Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SPANXN3 Gene

Aliases for SPANXN3 Gene

  • SPANX Family Member N3 2 3 4 5
  • Cancer/Testis Antigen Family 11, Member 8 2 3
  • Nuclear-Associated Protein SPAN-Xn3 3 4
  • SPANX-N3 3 4
  • Sperm Protein Associated With The Nucleus On The X Chromosome N3 3
  • SPANX Family, Member N3 2
  • CT11.8 3

External Ids for SPANXN3 Gene

Previous GeneCards Identifiers for SPANXN3 Gene

  • GC0XM142425
  • GC0XM142596
  • GC0XM131701

Summaries for SPANXN3 Gene

GeneCards Summary for SPANXN3 Gene

SPANXN3 (SPANX Family Member N3) is a Protein Coding gene. An important paralog of this gene is SPANXN2.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPANXN3 Gene

Genomics for SPANXN3 Gene

Regulatory Elements for SPANXN3 Gene

Enhancers for SPANXN3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG143579 0.7 Ensembl ENCODE 0.2 -62.7 -62741 1.7 FOS HNF4A SLITRK4 MYCLP3 SPANXN3
GH0XG143454 0.2 ENCODE 0.2 +62.4 62375 1.7 MTND2P39 SPANXN3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPANXN3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPANXN3 Gene

143,508,735 bp from pter
143,517,475 bp from pter
8,741 bases
Minus strand

Genomic View for SPANXN3 Gene

Genes around SPANXN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPANXN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPANXN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPANXN3 Gene

Proteins for SPANXN3 Gene

  • Protein details for SPANXN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sperm protein associated with the nucleus on the X chromosome N3
    Protein Accession:
    Secondary Accessions:
    • Q0ZNK4

    Protein attributes for SPANXN3 Gene

    141 amino acids
    Molecular mass:
    15595 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPANXN3 Gene

Post-translational modifications for SPANXN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPANXN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPANXN3 Gene

Domains & Families for SPANXN3 Gene

Protein Domains for SPANXN3 Gene


Suggested Antigen Peptide Sequences for SPANXN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPAN-X family.
  • Belongs to the SPAN-X family.
genes like me logo Genes that share domains with SPANXN3: view

No data available for Gene Families for SPANXN3 Gene

Function for SPANXN3 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPANXN3 Gene

Localization for SPANXN3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPANXN3 gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPANXN3 Gene

Pathways & Interactions for SPANXN3 Gene

SuperPathways for SPANXN3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPANXN3 Gene


No data available for Pathways by source and SIGNOR curated interactions for SPANXN3 Gene

Drugs & Compounds for SPANXN3 Gene

No Compound Related Data Available

Transcripts for SPANXN3 Gene

mRNA/cDNA for SPANXN3 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPANXN3 Gene

SPANX family, member N3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPANXN3 Gene

No ASD Table

Relevant External Links for SPANXN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPANXN3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPANXN3 Gene

mRNA differential expression in normal tissues according to GTEx for SPANXN3 Gene

This gene is overexpressed in Testis (x52.7).

Protein differential expression in normal tissues from HIPED for SPANXN3 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPANXN3 Gene

Protein tissue co-expression partners for SPANXN3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPANXN3 Gene:


SOURCE GeneReport for Unigene cluster for SPANXN3 Gene:

genes like me logo Genes that share expression patterns with SPANXN3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPANXN3 Gene

Orthologs for SPANXN3 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SPANXN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPANXN3 34 35
  • 96.9 (n)
Species where no ortholog for SPANXN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPANXN3 Gene

Gene Tree for SPANXN3 (if available)
Gene Tree for SPANXN3 (if available)

Paralogs for SPANXN3 Gene

Paralogs for SPANXN3 Gene

(12) SIMAP similar genes for SPANXN3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPANXN3: view

Variants for SPANXN3 Gene

Sequence variations from dbSNP and Humsavar for SPANXN3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs111381212 -- 143,509,214(+) ATAGG(A/G)TAGAG intron-variant
rs111851873 -- 143,517,726(+) CCACC(A/G)CTCCT upstream-variant-2KB
rs111865676 -- 143,514,265(+) GCTGG(C/T)GCCAT intron-variant
rs111877285 -- 143,517,627(+) ACTCC(C/T)TGGGC upstream-variant-2KB
rs112319223 -- 143,517,675(+) AATGC(G/T)GTTGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SPANXN3 Gene

Variant ID Type Subtype PubMed ID
dgv1403e199 CNV deletion 23128226
esv2740547 CNV deletion 23290073
nsv7129 CNV deletion 18451855

Variation tolerance for SPANXN3 Gene

Residual Variation Intolerance Score: 62.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPANXN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPANXN3 Gene

Disorders for SPANXN3 Gene

Relevant External Links for SPANXN3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SPANXN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPANXN3 Gene

Publications for SPANXN3 Gene

  1. The SPANX gene family of cancer/testis-specific antigens: rapid evolution and amplification in African great apes and hominids. (PMID: 14973187) Kouprina N. … Larionov V. (Proc. Natl. Acad. Sci. U.S.A. 2004) 2 3 4 64
  2. Hominoid-specific SPANXA/D genes demonstrate differential expression in individuals and protein localization to a distinct nuclear envelope domain during spermatid morphogenesis. (PMID: 17012309) Westbrook V.A. … Herr J.C. (Mol. Hum. Reprod. 2006) 2 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64
  5. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PMID: 19953087) Persaud A. … Rotin D. (Mol. Syst. Biol. 2009) 3 64

Products for SPANXN3 Gene

Sources for SPANXN3 Gene

Loading form....