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Aliases for SPANXB1 Gene

Aliases for SPANXB1 Gene

  • SPANX Family Member B1 2 3 4 5
  • Nuclear-Associated Protein SPAN-Xb 3 4
  • Cancer/Testis Antigen 11.2 3 4
  • SPANX Family, Member B2 2 3
  • SPANX Family, Member F1 2 3
  • SPANX Family, Member F2 2 3
  • SPANX Family, Member B1 2 3
  • SPANX Family Member F1 3 4
  • SPANXB2 3 4
  • SPANXF1 3 4
  • SPANX-B 3 4
  • CT11.2 3 4
  • SPANXB 3 4
  • Sperm Protein Associated With The Nucleus, X Chromosome, Family Member B1 3
  • Sperm Protein Associated With The Nucleus On The X Chromosome B/F 3
  • Cancer/Testis Antigen Family 11, Member 2 3
  • Nuclear-Associated Protein SPAN-Xf 3
  • Cancer/Testis Antigen Family 11 2
  • SPANX Family Member B/F 3
  • Member 2 2
  • SPANXF2 3
  • B1 3

External Ids for SPANXB1 Gene

Previous HGNC Symbols for SPANXB1 Gene

  • SPANXB2
  • SPANXF1
  • SPANXF2

Previous GeneCards Identifiers for SPANXB1 Gene

  • GC0XP134615
  • GC0XP136942
  • GC0XP138029
  • GC0XP138790
  • GC0XP139810
  • GC0XP139913
  • GC0XP139925
  • GC0XP139927
  • GC0XP140096

Summaries for SPANXB1 Gene

Entrez Gene Summary for SPANXB1 Gene

  • Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular family member contains an additional 18 nucleotides in its coding region compared to the other family members in the same gene cluster. This family member is also subject to gene copy number variation. Although the protein encoded by this gene contains consensus nuclear localization signals, the major site for subcellular localization of expressed protein is in the cytoplasmic droplets of ejaculated spermatozoa. This protein provides a biochemical marker for studying the unique structures in spermatazoa, while attempting to further define its role in spermatogenesis. [provided by RefSeq, Apr 2014]

GeneCards Summary for SPANXB1 Gene

SPANXB1 (SPANX Family Member B1) is a Protein Coding gene. An important paralog of this gene is SPANXD.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPANXB1 Gene

Genomics for SPANXB1 Gene

Regulatory Elements for SPANXB1 Gene

Enhancers for SPANXB1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SPANXB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPANXB1 Gene

Chromosome:
X
Start:
141,002,591 bp from pter
End:
141,003,706 bp from pter
Size:
1,116 bases
Orientation:
Plus strand

Genomic View for SPANXB1 Gene

Genes around SPANXB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPANXB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPANXB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPANXB1 Gene

Proteins for SPANXB1 Gene

  • Protein details for SPANXB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS25-SPNXB_HUMAN
    Recommended name:
    Sperm protein associated with the nucleus on the X chromosome B1
    Protein Accession:
    Q9NS25
    Secondary Accessions:
    • A0A0G2JJ56
    • B2RPP2
    • Q32WQ7
    • Q5JYZ7
    • Q8TAD5

    Protein attributes for SPANXB1 Gene

    Size:
    103 amino acids
    Molecular mass:
    11840 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPANXB1 Gene

Proteomics data for SPANXB1 Gene at MOPED

Post-translational modifications for SPANXB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPANXB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SPANXB1 Gene

Domains & Families for SPANXB1 Gene

Protein Domains for SPANXB1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPANXB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NS25

UniProtKB/Swiss-Prot:

SPNXB_HUMAN :
  • Belongs to the SPAN-X family.
Family:
  • Belongs to the SPAN-X family.
genes like me logo Genes that share domains with SPANXB1: view

No data available for Gene Families for SPANXB1 Gene

Function for SPANXB1 Gene

genes like me logo Genes that share phenotypes with SPANXB1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPANXB1 Gene

Localization for SPANXB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPANXB1 Gene

Cytoplasm. Nucleus. Note=Associated with nuclear craters.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPANXB1 Gene COMPARTMENTS Subcellular localization image for SPANXB1 gene
Compartment Confidence
nucleus 5
cytosol 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for SPANXB1 Gene

Pathways & Interactions for SPANXB1 Gene

SuperPathways for SPANXB1 Gene

No Data Available

Interacting Proteins for SPANXB1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000405202%0d%0a9606.ENSP00000405965%0d%0a
Selected Interacting proteins: ENSP00000405202 for SPANXB1 Gene via STRING

Symbol External ID(s) Details
SUMO2

Gene Ontology (GO) - Biological Process for SPANXB1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPANXB1 Gene

Drugs & Compounds for SPANXB1 Gene

No Compound Related Data Available

Transcripts for SPANXB1 Gene

mRNA/cDNA for SPANXB1 Gene

(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SPANXB1 Gene

No ASD Table

Relevant External Links for SPANXB1 Gene

GeneLoc Exon Structure for
SPANXB1
ECgene alternative splicing isoforms for
SPANXB1

Expression for SPANXB1 Gene

mRNA expression in normal human tissues for SPANXB1 Gene

Protein differential expression in normal tissues from HIPED for SPANXB1 Gene

This gene is overexpressed in Testis (50.9) and Ovary (18.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for SPANXB1 Gene



SOURCE GeneReport for Unigene cluster for SPANXB1 Gene Hs.711489

mRNA Expression by UniProt/SwissProt for SPANXB1 Gene

Q9NS25-SPNXB_HUMAN
Tissue specificity: Detected in testis and sperm.
genes like me logo Genes that share expression patterns with SPANXB1: view

Protein tissue co-expression partners for SPANXB1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SPANXB1 Gene

Orthologs for SPANXB1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SPANXB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 73 (a)
OneToMany
Species with no ortholog for SPANXB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPANXB1 Gene

ENSEMBL:
Gene Tree for SPANXB1 (if available)
TreeFam:
Gene Tree for SPANXB1 (if available)

Paralogs for SPANXB1 Gene

Paralogs for SPANXB1 Gene

(9) SIMAP similar genes for SPANXB1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPANXB1: view

Variants for SPANXB1 Gene

Sequence variations from dbSNP and Humsavar for SPANXB1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_021163 -
rs2315916 -- 141,002,800(-) cttca(A/G)aacct intron-variant
rs2315917 -- 141,002,535(-) AGCCA(A/G)TGGCA upstream-variant-2KB
rs3960611 -- 141,002,295(-) CCTAT(G/T)AAGTG upstream-variant-2KB
rs3976442 -- 141,001,579(+) ttaat(C/T)ataac upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SPANXB1 Gene

Variant ID Type Subtype PubMed ID
dgv2481e1 CNV Complex 17122850
dgv2482e1 CNV Complex 17122850
dgv2483e1 CNV Complex 17122850
nsv433463 CNV Gain 18776910
nsv524931 CNV Gain 19592680
nsv7462 OTHER Inversion 18451855
nsv511087 CNV Complex 20534489
nsv508805 CNV Insertion 20534489
nsv510863 CNV Loss 20534489
nsv7123 CNV Loss 18451855
nsv9978 CNV Gain 18304495
nsv7124 CNV Insertion 18451855
nsv821600 CNV Deletion 20802225
esv1002958 CNV Loss 20482838
esv25300 CNV Gain+Loss 19812545
nsv499192 CNV Loss 21111241
nsv515176 CNV Complex 21397061

Relevant External Links for SPANXB1 Gene

HapMap Linkage Disequilibrium report
SPANXB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SPANXB1 Gene

Disorders for SPANXB1 Gene

Relevant External Links for SPANXB1

Genetic Association Database (GAD)
SPANXB1
Human Genome Epidemiology (HuGE) Navigator
SPANXB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPANXB1

No disorders were found for SPANXB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPANXB1 Gene

Publications for SPANXB1 Gene

  1. SPANX gene variation in fertile and infertile males. (PMID: 20073942) Hansen S. … Carrell D. (Syst Biol Reprod Med 2010) 3 48 67
  2. Epigenetic mechanisms underlying the dynamic expression of cancer-testis genes, PAGE2, -2B and SPANX-B, during mesenchymal-to-epithelial transition. (PMID: 25229454) Yilmaz-Ozcan S. … Gure A.O. (PLoS ONE 2014) 3
  3. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3
  4. SPANX-B and SPANX-C (Xq27 region) gene dosage analysis in Down's syndrome subjects with undescended testes. (PMID: 19417550) Salemi M. … Bosco P. (J. Genet. 2009) 3
  5. A shared promoter region suggests a common ancestor for the human VCX/Y, SPANX, and CSAG gene families and the murine CYPT family. (PMID: 17342728) Hansen M.A. … Leffers H. (Mol. Reprod. Dev. 2008) 3

Products for SPANXB1 Gene

Sources for SPANXB1 Gene

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