SPANXE Gene
protein-coding GIFtS: 29
GCID: GC0XU900006
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SPANX family, member E
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Aliases
for SPANXE gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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| Aliases |
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| SPANX Family, Member E1 2 | | Nuclear-Associated Protein SPAN-Xe2 3 | | SPANX-E2 3 | | Sperm Protein Associated With The Nucleus On The X Chromosome E2 | | Sperm Protein Associated With The Nucleus, X Chromosome, Family Member E2 | | SPANX Family Member E3 |
Export aliases for SPANXE gene to outside databasesPrevious GC identifers: GC0XM135315 GC0XM139480 GC0XM139481 GC0XM140512 GC0XM140614 GC0XM140785 |
Summaries
for SPANXE gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SPANXE:
Temporally regulated transcription and translation of several testis-specific genes is required to initiate the seriesof molecular and morphological changes in the male germ cell lineage necessary for the formation of maturespermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in acluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize tovarious subcellular compartments. This particular gene encodes a sperm protein that contains a consensus nuclearlocalization signal but, although a role in spermatogenesis is suggested, the specific function of this family memberhas not yet been determined. (provided by RefSeq, Jul 2008)
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Genomic Views
for SPANXE gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for SPANXE
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPANXE
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPANXE |
Genomic Location:
Chromosome:X
Entrez Gene cytogenetic band: Xq27.2 HGNC cytogenetic band: Xq27.2GeneLoc information about chromosome X |
Proteins
for SPANXE gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: SPNXE_HUMAN, Q8TAD1 (See
protein sequence)Recommended Name: Sperm protein associated with the nucleus on the X chromosome E Size: 97 amino acids; 10982 Da
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Note=Associated with nuclear craters (Bysimilarity)
Developmental stage: Detected in round and elongating spermatids
Caution: According to PubMed:12758128, SPANXE has high homology to SPANXD and is identified in clone AC025096, thoughnot represented so far in the human genome sequence. The number of copies in this gene family may change according tohaplotypes
Secondary accessions: Q32WL2 Q32WM0 Q9BS24Explore the universe of human proteins at neXtProt for SPANXE: NX_Q8TAD1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TAD1
SPANXE Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_663698.1
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SPANXE for ontologies About GeneDecksing
SPANXE Antibody Products:
Assay Products for SPANXE: |
Protein
Domains /
Families
for SPANXE gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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SPANXE for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8TAD1ProtoNet protein and cluster: Q8TAD1 UniProtKB/Swiss-Prot: SPNXE_HUMAN, Q8TAD1Similarity: Belongs to the SPAN-X family |
Function
for SPANXE gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXE
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXE
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SPANXE (NM_145665) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPANXE | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPANXE |
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Pathways & Interactions
for SPANXE gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPANXE
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Drugs & Compounds
for SPANXE gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPANXE
Search CenterWatch for drugs/clinical trials and news about SPANXE / SPNXE
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Transcripts
for SPANXE gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for SPANXE gene: NM_145665.1
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXE
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXE
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPANXE (NM_145665) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPANXE | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPANXE |
12 AceView cDNA sequences: BM554791 AF312765 NM_032417 CB106942 CB119085 AI808260 AI143898 BC005382 NM_145665 AJ457795 BC062672 BF212177
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Expression
for SPANXE gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
UniProtKB/Swiss-Prot: SPNXE_HUMAN, Q8TAD1Tissue specificity: Detected in testis, sperm and a melanoma cell line
SABiosciences Custom PCR Arrays for SPANXE
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPANXE
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat SPANXE | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPANXE | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPANXE |
Orthologs
for SPANXE gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
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Paralogs
for SPANXE gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
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Genomic Variants
for SPANXE gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for SPANXE
9 CNVs: 4175 83800 74067 97032 0827 31568 97030 83798 83799 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for SPANXE gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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SPANXE for disorders About GeneDecksing
OMIM gene information: 300671
OMIM disorders: --
6  diseases for SPANXE: About MalaCardsmale germ cell tumor germ cell tumor prostate cancer infertility
prostatitis melanoma
Human Genome Epidemiology (HuGE) Navigator: SPANXE (1 document)
Export disorders for SPANXE gene to outside databases
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Publications
for SPANXE gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for SPANXE gene integrated from 9 sources:
(articles sorted by number of sources associating them with SPANXE) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines. (PubMed id 12758128)1, 2, 9 Zendman A.J.... van Muijen G.N.P. (2003)
- Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27. (PubMed id 16251457)1, 2 Kouprina N.... Larionov V. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- SPANX gene variation in fertile and infertile males. (PubMed id 20073942)1 Hansen S....Carrell D. (2010)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Differential nuclear localization of the cancer/testis-associated protein, SPAN-X/CTp11, in transfected cells and in 50% of human spermatozoa. (PubMed id 11133693)1 Westbrook V.A....Herr J.C. (2001)
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External Searches for SPANXE gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SPANXE gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing SPANXE gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPANXE gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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About This Section
| Patent Information for SPANXE gene:
Search GeneIP for patents involving SPANXE
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SPANXE gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPANXE | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPANXE | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPANXE | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPANXE | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXE | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXE | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SPANXE | | OriGene Custom Protein Services for SPANXE | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPANXE | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPANXE | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPANXE | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPANXE | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPANXE | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPANXE |
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| | | | Search Tocris compounds for SPANXE |
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 | | | SPANXE Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for SPANXE |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPANXE |
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