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Aliases for SPANXN2 Gene

Aliases for SPANXN2 Gene

  • SPANX Family Member N2 2 3 4 5
  • Cancer/Testis Antigen Family 11, Member 7 2 3
  • Nuclear-Associated Protein SPAN-Xn2 3 4
  • SPANX-N2 3 4
  • Sperm Protein Associated With The Nucleus On The X Chromosome N2 3
  • SPANX Family, Member N2 2
  • CT11.7 3

External Ids for SPANXN2 Gene

Previous GeneCards Identifiers for SPANXN2 Gene

  • GC0XM142623
  • GC0XM142795
  • GC0XM131909

Summaries for SPANXN2 Gene

GeneCards Summary for SPANXN2 Gene

SPANXN2 (SPANX Family Member N2) is a Protein Coding gene. An important paralog of this gene is SPANXN3.

Additional gene information for SPANXN2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPANXN2 Gene

Genomics for SPANXN2 Gene

Regulatory Elements for SPANXN2 Gene

Genomic Locations for SPANXN2 Gene

Genomic Locations for SPANXN2 Gene
9,469 bases
Minus strand

Genomic View for SPANXN2 Gene

Genes around SPANXN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPANXN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPANXN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPANXN2 Gene

Proteins for SPANXN2 Gene

  • Protein details for SPANXN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sperm protein associated with the nucleus on the X chromosome N2
    Protein Accession:
    Secondary Accessions:
    • Q0ZNM2

    Protein attributes for SPANXN2 Gene

    180 amino acids
    Molecular mass:
    19917 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPANXN2 Gene

Post-translational modifications for SPANXN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPANXN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPANXN2 Gene

Domains & Families for SPANXN2 Gene

Gene Families for SPANXN2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPANXN2 Gene


Suggested Antigen Peptide Sequences for SPANXN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPAN-X family.
  • Belongs to the SPAN-X family.
genes like me logo Genes that share domains with SPANXN2: view

Function for SPANXN2 Gene

Phenotypes From GWAS Catalog for SPANXN2 Gene

genes like me logo Genes that share phenotypes with SPANXN2: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPANXN2 Gene

Localization for SPANXN2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPANXN2 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPANXN2 Gene

Pathways & Interactions for SPANXN2 Gene

SuperPathways for SPANXN2 Gene

No Data Available

Interacting Proteins for SPANXN2 Gene

Selected Interacting proteins: Q5MJ10-SPXN2_HUMAN for SPANXN2 Gene via UniProtKB

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for SPANXN2 Gene


No data available for Pathways by source and SIGNOR curated interactions for SPANXN2 Gene

Drugs & Compounds for SPANXN2 Gene

No Compound Related Data Available

Transcripts for SPANXN2 Gene

mRNA/cDNA for SPANXN2 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPANXN2 Gene

SPANX family, member N2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPANXN2 Gene

No ASD Table

Relevant External Links for SPANXN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPANXN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPANXN2 Gene

mRNA differential expression in normal tissues according to GTEx for SPANXN2 Gene

This gene is overexpressed in Testis (x52.7).

NURSA nuclear receptor signaling pathways regulating expression of SPANXN2 Gene:


SOURCE GeneReport for Unigene cluster for SPANXN2 Gene:

genes like me logo Genes that share expression patterns with SPANXN2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPANXN2 Gene

Orthologs for SPANXN2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SPANXN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPANXN2 33
  • 97.6 (n)
Species where no ortholog for SPANXN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPANXN2 Gene

Gene Tree for SPANXN2 (if available)
Gene Tree for SPANXN2 (if available)

Paralogs for SPANXN2 Gene

Paralogs for SPANXN2 Gene

(12) SIMAP similar genes for SPANXN2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPANXN2: view

Variants for SPANXN2 Gene

Sequence variations from dbSNP and Humsavar for SPANXN2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs111276881 -- 143,720,076(+) GGCAG(C/G)AAGCA intron-variant
rs111298314 -- 143,712,837(+) AACAT(C/T)CCTAT intron-variant
rs111372484 -- 143,719,684(+) TAACA(C/T)TTTGC intron-variant
rs111386622 -- 143,712,430(+) TGTTA(A/C/G)ATATT reference, synonymous-codon, missense
rs111562170 -- 143,715,627(+) TTTTC(C/T)TTCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPANXN2 Gene

Variant ID Type Subtype PubMed ID
esv3574887 CNV loss 25503493
esv2740547 CNV deletion 23290073
dgv1403e199 CNV deletion 23128226

Variation tolerance for SPANXN2 Gene

Residual Variation Intolerance Score: 25.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.95; 49.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPANXN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPANXN2 Gene

Disorders for SPANXN2 Gene

Relevant External Links for SPANXN2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SPANXN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPANXN2 Gene

Publications for SPANXN2 Gene

  1. The SPANX gene family of cancer/testis-specific antigens: rapid evolution and amplification in African great apes and hominids. (PMID: 14973187) Kouprina N … Larionov V (Proceedings of the National Academy of Sciences of the United States of America 2004) 2 3 4 60
  2. Hominoid-specific SPANXA/D genes demonstrate differential expression in individuals and protein localization to a distinct nuclear envelope domain during spermatid morphogenesis. (PMID: 17012309) Westbrook VA … Herr JC (Molecular human reproduction 2006) 2 3 60
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 4 60
  4. Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27. (PMID: 16251457) Kouprina N … Larionov V (Genome research 2005) 4 60

Products for SPANXN2 Gene

Sources for SPANXN2 Gene

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