SPANXC Gene
protein-coding GIFtS: 45
GCID: GC0XM140335
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SPANX family, member C
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Aliases
for SPANXC gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SPANX Family, Member C1 2 | | Cancer-Testis-Associated Protein CTp112 | | CT11.31 2 3 | | Cancer/Testis Antigen Family 11, Member 32 | | CTp111 2 | | Cancer/Testis-Associated Protein Of 11 KD2 | | Cancer/Testis Antigen 11.32 3 | | SPAN-Xc Protein2 | | Cancer/Testis-Associated Protein CTp112 3 | | Sperm Protein Associated With The Nucleus On The X Chromosome C2 | | Nuclear-Associated Protein SPAN-Xc2 3 | | Sperm Protein Associated With The Nucleus, X Chromosome, Family Member C2 | | SPANX-C2 3 | | SPANX Family Member C3 | | C2 | | CTP115 |
Export aliases for SPANXC gene to outside databasesPrevious GC identifers: GC0XM134865 GC0XM137193 GC0XM138268 GC0XM139029 GC0XM140063 GC0XM140163 |
Summaries
for SPANXC gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SPANXC:
Temporally regulated transcription and translation of several testis-specific genes is required to initiate the seriesof molecular and morphological changes in the male germ cell lineage necessary for the formation of maturespermatozoa. This gene is a member of the SPANX family, which is located in a gene cluster on chromosome X. The SPANXgenes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. Thisparticular gene encodes a protein that localizes to the nucleus and is expressed in highly metastatic cell lines,making the protein a potential diagnostic and prognostic marker. The protein belongs to a family of cancer/testisantigens and represents a potential target for cancer immunotherapy. (provided by RefSeq, Jul 2008)
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Genomic Views
for SPANXC gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011786.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPANXC gene promoter:
Tal-1 E47 GATA-2 POU2F1 FOXJ2 (long isoform) POU2F1a POU2F1b Cart-1 POU2F1c FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPANXC
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPANXC |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq27.1 Ensembl cytogenetic band: Xq27.2 HGNC cytogenetic band: Xq27.2SPANXC Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM140335: view genomic region
(about GC identifiers)
Start:
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140,335,596 bp from pter |
End:
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140,336,646 bp from pter |
Size:
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1,051 bases |
Orientation:
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minus strand |
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Proteins
for SPANXC gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPNXC_HUMAN, Q9NY87 (See
protein sequence)Recommended Name: Sperm protein associated with the nucleus on the X chromosome C Size: 97 amino acids; 11002 Da
Subcellular location: Cytoplasm. Nucleus. Note=Associated with nuclear craters
Developmental stage: Detected in round and elongating spermatids
Secondary accessions: Q32WL9 Q5JX88Explore the universe of human proteins at neXtProt for SPANXC: NX_Q9NY87
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NY87
SPANXC Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_073152.1
ENSEMBL proteins: ENSP00000351884
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SPANXC for ontologies About GeneDecksing
SPANXC Antibody Products:
Assay Products for SPANXC: |
Protein
Domains /
Families
for SPANXC gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPANXC for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NY87ProtoNet protein and cluster: Q9NY87 UniProtKB/Swiss-Prot: SPNXC_HUMAN, Q9NY87Similarity: Belongs to the SPAN-X family |
Function
for SPANXC gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXC
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXC (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SPANXC (NM_022661) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPANXC | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPANXC |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
SPANXC for ontologies About GeneDecksing
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Pathways & Interactions
for SPANXC gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPANXC
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/6 Interacting proteins for SPANXC (ENSP000003518844) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
SPANXC for ontologies About GeneDecksing
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Drugs & Compounds
for SPANXC gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPANXC
Search CenterWatch for drugs/clinical trials and news about SPANXC / SPNXC
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Transcripts
for SPANXC gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPANXC gene: NM_022661.2 Unigene Cluster for SPANXC: SPANX family, member C Hs.558533 [show with all ESTs]Unigene Representative Sequence: BU5399111 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000358993(uc004fbk.3 uc004fbl.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXC
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXC (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPANXC (NM_022661) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPANXC | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPANXC |
Additional cDNA sequence: AJ238277.1 AK225988.1 BC054023.1 1 DOTS entry: DT.100036177 14 AceView cDNA sequences: AJ238277 BX280207 NM_022661 BV206967 BC054023 AA412270 BV201648 AA412605 BU540294 BU858340 BV201649 BG203498 BU539911 BG195937
GeneLoc Exon Structure
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Expression
for SPANXC gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPANXC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAATAATGG
About this image
See SPANXC Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPANXC
SOURCE GeneReport for Unigene cluster: Hs.558533
UniProtKB/Swiss-Prot: SPNXC_HUMAN, Q9NY87Tissue specificity: Detected in testis, melanoma and bladder carcinoma
SABiosciences Custom PCR Arrays for SPANXC
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPANXC
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat SPANXC | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPANXC | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPANXC |
Orthologs
for SPANXC gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for SPANXC (if available)
TreeFam Gene Tree for SPANXC (if available) |
Paralogs
for SPANXC gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SPANXC gene
- SPANXA21 2 SPANXA11 2 SPANXD1 2 SPANXB21 2 SPANXB11 2 SPANXN22 SPANXN12 SPANXN52
- SPANXN32 SPANXN42
11 SIMAP similar genes for SPANXC using alignment to 6 protein entries: SPNXC_HUMAN (see all proteins):SPANXA1 SPANXE SPANXA2 SPANXD SPANXB1 SPANXB2
SPANXF1 SPANXN1 SPANXN5 SPANXN2 SPANXN3
SPANXC for paralogs About GeneDecksing
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Genomic Variants
for SPANXC gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SPANXC (140335596 - 140336646 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for SPANXC
7 CNVs: 31566 97025 4175 3257 83792 74063 34509
1 Inversion: 37352 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPANXC |
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Disorders
/ Diseases
for SPANXC gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SPANXC for disorders About GeneDecksing
OMIM gene information: 300330
OMIM disorders: --
9  diseases for SPANXC: About MalaCardsmale germ cell tumor germ cell tumor down syndrome bladder carcinoma
prostate cancer infertility prostatitis melanoma
carcinoma
Human Genome Epidemiology (HuGE) Navigator: SPANXC (1 document)
Export disorders for SPANXC gene to outside databases
|
Publications
for SPANXC gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPANXC gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with SPANXC) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- CTp11, a novel member of the family of cancer-testis antigens. (PubMed id 10626816)1, 2, 3 Zendman A.J.W....Van Muijen G.N.P. (1999)
- Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27. (PubMed id 16251457)1, 2 Kouprina N.... Larionov V. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines. (PubMed id 12758128)1, 2 Zendman A.J.... van Muijen G.N.P. (2003)
- SPANX-B and SPANX-C (Xq27 region) gene dosage analysis in Sicilian patients with melanoma. (PubMed id 18626316)1, 9 Salemi M....Rappazzo G. (2008)
- SPANX gene variation in fertile and infertile males. (PubMed id 20073942)1 Hansen S....Carrell D. (2010)
- SPANX-B and SPANX-C (Xq27 region) gene dosage analysis in Down's syndrome subjects with undescended testes. (PubMed id 19417550)1 Salemi M....Bosco P. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
- Expression of SPANX proteins in human-ejaculated spermatozoa and sperm precursors. (PubMed id 15139967)1 Salemi M....Vicari E. (2004)
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External Searches for SPANXC gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SPANXC gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPANXC gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPANXC gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SPANXC gene:
Search GeneIP for patents involving SPANXC
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPANXC gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPANXC | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPANXC | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPANXC | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPANXC | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXC | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXC | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SPANXC | | OriGene Custom Protein Services for SPANXC | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPANXC | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPANXC | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPANXC | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPANXC | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPANXC | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPANXC |
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| | | | Search Tocris compounds for SPANXC |
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 | | | SPANXC Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for SPANXC |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPANXC |
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