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Aliases for SPANXA2 Gene

Aliases for SPANXA2 Gene

  • SPANX Family, Member A2 2 3
  • Nuclear-Associated Protein SPAN-Xa 3 4
  • Cancer/Testis Antigen 11.1 3 4
  • SPANX Family Member A 3 4
  • SPANX-A 3 4
  • CT11.1 3 4
  • SPANXA 3 4
  • Sperm Protein Associated With The Nucleus, X Chromosome, Family Member A2 3
  • SPAN-X 4
  • SPANX 3

External Ids for SPANXA2 Gene

Previous HGNC Symbols for SPANXA2 Gene


Previous GeneCards Identifiers for SPANXA2 Gene

  • GC0XU990342
  • GC0XM139366
  • GC0XM139367
  • GC0XM140397
  • GC0XM140500
  • GC0XP140506
  • GC0XP140677

Summaries for SPANXA2 Gene

Entrez Gene Summary for SPANXA2 Gene

  • Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-head orientation with SPANX family member A1 and appears to be a duplication of that locus. The protein encoded by this gene targets to the nucleus where it associates with nuclear vacuoles and the redundant nuclear envelope. Based on its association with these poorly characterized regions of the sperm nucleus, this protein provides a biochemical marker to study unique structures in spermatazoa while attempting to further define its role in spermatogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for SPANXA2 Gene

SPANXA2 (SPANX Family, Member A2) is a Protein Coding gene. An important paralog of this gene is SPANXD.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPANXA2 Gene

Genomics for SPANXA2 Gene

Regulatory Elements for SPANXA2 Gene

Transcription factor binding sites by QIAGEN in the SPANXA2 gene promoter:

Genomic Location for SPANXA2 Gene

141,589,435 bp from pter
141,590,772 bp from pter
1,338 bases
Plus strand

Genomic View for SPANXA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for SPANXA2 Gene

Proteins for SPANXA2 Gene

  • Protein details for SPANXA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sperm protein associated with the nucleus on the X chromosome A
    Protein Accession:
    Secondary Accessions:
    • Q5JWI0

    Protein attributes for SPANXA2 Gene

    97 amino acids
    Molecular mass:
    11038 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPANXA2 Gene

Proteomics data for SPANXA2 Gene at MOPED

Post-translational modifications for SPANXA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPANXA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPANXA2 Gene

Domains & Families for SPANXA2 Gene

Protein Domains for SPANXA2 Gene


Suggested Antigen Peptide Sequences for SPANXA2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPAN-X family.
  • Belongs to the SPAN-X family.
genes like me logo Genes that share domains with SPANXA2: view

No data available for Gene Families for SPANXA2 Gene

Function for SPANXA2 Gene

Gene Ontology (GO) - Molecular Function for SPANXA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SPANXA2: view

Phenotypes for SPANXA2 Gene

genes like me logo Genes that share phenotypes with SPANXA2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPANXA2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPANXA2 Gene

Localization for SPANXA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPANXA2 Gene

Cytoplasm. Nucleus. Note=Associated with nuclear craters.

Subcellular locations from

Jensen Localization Image for SPANXA2 Gene COMPARTMENTS Subcellular localization image for SPANXA2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for SPANXA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SPANXA2: view

Pathways & Interactions for SPANXA2 Gene

SuperPathways for SPANXA2 Gene

No Data Available

Interacting Proteins for SPANXA2 Gene

Selected Interacting proteins: Q9NS26-SPNXA_HUMAN for SPANXA2 Gene via UniProtKB

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for SPANXA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis TAS 10906052
genes like me logo Genes that share ontologies with SPANXA2: view

No data available for Pathways by source and SIGNOR curated interactions for SPANXA2 Gene

Drugs & Compounds for SPANXA2 Gene

No Compound Related Data Available

Transcripts for SPANXA2 Gene

mRNA/cDNA for SPANXA2 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPANXA2 Gene

SPANX family, member A2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPANXA2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPANXA2 Gene

No ASD Table

Relevant External Links for SPANXA2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPANXA2 Gene

mRNA expression in normal human tissues for SPANXA2 Gene

Protein differential expression in normal tissues from HIPED for SPANXA2 Gene

This gene is overexpressed in Bone (49.5) and Breast (19.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPANXA2 Gene

SOURCE GeneReport for Unigene cluster for SPANXA2 Gene Hs.711784

mRNA Expression by UniProt/SwissProt for SPANXA2 Gene

Tissue specificity: Detected in testis and sperm.
genes like me logo Genes that share expression patterns with SPANXA2: view

Protein tissue co-expression partners for SPANXA2 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SPANXA2 Gene

Orthologs for SPANXA2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SPANXA2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 36
  • 57 (a)
Species with no ortholog for SPANXA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPANXA2 Gene

Gene Tree for SPANXA2 (if available)
Gene Tree for SPANXA2 (if available)

Paralogs for SPANXA2 Gene

Paralogs for SPANXA2 Gene

(11) SIMAP similar genes for SPANXA2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SPANXA2: view

Variants for SPANXA2 Gene

Structural Variations from Database of Genomic Variants (DGV) for SPANXA2 Gene

Variant ID Type Subtype PubMed ID
dgv2483e1 CNV Complex 17122850
nsv7462 OTHER Inversion 18451855
nsv470367 CNV Loss 18288195
nsv516880 CNV Gain+Loss 19592680
dgv2485e1 CNV Complex 17122850
nsv470369 CNV Gain 18288195
esv2752315 CNV Gain 17911159
dgv2486e1 CNV Complex 17122850
essv9625 CNV CNV 17122850
nsv471606 CNV Gain 15918152
nsv469528 CNV Loss 16826518
nsv9983 CNV Gain 18304495
esv26320 CNV Gain+Loss 19812545
nsv515177 CNV Complex 21397061

Relevant External Links for SPANXA2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for SPANXA2 Gene

Disorders for SPANXA2 Gene

Relevant External Links for SPANXA2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SPANXA2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPANXA2 Gene

Publications for SPANXA2 Gene

  1. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  2. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 67
  3. SPANX gene variation in fertile and infertile males. (PMID: 20073942) Hansen S. … Carrell D. (Syst Biol Reprod Med 2010) 67
  4. Mutational analysis of SPANX genes in families with X-linked prostate cancer. (PMID: 17373721) Kouprina N. … Larionov V. (Prostate 2007) 67
  5. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang A.G. … Kim N.S. (Biochem. Biophys. Res. Commun. 2006) 67

Products for SPANXA2 Gene

Sources for SPANXA2 Gene

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