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SPANXN5 Gene

protein-coding   GIFtS: 32
GCID: GC0XM052825

SPANX Family, Member N5

  Search for SPANXN5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SPANX Family, Member N51 2     CT11.102
Nuclear-Associated Protein SPAN-Xn52 3     Cancer/Testis Antigen Family 11, Member 102
SPANX-N52 3     Sperm Protein Associated With The Nucleus On The X Chromosome N52
Cancer/Testis Antigen Family 111     SPANX Family Member N53
Member 101     

External Ids:    HGNC: 331781   Entrez Gene: 4941972   Ensembl: ENSG000002043637   OMIM: 3006685   UniProtKB: Q5MJ073   

Export aliases for SPANXN5 gene to outside databases

Previous GC identifers: GC0XM052842 GC0XM049890


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SPANXN5 Gene:
SPANXN5 (SPANX family, member N5) is a protein-coding gene. An important paralog of this gene is SPANXN2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_011630.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPANXN5 gene promoter:
         TBP   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPANXN5 promoter sequence
   Search Chromatin IP Primers for SPANXN5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPANXN5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.22   Ensembl cytogenetic band:  Xp11.22   HGNC cytogenetic band: Xp11.22

SPANXN5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPANXN5 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM052825:  view genomic region     (about GC identifiers)

Start:
52,825,184 bp from pter      End:
52,827,141 bp from pter
Size:
1,958 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SPXN5_HUMAN, Q5MJ07 (See protein sequence)
Recommended Name: Sperm protein associated with the nucleus on the X chromosome N5  
Size: 72 amino acids; 8277 Da

Explore the universe of human proteins at neXtProt for SPANXN5: NX_Q5MJ07

Explore proteomics data for SPANXN5 at MOPED


See SPANXN5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001009616.1  
ENSEMBL proteins: 
 ENSP00000364661  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR010007 SPANX_prot

Graphical View of Domain Structure for InterPro Entry Q5MJ07

ProtoNet protein and cluster: Q5MJ07

UniProtKB/Swiss-Prot: SPXN5_HUMAN, Q5MJ07
Similarity: Belongs to the SPAN-X family


Find genes that share domains with SPANXN5           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPANXN5
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular2
nucleus2
cytosol1
mitochondrion1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPANXN5
Interactions:

    Search GeneGlobe Interaction Network for SPANXN5

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SPANXN5 (SPXN5)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for SPANXN5 gene: 
NM_001009616.3  

Unigene Cluster for SPANXN5:

SPANX family, member N5
Hs.535218
Unigene Representative Sequence: NM_001009616
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000375511(uc004drc.1)
miRNA
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1 DOTS entry:

DT.75198048 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SPANXN5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
SPANXN5 Expression
About this image

SPANXN5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SPANXN5 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.535218
    Custom PCR Arrays for SPANXN5
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPANXN5

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and chimp.

Orthologs for SPANXN5 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia SPANXN51 SPANX family, member N5 99.54(n)
100(a)
  743501  XM_003317471.1  XP_003317519.1 


ENSEMBL Gene Tree for SPANXN5 (if available)
TreeFam Gene Tree for SPANXN5 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SPANXN5 gene
SPANXN22  SPANXN12  SPANXN32  SPANXN42  
12 SIMAP similar genes for SPANXN5 using alignment to 1 protein entry:     SPXN5_HUMAN:
SPANXN1    SPANXN2    SPANXN3    SPANXN4    SPANXA1    SPANXC
SPANXA2    SPANXD    SPANXE    SPANXB1    SPANXB2    SPANXF1

Find genes that share paralogs with SPANXN5           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SPANXN5 (see all 64)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1846242671,2
--52824701(+) CCCACC/TTCAGC 1 -- int10--------
rs1876267621,2
--52824731(+) ACAGGC/TGCAAG 1 -- int10--------
rs28070191,2
C,F,A,H--52824873(-) TCCTAG/TGTTAG 1 -- int115Minor allele frequency- T:0.02NS WA NA CSA 1050
rs1921149351,2
--52824930(+) CAGCAA/GAACTA 1 -- int10--------
rs1857409271,2
--52824965(+) AACATA/TTACAC 1 -- int10--------
rs771921191,2
C--52825024(+) GAATCA/GGTGCT 1 -- int10--------
rs1904439751,2
--52825145(+) CTTCTC/TCCCCA 1 -- int10--------
rs1444123021,2
C--52825196(+) CTCAAA/GCTTGA 1 -- ut310--------
rs1808853191,2
--52825267(+) AATTAA/GTCTTC 1 -- ut310--------
rs1478230651,2
--52825416(+) TTCAGA/GTAATT 1 -- ut310--------

HapMap Linkage Disequilibrium report for SPANXN5 (52825184 - 52827141 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for SPANXN5:    About this table    
Variant IDTypeSubtypePubMed ID
esv2740170CNV Deletion23290073
esv21492CNV Gain19812545
nsv7446OTHER Inversion18451855

Human Gene Mutation Database (HGMD): SPANXN5
Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 300668    OMIM disorders: --


Find genes that share disorders with SPANXN5           About GenesLikeMe


Export disorders for SPANXN5 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SPANXN5 gene integrated from 10 sources:
(articles sorted by number of sources associating them with SPANXN5)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The SPANX gene family of cancer/testis-specific antigens: rapid evolution and amplification in African great apes and hominids. (PubMed id 14973187)1, 2, 3 Kouprina N.... Larionov V. (Proc. Natl. Acad. Sci. U.S.A. 2004)
  2. Hominoid-specific SPANXA/D genes demonstrate differential expression in individuals and protein localization to a distinct nuclear envelope domain during spermatid morphogenesis. (PubMed id 17012309)1, 3 Westbrook V.A....Herr J.C. (Mol. Hum. Reprod. 2006)
  3. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (Nature 2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 494197 HGNC: 33178 Ensembl:ENSG00000204363 euGenes: HUgn494197 ECgene: SPANXN5
H-InvDB: SPANXN5

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SPANXN5 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SPANXN5 gene:
Search GeneIP for patents involving SPANXN5

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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