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Aliases for SPANXN3 Gene

Aliases for SPANXN3 Gene

  • SPANX Family Member N3 2 3 4 5
  • Cancer/Testis Antigen Family 11, Member 8 2 3
  • Nuclear-Associated Protein SPAN-Xn3 3 4
  • SPANX-N3 3 4
  • Sperm Protein Associated With The Nucleus On The X Chromosome N3 3
  • SPANX Family, Member N3 2
  • CT11.8 3

External Ids for SPANXN3 Gene

Previous GeneCards Identifiers for SPANXN3 Gene

  • GC0XM142425
  • GC0XM142596
  • GC0XM131701

Summaries for SPANXN3 Gene

GeneCards Summary for SPANXN3 Gene

SPANXN3 (SPANX Family Member N3) is a Protein Coding gene. An important paralog of this gene is SPANXN2.

Additional gene information for SPANXN3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPANXN3 Gene

Genomics for SPANXN3 Gene

GeneHancer (GH) Regulatory Elements for SPANXN3 Gene

Promoters and enhancers for SPANXN3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI143517 Promoter 0.5 EPDnew 550.8 0.0 -20 0.1 SPANXN3 MYCLP3
GH0XI143579 Enhancer 0.4 Ensembl ENCODE 0.2 -62.7 -62741 1.7 SLITRK4 MYCLP3 SPANXN3
GH0XI143454 Enhancer 0.2 ENCODE 0.2 +62.4 62374 1.7 MTND2P39 SPANXN3 ENSG00000227303
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPANXN3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SPANXN3 Gene

Genomic Locations for SPANXN3 Gene
chrX:143,508,735-143,517,475
(GRCh38/hg38)
Size:
8,741 bases
Orientation:
Minus strand
chrX:142,596,564-142,605,307
(GRCh37/hg19)

Genomic View for SPANXN3 Gene

Genes around SPANXN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPANXN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPANXN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPANXN3 Gene

Proteins for SPANXN3 Gene

  • Protein details for SPANXN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5MJ09-SPXN3_HUMAN
    Recommended name:
    Sperm protein associated with the nucleus on the X chromosome N3
    Protein Accession:
    Q5MJ09
    Secondary Accessions:
    • Q0ZNK4

    Protein attributes for SPANXN3 Gene

    Size:
    141 amino acids
    Molecular mass:
    15595 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPANXN3 Gene

Post-translational modifications for SPANXN3 Gene

No Post-translational modifications

Other Protein References for SPANXN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPANXN3 Gene

Domains & Families for SPANXN3 Gene

Gene Families for SPANXN3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPANXN3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPANXN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5MJ09

UniProtKB/Swiss-Prot:

SPXN3_HUMAN :
  • Belongs to the SPAN-X family.
Family:
  • Belongs to the SPAN-X family.
genes like me logo Genes that share domains with SPANXN3: view

Function for SPANXN3 Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPANXN3 Gene

Localization for SPANXN3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPANXN3 gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPANXN3 Gene

Pathways & Interactions for SPANXN3 Gene

SuperPathways for SPANXN3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPANXN3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPANXN3 Gene

Drugs & Compounds for SPANXN3 Gene

No Compound Related Data Available

Transcripts for SPANXN3 Gene

mRNA/cDNA for SPANXN3 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPANXN3 Gene

SPANX family, member N3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPANXN3 Gene

No ASD Table

Relevant External Links for SPANXN3 Gene

GeneLoc Exon Structure for
SPANXN3
ECgene alternative splicing isoforms for
SPANXN3

Expression for SPANXN3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPANXN3 Gene

mRNA differential expression in normal tissues according to GTEx for SPANXN3 Gene

This gene is overexpressed in Testis (x52.7).

Protein differential expression in normal tissues from HIPED for SPANXN3 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPANXN3 Gene



Protein tissue co-expression partners for SPANXN3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPANXN3 Gene:

SPANXN3

SOURCE GeneReport for Unigene cluster for SPANXN3 Gene:

Hs.447320
genes like me logo Genes that share expression patterns with SPANXN3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPANXN3 Gene

Orthologs for SPANXN3 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SPANXN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPANXN3 33 34
  • 96.9 (n)
Species where no ortholog for SPANXN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPANXN3 Gene

ENSEMBL:
Gene Tree for SPANXN3 (if available)
TreeFam:
Gene Tree for SPANXN3 (if available)

Paralogs for SPANXN3 Gene

Paralogs for SPANXN3 Gene

(12) SIMAP similar genes for SPANXN3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPANXN3: view

Variants for SPANXN3 Gene

Sequence variations from dbSNP and Humsavar for SPANXN3 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs111381212 -- 143,509,214(-) A/G intron_variant
rs111851873 -- 143,517,726(-) G/A upstream_transcript_variant
rs111865676 -- 143,514,265(-) T/C intron_variant
rs111877285 -- 143,517,627(-) T/C upstream_transcript_variant
rs112319223 -- 143,517,675(-) G/C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SPANXN3 Gene

Variant ID Type Subtype PubMed ID
dgv1403e199 CNV deletion 23128226
esv2740547 CNV deletion 23290073
nsv7129 CNV deletion 18451855

Variation tolerance for SPANXN3 Gene

Residual Variation Intolerance Score: 62.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPANXN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPANXN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPANXN3 Gene

Disorders for SPANXN3 Gene

Additional Disease Information for SPANXN3

No disorders were found for SPANXN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPANXN3 Gene

Publications for SPANXN3 Gene

  1. The SPANX gene family of cancer/testis-specific antigens: rapid evolution and amplification in African great apes and hominids. (PMID: 14973187) Kouprina N … Larionov V (Proceedings of the National Academy of Sciences of the United States of America 2004) 2 3 4 58
  2. Hominoid-specific SPANXA/D genes demonstrate differential expression in individuals and protein localization to a distinct nuclear envelope domain during spermatid morphogenesis. (PMID: 17012309) Westbrook VA … Herr JC (Molecular human reproduction 2006) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 58

Products for SPANXN3 Gene

Sources for SPANXN3 Gene

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