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Aliases for SPANXN3 Gene

Aliases for SPANXN3 Gene

  • SPANX Family, Member N3 2 3
  • Nuclear-Associated Protein SPAN-Xn3 3 4
  • SPANX-N3 3 4
  • Sperm Protein Associated With The Nucleus On The X Chromosome N3 3
  • Cancer/Testis Antigen Family 11, Member 8 3
  • Cancer/Testis Antigen Family 11 2
  • SPANX Family Member N3 4
  • Member 8 2
  • CT11.8 3

External Ids for SPANXN3 Gene

Summaries for SPANXN3 Gene

GeneCards Summary for SPANXN3 Gene

SPANXN3 (SPANX Family, Member N3) is a Protein Coding gene. An important paralog of this gene is SPANXN5.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPANXN3 Gene

Genomics for SPANXN3 Gene

Genomic Location for SPANXN3 Gene

Start:
143,508,735 bp from pter
End:
143,517,479 bp from pter
Size:
8,745 bases
Orientation:
Minus strand

Genomic View for SPANXN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPANXN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPANXN3 Gene

No data available for Regulatory Elements for SPANXN3 Gene

Proteins for SPANXN3 Gene

  • Protein details for SPANXN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5MJ09-SPXN3_HUMAN
    Recommended name:
    Sperm protein associated with the nucleus on the X chromosome N3
    Protein Accession:
    Q5MJ09
    Secondary Accessions:
    • Q0ZNK4

    Protein attributes for SPANXN3 Gene

    Size:
    141 amino acids
    Molecular mass:
    15595 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPANXN3 Gene

Proteomics data for SPANXN3 Gene at MOPED

Post-translational modifications for SPANXN3 Gene

No Post-translational modifications

Other Protein References for SPANXN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPANXN3 Gene

Domains for SPANXN3 Gene

Protein Domains for SPANXN3 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

SPXN3_HUMAN
Family:
  • Belongs to the SPAN-X family.:
    • Q5MJ09
genes like me logo Genes that share domains with SPANXN3: view

No data available for Gene Families for SPANXN3 Gene

Function for SPANXN3 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SPANXN3 Gene

Localization for SPANXN3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPANXN3 Gene COMPARTMENTS Subcellular localization image for SPANXN3 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for SPANXN3 Gene

Pathways for SPANXN3 Gene

SuperPathways for SPANXN3 Gene

No Data Available

Interacting Proteins for SPANXN3 Gene

Gene Ontology (GO) - Biological Process for SPANXN3 Gene

None

No data available for Pathways by source for SPANXN3 Gene

Transcripts for SPANXN3 Gene

mRNA/cDNA for SPANXN3 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPANXN3 Gene

SPANX family, member N3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPANXN3 Gene

No ASD Table

Relevant External Links for SPANXN3 Gene

GeneLoc Exon Structure for
SPANXN3
ECgene alternative splicing isoforms for
SPANXN3

Expression for SPANXN3 Gene

mRNA expression in normal human tissues for SPANXN3 Gene

mRNA differential expression in normal tissues according to GTEx for SPANXN3 Gene

This gene is overexpressed in Testis (52.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SPANXN3 Gene

SOURCE GeneReport for Unigene cluster for SPANXN3 Gene Hs.447320

genes like me logo Genes that share expressions with SPANXN3: view

Orthologs for SPANXN3 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SPANXN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPANXN3 36
  • 96.9 (n)
  • 92.86 (a)
SPANXN3 37
  • 93 (a)
OneToOne
Species with no ortholog for SPANXN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPANXN3 Gene

ENSEMBL:
Gene Tree for SPANXN3 (if available)
TreeFam:
Gene Tree for SPANXN3 (if available)

Paralogs for SPANXN3 Gene

Paralogs for SPANXN3 Gene

Selected SIMAP similar genes for SPANXN3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPANXN3: view

Variants for SPANXN3 Gene

Sequence variations from dbSNP and Humsavar for SPANXN3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs2076790 -- 143,508,582(+) TCCTC(C/T)GCCAG intron-variant
rs2281419 -- 143,517,033(-) TCTTG(A/G)AACTT intron-variant
rs2281420 -- 143,516,937(-) ggccc(A/G)aaccc intron-variant
rs4298619 -- 143,511,192(+) CATGA(A/G)AACAC intron-variant
rs4500197 -- 143,510,904(+) ccaac(C/G)ctctt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPANXN3 Gene

Variant ID Type Subtype PubMed ID
nsv7129 CNV Loss 18451855
esv2740547 CNV Deletion 23290073
dgv1403e199 CNV Deletion 23128226

Relevant External Links for SPANXN3 Gene

HapMap Linkage Disequilibrium report
SPANXN3

Disorders for SPANXN3 Gene

No disorders were found for SPANXN3 Gene.

No data available for UniProtKB/Swiss-Prot for SPANXN3 Gene

Publications for SPANXN3 Gene

  1. The SPANX gene family of cancer/testis-specific antigens: rapid evolution and amplification in African great apes and hominids. (PMID: 14973187) Kouprina N. … Larionov V. (Proc. Natl. Acad. Sci. U.S.A. 2004) 2 3 4
  2. Hominoid-specific SPANXA/D genes demonstrate differential expression in individuals and protein localization to a distinct nuclear envelope domain during spermatid morphogenesis. (PMID: 17012309) Westbrook V.A. … Herr J.C. (Mol. Hum. Reprod. 2006) 2 3
  3. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PMID: 19953087) Persaud A. … Rotin D. (Mol. Syst. Biol. 2009) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for SPANXN3 Gene

Sources for SPANXN3 Gene

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