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Aliases for SPANXN4 Gene

Aliases for SPANXN4 Gene

  • SPANX Family, Member N4 2 3
  • Nuclear-Associated Protein SPAN-Xn4 3 4
  • Cancer/Testis Antigen Family 11, Member 9 3
  • Cancer/Testis Antigen Family 11 2
  • SPANX Family Member N4 4
  • Member 9 2
  • SPANX-N4 4
  • CT11.9 3

External Ids for SPANXN4 Gene

Previous GeneCards Identifiers for SPANXN4 Gene

  • GC0XP141942
  • GC0XP142113
  • GC0XP131217

Summaries for SPANXN4 Gene

Entrez Gene Summary for SPANXN4 Gene

  • This gene represents one of several duplicated family members that are located on the X chromosome. This gene family encodes proteins that play a role in spermiogenesis. These proteins represent a specific subgroup of cancer/testis-associated antigens, and they may be candidates for tumor vaccines. This family member belongs to a subgroup of related genes that are present in all primates and rats and mice, and thus, it represents one of the ancestral family members. [provided by RefSeq, Sep 2009]

GeneCards Summary for SPANXN4 Gene

SPANXN4 (SPANX Family, Member N4) is a Protein Coding gene. An important paralog of this gene is SPANXN3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPANXN4 Gene

Genomics for SPANXN4 Gene

Regulatory Elements for SPANXN4 Gene

Genomic Location for SPANXN4 Gene

143,025,918 bp from pter
143,034,702 bp from pter
8,785 bases
Plus strand

Genomic View for SPANXN4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPANXN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPANXN4 Gene

Proteins for SPANXN4 Gene

  • Protein details for SPANXN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sperm protein associated with the nucleus on the X chromosome N4
    Protein Accession:
    Secondary Accessions:
    • Q0ZNK6
    • Q5W0S6

    Protein attributes for SPANXN4 Gene

    99 amino acids
    Molecular mass:
    11168 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAH71622.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for SPANXN4 Gene

Proteomics data for SPANXN4 Gene at MOPED

Post-translational modifications for SPANXN4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPANXN4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPANXN4 Gene

Domains & Families for SPANXN4 Gene

Protein Domains for SPANXN4 Gene


Suggested Antigen Peptide Sequences for SPANXN4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPAN-X family.
  • Belongs to the SPAN-X family.
genes like me logo Genes that share domains with SPANXN4: view

No data available for Gene Families for SPANXN4 Gene

Function for SPANXN4 Gene

Phenotypes for SPANXN4 Gene

GenomeRNAi human phenotypes for SPANXN4:
genes like me logo Genes that share phenotypes with SPANXN4: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPANXN4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPANXN4 Gene

Localization for SPANXN4 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SPANXN4 Gene

Pathways & Interactions for SPANXN4 Gene

SuperPathways for SPANXN4 Gene

No Data Available

Interacting Proteins for SPANXN4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000405210 for SPANXN4 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for SPANXN4 Gene


No data available for Pathways by source and SIGNOR curated interactions for SPANXN4 Gene

Drugs & Compounds for SPANXN4 Gene

No Compound Related Data Available

Transcripts for SPANXN4 Gene

mRNA/cDNA for SPANXN4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPANXN4 Gene

SPANX family, member N4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPANXN4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPANXN4 Gene

No ASD Table

Relevant External Links for SPANXN4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPANXN4 Gene

mRNA expression in normal human tissues for SPANXN4 Gene

mRNA differential expression in normal tissues according to GTEx for SPANXN4 Gene

This gene is overexpressed in Testis (x52.8).

Protein differential expression in normal tissues from HIPED for SPANXN4 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPANXN4 Gene

SOURCE GeneReport for Unigene cluster for SPANXN4 Gene Hs.535082

genes like me logo Genes that share expression patterns with SPANXN4: view

Protein tissue co-expression partners for SPANXN4 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SPANXN4 Gene

Orthologs for SPANXN4 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for SPANXN4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC740280 35
  • 98.32 (n)
  • 96.97 (a)
  • 63 (a)
(Mus musculus)
Mammalia Spanxn4 16
Species with no ortholog for SPANXN4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPANXN4 Gene

Gene Tree for SPANXN4 (if available)
Gene Tree for SPANXN4 (if available)

Paralogs for SPANXN4 Gene

Paralogs for SPANXN4 Gene

(4) SIMAP similar genes for SPANXN4 Gene using alignment to 1 proteins: Pseudogenes for SPANXN4 Gene

genes like me logo Genes that share paralogs with SPANXN4: view

Variants for SPANXN4 Gene

Sequence variations from dbSNP and Humsavar for SPANXN4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1815283 -- 143,028,696(+) tatta(G/T)cagaa intron-variant
rs1886121 -- 143,029,053(+) tgttc(C/T)gcgtg intron-variant
rs4825148 -- 143,033,943(+) CTTCT(C/T)ATAAA intron-variant
rs5907378 -- 143,024,557(+) aattt(G/T)tatta upstream-variant-2KB
rs5907379 -- 143,032,884(+) agaat(A/G)gacgt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPANXN4 Gene

Variant ID Type Subtype PubMed ID
esv2664441 CNV Deletion 23128226

Variation tolerance for SPANXN4 Gene

Gene Damage Index Score: 3.28; 52.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPANXN4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPANXN4 Gene

Disorders for SPANXN4 Gene

Relevant External Links for SPANXN4

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SPANXN4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPANXN4 Gene

Publications for SPANXN4 Gene

  1. Hominoid-specific SPANXA/D genes demonstrate differential expression in individuals and protein localization to a distinct nuclear envelope domain during spermatid morphogenesis. (PMID: 17012309) Westbrook V.A. … Herr J.C. (Mol. Hum. Reprod. 2006) 2 67
  2. The SPANX gene family of cancer/testis-specific antigens: rapid evolution and amplification in African great apes and hominids. (PMID: 14973187) Kouprina N. … Larionov V. (Proc. Natl. Acad. Sci. U.S.A. 2004) 2 67
  3. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 67
  4. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PMID: 17903302) Levy D. … Mitchell G.F. (BMC Med. Genet. 2007) 67
  5. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PMID: 17903300) Fox C.S. … Atwood L.D. (BMC Med. Genet. 2007) 67

Products for SPANXN4 Gene

Sources for SPANXN4 Gene

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