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Aliases for SPANXN5 Gene

Aliases for SPANXN5 Gene

  • SPANX Family Member N5 2 3 4 5
  • Cancer/Testis Antigen Family 11, Member 10 2 3
  • Nuclear-Associated Protein SPAN-Xn5 3 4
  • SPANX-N5 3 4
  • Sperm Protein Associated With The Nucleus On The X Chromosome N5 3
  • SPANX Family, Member N5 2
  • CT11.10 3

External Ids for SPANXN5 Gene

Previous GeneCards Identifiers for SPANXN5 Gene

  • GC0XM052842
  • GC0XM052825
  • GC0XM049890

Summaries for SPANXN5 Gene

GeneCards Summary for SPANXN5 Gene

SPANXN5 (SPANX Family Member N5) is a Protein Coding gene. An important paralog of this gene is SPANXN1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPANXN5 Gene

Genomics for SPANXN5 Gene

Regulatory Elements for SPANXN5 Gene

Transcription factor binding sites by QIAGEN in the SPANXN5 gene promoter:

Genomic Location for SPANXN5 Gene

52,796,144 bp from pter
52,798,101 bp from pter
1,958 bases
Minus strand

Genomic View for SPANXN5 Gene

Genes around SPANXN5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPANXN5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPANXN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPANXN5 Gene

Proteins for SPANXN5 Gene

  • Protein details for SPANXN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sperm protein associated with the nucleus on the X chromosome N5
    Protein Accession:

    Protein attributes for SPANXN5 Gene

    72 amino acids
    Molecular mass:
    8277 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPANXN5 Gene

Post-translational modifications for SPANXN5 Gene

No Post-translational modifications

Other Protein References for SPANXN5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPANXN5 Gene

Domains & Families for SPANXN5 Gene

Protein Domains for SPANXN5 Gene


Suggested Antigen Peptide Sequences for SPANXN5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPAN-X family.
  • Belongs to the SPAN-X family.
genes like me logo Genes that share domains with SPANXN5: view

No data available for Gene Families for SPANXN5 Gene

Function for SPANXN5 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPANXN5 Gene

Localization for SPANXN5 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPANXN5 gene
Compartment Confidence
extracellular 2
nucleus 2
mitochondrion 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPANXN5 Gene

Pathways & Interactions for SPANXN5 Gene

SuperPathways for SPANXN5 Gene

No Data Available

Interacting Proteins for SPANXN5 Gene

Gene Ontology (GO) - Biological Process for SPANXN5 Gene


No data available for Pathways by source and SIGNOR curated interactions for SPANXN5 Gene

Drugs & Compounds for SPANXN5 Gene

No Compound Related Data Available

Transcripts for SPANXN5 Gene

mRNA/cDNA for SPANXN5 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPANXN5 Gene

SPANX family, member N5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPANXN5 Gene

No ASD Table

Relevant External Links for SPANXN5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPANXN5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPANXN5 Gene

mRNA differential expression in normal tissues according to GTEx for SPANXN5 Gene

This gene is overexpressed in Testis (x52.5).

Protein differential expression in normal tissues from HIPED for SPANXN5 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPANXN5 Gene

Protein tissue co-expression partners for SPANXN5 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPANXN5 Gene:


SOURCE GeneReport for Unigene cluster for SPANXN5 Gene:

genes like me logo Genes that share expression patterns with SPANXN5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPANXN5 Gene

Orthologs for SPANXN5 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SPANXN5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPANXN5 34
  • 99.54 (n)
  • 45 (a)
Species where no ortholog for SPANXN5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPANXN5 Gene

Gene Tree for SPANXN5 (if available)
Gene Tree for SPANXN5 (if available)

Paralogs for SPANXN5 Gene

Paralogs for SPANXN5 Gene

(12) SIMAP similar genes for SPANXN5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPANXN5: view

Variants for SPANXN5 Gene

Sequence variations from dbSNP and Humsavar for SPANXN5 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1003287662 -- 52,795,803(+) GAACA(A/T)TAACT downstream-variant-500B
rs1022194585 -- 52,795,849(+) TCAAA(C/T)GGAAA downstream-variant-500B
rs1038571165 -- 52,795,711(+) CCGGC(A/C)CTATA downstream-variant-500B
rs1047476817 -- 52,795,791(+) TTGTG(C/T)TTTAC downstream-variant-500B
rs1047885944 -- 52,795,970(+) AAAAT(A/T)TTCTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SPANXN5 Gene

Variant ID Type Subtype PubMed ID
esv21492 CNV gain 19812545
esv2740170 CNV deletion 23290073
esv3576877 CNV gain 25503493
nsv7446 OTHER inversion 18451855

Variation tolerance for SPANXN5 Gene

Residual Variation Intolerance Score: 43.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.00; 0.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPANXN5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPANXN5 Gene

Disorders for SPANXN5 Gene

Relevant External Links for SPANXN5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SPANXN5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPANXN5 Gene

Publications for SPANXN5 Gene

  1. The SPANX gene family of cancer/testis-specific antigens: rapid evolution and amplification in African great apes and hominids. (PMID: 14973187) Kouprina N. … Larionov V. (Proc. Natl. Acad. Sci. U.S.A. 2004) 2 3 4 64
  2. Hominoid-specific SPANXA/D genes demonstrate differential expression in individuals and protein localization to a distinct nuclear envelope domain during spermatid morphogenesis. (PMID: 17012309) Westbrook V.A. … Herr J.C. (Mol. Hum. Reprod. 2006) 2 3 64
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 4 64

Products for SPANXN5 Gene

Sources for SPANXN5 Gene

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