SPANXN3 Gene
protein-coding GIFtS: 36
GCID: GC0XM142596
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SPANX family, member N3
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Aliases
for SPANXN3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SPANX Family, Member N31 2 | | Cancer/Testis Antigen Family 11, Member 82 | | SPANX-N31 2 3 | | Sperm Protein Associated With The Nucleus On The X Chromosome N32 | | CT11.81 2 | | SPANX Family Member N33 | | Nuclear-Associated Protein SPAN-Xn32 3 | | |
Export aliases for SPANXN3 gene to outside databasesPrevious GC identifers: GC0XM142425 GC0XM131701 |
Summaries
for SPANXN3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SPANXN3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011786.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for SPANXN3
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPANXN3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPANXN3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq27.3 Ensembl cytogenetic band: Xq27.3 HGNC cytogenetic band: Xq27.3SPANXN3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM142596: view genomic region
(about GC identifiers)
Start:
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142,596,564 bp from pter |
End:
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142,605,307 bp from pter |
Size:
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8,744 bases |
Orientation:
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minus strand |
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Proteins
for SPANXN3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPXN3_HUMAN, Q5MJ09 (See
protein sequence)Recommended Name: Sperm protein associated with the nucleus on the X chromosome N3 Size: 141 amino acids; 15595 Da
Secondary accessions: Q0ZNK4Explore the universe of human proteins at neXtProt for SPANXN3: NX_Q5MJ09
SPANXN3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001009609.1
ENSEMBL proteins: ENSP00000359534
Human Recombinant Protein Products:
SPANXN3 Antibody Products:
Assay Products for SPANXN3: |
Protein
Domains /
Families
for SPANXN3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPANXN3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5MJ09ProtoNet protein and cluster: Q5MJ09 UniProtKB/Swiss-Prot: SPXN3_HUMAN, Q5MJ09Similarity: Belongs to the SPAN-X family |
Function
for SPANXN3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXN3
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXN3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for SPANXN3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPANXN3 |
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Pathways & Interactions
for SPANXN3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPANXN3
|
Drugs & Compounds
for SPANXN3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPANXN3
Search CenterWatch for drugs/clinical trials and news about SPANXN3 / SPXN3
|
Transcripts
for SPANXN3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPANXN3 gene: NM_001009609.2 Unigene Cluster for SPANXN3: SPANX family, member N3 Hs.447320 Unigene Representative Sequence: BU5699371 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000370503(uc004fbw.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXN3
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXN3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPANXN3 (NM_001009609) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPANXN3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPANXN3 |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPANXN3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SPANXN3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPANXN3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPANXN3 |
Additional cDNA sequence: BC062750.1 1 DOTS entry: DT.99962424 2 AceView cDNA sequences: BC062750 BU569937
GeneLoc Exon Structure
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Expression
for SPANXN3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPANXN3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGAAACCAA
About this image
See SPANXN3 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.447320
SABiosciences Custom PCR Arrays for SPANXN3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPANXN3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SPANXN3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPANXN3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPANXN3 |
Orthologs
for SPANXN3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for SPANXN3 (if available)
TreeFam Gene Tree for SPANXN3 (if available) |
Paralogs
for SPANXN3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SPANXN3 gene
- SPANXN22 SPANXN12 SPANXN52 SPANXB22 SPANXB12 SPANXD2 SPANXA22 SPANXC2
- SPANXN42 SPANXA12
12 SIMAP similar genes for SPANXN3 using alignment to 1 protein entry: SPXN3_HUMAN:SPANXN2 SPANXN1 SPANXN5 SPANXN4 SPANXA1 SPANXA2
SPANXC SPANXD SPANXE SPANXB1 SPANXB2 SPANXF1
SPANXN3 for paralogs About GeneDecksing
|
Genomic Variants
for SPANXN3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for SPANXN3 (142596564 - 142605307 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SPANXN3
1 CNV: 37008 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPANXN3 |
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Disorders
/ Diseases
for SPANXN3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SPANXN3 for disorders About GeneDecksing
OMIM gene information: 300666
OMIM disorders: --
2  diseases for SPANXN3: About MalaCardsprostate cancer prostatitis
Export disorders for SPANXN3 gene to outside databases
|
Publications
for SPANXN3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPANXN3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SPANXN3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The SPANX gene family of cancer/testis-specific antigens: rapid evolution and amplification in African great apes and hominids. (PubMed id 14973187)1, 2, 3 Kouprina N.... Larionov V. (2004)
- Hominoid-specific SPANXA/D genes demonstrate differential expression in individuals and protein localization to a distinct nuclear envelope domain during spermatid morphogenesis. (PubMed id 17012309)1, 3 Westbrook V.A....Herr J.C. (2006)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (2009)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
- Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27. (PubMed id 16251457)2 Kouprina N.... Larionov V. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for SPANXN3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SPANXN3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing SPANXN3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPANXN3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPANXN3 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for SPANXN3 gene:
Search GeneIP for patents involving SPANXN3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPANXN3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPANXN3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPANXN3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPANXN3 | | | OriGene Protein Over-expression Lysate for SPANXN3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPANXN3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXN3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXN3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SPANXN3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for SPANXN3 |
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 | | | SPANXN3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for SPANXN3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPANXN3 |
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