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Aliases for SPARC Gene

Aliases for SPARC Gene

  • Secreted Protein Acidic And Cysteine Rich 2 3 5
  • Secreted Protein Acidic And Rich In Cysteine 2 4
  • Basement-Membrane Protein 40 3 4
  • Osteonectin 2 4
  • BM-40 3 4
  • ON 3 4
  • Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) 3
  • Cysteine-Rich Protein 2
  • OI17 3

External Ids for SPARC Gene

Previous HGNC Symbols for SPARC Gene

  • ON

Previous GeneCards Identifiers for SPARC Gene

  • GC05M151110
  • GC05M151025
  • GC05M151070
  • GC05M151021
  • GC05M146186

Summaries for SPARC Gene

Entrez Gene Summary for SPARC Gene

  • This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2015]

GeneCards Summary for SPARC Gene

SPARC (Secreted Protein Acidic And Cysteine Rich) is a Protein Coding gene. Diseases associated with SPARC include Osteogenesis Imperfecta, Type Xvii and Sparc-Related Osteogenesis Imperfecta. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and ECM proteoglycans. GO annotations related to this gene include calcium ion binding and extracellular matrix binding. An important paralog of this gene is SPARCL1.

UniProtKB/Swiss-Prot for SPARC Gene

  • Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.

Gene Wiki entry for SPARC Gene

Additional gene information for SPARC Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPARC Gene

Genomics for SPARC Gene

Regulatory Elements for SPARC Gene

Enhancers for SPARC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H151706 1.6 FANTOM5 Ensembl ENCODE dbSUPER 16.2 -21.0 -20987 2 HDAC1 ELF3 TBP FOXA2 ATF1 CEBPG RARA YY1 FOSL1 GATA3 SPARC CLMAT3 SLC36A3 RN7SKP232 ENSG00000272112
GH05H151737 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.5 -54.9 -54895 9 PKNOX1 SIN3A BATF RAD21 ZNF143 FOS ATF7 RCOR1 RUNX3 CREM RPLP1P6 ZNF300 G3BP1 ATOX1 SPARC GC05M151735 LOC105378235
GH05H151668 1.4 Ensembl ENCODE dbSUPER 13.2 +8.9 8864 19 PKNOX1 BMI1 RAD21 RFX5 GATA2 EGR1 SCRT2 FOS RCOR1 RUNX3 LOC105378231 CLMAT3 LOC105378235 RPLP1P6 SPARC ATOX1 G3BP1
GH05H151717 1.3 FANTOM5 Ensembl ENCODE dbSUPER 13.8 -31.8 -31754 2 CTCF REST ZNF2 RAD21 RPLP1P6 SPARC G3BP1 ATOX1 FAT2 LOC105378231 ENSG00000272112 RN7SKP232
GH05H151658 1.3 Ensembl ENCODE dbSUPER 13.7 +27.0 27015 3 CTCF ATF1 RAD21 CC2D1A GATA3 POLR2A SMC3 ZNF143 FOS MAFK LOC105378231 SPARC FAT2 CLMAT3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPARC on UCSC Golden Path with GeneCards custom track

Promoters for SPARC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000189161 1365 2801 CTCF ESRRA TAF1 JUN BMI1 RAD21 FOSL1 CTBP1 GATA3 GATA2

Transcription factor binding sites by QIAGEN in the SPARC gene promoter:

Genomic Location for SPARC Gene

Chromosome:
5
Start:
151,661,096 bp from pter
End:
151,687,165 bp from pter
Size:
26,070 bases
Orientation:
Minus strand

Genomic View for SPARC Gene

Genes around SPARC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPARC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPARC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPARC Gene

Proteins for SPARC Gene

  • Protein details for SPARC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09486-SPRC_HUMAN
    Recommended name:
    SPARC
    Protein Accession:
    P09486
    Secondary Accessions:
    • D3DQH9
    • Q6IBK4

    Protein attributes for SPARC Gene

    Size:
    303 amino acids
    Molecular mass:
    34632 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA60993.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SPARC Gene

neXtProt entry for SPARC Gene

Post-translational modifications for SPARC Gene

  • Glycosylation at posLast=116116
  • Modification sites at PhosphoSitePlus

Other Protein References for SPARC Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SPARC (SPARC)

Assay Products

  • Cloud-Clone Corp. Assay Kits for SPARC

No data available for DME Specific Peptides for SPARC Gene

Domains & Families for SPARC Gene

Gene Families for SPARC Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

P09486

UniProtKB/Swiss-Prot:

SPRC_HUMAN :
  • Belongs to the SPARC family.
Family:
  • Belongs to the SPARC family.
genes like me logo Genes that share domains with SPARC: view

Function for SPARC Gene

Molecular function for SPARC Gene

GENATLAS Biochemistry:
glycoprotein,acidic,cysteine rich,into the basement membrane,involved in extracellular matrix remodeling,interacting with collagen,thrombospondin,regulator of cell growth (osteonectin/BM40),and of activator of MMP2 at the cell surface,contributing to the proteolytic pathway associated with tumor invasion,overexpressed in hepatocellular carcinoma
UniProtKB/Swiss-Prot Function:
Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.

Phenotypes From GWAS Catalog for SPARC Gene

Gene Ontology (GO) - Molecular Function for SPARC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA,IDA 7034958
GO:0005515 protein binding IPI 3402455
GO:0005518 collagen binding IDA 7034958
GO:0046872 metal ion binding IEA --
GO:0050840 extracellular matrix binding IBA,IEA --
genes like me logo Genes that share ontologies with SPARC: view
genes like me logo Genes that share phenotypes with SPARC: view

Human Phenotype Ontology for SPARC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SPARC Gene

MGI Knock Outs for SPARC:

Animal Model Products

  • Taconic Biosciences Mouse Models for SPARC

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SPARC
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SPARC Gene

Localization for SPARC Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPARC Gene

Secreted, extracellular space, extracellular matrix, basement membrane. Note=In or around the basement membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPARC gene
Compartment Confidence
extracellular 5
nucleus 5
mitochondrion 3
plasma membrane 2
cytoskeleton 2
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SPARC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005604 basement membrane IEA --
GO:0005615 extracellular space IEA,IBA --
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with SPARC: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SPARC Gene

Pathways & Interactions for SPARC Gene

genes like me logo Genes that share pathways with SPARC: view

Pathways by source for SPARC Gene

1 GeneGo (Thomson Reuters) pathway for SPARC Gene

Gene Ontology (GO) - Biological Process for SPARC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0001937 negative regulation of endothelial cell proliferation IDA 12867428
GO:0002576 platelet degranulation TAS --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with SPARC: view

No data available for SIGNOR curated interactions for SPARC Gene

Drugs & Compounds for SPARC Gene

(37) Drugs for SPARC Gene - From: DrugBank, ClinicalTrials, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Paclitaxel Approved, Vet_approved Pharma Tubulin and Bcl2 inhibitor, Taxanes 2948
Calcium Citrate Approved Pharma Target, ligand 0
Calcium Phosphate Approved Pharma Target, ligand 0
Gemcitabine Approved Pharma Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 2049
Abraxane Approved October 2012 Pharma Biomarker Taxanes 0

(26) Additional Compounds for SPARC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SPARC: view

Transcripts for SPARC Gene

Unigene Clusters for SPARC Gene

Secreted protein, acidic, cysteine-rich (osteonectin):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SPARC
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SPARC Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b · 11c
SP1:
SP2: - -
SP3: - - - - -
SP4:

Relevant External Links for SPARC Gene

GeneLoc Exon Structure for
SPARC
ECgene alternative splicing isoforms for
SPARC

Expression for SPARC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPARC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPARC Gene

This gene is overexpressed in Artery - Aorta (x4.0).

Protein differential expression in normal tissues from HIPED for SPARC Gene

This gene is overexpressed in Amniocyte (60.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SPARC Gene



NURSA nuclear receptor signaling pathways regulating expression of SPARC Gene:

SPARC

SOURCE GeneReport for Unigene cluster for SPARC Gene:

Hs.111779

Evidence on tissue expression from TISSUES for SPARC Gene

  • Skin(5)
  • Nervous system(5)
  • Bone(4.9)
  • Muscle(4.7)
  • Eye(4.6)
  • Pancreas(4.6)
  • Lung(4.5)
  • Kidney(4.3)
  • Intestine(4.2)
  • Heart(4.1)
  • Stomach(4.1)
  • Liver(3.9)
  • Gall bladder(3.1)
  • Lymph node(2.9)
  • Bone marrow(2.7)
  • Spleen(2.7)
  • Adrenal gland(2.6)
  • Blood(2.5)
  • Thyroid gland(2.5)

Phenotype-based relationships between genes and organs from Gene ORGANizer for SPARC Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Organs:
Head and neck:
  • brain
  • cheek
  • chin
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • middle ear
  • mouth
  • neck
  • nose
  • skull
  • tooth
Thorax:
  • chest wall
  • clavicle
  • heart
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • biliary tract
  • kidney
  • liver
Pelvis:
  • pelvis
  • ureter
  • uterus
  • vagina
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • skin
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with SPARC: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SPARC Gene

Orthologs for SPARC Gene

This gene was present in the common ancestor of animals.

Orthologs for SPARC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPARC 33 34
  • 99.34 (n)
oppossum
(Monodelphis domestica)
Mammalia SPARC 34
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPARC 34
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPARC 33 34
  • 92.96 (n)
dog
(Canis familiaris)
Mammalia SPARC 33 34
  • 92.63 (n)
mouse
(Mus musculus)
Mammalia Sparc 16 34 33
  • 88.3 (n)
rat
(Rattus norvegicus)
Mammalia Sparc 33
  • 87.49 (n)
chicken
(Gallus gallus)
Aves SPARC 33 34
  • 84.56 (n)
lizard
(Anolis carolinensis)
Reptilia SPARC 34
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sparc 33
  • 77 (n)
MGC76263 33
zebrafish
(Danio rerio)
Actinopterygii sparc 33 34
  • 76.86 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8852 33
fruit fly
(Drosophila melanogaster)
Insecta BM-40-SPARC 34
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ost-1 34
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
OneToMany
Species where no ortholog for SPARC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPARC Gene

ENSEMBL:
Gene Tree for SPARC (if available)
TreeFam:
Gene Tree for SPARC (if available)

Paralogs for SPARC Gene

Paralogs for SPARC Gene

(2) SIMAP similar genes for SPARC Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SPARC: view

Variants for SPARC Gene

Sequence variations from dbSNP and Humsavar for SPARC Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_075142 Osteogenesis imperfecta 17 (OI17) [MIM:616507]
VAR_075143 Osteogenesis imperfecta 17 (OI17) [MIM:616507]
rs1057517662 Pathogenic 151,667,555(-) CCTGC(A/G)CATGC reference, missense
rs1057517663 Pathogenic 151,664,183(-) CCATG(A/G)AGCAT reference, missense
rs1000117864 -- 151,670,719(+) AGCCT(C/G)TGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPARC Gene

Variant ID Type Subtype PubMed ID
nsv1026176 CNV gain 25217958
nsv5069 CNV insertion 18451855

Variation tolerance for SPARC Gene

Residual Variation Intolerance Score: 56.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.64; 56.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPARC Gene

Human Gene Mutation Database (HGMD)
SPARC
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPARC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPARC Gene

Disorders for SPARC Gene

MalaCards: The human disease database

(29) MalaCards diseases for SPARC Gene - From: HGMD, OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
osteogenesis imperfecta, type xvii
  • osteogenesis imperfecta type 17
sparc-related osteogenesis imperfecta
  • osteogenesis imperfecta type xvii
osteogenesis imperfecta, type iv
  • osteogenesis imperfecta type 4
clear cell chondrosarcoma
papillary cystadenocarcinoma
  • papillary cystadenocarcinoma, nos
- elite association - COSMIC cancer census association via MalaCards
Search SPARC in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

SPRC_HUMAN
  • Osteogenesis imperfecta 17 (OI17) [MIM:616507]: An autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. {ECO:0000269 PubMed:26027498}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SPARC

Genetic Association Database (GAD)
SPARC
Human Genome Epidemiology (HuGE) Navigator
SPARC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPARC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPARC
genes like me logo Genes that share disorders with SPARC: view

No data available for Genatlas for SPARC Gene

Publications for SPARC Gene

  1. SPARC gene polymorphism in renal transplant patients with gingival overgrowth. (PMID: 17970686) Drozdzik A … Drozdzik M (Journal of periodontology 2007) 3 22 45 60
  2. Gene polymorphisms, bone mineral density and bone mineral content in young children: the Iowa Bone Development Study. (PMID: 12879219) Willing MC … Levy SM (Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2003) 3 22 45 60
  3. Association of novel polymorphisms with the expression of SPARC in normal fibroblasts and with susceptibility to scleroderma. (PMID: 12428242) Zhou X … Arnett FC (Arthritis and rheumatism 2002) 3 22 45 60
  4. BM-40 (osteonectin, SPARC) is expressed both in the epidermal and in the dermal compartment of adult human skin. (PMID: 9457905) Hunzelmann N … Nischt R (The Journal of investigative dermatology 1998) 3 4 22 60
  5. Crystal structure of a pair of follistatin-like and EF-hand calcium-binding domains in BM-40. (PMID: 9233787) Hohenester E … Timpl R (The EMBO journal 1997) 3 4 22 60

Products for SPARC Gene

Sources for SPARC Gene

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