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SPANXC Gene

protein-coding   GIFtS: 47
GCID: GC0XM140335

SPANX Family, Member C

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SPANX Family, Member C1 2     CTp112
Cancer/Testis Antigen 11.32 3     Cancer-Testis-Associated Protein CTp112
Cancer/Testis-Associated Protein CTp112 3     Cancer/Testis Antigen Family 11, Member 32
Nuclear-Associated Protein SPAN-Xc2 3     Cancer/Testis-Associated Protein Of 11 KD2
CT11.32 3     SPAN-Xc Protein2
SPANX-C2 3     Sperm Protein Associated With The Nucleus On The X Chromosome C2
Cancer/Testis Antigen Family 111     Sperm Protein Associated With The Nucleus, X Chromosome, Family Member C2
Member 31     SPANX Family Member C3
C2     CTP115

External Ids:    HGNC: 143311   Entrez Gene: 646632   Ensembl: ENSG000001985737   OMIM: 3003305   UniProtKB: Q9NY873   

Export aliases for SPANXC gene to outside databases

Previous GC identifers: GC0XM134865 GC0XM137193 GC0XM138268 GC0XM139029 GC0XM140063 GC0XM140163


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SPANXC Gene:
Temporally regulated transcription and translation of several testis-specific genes is required to initiate the
series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature
spermatozoa. This gene is a member of the SPANX family, which is located in a gene cluster on chromosome X. The
SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular
compartments. This particular gene encodes a protein that localizes to the nucleus and is expressed in highly
metastatic cell lines, making the protein a potential diagnostic and prognostic marker. The protein belongs to a
family of cancer/testis antigens and represents a potential target for cancer immunotherapy. (provided by RefSeq,
Jul 2008)

GeneCards Summary for SPANXC Gene:
SPANXC (SPANX family, member C) is a protein-coding gene. An important paralog of this gene is SPANXA2.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011786.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPANXC gene promoter:
         Tal-1   E47   GATA-2   POU2F1   FOXJ2 (long isoform)   POU2F1a   POU2F1b   Cart-1   POU2F1c   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPANXC promoter sequence
   Search Chromatin IP Primers for SPANXC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPANXC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq27.1   Ensembl cytogenetic band:  Xq27.2   HGNC cytogenetic band: Xq27.2

SPANXC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPANXC gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM140335:  view genomic region     (about GC identifiers)

Start:
140,335,596 bp from pter      End:
140,336,646 bp from pter
Size:
1,051 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SPNXC_HUMAN, Q9NY87 (See protein sequence)
Recommended Name: Sperm protein associated with the nucleus on the X chromosome C  
Size: 97 amino acids; 11002 Da
Developmental stage: Detected in round and elongating spermatids
Secondary accessions: Q32WL9 Q5JX88

Explore the universe of human proteins at neXtProt for SPANXC: NX_Q9NY87

Explore proteomics data for SPANXC at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SPANXC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_073152.1  
    ENSEMBL proteins: 
     ENSP00000351884  

    SPANXC Human Recombinant Protein Products:

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    antibodies-online peptides for SPANXC

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    Cloud-Clone Corp. CLIAs for SPANXC
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    antibodies-online kits for SPANXC (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR010007 SPANX_prot

    Graphical View of Domain Structure for InterPro Entry Q9NY87

    ProtoNet protein and cluster: Q9NY87

    UniProtKB/Swiss-Prot: SPNXC_HUMAN, Q9NY87
    Similarity: Belongs to the SPAN-X family


    Find genes that share domains with SPANXC           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    Find genes that share ontologies with SPANXC           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SPANXC

    miRNA
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPNXC_HUMAN, Q9NY87: Cytoplasm. Nucleus. Note=Associated with nuclear craters
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS10626816
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with SPANXC           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPANXC
    Interactions:

        Search GeneGlobe Interaction Network for SPANXC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for SPANXC (ENSP000003518844) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRPV4ENSP000002617404STRING: ENSP00000261740
    RASSF1ENSP000003495474STRING: ENSP00000349547
    RASSF2ENSP000003686844STRING: ENSP00000368684
    RASSF4ENSP000003396924STRING: ENSP00000339692
    STK3ENSP000003905004STRING: ENSP00000390500
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    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with SPANXC           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPANXC (SPNXC)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SPANXC gene: 
    NM_022661.2  

    Unigene Cluster for SPANXC:

    SPANX family, member C
    Hs.558533  [show with all ESTs]
    Unigene Representative Sequence: BU539911
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000358993(uc004fbk.3 uc004fbl.3)
    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SPANXC
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      QuantiTect SYBR Green Assays in human, mouse, rat SPANXC
      QuantiFast Probe-based Assays in human, mouse, rat SPANXC

    Additional mRNA sequence: 

    AJ238277.1 AK225988.1 BC054023.1 

    1 DOTS entry:

    DT.100036177 

    14 AceView cDNA sequences:

    AJ238277 NM_022661 BX280207 BC054023 BV201648 AA412270 BV206967 AA412605 
    BU540294 BU858340 BV201649 BU539911 BG203498 BG195937 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SPANXC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAATAATGG
    SPANXC Expression
    About this image

    SPANXC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPANXC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.558533

    UniProtKB/Swiss-Prot: SPNXC_HUMAN, Q9NY87
    Tissue specificity: Detected in testis, melanoma and bladder carcinoma

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPANXC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and chimp.

    Orthologs for SPANXC gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia --
    Pan troglodytes SPANX A/D member 3 (LOC493983), mR...
    61(a)
    1 → many
    GL393313.1(41016-41996)


    ENSEMBL Gene Tree for SPANXC (if available)
    TreeFam Gene Tree for SPANXC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SPANXC gene
    SPANXA21 2  SPANXA11 2  SPANXD1 2  SPANXB11 2  SPANXB22  
    11 SIMAP similar genes for SPANXC using alignment to 6 protein entries:     SPNXC_HUMAN (see all proteins):
    SPANXA1    SPANXE    SPANXA2    SPANXD    SPANXB1    SPANXB2
    SPANXF1    SPANXN1    SPANXN5    SPANXN2    SPANXN3

    Find genes that share paralogs with SPANXC           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SPANXC (see all 15)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2021077501,2
    C--140335742(+) ATTCAC/GCAGTT 2 L V mis10--------
    rs598009711,2
    C,F--140335818(+) GTTTTC/TATTTT 2 I M mis11Minor allele frequency- T:0.20NA 42
    rs578358301,2
    C,F--140335820(+) TTTCAT/GTTTTT 2 /M /L mis11Minor allele frequency- G:0.20NA 42
    rs561903261,2
    C,F--140335827(+) TTTTTA/CGGAGC 2 P syn11Minor allele frequency- C:0.12NA 42
    rs561975241,2
    C,F--140335850(+) TGAGTC/ACCCAG 2 /D /Y mis11Minor allele frequency- A:0.09NA 42
    rs562012411,2
    C,F--140335855(+) CCCCAG/CTTGGG 2 /T /S mis11Minor allele frequency- C:0.11NA 42
    rs568977231,2
    C,F--140335857(+) CCAGTT/CGGGGT 2 /P syn11Minor allele frequency- C:0.20NA 42
    rs562562771,2
    C,F--140335859(+) AGTTGG/AGGTCT 2 /P /S mis11Minor allele frequency- A:0.17NA 42
    rs588744061,2
    C,F--140336520(+) TTACCG/ATCTCA 2 /T /M mis12Minor allele frequency- A:0.03NA 3558
    rs598321401,2
    C,F--140336525(+) GTCTCA/GTTCAC 2 N syn12Minor allele frequency- G:0.05NA 3556

    HapMap Linkage Disequilibrium report for SPANXC (140335596 - 140336646 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for SPANXC:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv470367CNV Loss18288195
    nsv470368CNV Gain18288195
    nsv9980CNV Gain18304495
    esv27688CNV Gain+Loss19812545
    nsv516880CNV Gain+Loss19592680
    dgv2483e1CNV Complex17122850
    dgv2482e1CNV Complex17122850
    dgv2485e1CNV Complex17122850
    nsv7462OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SPANXC
    DNA2.0 Custom Variant and Variant Library Synthesis for SPANXC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300330    OMIM disorders: --


    Find genes that share disorders with SPANXC           About GenesLikeMe

    Genetic Association Database (GAD): SPANXC
    Human Genome Epidemiology (HuGE) Navigator: SPANXC (1 document)

    Export disorders for SPANXC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPANXC gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with SPANXC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CTp11, a novel member of the family of cancer-testis antigens. (PubMed id 10626816)1, 2, 3 Zendman A.J.W....Van Muijen G.N.P. (Cancer Res. 1999)
    2. SPANX gene variation in fertile and infertile males. (PubMed id 20073942)1, 4 Hansen S....Carrell D. (Syst Biol Reprod Med 2010)
    3. Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27. (PubMed id 16251457)1, 2 Kouprina N.... Larionov V. (Genome Res. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines. (PubMed id 12758128)1, 2 Zendman A.J.... van Muijen G.N.P. (Gene 2003)
    6. SPANX-B and SPANX-C (Xq27 region) gene dosage analysis in Sicilian patients with melanoma. (PubMed id 18626316)1, 9 Salemi M....Rappazzo G. (Melanoma Res. 2008)
    7. Identification of the cancer/testis antigens AKAP3 and CTp11 by SEREX in hepatocellular carcinoma. (PubMed id 22941507)1 Song M.H....Lee S.Y. (Oncol. Rep. 2012)
    8. SPANX-B and SPANX-C (Xq27 region) gene dosage analysis in Down's syndrome subjects with undescended testes. (PubMed id 19417550)1 Salemi M....Bosco P. (J. Genet. 2009)
    9. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64663 HGNC: 14331 AceView: SPANXC Ensembl:ENSG00000198573 euGenes: HUgn64663
    ECgene: SPANXC H-InvDB: SPANXC

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SPANXC Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SPANXC Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SPANXC gene:
    Search GeneIP for patents involving SPANXC

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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