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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPARC Gene

protein-coding   GIFtS: 69
GCID: GC05M151021

secreted protein, acidic, cysteine-rich (osteonectin)


(Previous symbol: ON)
 Explore 107 diseases affiliated with
SPARC via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SPARC    

Aliases
for SPARC gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Secreted Protein, Acidic, Cysteine-Rich (Osteonectin)1 2     BM-402 3
ON1 2 3 5     Cysteine-Rich Protein2
Basement-Membrane Protein 402 3     Osteonectin3
Secreted Protein Acidic And Rich In Cysteine2 3     Osteonectin3

External Ids:    HGNC: 112191   Entrez Gene: 66782   Ensembl: ENSG000001131407   OMIM: 1821205   UniProtKB: P094863   

Export aliases for SPARC gene to outside databases

Previous GC identifers: GC05M151110 GC05M151639 GC05M151025 GC05M151070 GC05M146186


Summaries
for SPARC gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SPARC:
This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in
bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell
shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based
on changes to cell shape which can promote tumor cell invasion. (provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: SPRC_HUMAN, P09486
Function: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds
calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium
binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+)
ion with a high affinity

Gene Wiki entry for SPARC (Osteonectin)


Genomic Views
for SPARC gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_029289.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPARC gene promoter:
         AML1a   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SPARC promoter sequence
   Search SABiosciences Chromatin IP Primers for SPARC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPARC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.3-q32   Ensembl cytogenetic band:  5q33.1   HGNC cytogenetic band: 5q31-q33

SPARC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPARC gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M151021:  view genomic region     (about GC identifiers)

Start:
 151,040,657 bp from pter      End:
 151,066,726 bp from pter
Size:
 26,070 bases      Orientation:
 minus strand

Proteins
for SPARC gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SPRC_HUMAN, P09486 (See protein sequence)
Recommended Name: SPARC precursor  
Size: 303 amino acids; 34632 Da
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane. Note=In or around the
basement membrane
Developmental stage: Expressed at high levels in tissues undergoing morphogenesis, remodeling and wound repair
Sequence caution: Sequence=AAA60993.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown
origin in the C-terminal part;
4 PDB 3D structures from and Proteopedia for SPARC:
1BMO (3D)        1NUB (3D)        1SRA (3D)        2V53 (3D)    
Secondary accessions: D3DQH9 Q6IBK4

Explore the universe of human proteins at neXtProt for SPARC: NX_P09486

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P09486

    • SPARC Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003109.1  
    ENSEMBL proteins: 
     ENSP00000231061   ENSP00000440127   ENSP00000428119   ENSP00000444998   ENSP00000429152  
    Reactome Protein details: P09486
    Human Recombinant Protein Products: 
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    R&D Systems Recombinant & Natural Proteins for SPARC
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    OriGene Purified Protein: SPARC
    OriGene Protein Over-expression Lysate: SPARC
    OriGene Custom Protein Services for SPARC 
    GenScript Purified and Recombinant Proteins for SPARC
    Novus Biologicals SPARC Protein
    Novus Biologicals SPARC Lysate
    Sino Biological Recombinant Protein for SPARC
    ProSpec Recombinant Protein for SPARC
    Uscn Proteins for SPARC

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix TAS7034958
    GO:0005604basement membrane IEA--
    GO:0005615extracellular space IEA--
    GO:0005622intracellular ----


    SPARC for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SPARC

    Protein Domains /
    Families
    for SPARC gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SPARC for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR018247 EF_Hand_1_Ca_BS
     IPR002350 Prot_inh_Kazal
     IPR011992 EF-hand-like_dom
     IPR019577 SPARC/Testican_Ca-bd-dom
     IPR001999 Osteonectin_CS

    Graphical View of Domain Structure for InterPro Entry P09486

    ProtoNet protein and cluster: P09486

    2 Blocks protein families:
    IPB001999 Osteonectin-like
    IPB003645 Follistatin-like


    UniProtKB/Swiss-Prot: SPRC_HUMAN, P09486
    Similarity: Belongs to the SPARC family
    Similarity: Contains 1 EF-hand domain
    Similarity: Contains 1 follistatin-like domain
    Similarity: Contains 1 Kazal-like domain


    Function
    for SPARC gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SPRC_HUMAN, P09486
    Function: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds
    calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium
    binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+)
    ion with a high affinity

         Genatlas biochemistry entry for SPARC:
    glycoprotein,acidic,cysteine rich,into the basement membrane,involved in extracellular matrix remodeling,interacting
    with collagen,thrombospondin,regulator of cell growth (osteonectin/BM40),and of activator of MMP2 at the cell
    surface,contributing to the proteolytic pathway associated with tumor invasion,overexpressed in hepatocellular
    carcinoma

    miRNA
    Products:            		miRTarBase miRNAs that target SPARC:
    hsa-mir-192 (MIRT004126), hsa-mir-29c (MIRT001922)

    OriGene 3'-UTR Clone: SPARC
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPARC
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate SPARC (see all 25):
    hsa-miR-34b* hsa-miR-495 hsa-miR-4263 hsa-miR-29c hsa-miR-29a hsa-miR-3653 hsa-miR-1205 hsa-miR-204
    SwitchGear 3'UTR luciferase reporter plasmid: SPARC 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPARC (see all 7)
    OriGene shRNA RFP: SPARC
    OriGene siRNA: SPARC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPARC

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SPARC

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPARC (see all 3)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SPARC (NM_003118)
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI3402455
    GO:0005518collagen binding TAS7034958
    GO:0050840extracellular matrix binding IEA--


    SPARC for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for SPARC: Sparctm1Anjm Sparctm1Hwe
         8 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Sparc):
     behavior/neurological  craniofacial  hematopoietic system  homeostasis/metabolism  immune system 
     skeleton  tumorigenesis  vision/eye 

    SPARC for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SPARC gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Platelet activation, signaling and aggregation
    		Platelet activation, signaling and aggregation1.00
    		Hemostasis0.43
    2Platelet degranulation
    		Platelet degranulation 1.00
    		Response to elevated platelet cytosolic Ca2+0.94
    3Cell adhesion_ECM remodeling
    		Cell adhesion_ECM remodeling1.00
    		Cell adhesion ECM remodeling1.00
    4Wnt / Hedgehog / Notch
    		Wnt / Hedgehog / Notch1.00
    5Senescence and Autophagy
    		Senescence and Autophagy1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for SPARC
        Cell adhesion ECM remodeling


    1 Cell Signaling Technology (CST) Pathway for SPARC
        Wnt / Hedgehog / Notch

    1 GeneGo (Thomson Reuters) Pathway for SPARC
        Cell adhesion ECM remodeling

    2 BioSystems Pathways for SPARC 
        Senescence and Autophagy
    TGF-beta Receptor Signaling Pathway

    4        Reactome Pathways for SPARC
        Hemostasis
    Platelet degranulation
    Platelet activation, signaling and aggregation
    Response to elevated platelet cytosolic Ca2+



    SPARC for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SPARC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/62 Interacting proteins for SPARC (P094861, 2, 3 ENSP000002310614) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    XRCC6P129562, 3, ENSP000003522574MINT-8271916 I2D: score=2 STRING: ENSP00000352257
    ZNF579Q8NAF02, 3, ENSP000003201884MINT-8271927 I2D: score=2 STRING: ENSP00000320188
    COL3A1P024613, ENSP000003044084I2D: score=4 STRING: ENSP00000304408
    COL1A1P024523, ENSP000002259644I2D: score=3 STRING: ENSP00000225964
    PDGFAP040853, ENSP000003465084I2D: score=3 STRING: ENSP00000346508
    About this table

    Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0002576platelet degranulation TAS--
    GO:0007165signal transduction IEA--
    GO:0007507heart development IEA--
    GO:0007596blood coagulation TAS--


    SPARC for ontologies           About GeneDecksing



    Drugs & Compounds
    for SPARC gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SPARC for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPARC

    2 HMDB Compounds for SPARC    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    CopperCu (see all 2)7440-50-8--
    10/50 Novoseek chemical compound relationships for SPARC gene (see all 50)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 72.5 158 15838642 (2), 9008236 (2), 1555584 (1), 8500547 (1) (see all 99)
    hydroxyapatite 63.8 17 8547349 (3), 8443690 (1), 17579299 (1), 17266017 (1) (see all 11)
    alizarin 63.1 2 19642865 (1), 17177849 (1)
    procollagen 46.7 7 8826089 (2), 14722903 (1), 9173088 (1), 12381951 (1) (see all 6)
    titanium 43.6 2 12419636 (1)
    dexamethasone 40.2 14 16934542 (1), 7953977 (1), 15988617 (1), 8275945 (1) (see all 9)
    octacalcium phosphate 33.6 2 8443690 (1)
    thymidine 32.9 7 8419407 (2), 17066632 (1), 7649376 (1), 14765266 (1) (see all 5)
    ascorbic acid 31.1 3 9495521 (1), 16934542 (1)
    calcium 29.2 35 1555584 (5), 7563094 (4), 10446063 (3), 15065403 (2) (see all 18)

    Search CenterWatch for drugs/clinical trials and news about SPARC / SPRC 

    Transcripts
    for SPARC gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SPARC gene: 
    NM_003118.3  

    Unigene Cluster for SPARC:

    Secreted protein, acidic, cysteine-rich (osteonectin)
    Hs.111779  [show with all ESTs]
    Unigene Representative Sequence: AK126525
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000231061(uc003lug.3 uc003lui.3) ENST00000520687 ENST00000538026
    ENST00000537849 ENST00000521569 ENST00000524277 ENST00000539687 ENST00000521327
    ENST00000522348

    miRNA
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    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate SPARC (see all 25):
    hsa-miR-34b* hsa-miR-495 hsa-miR-4263 hsa-miR-29c hsa-miR-29a hsa-miR-3653 hsa-miR-1205 hsa-miR-204
    SwitchGear 3'UTR luciferase reporter plasmid: SPARC 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK096969.1 AK126525.1 AK299441.1 AK315591.1 AY545555.1 BC004974.1 BC008011.1 BC072457.1 
    CR456799.1 J03040.1 Y00755.1 

    24/93 DOTS entries (see all 93):

    DT.80101600  DT.100060104  DT.95194845  DT.100060108  DT.101986038  DT.91856216  DT.100702514  DT.100702534 
    DT.95275147  DT.100853342  DT.100702480  DT.100702495  DT.100702491  DT.91782050  DT.100638608  DT.97821055 
    DT.100702493  DT.97777033  DT.100702535  DT.91849618  DT.120857232  DT.100702545  DT.120857190  DT.100767409 

    24/2827 AceView cDNA sequences (see all 2827):

    CA310374 AL542739 CR622084 AL552465 CR604100 BM697232 CA414941 CA425303 
    AI754674 CN482066 AA398478 AI754420 BU188430 BX343813 AU156504 CD358322 
    CA437693 BU846056 BQ019665 AA775486 BM698389 BQ278139 CA449133 BM722538 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SPARC    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b · 11c
    SP1:                                                                                                            
    SP2:                                -     -                                                                     
    SP3:                                      -     -     -     -     -                                             
    SP4:                                                                                                            


    ECgene alternative splicing isoforms for SPARC

    Expression
    for SPARC gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPARC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATGTGAAGAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SPARC expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/18 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 18) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneAutopod PeriosteumEndochondral OsteocytesBone
    BoneCaudal Endochondral BonesEndochondral OsteocytesBone
    BoneCaudal Endochondral BonesEndochondral PreosteoblastsBone
    BoneEndochondral Facial BonesEndochondral OsteocytesBone
    BoneEndochondral Facial BonesEndochondral PreosteoblastsBone
    BoneMembranous Facial BonesIntramembranous OsteoblastsBone
    BoneMembranous Facial BonesIntramembranous PreosteoblastsBone
    BoneMembranous Facial BonesIntramembrenous OsteocytesBone
    BoneRostral Endochondral Facial BonesEndochondral OsteocytesBone
    BoneRostral Endochondral Facial BonesEndochondral PreosteoblastsBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    Extra-embryonic endoderm cells (Fetal Stem / Progenitor Cell)Extraembryonic Tissues
    Extraembryonic endoderm-like cells (Generation of extrae...)
    Connective tissue progenitor cells (Generation of connec...)
    Definitive endoderm-like cells (A scalable, suspensi...)

    See SPARC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPARC

    SOURCE GeneReport for Unigene cluster: Hs.111779
        SABiosciences Expression via Pathway-Focused PCR Arrays including SPARC: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Cellular Senescence in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

    Primer
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    Orthologs
    for SPARC gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SPARC gene from 7/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Sparc1 , 5 secreted acidic cysteine rich glycoprotein1, 5 89.51(n)1
    92.72(a)1    		   11 (33.04 cM)5
    206921  NM_009242.41  NP_033268.11 
     553945005 
    chicken
    (Gallus gallus)    		 Aves SPARC1 secreted protein, acidic, cysteine-rich (osteonectin) 84.45(n)
    86.58(a)    		   386571  NM_204410.1  NP_989741.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SPARC6
    		 --
    		 86(a)
    		 1 ↔ 1
    		 1(152373909-152386905)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BQ884411.12   -- 88.23(n)    BQ884411.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii sparc1 secreted acidic cysteine rich glycoprotein 77.78(n)
    80.76(a)    		   321357  NM_001001942.1  NP_001001942.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta BM-40-SPARC6
    		 BM-40-SPARC
    		 24(a)
    		 1 → many
    		 3R(22694960-22697738)
    worm
    (Caenorhabditis elegans)    		 Secernentea ost-16
    		 SPARC
    		 33(a)
    		 1 → many
    		 IV(1107396-1110860)


    ENSEMBL Gene Tree for SPARC (if available)
    TreeFam Gene Tree for SPARC (if available) 

    Paralogs
    for SPARC gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPARC gene
    SPARCL12  
    2 SIMAP similar genes for SPARC using alignment to 7 protein entries:     SPRC_HUMAN (see all proteins):
    SPARCL1    SMOC2

    SPARC for paralogs           About GeneDecksing



    Genomic Variants
    for SPARC gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/571 NCBI SNPs in SPARC are shown (see all 571)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2014228181,2
    		--151040160(+) TAAAA-/TTTTTT 1 -- int10--------
    rs577321451,2
    		C--151040166(+) TTTTTG/TTTTTT 1 -- int10--------
    rs757257131,2
    		C,--151040179(+) TTTTTA/TAAAAA 1 -- int10--------
    rs23471231,2
    		C,--151040180(+) TTTTTT/AAAAAA 1 -- int11Minor allele frequency- A:0.00NA 2
    rs1407445121,2
    		--151040180(+) TTTTT-/AAAAAAAT 1 -- int10--------
    rs23471241,2
    		C,--151040181(+) TTTTAT/AAAAAA 1 -- int11Minor allele frequency- A:0.00NA 2
    rs1826384071,2
    		--151040213(+) GACAGA/GTAGAA 1 -- int10--------
    rs799056971,2
    		--151040265(+) AGGGAC/TCCTGT 1 -- int10--------
    rs68988151,2
    		C,F,A,--151040266(+) GGGACC/GCTGTT 1 -- int111Minor allele frequency- G:0.36NA CSA WA EA 510
    rs1422327571,2
    		--151040335(+) CGCCCA/GGGGCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for SPARC (151040657 - 151066726 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SPARC: --

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    Disorders / Diseases
    for SPARC gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SPARC for disorders           About GeneDecksing

    OMIM gene information: 182120    OMIM disorders: --

    20/107 diseases for SPARC (see all 107):    About MalaCards
    angle-closure glaucoma    open-angle glaucoma    primary angle-closure glaucoma    gray platelet syndrome
    malignant fibrous histiocytoma    fibrous histiocytoma    osteogenesis imperfecta    diffuse large b-cell lymphoma
    primary open angle glaucoma    quebec platelet disorder    osteofibrous dysplasia    spinal stenosis
    mccune albright syndrome    lateral cystocele    osteoblastoma    b-cell lymphomas
    acute myocardial infarction    back pain    fibrous dysplasia    primitive neuroectodermal tumor

    4 diseases from the University of Copenhagen DISEASES database for SPARC:
    Parkinson's disease     Cancer     Lateral cystocele     Akinetopsia

    10/74 Novoseek disease relationships for SPARC gene (see all 74)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteosarcoma 63.3 27 8717113 (5), 1622861 (3), 1637573 (2), 2287591 (2) (see all 14)
    gray platelet syndrome 62.1 2 1796754 (1), 1737102 (1)
    calcification 59.7 25 7649376 (3), 10446063 (3), 16709694 (2), 18422975 (1) (see all 19)
    osteofibrous dysplasia 45.9 5 10667418 (5)
    bone tumor 43.9 7 2287591 (2), 8717113 (1), 1468768 (1), 1997469 (1) (see all 5)
    tumors 36.2 175 12414657 (6), 16596217 (4), 10502421 (4), 18350569 (4) (see all 65)
    chondrosarcoma mesenchymal 33.4 2 8717113 (1), 1997469 (1)
    osteogenesis imperfecta 32.8 1 8725177 (1)
    fibrous dysplasia 30.5 7 10667418 (5), 9403710 (1)
    chondrosarcoma 28.7 16 1997469 (5), 19594492 (3), 8336066 (2), 8717113 (1) (see all 5)

    Genetic Association Database (GAD): SPARC
    Human Genome Epidemiology (HuGE) Navigator: SPARC (19 documents)

    Export disorders for SPARC gene to outside databases

    Publications
    for SPARC gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPARC gene, integrated from 9 sources (see all 683):
    (articles sorted by number of sources associating them with SPARC)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and complete amino acid sequences of human and murine basement membrane protein BM-40 (SPARC, osteonectin). (PubMed id 3410046)1, 2, 3 Lankat-Buttgereit B.... Krieg T. (1988)
    2. Molecular analysis of the cDNA for human SPARC/osteonectin/BM-40: sequence, expression, and localization of the gene to chromosome 5q31- q33. (PubMed id 2838412)1, 2, 3 Swaroop A.... Francke U. (1988)
    3. BM-40 (osteonectin, SPARC) is expressed both in the epidermal and in the dermal compartment of adult human skin. (PubMed id 9457905)1, 2, 9 Hunzelmann N.... Nischt R. (1998)
    4. Association of novel polymorphisms with the expression of SPARC in normal fibroblasts and with susceptibility to scleroderma. (PubMed id 12428242)1, 4, 9 Zhou X....Arnett F.C. (2002)
    5. Crystal structure of a pair of follistatin-like and EF-hand calcium- binding domains in BM-40. (PubMed id 9233787)1, 2, 9 Hohenester E.... Timpl R. (1997)
    6. Gene polymorphisms, bone mineral density and bone mineral content in young children: the Iowa Bone Development Study. (PubMed id 12879219)1, 4, 9 Willing M.C....Levy S.M. (2003)
    7. Single-nucleotide polymorphisms in the SPARC gene are not associated with susceptibility to scleroderma. (PubMed id 15546965)1, 4 Lagan A.L....Welsh K.I. (2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Crystal structure and mapping by site-directed mutagenesis of the collagen-binding epitope of an activated form of BM- 40/SPARC/osteonectin. (PubMed id 9501084)1, 2 Sasaki T.... Timpl R. (1998)
    10. Structure of a novel extracellular Ca(2+)-binding module in BM-40. (PubMed id 8548457)1, 2 Hohenester E....Engel J. (1996)

    External Searches for SPARC gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SPARC gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6678 HGNC: 11219 AceView: SPARC Ensembl:ENSG00000113140 euGenes: HUgn6678
    ECgene: SPARC H-InvDB: SPARC

    Other Databases showing SPARC gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SPARC gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPARC Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SPARC Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Osteonectin

    Intellectual Property
    for SPARC gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SPARC gene:
    Search GeneIP for patents involving SPARC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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