Appears to regulate cell growth through interactions with the extracellular matrix and

cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and

cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+)

with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity

Genatlas biochemistry entry for SPARC:

glycoprotein,acidic,cysteine rich,into the basement membrane,involved in extracellular matrix

remodeling,interacting with collagen,thrombospondin,regulator of cell growth

(osteonectin/BM40),and of activator of MMP2 at the cell surface,contributing to the proteolytic

pathway associated with tumor invasion,overexpressed in hepatocellular carcinoma

7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Sparc):

behavior/neurological	hematopoietic system	homeostasis/metabolism	immune system	skeleton
tumorigenesis	vision/eye

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005507	copper ion binding	IEA	--
GO:0005509	calcium ion binding	TAS	7034958
GO:0005518	collagen binding	TAS	7034958

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for SPARC

5/56 Interacting proteins for SPARC (ENSP00000231061³) via UniProtKB, MINT, and/or STRING (see all 56 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
COL1A1	ENSP00000225964³	STRING (score=.994)
PLG	ENSP00000308938³	STRING (score=.976)
COL1A2	ENSP00000297268³	STRING (score=.936)
VTN	ENSP00000226218³	STRING (score=.936)
COL3A1	ENSP00000304408³	STRING (score=.925)

About this table

4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001503	ossification	TAS	7034958
GO:0007165	signal transduction	IEA	--
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	NAS	15609325
GO:0042127	regulation of cell proliferation	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for SPARC
10/28 Novoseek chemical compound relationships for SPARC gene (see all 28 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hydroxyapatite	64.19	16	8547349 (3), 8443690 (1), 17579299 (1), 17266017 (1) (see all 10)
alizarin	52.64	1	17177849 (1)
procollagen	48.44	7	8826089 (2), 14722903 (1), 9173088 (1), 12381951 (1) (see all 6)
titanium	41.50	2	12419636 (1)
octacalcium phosphate	36.01	2	8443690 (1)
thymidine	34.36	7	8419407 (2), 17066632 (1), 7649376 (1), 14765266 (1) (see all 5)
calcium	24.57	32	1555584 (5), 7563094 (4), 10446063 (3), 15065403 (2) (see all 15)
heparan sulfate	23.84	1	9164872 (1)
tgf beta1	19.97	2	15668800 (1), 10453937 (1)
hydroxyproline	17.02	4	18487610 (1), 1927060 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SPARC)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SPARC)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003118

Sigma-Aldrich siRNA for SPARC

Sigma-Aldrich shRNA Panels and shRNA for SPARC

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003118

REFSEQ mRNAs for SPARC gene:

NM_003118.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003118

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003118
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003118
                                 untagged cDNA clone in CMV expression vector: NM_003118

Additional cDNA sequence:

AK096969.1 AK126525.1 AK299441.1 AK315591.1 AY545555.1 BC004974.1 BC008011.1 BC072457.1

CR456799.1 CR590539.1 CR591920.1 CR592746.1 CR595836.1 CR597190.1 CR598169.1 CR602678.1

CR603121.1 CR604100.1 CR604469.1 CR604596.1 CR605054.1 CR606233.1 CR609302.1 CR610277.1

CR611574.1 CR611642.1 CR611817.1 CR611867.1 CR612102.1 CR612789.1 CR613247.1 CR613457.1

CR615120.1 CR616783.1 CR617910.1 CR622084.1 CR623565.1 CR623752.1 CR625661.1 CR625859.1

CR626474.1 J03040.1 Y00755.1

24/94 DOTS entries (see all 94 ):

DT.80101600 DT.100060104 DT.95194845 DT.101986038 DT.100060108 DT.91856216 DT.100702514 DT.100702534

DT.100702480 DT.100853342 DT.95275147 DT.100702495 DT.100702491 DT.91782050 DT.100638608 DT.97821055

DT.100702493 DT.97777033 DT.100702535 DT.91849618 DT.120857232 DT.100035054 DT.120857190 DT.100702545

24/2827 AceView cDNA sequences (see all 2827 ):

BX351881 AL551854 AW069491 BE386253 BQ420907 BX439107 CR592148 CR626474

AI659571 CR593385 CN480225 CR613247 BU616361 CN480235 BP373198 BQ181715

AW069873 BI492588 AL541687 CA412333 BQ684596 BU855941 BM989743 BQ684442

highest scoring ESTs for SPARC:

J03040 AL540785 AL541129 AL542518 AL542739 AL543216 AL551204 AL552240 AL552491 AL552739

Unigene Cluster for SPARC:

Secreted protein, acidic, cysteine-rich (osteonectin)

Hs.111779 [show with all ESTs]

Unigene Representative Sequence: AK126525

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for SPARC

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	·	5c	^	6	^	7	^	8	^	9a	·	9b	^	10a	·	10b	·	10c	^	11a	·	11b	·	11c
SP1:
SP2:											-		-
SP3:													-		-		-		-		-
SP4:

About this scheme

ECgene alternative splicing isoforms for SPARC

1 Ensembl transcript including schematic representation:

ENST00000231061

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

SPARC expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SPARC

¹ / ² / ³

7 probe-sets matching SPARC gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
73433_at²^{, 3}	U95-E	1	1.00	1.00	0.97	1.18	AI754769	0.60	1.00	0.82	1
671_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.93	J03040	1.00	1.00	1.00	1
71862_at*²^{, 3}	U95-E	1	0.94	1.00	0.57	0.89	AA127769	0.40	1.00	0.76	1
212667_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AL575922	0.40	1.00	0.76	1
200665_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003118	0.60	1.00	0.82	1
212667_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
200665_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAATGCTTGG

SOURCE GeneReport for Unigene cluster: Hs.111779
Expression variation in blood from EXPOLDB for SPARC

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SPARC gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SPARC¹	--	secreted protein, acidic, cysteine-rich (osteonectin)	92.63(n) 97.36(a)	612159 XM_849889.1 XP_854982.1
chimpanzee (Pan troglodytes)	SPARC¹	--	secreted protein, acidic, cysteine-rich (osteonectin)	99.34(n) 100(a)	471709 XM_527087.2 XP_527087.2
cow (Bos taurus)	SPARC¹	--	secreted protein, acidic, cysteine-rich (osteonectin)	92.96(n) 99.01(a)	282077 NM_174464.2 NP_776889.1
rat (Rattus norvegicus)	Sparc¹	--	secreted protein, acidic, cysteine-rich (osteonectin)	89.26(n) 93.02(a)	24791 NM_012656.1 NP_036788.1
mouse (Mus musculus)	Sparc^{1, 5}	11 (29.90 cM)⁵	secreted acidic cysteine rich glycoprotein^{1, 5}	89.74(n)¹ 92.72(a)¹	20692¹ NM_009242.2¹ NP_033268.1¹ AA517111⁵ AK003162⁵ (see all 36)

About this table Species with no ortholog for SPARC

ENSEMBL Gene Tree for SPARC

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SPARC gene

SPARCL1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/205 NCBI SNPs in SPARC are shown (see all 205 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 110)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs3549^1,2	A,C,F,H,O	151021343(+)	`AAGGGG/CAGTCT`	1	--	ut3¹ ese³		8		MN EU EA WA NA	738
	rs1545030^1,2	A,C,F,H,O	151047605(+)	`TATTTT/CGTGCC`	1	--	ng3¹ tfbs³		8		EU EA WA NA	636
	rs3210714^1,2	A,C,F,H,O	151022125(-)	`CACATG/AAGCAT`	1	--	ut3¹ ese³		8		MN NA EU EA WA	742
	rs1054204^1,2	A,C,F,H	151022743(-)	`GCTGTG/CTTATG`	1	--	ut3¹ ese³		15		EA MN NA EU WA	2436
	rs707156^1,2	A,C,F,H	151021381(+)	`AACATG/CATGAA`	1	--	ut3¹ ese³		8		MN EU EA WA NA	742
	rs1059829^1,2	A,C,F,H	151022222(-)	`AAATCC/TTTCAA`	1	--	ut3¹		9		MN EA NA EU WA	818
	rs6874468^1,2	C,F,H	151035888(+)	`TACAGG/AGGCTG`	1	S/P	mis¹		9		EU EA WA NA	916
	rs4958278^1,2	A,C,F	151021077(+)	`CTCTCT/CACAGA`	1	--	ng5¹		3		NA	142
	rs1053411^1,2	A,C,F	151023296(-)	`ATTCTC/GTCTTT`	1	--	ut3¹ trp³		5		EA MN NA	1638
--	rs4958282^1,2	A,C	151048706(+)	`ctctcA/Taagtg`	1	--	ng3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for SPARC (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 182120

10/74 Novoseek disease relationships for SPARC gene (see all 74 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
osteosarcoma	64.92	27	8717113 (5), 1622861 (3), 1637573 (2), 2287591 (2) (see all 14)
gray platelet syndrome	63.42	2	1796754 (1), 1737102 (1)
calcification	57.93	24	7649376 (3), 10446063 (3), 16709694 (2), 18422975 (1) (see all 18)
osteofibrous dysplasia	47.70	5	10667418 (5)
bone tumor	46.15	7	2287591 (2), 8717113 (1), 1468768 (1), 1997469 (1) (see all 5)
tumors	36.13	164	12414657 (6), 16596217 (4), 10502421 (4), 17487382 (4) (see all 59)
chondrosarcoma mesenchymal	35.16	2	8717113 (1), 1997469 (1)
osteogenesis imperfecta	34.75	1	8725177 (1)
fibrous dysplasia	32.39	7	10667418 (5), 9403710 (1)
ossification heterotopic	29.85	1	8291407 (1)

About this table

1 PharmGKB disease relationship for SPARC gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872 12730115

About this table

Genetic Association Database: SPARC
Human Genome Epidemiology Navigator: SPARC (9 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

A Simple Tool Can Enhance How Diabetics Take Their Medications

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/551 PubMed articles for SPARC gene (see all 551 ):

Cloning and complete amino acid sequences of human and murine basement membrane protein BM-40 (SPARC, osteonectin). (PubMed id 3410046)^{2, 3, 4} Lankat-Buttgereit B....Krieg T. (1988)
Molecular analysis of the cDNA for human SPARC/osteonectin/BM-40: sequence, expression, and localization of the gene to chromosome 5q31- q33. (PubMed id 2838412)^{2, 3, 4} Swaroop A.... Francke U. (1988)
BM-40 (osteonectin, SPARC) is expressed both in the epidermal and in the dermal compartment of adult human skin. (PubMed id 9457905)^{1, 3, 4} Hunzelmann N.... Nischt R. (1998)
Association of novel polymorphisms with the expression of SPARC in normal fibroblasts and with susceptibility to scleroderma. (PubMed id 12428242)^{1, 3, 6} Zhou X....Arnett F.C. (2002)
Crystal structure of a pair of follistatin-like and EF-hand calcium- binding domains in BM-40. (PubMed id 9233787)^{1, 3, 4} Hohenester E.... Timpl R. (1997)
Gene polymorphisms, bone mineral density and bone mineral content in young children: the Iowa Bone Development Study. (PubMed id 12879219)^{1, 3, 6} Willing M.C....Levy S.M. (2003)
Single-nucleotide polymorphisms in the SPARC gene are not associated with susceptibility to scleroderma. (PubMed id 15546965)^{3, 6} Lagan A.L....Welsh K.I. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Crystal structure and mapping by site-directed mutagenesis of the collagen-binding epitope of an activated form of BM- 40/SPARC/osteonectin. (PubMed id 9501084)^{3, 4} Sasaki T.... Timpl R. (1998)
Structure of a novel extracellular Ca(2+)-binding module in BM-40. (PubMed id 8548457)^{3, 4} Hohenester E....Engel J. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6678	HGNC: 11219	AceView: SPARC	Ensembl:ENSG00000113140	euGenes: HUgn6678
ECgene: SPARC	H-InvDB: SPARC

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for SPARC	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Osteonectin

Licensable Technologies for SPARC
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for SPARC:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SPARC-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SPARC		Antibodies for SPARC
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for SPARC		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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	Recombinant Proteins (SPARC)
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	Chimera RNAi (SPARC)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (SPARC)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

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Antibodies for SPARC

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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SPARC Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for SPARC

Summaries
for SPARC

Genomic Location
for SPARC

Proteins
for SPARC

Protein Domains/
Families
for SPARC

Gene Function
for SPARC

Pathways & Interactions
for SPARC

Drugs & Compounds
for SPARC

Transcripts
for SPARC

Expression
for SPARC

Orthologs
for SPARC

Paralogs
for SPARC

SNPs/Variants
for SPARC

Disorders & Mutations
for SPARC

Medical News
for SPARC

Publications
for SPARC

Search for SPARC

Genome Databases showing SPARC

Other Databases showing SPARC

Specialized Databases showing SPARC

Licensable Technologies
for SPARC

Services
for SPARC

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SPARC Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor SPARC

Summariesfor SPARC

Genomic Locationfor SPARC

Proteinsfor SPARC

Protein Domains/Familiesfor SPARC

Gene Functionfor SPARC

Pathways & Interactionsfor SPARC

Drugs & Compoundsfor SPARC

Transcriptsfor SPARC

Expression for SPARC

Orthologsfor SPARC

Paralogsfor SPARC

SNPs/Variantsfor SPARC

Disorders & Mutationsfor SPARC

Medical Newsfor SPARC

Publicationsfor SPARC

Search for SPARC

Genome Databases showing SPARC

Other Databases showing SPARC

Specialized Databases showing SPARC

Licensable Technologiesfor SPARC

Servicesfor SPARC

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SPARC

Summaries
for SPARC

Genomic Location
for SPARC

Proteins
for SPARC

Protein Domains/
Families
for SPARC

Gene Function
for SPARC

Pathways & Interactions
for SPARC

Drugs & Compounds
for SPARC

Transcripts
for SPARC

Expression
for SPARC

Orthologs
for SPARC

Paralogs
for SPARC

SNPs/Variants
for SPARC

Disorders & Mutations
for SPARC

Medical News
for SPARC

Publications
for SPARC

Licensable Technologies
for SPARC

Services
for SPARC