SPANXN2 Gene
protein-coding GIFtS: 35
GCID: GC0XM142795
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SPANX family, member N2
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Aliases
for SPANXN2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SPANX Family, Member N21 2 | | Cancer/Testis Antigen Family 11, Member 72 | | SPANX-N21 2 3 | | Sperm Protein Associated With The Nucleus On The X Chromosome N22 | | CT11.71 2 | | SPANX Family Member N23 | | Nuclear-Associated Protein SPAN-Xn22 3 | | |
Export aliases for SPANXN2 gene to outside databasesPrevious GC identifers: GC0XM142623 GC0XM131909 |
Summaries
for SPANXN2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SPANXN2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011786.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPANXN2 gene promoter:
SRF RFX1 FOXF2 AML1a SRF (504 AA) POU3F2 HNF-3beta Gfi-1 FAC1 FOXO4
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPANXN2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPANXN2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq27.3 Ensembl cytogenetic band: Xq27.3 HGNC cytogenetic band: Xq27.3SPANXN2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM142795: view genomic region
(about GC identifiers)
Start:
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142,795,055 bp from pter |
End:
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142,804,516 bp from pter |
Size:
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9,462 bases |
Orientation:
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minus strand |
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Proteins
for SPANXN2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPXN2_HUMAN, Q5MJ10 (See
protein sequence)Recommended Name: Sperm protein associated with the nucleus on the X chromosome N2 Size: 180 amino acids; 19917 Da
Secondary accessions: Q0ZNM2Explore the universe of human proteins at neXtProt for SPANXN2: NX_Q5MJ10
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5MJ10
SPANXN2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001009615.1
ENSEMBL proteins: ENSP00000359529
Human Recombinant Protein Products:
SPANXN2 Antibody Products:
Assay Products for SPANXN2: |
Protein
Domains /
Families
for SPANXN2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPANXN2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5MJ10ProtoNet protein and cluster: Q5MJ10 UniProtKB/Swiss-Prot: SPXN2_HUMAN, Q5MJ10Similarity: Belongs to the SPAN-X family |
Function
for SPANXN2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXN2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXN2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SPANXN2 (NM_001009615) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPANXN2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPANXN2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPANXN2 |
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Pathways & Interactions
for SPANXN2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPANXN2
|
Drugs & Compounds
for SPANXN2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPANXN2
Search CenterWatch for drugs/clinical trials and news about SPANXN2 / SPXN2
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Transcripts
for SPANXN2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPANXN2 gene: NM_001009615.1 Unigene Cluster for SPANXN2: SPANX family, member N2 Hs.535083 [show with all ESTs]Unigene Representative Sequence: NM_0010096151 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000370498(uc004fbz.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXN2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXN2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPANXN2 (NM_001009615) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPANXN2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPANXN2 |
1 DOTS entry: DT.91834751
GeneLoc Exon Structure
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Expression
for SPANXN2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPANXN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SPANXN2 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.535083
SABiosciences Custom PCR Arrays for SPANXN2
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SPANXN2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPANXN2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPANXN2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPANXN2 |
Orthologs
for SPANXN2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for SPANXN2 (if available)
TreeFam Gene Tree for SPANXN2 (if available) |
Paralogs
for SPANXN2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SPANXN2 gene
- SPANXN12 SPANXN52 SPANXB22 SPANXB12 SPANXD2 SPANXA22 SPANXN32 SPANXC2
- SPANXN42 SPANXA12
12 SIMAP similar genes for SPANXN2 using alignment to 1 protein entry: SPXN2_HUMAN:SPANXN3 SPANXN1 SPANXN5 SPANXN4 SPANXC SPANXA1
SPANXA2 SPANXE SPANXD SPANXB1 SPANXB2 SPANXF1
SPANXN2 for paralogs About GeneDecksing
|
Genomic Variants
for SPANXN2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for SPANXN2 (142795055 - 142804516 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SPANXN2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPANXN2 |
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Disorders
/ Diseases
for SPANXN2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SPANXN2 for disorders About GeneDecksing
OMIM gene information: 300665
OMIM disorders: --
2  diseases for SPANXN2: About MalaCardsprostate cancer prostatitis
Export disorders for SPANXN2 gene to outside databases
|
Publications
for SPANXN2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPANXN2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SPANXN2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The SPANX gene family of cancer/testis-specific antigens: rapid evolution and amplification in African great apes and hominids. (PubMed id 14973187)1, 2, 3 Kouprina N.... Larionov V. (2004)
- Hominoid-specific SPANXA/D genes demonstrate differential expression in individuals and protein localization to a distinct nuclear envelope domain during spermatid morphogenesis. (PubMed id 17012309)1, 3 Westbrook V.A....Herr J.C. (2006)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
- Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27. (PubMed id 16251457)2 Kouprina N.... Larionov V. (2005)
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External Searches for SPANXN2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SPANXN2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing SPANXN2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPANXN2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPANXN2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SPANXN2 gene:
Search GeneIP for patents involving SPANXN2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPANXN2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPANXN2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPANXN2 | | Browse OriGene genome-wide validated SYBR primer pairs | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPANXN2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXN2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXN2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SPANXN2 | | OriGene Custom Protein Services for SPANXN2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPANXN2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPANXN2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPANXN2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPANXN2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPANXN2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPANXN2 |
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 | | | SPANXN2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPANXN2 |
|  |  |  | | | | Search ThermoFisher Antibodies for SPANXN2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPANXN2 |
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