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Aliases for SPANXC Gene

Aliases for SPANXC Gene

  • SPANX Family Member C 2 3 4 5
  • Cancer/Testis Antigen Family 11, Member 3 2 3
  • Nuclear-Associated Protein SPAN-Xc 3 4
  • Cancer/Testis Antigen 11.3 3 4
  • SPANX-C 3 4
  • CT11.3 3 4
  • Sperm Protein Associated With The Nucleus, X Chromosome, Family Member C 3
  • Sperm Protein Associated With The Nucleus On The X Chromosome E 3
  • Sperm Protein Associated With The Nucleus On The X Chromosome C 3
  • Cancer/Testis-Associated Protein Of 11 KD 3
  • Cancer-Testis-Associated Protein CTp11 3
  • Cancer/Testis-Associated Protein CTp11 4
  • Nuclear-Associated Protein SPAN-Xe 3
  • SPANX Family, Member C 2
  • SPAN-Xc Protein 3
  • SPANX-E 3
  • SPANXE 3
  • CTp11 3
  • C 3

External Ids for SPANXC Gene

Previous GeneCards Identifiers for SPANXC Gene

  • GC0XM134865
  • GC0XM137193
  • GC0XM138268
  • GC0XM139029
  • GC0XM140063
  • GC0XM140163
  • GC0XM140335

Summaries for SPANXC Gene

Entrez Gene Summary for SPANXC Gene

  • Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family, which is located in a gene cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a protein that localizes to the nucleus and is expressed in highly metastatic cell lines, making the protein a potential diagnostic and prognostic marker. The protein belongs to a family of cancer/testis antigens and represents a potential target for cancer immunotherapy. [provided by RefSeq, Jul 2008]

GeneCards Summary for SPANXC Gene

SPANXC (SPANX Family Member C) is a Protein Coding gene. An important paralog of this gene is SPANXD.

Additional gene information for SPANXC Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPANXC Gene

Genomics for SPANXC Gene

GeneHancer (GH) Regulatory Elements for SPANXC Gene

Promoters and enhancers for SPANXC Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI141242 Promoter 0.5 EPDnew 550.8 +0.0 13 0.1 SPANXC GC0XP141237
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPANXC on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPANXC gene promoter:

Genomic Locations for SPANXC Gene

Genomic Locations for SPANXC Gene
1,088 bases
Minus strand

Genomic View for SPANXC Gene

Genes around SPANXC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPANXC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPANXC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPANXC Gene

Proteins for SPANXC Gene

  • Protein details for SPANXC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sperm protein associated with the nucleus on the X chromosome C
    Protein Accession:
    Secondary Accessions:
    • Q32WL2
    • Q32WL9
    • Q32WM0
    • Q5JX88
    • Q8TAD1
    • Q9BS24

    Protein attributes for SPANXC Gene

    97 amino acids
    Molecular mass:
    10982 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPANXC Gene

Post-translational modifications for SPANXC Gene

No Post-translational modifications

Other Protein References for SPANXC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPANXC Gene

Domains & Families for SPANXC Gene

Gene Families for SPANXC Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPANXC Gene


Suggested Antigen Peptide Sequences for SPANXC Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPAN-X family.
  • Belongs to the SPAN-X family.
genes like me logo Genes that share domains with SPANXC: view

Function for SPANXC Gene

Gene Ontology (GO) - Molecular Function for SPANXC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SPANXC: view
genes like me logo Genes that share phenotypes with SPANXC: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPANXC Gene

Localization for SPANXC Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPANXC Gene

Cytoplasm. Nucleus. Note=Associated with nuclear craters.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPANXC gene
Compartment Confidence
nucleus 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SPANXC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10626816
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SPANXC: view

Pathways & Interactions for SPANXC Gene

SuperPathways for SPANXC Gene

No Data Available

Interacting Proteins for SPANXC Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000351884 Q9NY87-SPNXC_HUMAN for SPANXC Gene via STRING UniProtKB IID

Gene Ontology (GO) - Biological Process for SPANXC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SPANXC: view

No data available for Pathways by source and SIGNOR curated interactions for SPANXC Gene

Drugs & Compounds for SPANXC Gene

No Compound Related Data Available

Transcripts for SPANXC Gene


(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPANXC Gene

SPANX family, member C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPANXC Gene

No ASD Table

Relevant External Links for SPANXC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPANXC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPANXC Gene

mRNA differential expression in normal tissues according to GTEx for SPANXC Gene

This gene is overexpressed in Testis (x52.4).

NURSA nuclear receptor signaling pathways regulating expression of SPANXC Gene:


SOURCE GeneReport for Unigene cluster for SPANXC Gene:


mRNA Expression by UniProt/SwissProt for SPANXC Gene:

Tissue specificity: Detected in testis, melanoma and bladder carcinoma.

Evidence on tissue expression from TISSUES for SPANXC Gene

  • Bone marrow(4.1)
genes like me logo Genes that share expression patterns with SPANXC: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPANXC Gene

Orthologs for SPANXC Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SPANXC Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 61 (a)
Species where no ortholog for SPANXC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPANXC Gene

Gene Tree for SPANXC (if available)
Gene Tree for SPANXC (if available)

Paralogs for SPANXC Gene

Paralogs for SPANXC Gene

genes like me logo Genes that share paralogs with SPANXC: view

Variants for SPANXC Gene

Sequence variations from dbSNP and Humsavar for SPANXC Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs113495682 -- 141,241,125(-) T/A downstream_transcript_variant
rs12389358 -- 141,243,312(-) T/C/G upstream_transcript_variant
rs12389456 -- 141,243,567(-) G/C/T upstream_transcript_variant
rs12394263 -- 141,243,572(-) A/G upstream_transcript_variant
rs12394302 -- 141,243,552(-) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SPANXC Gene

Variant ID Type Subtype PubMed ID
dgv2498e212 CNV gain 25503493
esv2758896 CNV gain+loss 17122850
esv27688 CNV gain+loss 19812545
esv3577441 CNV gain 25503493
nsv470367 CNV loss 18288195
nsv470368 CNV gain 18288195
nsv516880 CNV gain+loss 19592680
nsv7462 OTHER inversion 18451855
nsv9980 CNV gain 18304495

Variation tolerance for SPANXC Gene

Residual Variation Intolerance Score: 94.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPANXC Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPANXC Gene

Disorders for SPANXC Gene

Additional Disease Information for SPANXC

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SPANXC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPANXC Gene

Publications for SPANXC Gene

  1. CTp11, a novel member of the family of human cancer/testis antigens. (PMID: 10626816) Zendman AJ … van Muijen GN (Cancer research 1999) 2 3 4 58
  2. SPANX gene variation in fertile and infertile males. (PMID: 20073942) Hansen S … Carrell D (Systems biology in reproductive medicine 2010) 3 44 58
  3. SPANX-B and SPANX-C (Xq27 region) gene dosage analysis in Sicilian patients with melanoma. (PMID: 18626316) Salemi M … Rappazzo G (Melanoma research 2008) 3 22 58
  4. Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27. (PMID: 16251457) Kouprina N … Larionov V (Genome research 2005) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for SPANXC Gene

Sources for SPANXC Gene

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