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Aliases for SPANXC Gene

Aliases for SPANXC Gene

  • SPANX Family, Member C 2 3
  • Cancer/Testis-Associated Protein CTp11 3 4
  • Nuclear-Associated Protein SPAN-Xc 3 4
  • Cancer/Testis Antigen 11.3 3 4
  • SPANX-C 3 4
  • CT11.3 3 4
  • CTp11 3 6
  • Sperm Protein Associated With The Nucleus, X Chromosome, Family Member C 3
  • Sperm Protein Associated With The Nucleus On The X Chromosome C 3
  • Cancer/Testis Antigen Family 11, Member 3 3
  • Cancer/Testis-Associated Protein Of 11 KD 3
  • Cancer-Testis-Associated Protein CTp11 3
  • Cancer/Testis Antigen Family 11 2
  • SPANX Family Member C 4
  • SPAN-Xc Protein 3
  • Member 3 2
  • C 3

External Ids for SPANXC Gene

Summaries for SPANXC Gene

Entrez Gene Summary for SPANXC Gene

  • Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family, which is located in a gene cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a protein that localizes to the nucleus and is expressed in highly metastatic cell lines, making the protein a potential diagnostic and prognostic marker. The protein belongs to a family of cancer/testis antigens and represents a potential target for cancer immunotherapy. [provided by RefSeq, Jul 2008]

GeneCards Summary for SPANXC Gene

SPANXC (SPANX Family, Member C) is a Protein Coding gene. An important paralog of this gene is SPANXD.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPANXC Gene

Genomics for SPANXC Gene

Genomic Location for SPANXC Gene

Start:
141,241,463 bp from pter
End:
141,242,513 bp from pter
Size:
1,051 bases
Orientation:
Minus strand

Genomic View for SPANXC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPANXC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPANXC Gene

Regulatory Elements for SPANXC Gene

Proteins for SPANXC Gene

  • Protein details for SPANXC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NY87-SPNXC_HUMAN
    Recommended name:
    Sperm protein associated with the nucleus on the X chromosome C
    Protein Accession:
    Q9NY87
    Secondary Accessions:
    • Q32WL9
    • Q5JX88

    Protein attributes for SPANXC Gene

    Size:
    97 amino acids
    Molecular mass:
    11002 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPANXC Gene

Proteomics data for SPANXC Gene at MOPED

Post-translational modifications for SPANXC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPANXC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPANXC Gene

Domains for SPANXC Gene

Protein Domains for SPANXC Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

SPNXC_HUMAN
Family:
  • Belongs to the SPAN-X family.:
    • Q9NY87
genes like me logo Genes that share domains with SPANXC: view

No data available for Gene Families for SPANXC Gene

Function for SPANXC Gene

Gene Ontology (GO) - Molecular Function for SPANXC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SPANXC: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SPANXC Gene

Localization for SPANXC Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPANXC Gene

Cytoplasm. Nucleus. Note=Associated with nuclear craters.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPANXC Gene COMPARTMENTS Subcellular localization image for SPANXC gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for SPANXC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10626816
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SPANXC: view

Pathways for SPANXC Gene

SuperPathways for SPANXC Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPANXC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SPANXC: view

No data available for Pathways by source for SPANXC Gene

Transcripts for SPANXC Gene

mRNA/cDNA for SPANXC Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPANXC Gene

SPANX family, member C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPANXC Gene

No ASD Table

Relevant External Links for SPANXC Gene

GeneLoc Exon Structure for
SPANXC
ECgene alternative splicing isoforms for
SPANXC

Expression for SPANXC Gene

mRNA expression in normal human tissues for SPANXC Gene

mRNA differential expression in normal tissues according to GTEx for SPANXC Gene

This gene is overexpressed in Testis (52.4).

SOURCE GeneReport for Unigene cluster for SPANXC Gene Hs.558533

mRNA Expression by UniProt/SwissProt for SPANXC Gene

Q9NY87-SPNXC_HUMAN
Tissue specificity: Detected in testis, melanoma and bladder carcinoma.
genes like me logo Genes that share expressions with SPANXC: view

Orthologs for SPANXC Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SPANXC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 61 (a)
OneToMany
Species with no ortholog for SPANXC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPANXC Gene

ENSEMBL:
Gene Tree for SPANXC (if available)
TreeFam:
Gene Tree for SPANXC (if available)

Paralogs for SPANXC Gene

Paralogs for SPANXC Gene

genes like me logo Genes that share paralogs with SPANXC: view

Variants for SPANXC Gene

Sequence variations from dbSNP and Humsavar for SPANXC Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs368882 -- 141,243,640(-) aatgt(C/T)attga upstream-variant-2KB
rs845136 -- 141,244,362(+) tactg(G/T)gcctg upstream-variant-2KB
rs2144605 -- 141,243,098(-) TTGGA(A/G)ATAGG upstream-variant-2KB
rs3179143 -- 141,242,407(-) TGTGA(A/T)TCCAA missense, reference
rs3180809 -- 141,242,396(-) CGAGG(C/T)GAATG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SPANXC Gene

Variant ID Type Subtype PubMed ID
dgv2482e1 CNV Complex 17122850
dgv2483e1 CNV Complex 17122850
nsv7462 OTHER Inversion 18451855
nsv470368 CNV Gain 18288195
nsv470367 CNV Loss 18288195
nsv516880 CNV Gain+Loss 19592680
dgv2485e1 CNV Complex 17122850
nsv9980 CNV Gain 18304495
esv27688 CNV Gain+Loss 19812545

Relevant External Links for SPANXC Gene

HapMap Linkage Disequilibrium report
SPANXC

Disorders for SPANXC Gene

Relevant External Links for SPANXC

Genetic Association Database (GAD)
SPANXC
Human Genome Epidemiology (HuGE) Navigator
SPANXC
genes like me logo Genes that share disorders with SPANXC: view

No data available for UniProtKB/Swiss-Prot for SPANXC Gene

Publications for SPANXC Gene

  1. CTp11, a novel member of the family of cancer-testis antigens. (PMID: 10626816) Zendman A.J.W. … Van Muijen G.N.P. (Cancer Res. 1999) 2 3 4
  2. SPANX-B and SPANX-C (Xq27 region) gene dosage analysis in Sicilian patients with melanoma. (PMID: 18626316) Salemi M. … Rappazzo G. (Melanoma Res. 2008) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27. (PMID: 16251457) Kouprina N. … Larionov V. (Genome Res. 2005) 3 4
  5. SPANX gene variation in fertile and infertile males. (PMID: 20073942) Hansen S. … Carrell D. (Syst Biol Reprod Med 2010) 3 49

Products for SPANXC Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate SPANXC
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for SPANXC
    • Block miRNA regulation of SPANXC using miScript Target Protectors

    Sources for SPANXC Gene

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