Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SPANXC Gene

Aliases for SPANXC Gene

  • SPANX Family Member C 2 3 4 5
  • Cancer/Testis-Associated Protein CTp11 3 4
  • Nuclear-Associated Protein SPAN-Xc 3 4
  • Cancer/Testis Antigen 11.3 3 4
  • SPANX Family, Member C 2 3
  • SPANX-C 3 4
  • CT11.3 3 4
  • Sperm Protein Associated With The Nucleus, X Chromosome, Family Member C 3
  • Cancer/Testis-Associated Protein Of 11 KD 3
  • Cancer/Testis Antigen Family 11, Member 3 3
  • Cancer-Testis-Associated Protein CTp11 3
  • Cancer/Testis Antigen Family 11 2
  • SPAN-Xc Protein 3
  • Member 3 2
  • CTp11 3
  • C 3

External Ids for SPANXC Gene

Previous GeneCards Identifiers for SPANXC Gene

  • GC0XM134865
  • GC0XM137193
  • GC0XM138268
  • GC0XM139029
  • GC0XM140063
  • GC0XM140163
  • GC0XM140335

Summaries for SPANXC Gene

Entrez Gene Summary for SPANXC Gene

  • Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family, which is located in a gene cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a protein that localizes to the nucleus and is expressed in highly metastatic cell lines, making the protein a potential diagnostic and prognostic marker. The protein belongs to a family of cancer/testis antigens and represents a potential target for cancer immunotherapy. [provided by RefSeq, Jul 2008]

GeneCards Summary for SPANXC Gene

SPANXC (SPANX Family Member C) is a Protein Coding gene. An important paralog of this gene is SPANXD.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPANXC Gene

Genomics for SPANXC Gene

Regulatory Elements for SPANXC Gene

Enhancers for SPANXC Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SPANXC on UCSC Golden Path with GeneCards custom track

Genomic Location for SPANXC Gene

141,241,463 bp from pter
141,242,550 bp from pter
1,088 bases
Minus strand

Genomic View for SPANXC Gene

Genes around SPANXC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPANXC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPANXC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPANXC Gene

Proteins for SPANXC Gene

  • Protein details for SPANXC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sperm protein associated with the nucleus on the X chromosome C
    Protein Accession:
    Secondary Accessions:
    • Q32WL2
    • Q32WL9
    • Q32WM0
    • Q5JX88
    • Q8TAD1
    • Q9BS24

    Protein attributes for SPANXC Gene

    97 amino acids
    Molecular mass:
    10982 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPANXC Gene

Proteomics data for SPANXC Gene at MOPED

Post-translational modifications for SPANXC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPANXC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPANXC Gene

Domains & Families for SPANXC Gene

Protein Domains for SPANXC Gene


Suggested Antigen Peptide Sequences for SPANXC Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPAN-X family.
  • Belongs to the SPAN-X family.
genes like me logo Genes that share domains with SPANXC: view

No data available for Gene Families for SPANXC Gene

Function for SPANXC Gene

Gene Ontology (GO) - Molecular Function for SPANXC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SPANXC: view

Phenotypes for SPANXC Gene

genes like me logo Genes that share phenotypes with SPANXC: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPANXC Gene

Localization for SPANXC Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPANXC Gene

Cytoplasm. Nucleus. Note=Associated with nuclear craters.

Subcellular locations from

Jensen Localization Image for SPANXC Gene COMPARTMENTS Subcellular localization image for SPANXC gene
Compartment Confidence
nucleus 5
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for SPANXC Gene

Pathways & Interactions for SPANXC Gene

SuperPathways for SPANXC Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPANXC Gene


No data available for Pathways by source and SIGNOR curated interactions for SPANXC Gene

Drugs & Compounds for SPANXC Gene

No Compound Related Data Available

Transcripts for SPANXC Gene


(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPANXC Gene

SPANX family, member C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPANXC Gene

No ASD Table

Relevant External Links for SPANXC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPANXC Gene

mRNA expression in normal human tissues for SPANXC Gene

mRNA differential expression in normal tissues according to GTEx for SPANXC Gene

This gene is overexpressed in Testis (x52.4).

SOURCE GeneReport for Unigene cluster for SPANXC Gene Hs.558533

mRNA Expression by UniProt/SwissProt for SPANXC Gene

Tissue specificity: Detected in testis, melanoma and bladder carcinoma.
genes like me logo Genes that share expression patterns with SPANXC: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SPANXC Gene

Orthologs for SPANXC Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SPANXC Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 36
  • 61 (a)
Species with no ortholog for SPANXC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPANXC Gene

Gene Tree for SPANXC (if available)
Gene Tree for SPANXC (if available)

Paralogs for SPANXC Gene

Paralogs for SPANXC Gene

genes like me logo Genes that share paralogs with SPANXC: view

Variants for SPANXC Gene

Sequence variations from dbSNP and Humsavar for SPANXC Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_032024 -
rs368882 -- 141,243,640(-) aatgt(C/T)attga upstream-variant-2KB
rs845136 -- 141,244,362(+) tactg(G/T)gcctg upstream-variant-2KB
rs2057217 -- 141,242,142(-) tttgg(C/T)ccttt intron-variant
rs2144605 -- 141,243,098(-) TTGGA(A/G)ATAGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SPANXC Gene

Variant ID Type Subtype PubMed ID
dgv2482e1 CNV Complex 17122850
dgv2483e1 CNV Complex 17122850
nsv7462 OTHER Inversion 18451855
nsv470368 CNV Gain 18288195
nsv470367 CNV Loss 18288195
nsv516880 CNV Gain+Loss 19592680
dgv2485e1 CNV Complex 17122850
nsv9980 CNV Gain 18304495
esv27688 CNV Gain+Loss 19812545

Variation tolerance for SPANXC Gene

Residual Variation Intolerance Score: 94.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.43% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SPANXC Gene

Disorders for SPANXC Gene

Relevant External Links for SPANXC

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SPANXC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPANXC Gene

Publications for SPANXC Gene

  1. CTp11, a novel member of the family of cancer-testis antigens. (PMID: 10626816) Zendman A.J.W. … Van Muijen G.N.P. (Cancer Res. 1999) 2 3 4 67
  2. SPANX-B and SPANX-C (Xq27 region) gene dosage analysis in Sicilian patients with melanoma. (PMID: 18626316) Salemi M. … Rappazzo G. (Melanoma Res. 2008) 3 23
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Identification of the cancer/testis antigens AKAP3 and CTp11 by SEREX in hepatocellular carcinoma. (PMID: 22941507) Song M.H. … Lee S.Y. (Oncol. Rep. 2012) 3
  5. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3

Products for SPANXC Gene

Sources for SPANXC Gene