SPANXB2 Gene
protein-coding GIFtS: 36
GCID: GC0XP140085
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SPANX family, member B2
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Aliases
for SPANXB2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SPANX Family, Member B21 2 | | SPAN-Xf2 | | Cancer/Testis Antigen 11.22 3 | | SPANX2 | | Nuclear-Associated Protein SPAN-Xb2 3 | | SPANX-C2 | | Nuclear-Associated Protein SPAN-Xf2 3 | | HCG20367081 | | CT11.22 3 | | SPAN-Xb Protein2 | | SPANX-B2 3 | | SPANX Family Member B12 | | SPANX-F2 3 | | Sperm Protein Associated With The Nucleus On The X Chromosome B/F2 | | SPANXB2 3 | | Sperm Protein Associated With The Nucleus, X Chromosome, Family Member B22 | | SPANX Family Member B/F2 3 | | |
Export aliases for SPANXB2 gene to outside databasesPrevious GC identifers: GC0XU990343 GC0XP138793 GC0XP138795 GC0XM140061 GC0XP139914 GC0XP139915 |
Summaries
for SPANXB2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SPANXB2:
Temporally regulated transcription and translation of several testis-specific genes is required to initiate the seriesof molecular and morphological changes in the male germ cell lineage necessary for the formation of maturespermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in acluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize tovarious subcellular compartments. This particular gene maps to chromosome X in a head-to-tail orientation with SPANXfamily member B1 and appears to be a duplication of that locus. The SPANXB genes are unique members of this genefamily, since they contain an additional 18 nt in their coding region compared to the majority of family members.Although the protein encoded by this gene contains consensus nuclear localization signals, the major site forsubcellular localization of expressed protein is in the cytoplasmic droplets of ejaculated spermatozoa. This proteinprovides a biochemical marker for studying the unique structures in spermatazoa, while attempting to further defineits role in spermatogenesis. (provided by RefSeq, Jul 2008)
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Genomic Views
for SPANXB2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NT_011786.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPANXB2 gene promoter:
HFH-3 USF1 CUTL1 POU6F1 (c2) CREB FOXI1 POU2F1 POU2F1a USF-1 En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPANXB2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPANXB2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq27.1 Ensembl cytogenetic band: Xq27.1 HGNC cytogenetic band: Xq27.1SPANXB2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP140085: view genomic region
(about GC identifiers)
Start:
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140,084,756 bp from pter |
End:
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140,085,871 bp from pter |
Size:
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1,116 bases |
Orientation:
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plus strand |
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Proteins
for SPANXB2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPNXB_HUMAN, Q9NS25 (See
protein sequence)Recommended Name: Sperm protein associated with the nucleus on the X chromosome B/F Size: 103 amino acids; 11826 Da
Subcellular location: Cytoplasm. Nucleus. Note=Associated with nuclear craters
Developmental stage: Detected in round and elongating spermatids
Secondary accessions: B2RPP2 Q32WQ7 Q5JYZ7 Q8TAD5Explore the universe of human proteins at neXtProt for SPANXB2: NX_Q9NS25
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NS25
SPANXB2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_663697.1
ENSEMBL proteins: ENSP00000405202
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SPANXB2 for ontologies About GeneDecksing
SPANXB2 Antibody Products:
Assay Products for SPANXB2: |
Protein
Domains /
Families
for SPANXB2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPANXB2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NS25ProtoNet protein and cluster: Q9NS25 UniProtKB/Swiss-Prot: SPNXB_HUMAN, Q9NS25Similarity: Belongs to the SPAN-X family |
Function
for SPANXB2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXB2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXB2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
SPANXB2 for ontologies About GeneDecksing
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Pathways & Interactions
for SPANXB2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPANXB2
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
SPANXB2 for ontologies About GeneDecksing
|
Drugs & Compounds
for SPANXB2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPANXB2
Search CenterWatch for drugs/clinical trials and news about SPANXB2 / SPNXB
|
Transcripts
for SPANXB2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPANXB2 gene: NM_145664.1 Unigene Cluster for SPANXB2: SPANX family, member B2 Hs.434105 [show with all ESTs]Unigene Representative Sequence: BG7210881 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000449283(uc004fbh.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXB2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXB2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPANXB2 (NM_145664) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPANXB2 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SPANXB2 |
Additional cDNA sequence: AJ457796.1 BC137533.1 BC137536.1 BC144689.1 4 DOTS entries: DT.121301246 DT.99934860 DT.121301248 DT.92424949
GeneLoc Exon Structure
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Expression
for SPANXB2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPANXB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SPANXB2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPANXB2
SOURCE GeneReport for Unigene cluster: Hs.434105
UniProtKB/Swiss-Prot: SPNXB_HUMAN, Q9NS25Tissue specificity: Detected in testis and sperm
SABiosciences Custom PCR Arrays for SPANXB2
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SPANXB2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPANXB2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPANXB2 |
Orthologs
for SPANXB2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
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ENSEMBL Gene Tree for SPANXB2 (if available)
TreeFam Gene Tree for SPANXB2 (if available) |
Paralogs
for SPANXB2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SPANXB2 gene
- SPANXB11 2 SPANXC1 2 SPANXA21 2 SPANXA11 2 SPANXD1 2 SPANXN22 SPANXN12 SPANXN52
- SPANXN32 SPANXN42
9 SIMAP similar genes for SPANXB2 using alignment to 1 protein entry: SPNXB_HUMAN:SPANXC SPANXA1 SPANXE SPANXA2 SPANXD SPANXN1
SPANXN2 SPANXN5 SPANXN3
SPANXB2 for paralogs About GeneDecksing
|
Genomic Variants
for SPANXB2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SPANXB2 (140084756 - 140085871 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for SPANXB2
6 CNVs: 4175 31565 37005 37006 74062 37597
1 Inversion: 37352 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPANXB2 |
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Disorders
/ Diseases
for SPANXB2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SPANXB2 for disorders About GeneDecksing
5  diseases for SPANXB2: About MalaCardsmale germ cell tumor germ cell tumor prostate cancer infertility
prostatitis
Human Genome Epidemiology (HuGE) Navigator: SPANXB2 (1 document)
Export disorders for SPANXB2 gene to outside databases
|
Publications
for SPANXB2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPANXB2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SPANXB2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27. (PubMed id 16251457)1, 2 Kouprina N.... Larionov V. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines. (PubMed id 12758128)1, 2 Zendman A.J.... van Muijen G.N.P. (2003)
- Spermatid-specific expression of the novel X-linked gene product SPAN-X localized to the nucleus of human spermatozoa. (PubMed id 10906052)1, 2 Westbrook V.A.... Herr J.C. (2000)
- SPANX gene variation in fertile and infertile males. (PubMed id 20073942)1 Hansen S....Carrell D. (2010)
- A shared promoter region suggests a common ancestor for the human VCX/Y, SPANX, and CSAG gene families and the murine CYPT family. (PubMed id 17342728)1 Hansen M.A....Leffers H. (2008)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Differential nuclear localization of the cancer/testis-associated protein, SPAN-X/CTp11, in transfected cells and in 50% of human spermatozoa. (PubMed id 11133693)1 Westbrook V.A....Herr J.C. (2001)
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External Searches for SPANXB2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SPANXB2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPANXB2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPANXB2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SPANXB2 gene:
Search GeneIP for patents involving SPANXB2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPANXB2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | SPANXB2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for SPANXB2 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SPANXB2 |
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