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Aliases for SPANXD Gene

Aliases for SPANXD Gene

  • SPANX Family Member D 2 3 4 5
  • Nuclear-Associated Protein SPAN-Xd 3 4
  • Cancer/Testis Antigen 11.4 3 4
  • SPANX Family, Member E 2 3
  • SPANX Family, Member D 2 3
  • SPANX-D 3 4
  • SPANXE 3 4
  • CT11.4 3 4
  • Sperm Protein Associated With The Nucleus, X Chromosome, Family Member D 3
  • Sperm Protein Associated With The Nucleus, X Chromosome, Family Member E 3
  • Cancer/Testis Antigen Family 11, Member 4 3
  • Nuclear-Associated Protein SPAN-Xe 3
  • Cancer/Testis Antigen Family 11 2
  • DJ171K16.1 3
  • Member 4 2
  • SPANX-C 3
  • SPANX-E 3

External Ids for SPANXD Gene

Previous HGNC Symbols for SPANXD Gene


Previous GeneCards Identifiers for SPANXD Gene

  • GC0XU990341
  • GC0XM137643
  • GC0XM138718
  • GC0XM139479
  • GC0XM140511
  • GC0XM140613
  • GC0XM140786

Summaries for SPANXD Gene

Entrez Gene Summary for SPANXD Gene

  • Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a sperm protein that is associated with the nucleus but, although a role in spermatogenesis is suggested, the specific function of this family member has not yet been determined. Polymorphisms in this gene may be associated with prostate cancer susceptibility. [provided by RefSeq, Apr 2014]

GeneCards Summary for SPANXD Gene

SPANXD (SPANX Family Member D) is a Protein Coding gene. Diseases associated with SPANXD include Prostate Cancer Susceptibility. An important paralog of this gene is SPANXA2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPANXD Gene

Genomics for SPANXD Gene

Regulatory Elements for SPANXD Gene

Genomic Location for SPANXD Gene

141,697,401 bp from pter
141,698,739 bp from pter
1,339 bases
Minus strand

Genomic View for SPANXD Gene

Genes around SPANXD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPANXD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPANXD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPANXD Gene

Proteins for SPANXD Gene

  • Protein details for SPANXD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sperm protein associated with the nucleus on the X chromosome D
    Protein Accession:
    Secondary Accessions:
    • Q5JWI1

    Protein attributes for SPANXD Gene

    97 amino acids
    Molecular mass:
    11029 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPANXD Gene

Proteomics data for SPANXD Gene at MOPED

Post-translational modifications for SPANXD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPANXD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPANXD Gene

Domains & Families for SPANXD Gene

Protein Domains for SPANXD Gene


Suggested Antigen Peptide Sequences for SPANXD Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPAN-X family.
  • Belongs to the SPAN-X family.
genes like me logo Genes that share domains with SPANXD: view

No data available for Gene Families for SPANXD Gene

Function for SPANXD Gene

genes like me logo Genes that share phenotypes with SPANXD: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPANXD Gene

Localization for SPANXD Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPANXD Gene

Cytoplasm. Nucleus. Note=Associated with nuclear craters. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for SPANXD Gene COMPARTMENTS Subcellular localization image for SPANXD gene
Compartment Confidence
nucleus 5
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for SPANXD Gene

Pathways & Interactions for SPANXD Gene

SuperPathways for SPANXD Gene

No Data Available

Interacting Proteins for SPANXD Gene

Selected Interacting proteins: Q9BXN6-SPNXD_HUMAN for SPANXD Gene via UniProtKB

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for SPANXD Gene


No data available for Pathways by source and SIGNOR curated interactions for SPANXD Gene

Drugs & Compounds for SPANXD Gene

No Compound Related Data Available

Transcripts for SPANXD Gene


(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPANXD Gene

SPANX family, member D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPANXD Gene

No ASD Table

Relevant External Links for SPANXD Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPANXD Gene

mRNA expression in normal human tissues for SPANXD Gene

mRNA differential expression in normal tissues according to GTEx for SPANXD Gene

This gene is overexpressed in Testis (x52.8).

SOURCE GeneReport for Unigene cluster for SPANXD Gene Hs.375036

mRNA Expression by UniProt/SwissProt for SPANXD Gene

Tissue specificity: Detected in testis, sperm and a melanoma cell line.
genes like me logo Genes that share expression patterns with SPANXD: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SPANXD Gene

Orthologs for SPANXD Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SPANXD Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 36
  • 57 (a)
Species with no ortholog for SPANXD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPANXD Gene

Gene Tree for SPANXD (if available)
Gene Tree for SPANXD (if available)

Paralogs for SPANXD Gene

Paralogs for SPANXD Gene

genes like me logo Genes that share paralogs with SPANXD: view

Variants for SPANXD Gene

Sequence variations from dbSNP and Humsavar for SPANXD Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs5953618 - 141,697,557(+) ATTCA(A/C/G)CAGTT reference, missense
rs598575 -- 141,697,170(+) GCTGC(C/T)GGGTA downstream-variant-500B
rs610102 -- 141,697,431(+) TTATT(G/T)TCATT utr-variant-3-prime
rs2744409 -- 141,700,315(+) ctgaa(A/G)atgag upstream-variant-2KB
rs2867981 -- 141,700,644(+) atttt(G/T)gcCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SPANXD Gene

Variant ID Type Subtype PubMed ID
dgv2483e1 CNV Complex 17122850
essv9625 CNV CNV 17122850
nsv471606 CNV Gain 15918152
nsv9984 CNV Gain 18304495
esv25564 CNV Gain+Loss 19812545

Variation tolerance for SPANXD Gene

Residual Variation Intolerance Score: 92.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.85; 34.68% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SPANXD Gene

Disorders for SPANXD Gene

MalaCards: The human disease database

(1) MalaCards diseases for SPANXD Gene - From: GeneCards

Disorder Aliases PubMed IDs
prostate cancer susceptibility
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SPANXD

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SPANXD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPANXD Gene

Publications for SPANXD Gene

  1. SPANX gene variation in fertile and infertile males. (PMID: 20073942) Hansen S. … Carrell D. (Syst Biol Reprod Med 2010) 3 48 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3
  4. Mutational analysis of SPANX genes in families with X-linked prostate cancer. (PMID: 17373721) Kouprina N. … Larionov V. (Prostate 2007) 3
  5. Hominoid-specific SPANXA/D genes demonstrate differential expression in individuals and protein localization to a distinct nuclear envelope domain during spermatid morphogenesis. (PMID: 17012309) Westbrook V.A. … Herr J.C. (Mol. Hum. Reprod. 2006) 3

Products for SPANXD Gene

Sources for SPANXD Gene