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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPANXN5 Gene

protein-coding   GIFtS: 32
GCID: GC0XM052825

SPANX Family, Member N5

  Search for SPANXN5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SPANX Family, Member N51 2     CT11.102
Nuclear-Associated Protein SPAN-Xn52 3     Cancer/Testis Antigen Family 11, Member 102
SPANX-N52 3     Sperm Protein Associated With The Nucleus On The X Chromosome N52
Cancer/Testis Antigen Family 111     SPANX Family Member N53
Member 101     

External Ids:    HGNC: 331781   Entrez Gene: 4941972   Ensembl: ENSG000002043637   OMIM: 3006685   UniProtKB: Q5MJ073   

Export aliases for SPANXN5 gene to outside databases

Previous GC identifers: GC0XM052842 GC0XM049890


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SPANXN5 Gene: 
SPANXN5 (SPANX family, member N5) is a protein-coding gene. An important paralog of this gene is SPANXN2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_011630.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPANXN5 gene promoter:
         TBP   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPANXN5 promoter sequence
   Search SABiosciences Chromatin IP Primers for SPANXN5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPANXN5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.22   Ensembl cytogenetic band:  Xp11.22   HGNC cytogenetic band: Xp11.22

SPANXN5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPANXN5 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM052825:  view genomic region     (about GC identifiers)

Start:
52,825,184 bp from pter      End:
52,827,141 bp from pter
Size:
1,958 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPXN5_HUMAN, Q5MJ07 (See protein sequence)
Recommended Name: Sperm protein associated with the nucleus on the X chromosome N5  
Size: 72 amino acids; 8277 Da

Explore the universe of human proteins at neXtProt for SPANXN5: NX_Q5MJ07

Explore proteomics data for SPANXN5 at MOPED 

SPANXN5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

SPANXN5 Protein Expression

REFSEQ proteins: NP_001009616.1  
ENSEMBL proteins: 
 ENSP00000364661  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR010007 SPANX_prot

Graphical View of Domain Structure for InterPro Entry Q5MJ07

ProtoNet protein and cluster: Q5MJ07

UniProtKB/Swiss-Prot: SPXN5_HUMAN, Q5MJ07
Similarity: Belongs to the SPAN-X family


SPANXN5 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPANXN5

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SPANXN5 (SPXN5)

Search CenterWatch for drugs/clinical trials and news about SPANXN5 / SPXN5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SPANXN5 gene: 
NM_001009616.3  

Unigene Cluster for SPANXN5:

SPANX family, member N5
Hs.535218
Unigene Representative Sequence: NM_001009616
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000375511(uc004drc.1)
miRNA
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1 DOTS entry:

DT.75198048 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SPANXN5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
SPANXN5 Expression
About this image


See SPANXN5 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.535218
    SABiosciences Custom PCR Arrays for SPANXN5
Primer
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and chimp.

Orthologs for SPANXN5 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia SPANXN51 SPANX family, member N5 100(n)
100(a)
  743501  XM_003317471.1  XP_003317519.1 


ENSEMBL Gene Tree for SPANXN5 (if available)
TreeFam Gene Tree for SPANXN5 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for SPANXN5 gene
SPANXN22  SPANXN12  SPANXN32  SPANXN42  
12 SIMAP similar genes for SPANXN5 using alignment to 1 protein entry:     SPXN5_HUMAN:
SPANXN1    SPANXN2    SPANXN3    SPANXN4    SPANXA1    SPANXC
SPANXA2    SPANXD    SPANXE    SPANXB1    SPANXB2    SPANXF1

SPANXN5 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/64 SNPs in SPANXN5 are shown (see all 64)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1846242671,2
--52824701(+) CCCACC/TTCAGC 1 -- int10--------
rs1876267621,2
--52824731(+) ACAGGC/TGCAAG 1 -- int10--------
rs28070191,2
C,F,A,H--52824873(-) TCCTAG/TGTTAG 1 -- int115Minor allele frequency- T:0.02NS WA NA CSA 1050
rs1921149351,2
--52824930(+) CAGCAA/GAACTA 1 -- int10--------
rs1857409271,2
--52824965(+) AACATA/TTACAC 1 -- int10--------
rs771921191,2
C--52825024(+) GAATCA/GGTGCT 1 -- int10--------
rs1904439751,2
--52825145(+) CTTCTC/TCCCCA 1 -- int10--------
rs1444123021,2
C--52825196(+) CTCAAA/GCTTGA 1 -- ut310--------
rs1808853191,2
--52825267(+) AATTAA/GTCTTC 1 -- ut310--------
rs1478230651,2
--52825416(+) TTCAGA/GTAATT 1 -- ut310--------

HapMap Linkage Disequilibrium report for SPANXN5 (52825184 - 52827141 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for SPANXN5:    About this table     
Variant IDTypeSubtypePubMed ID
esv2740170CNV Deletion23290073
esv21492CNV Gain19812545
nsv7446OTHER Inversion18451855


Human Gene Mutation Database (HGMD): SPANXN5
SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SPANXN5 for disorders           About MalaCards
OMIM gene information: 300668    OMIM disorders: --


SPANXN5 for disorders           About GeneDecksing


Export disorders for SPANXN5 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for SPANXN5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SPANXN5)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The SPANX gene family of cancer/testis-specific antigens: rapid evolution and amplification in African great apes and hominids. (PubMed id 14973187)1, 2, 3 Kouprina N.... Larionov V. (2004)
  2. Hominoid-specific SPANXA/D genes demonstrate differential expression in individuals and protein localization to a distinct nuclear envelope domain during spermatid morphogenesis. (PubMed id 17012309)1, 3 Westbrook V.A....Herr J.C. (2006)
  3. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 494197 HGNC: 33178 Ensembl:ENSG00000204363 euGenes: HUgn494197 ECgene: SPANXN5
H-InvDB: SPANXN5

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for SPANXN5 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for SPANXN5 gene:
Search GeneIP for patents involving SPANXN5

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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