SPANXA2 Gene
protein-coding GIFtS: 36
GCID: GC0XP140677
|
|
SPANX family, member A2
(Previous symbol: SPANX)
| |
Aliases
for SPANXA2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SPANX Family, Member A21 2 | | SPANXA2 3 | | SPANX1 2 | | SPANX Family Member A2 3 | | Cancer/Testis Antigen 11.12 3 | | Sperm Protein Associated With The Nucleus On The X Chromosome A2 | | Nuclear-Associated Protein SPAN-Xa2 3 | | Sperm Protein Associated With The Nucleus, X Chromosome, Family Member A22 | | CT11.12 3 | | SPAN-X3 | | SPANX-A2 3 | | |
Export aliases for SPANXA2 gene to outside databasesPrevious GC identifers: GC0XU990342 GC0XM139366 GC0XM139367 GC0XM140397 GC0XM140500 GC0XP140506 |
Summaries
for SPANXA2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SPANXA2:
Temporally regulated transcription and translation of several testis-specific genes is required to initiate the seriesof molecular and morphological changes in the male germ cell lineage necessary for the formation of maturespermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in acluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize tovarious subcellular compartments. This particular gene maps to chromosome X in a head-to-head orientation with SPANXfamily member A1 and appears to be a duplication of that locus. The protein encoded by this gene targets to thenucleus where it associates with nuclear vacuoles and the redundant nuclear envelope. Based on its association withthese poorly characterized regions of the sperm nucleus, this protein provides a biochemical marker to study uniquestructures in spermatazoa while attempting to further define its role in spermatogenesis. (provided by RefSeq, Jul2008)
|
Genomic Views
for SPANXA2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011786.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPANXA2 gene promoter:
Max1 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPANXA2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPANXA2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq27.1 Ensembl cytogenetic band: Xq27.2 HGNC cytogenetic band: Xq27.2SPANXA2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP140677: view genomic region
(about GC identifiers)
Start:
|
140,677,562 bp from pter |
End:
|
140,678,899 bp from pter |
Size:
|
1,338 bases |
Orientation:
|
plus strand |
|
Proteins
for SPANXA2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPNXA_HUMAN, Q9NS26 (See
protein sequence)Recommended Name: Sperm protein associated with the nucleus on the X chromosome A Size: 97 amino acids; 11038 Da
Subcellular location: Cytoplasm. Nucleus. Note=Associated with nuclear craters
Developmental stage: Detected in round and elongating spermatids
Secondary accessions: Q5JWI0Explore the universe of human proteins at neXtProt for SPANXA2: NX_Q9NS26
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NS26
SPANXA2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_663695.1
ENSEMBL proteins: ENSP00000359549
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SPANXA2 for ontologies About GeneDecksing
SPANXA2 Antibody Products:
Assay Products for SPANXA2: |
Protein
Domains /
Families
for SPANXA2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPANXA2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NS26ProtoNet protein and cluster: Q9NS26 UniProtKB/Swiss-Prot: SPNXA_HUMAN, Q9NS26Similarity: Belongs to the SPAN-X family |
Function
for SPANXA2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXA2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXA2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SPANXA2 (NM_145662) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPANXA2 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SPANXA2 |
|
Pathways & Interactions
for SPANXA2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPANXA2
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
SPANXA2 for ontologies About GeneDecksing
|
Drugs & Compounds
for SPANXA2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPANXA2
Search CenterWatch for drugs/clinical trials and news about SPANXA2 / SPNXA
|
Transcripts
for SPANXA2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPANXA2 gene: NM_145662.2 Unigene Cluster for SPANXA2: SPANX family, member A2 Hs.711784 Unigene Representative Sequence: CB1138911 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000370518(uc004fbo.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXA2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXA2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPANXA2 (NM_145662) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPANXA2 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SPANXA2 |
Additional cDNA sequence: AF098306.1 BC069393.1 BC069816.1 2 DOTS entries: DT.100036177 DT.121307159
GeneLoc Exon Structure
|
Expression
for SPANXA2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPANXA2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SPANXA2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPANXA2
SOURCE GeneReport for Unigene cluster: Hs.711784
UniProtKB/Swiss-Prot: SPNXA_HUMAN, Q9NS26Tissue specificity: Detected in testis and sperm
SABiosciences Custom PCR Arrays for SPANXA2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPANXA2
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat SPANXA2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPANXA2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPANXA2 |
Orthologs
for SPANXA2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for SPANXA2 (if available)
TreeFam Gene Tree for SPANXA2 (if available) |
Paralogs
for SPANXA2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SPANXA2 gene
- SPANXA11 2 SPANXC1 2 SPANXD1 2 SPANXB21 2 SPANXB11 2 SPANXN22 SPANXN12 SPANXN52
- SPANXN32 SPANXN42
11 SIMAP similar genes for SPANXA2 using alignment to 4 protein entries: SPNXA_HUMAN (see all proteins):SPANXA1 SPANXD SPANXE SPANXC SPANXB1 SPANXB2
SPANXF1 SPANXN5 SPANXN1 SPANXN2 SPANXN3
SPANXA2 for paralogs About GeneDecksing
|
Genomic Variants
for SPANXA2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 16 variations for SPANXA2
14 CNVs: 74066 52941 83797 4175 97029 83796 3257 74065 8312 0827 2282 74064 31567 34509
2 Inversions: 37352 37353 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPANXA2 |
|
Disorders
/ Diseases
for SPANXA2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SPANXA2 for disorders About GeneDecksing
OMIM gene information: 300493
OMIM disorders: --
7  diseases for SPANXA2: About MalaCardsmale germ cell tumor germ cell tumor intrahepatic cholangiocarcinoma cholangiocarcinoma
prostate cancer infertility prostatitis
Human Genome Epidemiology (HuGE) Navigator: SPANXA2 (1 document)
Export disorders for SPANXA2 gene to outside databases
|
Publications
for SPANXA2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPANXA2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SPANXA2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Spermatid-specific expression of the novel X-linked gene product SPAN-X localized to the nucleus of human spermatozoa. (PubMed id 10906052)1, 2 Westbrook V.A.... Herr J.C. (2000)
- SPANX gene variation in fertile and infertile males. (PubMed id 20073942)1 Hansen S....Carrell D. (2010)
- Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
- Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27. (PubMed id 16251457)2 Kouprina N.... Larionov V. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines. (PubMed id 12758128)2 Zendman A.J.... van Muijen G.N.P. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Differential nuclear localization of the cancer/testis-associated protein, SPAN-X/CTp11, in transfected cells and in 50% of human spermatozoa. (PubMed id 11133693)1 Westbrook V.A....Herr J.C. (2001)
|
External Searches for SPANXA2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SPANXA2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPANXA2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPANXA2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SPANXA2 gene:
Search GeneIP for patents involving SPANXA2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPANXA2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPANXA2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPANXA2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPANXA2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPANXA2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXA2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXA2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SPANXA2 | | OriGene Custom Protein Services for SPANXA2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPANXA2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPANXA2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPANXA2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPANXA2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPANXA2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPANXA2 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for SPANXA2 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | SPANXA2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for SPANXA2 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SPANXA2 |
|
|
|
|
