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Aliases for SPANXN2 Gene

Aliases for SPANXN2 Gene

  • SPANX Family, Member N2 2 3
  • Nuclear-Associated Protein SPAN-Xn2 3 4
  • SPANX-N2 3 4
  • Cancer/Testis Antigen Family 11, Member 7 3
  • Cancer/Testis Antigen Family 11 2
  • SPANX Family Member N2 4
  • Member 7 2
  • CT11.7 3

External Ids for SPANXN2 Gene

Previous GeneCards Identifiers for SPANXN2 Gene

  • GC0XM142623
  • GC0XM142795
  • GC0XM131909

Summaries for SPANXN2 Gene

GeneCards Summary for SPANXN2 Gene

SPANXN2 (SPANX Family, Member N2) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPANXN2 Gene

Genomics for SPANXN2 Gene

Regulatory Elements for SPANXN2 Gene

Genomic Location for SPANXN2 Gene

143,711,955 bp from pter
143,721,423 bp from pter
9,469 bases
Minus strand

Genomic View for SPANXN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for SPANXN2 Gene

Proteins for SPANXN2 Gene

  • Protein details for SPANXN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sperm protein associated with the nucleus on the X chromosome N2
    Protein Accession:
    Secondary Accessions:
    • Q0ZNM2

    Protein attributes for SPANXN2 Gene

    180 amino acids
    Molecular mass:
    19917 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPANXN2 Gene

Proteomics data for SPANXN2 Gene at MOPED

Post-translational modifications for SPANXN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPANXN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPANXN2 Gene

Domains & Families for SPANXN2 Gene

Protein Domains for SPANXN2 Gene


Suggested Antigen Peptide Sequences for SPANXN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPAN-X family.
  • Belongs to the SPAN-X family.
genes like me logo Genes that share domains with SPANXN2: view

No data available for Gene Families for SPANXN2 Gene

Function for SPANXN2 Gene

Phenotypes for SPANXN2 Gene

genes like me logo Genes that share phenotypes with SPANXN2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPANXN2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPANXN2 Gene

Localization for SPANXN2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SPANXN2 Gene

Pathways & Interactions for SPANXN2 Gene

SuperPathways for SPANXN2 Gene

No Data Available

Interacting Proteins for SPANXN2 Gene

Gene Ontology (GO) - Biological Process for SPANXN2 Gene


No data available for Pathways by source and SIGNOR curated interactions for SPANXN2 Gene

Drugs & Compounds for SPANXN2 Gene

No Compound Related Data Available

Transcripts for SPANXN2 Gene

mRNA/cDNA for SPANXN2 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPANXN2 Gene

SPANX family, member N2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPANXN2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPANXN2 Gene

No ASD Table

Relevant External Links for SPANXN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPANXN2 Gene

mRNA expression in normal human tissues for SPANXN2 Gene

mRNA differential expression in normal tissues according to GTEx for SPANXN2 Gene

This gene is overexpressed in Testis (x52.7).

SOURCE GeneReport for Unigene cluster for SPANXN2 Gene Hs.535083

genes like me logo Genes that share expression patterns with SPANXN2: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SPANXN2 Gene

Orthologs for SPANXN2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SPANXN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPANXN2 35
  • 97.6 (n)
  • 96.4 (a)
Species with no ortholog for SPANXN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPANXN2 Gene

Gene Tree for SPANXN2 (if available)
Gene Tree for SPANXN2 (if available)

Paralogs for SPANXN2 Gene

(12) SIMAP similar genes for SPANXN2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPANXN2: view

No data available for Paralogs for SPANXN2 Gene

Variants for SPANXN2 Gene

Sequence variations from dbSNP and Humsavar for SPANXN2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs851089 -- 143,722,169(-) ccata(G/T)gaata upstream-variant-2KB
rs851090 -- 143,721,400(-) GACTA(A/G)GATAC upstream-variant-2KB
rs851091 -- 143,721,233(-) TGCAT(A/G)TGAAG upstream-variant-2KB
rs851092 -- 143,720,477(-) ggacc(C/T)gctta intron-variant
rs851093 -- 143,720,445(-) tacag(C/G)ctggg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPANXN2 Gene

Variant ID Type Subtype PubMed ID
esv2740547 CNV Deletion 23290073
dgv1403e199 CNV Deletion 23128226

Variation tolerance for SPANXN2 Gene

Residual Variation Intolerance Score: 25.74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.95; 49.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPANXN2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPANXN2 Gene

Disorders for SPANXN2 Gene

Relevant External Links for SPANXN2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SPANXN2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPANXN2 Gene

Publications for SPANXN2 Gene

  1. Hominoid-specific SPANXA/D genes demonstrate differential expression in individuals and protein localization to a distinct nuclear envelope domain during spermatid morphogenesis. (PMID: 17012309) Westbrook V.A. … Herr J.C. (Mol. Hum. Reprod. 2006) 2 67
  2. The SPANX gene family of cancer/testis-specific antigens: rapid evolution and amplification in African great apes and hominids. (PMID: 14973187) Kouprina N. … Larionov V. (Proc. Natl. Acad. Sci. U.S.A. 2004) 2 67
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 67
  4. Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27. (PMID: 16251457) Kouprina N. … Larionov V. (Genome Res. 2005) 67

Products for SPANXN2 Gene

Sources for SPANXN2 Gene

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