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Aliases for SPANXD Gene

Aliases for SPANXD Gene

  • SPANX Family, Member D 2 3
  • Nuclear-Associated Protein SPAN-Xd 3 4
  • Cancer/Testis Antigen 11.4 3 4
  • SPANX Family, Member E 2 3
  • SPANX-D 3 4
  • CT11.4 3 4
  • Sperm Protein Associated With The Nucleus, X Chromosome, Family Member D 3
  • Sperm Protein Associated With The Nucleus, X Chromosome, Family Member E 3
  • Sperm Protein Associated With The Nucleus On The X Chromosome D 3
  • Cancer/Testis Antigen Family 11, Member 4 3
  • Nuclear-Associated Protein SPAN-Xe 3
  • Cancer/Testis Antigen Family 11 2
  • SPANX Family Member D 4
  • DJ171K16.1 3
  • Member 4 2
  • SPANX-C 3
  • SPANX-E 3
  • SPANXE 3

External Ids for SPANXD Gene

Previous Symbols for SPANXD Gene

  • SPANXE

Summaries for SPANXD Gene

Entrez Gene Summary for SPANXD Gene

  • Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a sperm protein that is associated with the nucleus but, although a role in spermatogenesis is suggested, the specific function of this family member has not yet been determined. Polymorphisms in this gene may be associated with prostate cancer susceptibility. [provided by RefSeq, Apr 2014]

GeneCards Summary for SPANXD Gene

SPANXD (SPANX Family, Member D) is a Protein Coding gene. An important paralog of this gene is SPANXA2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPANXD Gene

Genomics for SPANXD Gene

Genomic Location for SPANXD Gene

Start:
141,697,411 bp from pter
End:
141,698,739 bp from pter
Size:
1,329 bases
Orientation:
Minus strand

Genomic View for SPANXD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPANXD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPANXD Gene

Regulatory Elements for SPANXD Gene

Proteins for SPANXD Gene

  • Protein details for SPANXD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXN6-SPNXD_HUMAN
    Recommended name:
    Sperm protein associated with the nucleus on the X chromosome D
    Protein Accession:
    Q9BXN6
    Secondary Accessions:
    • Q5JWI1

    Protein attributes for SPANXD Gene

    Size:
    97 amino acids
    Molecular mass:
    11029 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPANXD Gene

Proteomics data for SPANXD Gene at MOPED

Post-translational modifications for SPANXD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPANXD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPANXD Gene

Domains for SPANXD Gene

Protein Domains for SPANXD Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

SPNXD_HUMAN
Family:
  • Belongs to the SPAN-X family.:
    • Q9BXN6
genes like me logo Genes that share domains with SPANXD: view

No data available for Gene Families for SPANXD Gene

Function for SPANXD Gene

Gene Ontology (GO) - Molecular Function for SPANXD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SPANXD: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SPANXD Gene

Localization for SPANXD Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPANXD Gene

Cytoplasm. Nucleus. Note=Associated with nuclear craters. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPANXD Gene COMPARTMENTS Subcellular localization image for SPANXD gene
Compartment Confidence
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for SPANXD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SPANXD: view

Pathways for SPANXD Gene

SuperPathways for SPANXD Gene

No Data Available

Interacting Proteins for SPANXD Gene

Selected Interacting proteins: Q9BXN6-SPNXD_HUMAN for SPANXD Gene via UniProtKB

Symbol External ID(s) Details
SETBP1

Gene Ontology (GO) - Biological Process for SPANXD Gene

None

No data available for Pathways by source for SPANXD Gene

Transcripts for SPANXD Gene

mRNA/cDNA for SPANXD Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPANXD Gene

SPANX family, member D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPANXD Gene

No ASD Table

Relevant External Links for SPANXD Gene

GeneLoc Exon Structure for
SPANXD
ECgene alternative splicing isoforms for
SPANXD

Expression for SPANXD Gene

mRNA expression in normal human tissues for SPANXD Gene

mRNA differential expression in normal tissues according to GTEx for SPANXD Gene

This gene is overexpressed in Testis (52.8).

SOURCE GeneReport for Unigene cluster for SPANXD Gene Hs.375036

mRNA Expression by UniProt/SwissProt for SPANXD Gene

Q9BXN6-SPNXD_HUMAN
Tissue specificity: Detected in testis, sperm and a melanoma cell line.
genes like me logo Genes that share expressions with SPANXD: view

Orthologs for SPANXD Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SPANXD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 57 (a)
OneToMany
Species with no ortholog for SPANXD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPANXD Gene

ENSEMBL:
Gene Tree for SPANXD (if available)
TreeFam:
Gene Tree for SPANXD (if available)

Paralogs for SPANXD Gene

Paralogs for SPANXD Gene

Selected SIMAP similar genes for SPANXD Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SPANXD: view

Variants for SPANXD Gene

Sequence variations from dbSNP and Humsavar for SPANXD Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs610102 -- 141,697,431(+) TTATT(G/T)TCATT utr-variant-3-prime
rs2744409 -- 141,700,315(+) ctgaa(A/G)atgag upstream-variant-2KB
rs2867981 -- 141,700,644(+) atttt(G/T)gcCCT upstream-variant-2KB
rs2867982 -- 141,700,646(+) tttGG(C/G)CCTGT upstream-variant-2KB
rs2903712 -- 141,700,630(+) acctt(G/T)aagaa upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SPANXD Gene

Variant ID Type Subtype PubMed ID
dgv2483e1 CNV Complex 17122850
essv9625 CNV CNV 17122850
nsv471606 CNV Gain 15918152
nsv9984 CNV Gain 18304495
esv25564 CNV Gain+Loss 19812545

Relevant External Links for SPANXD Gene

HapMap Linkage Disequilibrium report
SPANXD

Disorders for SPANXD Gene

Relevant External Links for SPANXD

Genetic Association Database (GAD)
SPANXD
Human Genome Epidemiology (HuGE) Navigator
SPANXD
genes like me logo Genes that share disorders with SPANXD: view

No data available for UniProtKB/Swiss-Prot for SPANXD Gene

Publications for SPANXD Gene

  1. The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines. (PMID: 12758128) Zendman A.J. … van Muijen G.N.P. (Gene 2003) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27. (PMID: 16251457) Kouprina N. … Larionov V. (Genome Res. 2005) 3 4
  4. SPANX gene variation in fertile and infertile males. (PMID: 20073942) Hansen S. … Carrell D. (Syst Biol Reprod Med 2010) 3 49
  5. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3

Products for SPANXD Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate SPANXD
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for SPANXD
    • Block miRNA regulation of SPANXD using miScript Target Protectors

    Sources for SPANXD Gene

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