SPANXD Gene
protein-coding GIFtS: 37
GCID: GC0XM140786
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SPANX family, member D
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Aliases
for SPANXD gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SPANX Family, Member D1 2 | | Cancer/Testis Antigen Family 11, Member 42 | | CT11.41 2 3 | | DJ171K16.11 | | Cancer/Testis Antigen 11.42 3 | | SPAN-Xd Protein2 | | Nuclear-Associated Protein SPAN-Xd2 3 | | Sperm Protein Associated With The Nucleus On The X Chromosome D2 | | SPANX-D2 3 | | Sperm Protein Associated With The Nucleus, X Chromosome, Family Member D2 | | SPANX-C2 | | SPANX Family Member D3 |
Export aliases for SPANXD gene to outside databasesPrevious GC identifers: GC0XU990341 GC0XM137643 GC0XM138718 GC0XM139479 GC0XM140511 GC0XM140613 |
Summaries
for SPANXD gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SPANXD:
Temporally regulated transcription and translation of several testis-specific genes is required to initiate the seriesof molecular and morphological changes in the male germ cell lineage necessary for the formation of maturespermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in acluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize tovarious subcellular compartments. This particular gene encodes a sperm protein that is associated with the nucleusbut, although a role in spermatogenesis is suggested, the specific function of this family member has not yet beendetermined. (provided by RefSeq, Jul 2008)
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Genomic Views
for SPANXD gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NT_011786.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPANXD gene promoter:
Max1 POU3F2 Evi-1 MEF-2A S8 CBF-A CBF-B CP1A aMEF-2 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPANXD
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPANXD |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq27.1 Ensembl cytogenetic band: Xq27.2 HGNC cytogenetic band: Xq27.2SPANXD Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM140786: view genomic region
(about GC identifiers)
Start:
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140,785,568 bp from pter |
End:
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140,786,896 bp from pter |
Size:
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1,329 bases |
Orientation:
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minus strand |
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Proteins
for SPANXD gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPNXD_HUMAN, Q9BXN6 (See
protein sequence)Recommended Name: Sperm protein associated with the nucleus on the X chromosome D Size: 97 amino acids; 11029 Da
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Note=Associated with nuclear craters (Bysimilarity)
Developmental stage: Detected in round and elongating spermatids
Secondary accessions: Q5JWI1Explore the universe of human proteins at neXtProt for SPANXD: NX_Q9BXN6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BXN6
SPANXD Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115793.1
ENSEMBL proteins: ENSP00000359546
Human Recombinant Protein Products for SPANXD:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SPANXD for ontologies About GeneDecksing
SPANXD Antibody Products:
Assay Products for SPANXD: |
Protein
Domains /
Families
for SPANXD gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPANXD for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BXN6ProtoNet protein and cluster: Q9BXN6 UniProtKB/Swiss-Prot: SPNXD_HUMAN, Q9BXN6Similarity: Belongs to the SPAN-X family |
Function
for SPANXD gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXD
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXD
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SPANXD (NM_032417) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPANXD | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPANXD |
|
Pathways & Interactions
for SPANXD gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPANXD
|
Drugs & Compounds
for SPANXD gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPANXD
Search CenterWatch for drugs/clinical trials and news about SPANXD / SPNXD
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Transcripts
for SPANXD gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPANXD gene: NM_032417.2 Unigene Cluster for SPANXD: SPANX family, member D Hs.375036 [show with all ESTs]Unigene Representative Sequence: BM5547911 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000370515(uc004fbq.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXD
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXD
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPANXD (NM_032417) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPANXD | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPANXD |
Additional cDNA sequence: AF312765.1 AJ457795.1 BC005382.1 BC062672.1 BC103960.1 BC103961.1 BC121070.2 BC134418.1 2 DOTS entries: DT.101961078 DT.100036177 12 AceView cDNA sequences: BM554791 AF312765 NM_032417 CB119085 CB106942 AI808260 NM_145665 AJ457795 AI143898 BC005382 BC062672 BF212177
GeneLoc Exon Structure
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Expression
for SPANXD gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPANXD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SPANXD Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.375036
UniProtKB/Swiss-Prot: SPNXD_HUMAN, Q9BXN6Tissue specificity: Detected in testis, sperm and a melanoma cell line
SABiosciences Custom PCR Arrays for SPANXD
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPANXD
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat SPANXD | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPANXD | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPANXD |
Orthologs
for SPANXD gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
ENSEMBL Gene Tree for SPANXD (if available)
TreeFam Gene Tree for SPANXD (if available) |
Paralogs
for SPANXD gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SPANXD gene
- SPANXA21 2 SPANXA11 2 SPANXC1 2 SPANXB21 2 SPANXB11 2 SPANXN22 SPANXN12 SPANXN52
- SPANXN32 SPANXN42
11 SIMAP similar genes for SPANXD using alignment to 5 protein entries: SPNXD_HUMAN (see all proteins):SPANXA2 SPANXE SPANXA1 SPANXC SPANXB1 SPANXB2
SPANXF1 SPANXN5 SPANXN2 SPANXN1 SPANXN3
SPANXD for paralogs About GeneDecksing
|
Genomic Variants
for SPANXD gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SPANXD (140785568 - 140786896 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for SPANXD
9 CNVs: 4175 83800 74067 97032 0827 31568 97030 83798 83799 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for SPANXD gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SPANXD for disorders About GeneDecksing
OMIM gene information: 300670
OMIM disorders: --
6  diseases for SPANXD: About MalaCardsmale germ cell tumor germ cell tumor prostate cancer infertility
prostatitis melanoma
Human Genome Epidemiology (HuGE) Navigator: SPANXD (1 document)
Export disorders for SPANXD gene to outside databases
|
Publications
for SPANXD gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPANXD gene integrated from 9 sources:
(articles sorted by number of sources associating them with SPANXD) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27. (PubMed id 16251457)1, 2 Kouprina N.... Larionov V. (2005)
- The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines. (PubMed id 12758128)1, 2 Zendman A.J.... van Muijen G.N.P. (2003)
- SPANX gene variation in fertile and infertile males. (PubMed id 20073942)1 Hansen S....Carrell D. (2010)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Differential nuclear localization of the cancer/testis-associated protein, SPAN-X/CTp11, in transfected cells and in 50% of human spermatozoa. (PubMed id 11133693)1 Westbrook V.A....Herr J.C. (2001)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for SPANXD gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SPANXD gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing SPANXD gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPANXD gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SPANXD gene:
Search GeneIP for patents involving SPANXD
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPANXD gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPANXD | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPANXD | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPANXD | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPANXD | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXD | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXD | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SPANXD | | OriGene Custom Protein Services for SPANXD | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPANXD | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPANXD | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPANXD | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPANXD | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPANXD | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPANXD |
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| | | | Search Tocris compounds for SPANXD |
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 | | | SPANXD Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | Search ThermoFisher Antibodies for SPANXD |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPANXD |
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