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Aliases for SPANXA1 Gene

Aliases for SPANXA1 Gene

  • Sperm Protein Associated With The Nucleus, X-Linked, Family Member A1 2 3 5
  • Sperm Protein Associated With The Nucleus, X Chromosome, Family Member A1 2 3
  • Cancer/Testis Antigen Family 11, Member 1 2 3
  • Nuclear-Associated Protein SPAN-Xa 3 4
  • Cancer/Testis Antigen 11.1 3 4
  • SPANX Family Member A 3 4
  • SPANX-A 3 4
  • CT11.1 3 4
  • SPAN-X 3 4
  • Sperm Protein Associated With The Nucleus On The X Chromosome A 3
  • SPANX Family, Member A1 3
  • SPAN-Xa 3
  • SPAN-Xb 3
  • SPANXA 4
  • NAP-X 3
  • SPANX 3

External Ids for SPANXA1 Gene

Previous HGNC Symbols for SPANXA1 Gene


Previous GeneCards Identifiers for SPANXA1 Gene

  • GC0XP135207
  • GC0XM137529
  • GC0XM138604
  • GC0XM139365
  • GC0XP139371
  • GC0XM140398
  • GC0XM140499
  • GC0XM140671

Summaries for SPANXA1 Gene

Entrez Gene Summary for SPANXA1 Gene

  • Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-head orientation with SPANX family member A2, which appears to be a duplication of the A1 locus. The protein encoded by this gene targets to the nucleus where it associates with nuclear vacuoles and the redundant nuclear envelope. Based on its association with these poorly characterized regions of the sperm nucleus, this protein provides a biochemical marker to study unique structures in spermatazoa while attempting to further define its role in spermatogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for SPANXA1 Gene

SPANXA1 (Sperm Protein Associated With The Nucleus, X-Linked, Family Member A1) is a Protein Coding gene. An important paralog of this gene is SPANXA2.

Gene Wiki entry for SPANXA1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPANXA1 Gene

Genomics for SPANXA1 Gene

Regulatory Elements for SPANXA1 Gene

Genomic Location for SPANXA1 Gene

141,583,674 bp from pter
141,585,011 bp from pter
1,338 bases
Minus strand

Genomic View for SPANXA1 Gene

Genes around SPANXA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPANXA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPANXA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPANXA1 Gene

Proteins for SPANXA1 Gene

  • Protein details for SPANXA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sperm protein associated with the nucleus on the X chromosome A
    Protein Accession:
    Secondary Accessions:
    • Q5JWI0

    Protein attributes for SPANXA1 Gene

    97 amino acids
    Molecular mass:
    11038 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPANXA1 Gene

Post-translational modifications for SPANXA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPANXA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPANXA1 Gene

Domains & Families for SPANXA1 Gene

Protein Domains for SPANXA1 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPAN-X family.
  • Belongs to the SPAN-X family.
genes like me logo Genes that share domains with SPANXA1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for SPANXA1 Gene

Function for SPANXA1 Gene

Gene Ontology (GO) - Molecular Function for SPANXA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SPANXA1: view

Phenotypes for SPANXA1 Gene

GenomeRNAi human phenotypes for SPANXA1:
genes like me logo Genes that share phenotypes with SPANXA1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPANXA1 Gene

Localization for SPANXA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPANXA1 Gene

Cytoplasm. Nucleus. Note=Associated with nuclear craters.

Gene Ontology (GO) - Cellular Components for SPANXA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SPANXA1: view

No data available for Subcellular locations from COMPARTMENTS for SPANXA1 Gene

Pathways & Interactions for SPANXA1 Gene

SuperPathways for SPANXA1 Gene

No Data Available

Interacting Proteins for SPANXA1 Gene

Selected Interacting proteins: Q9NS26-SPNXA_HUMAN for SPANXA1 Gene via UniProtKB IID

Gene Ontology (GO) - Biological Process for SPANXA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis TAS 10906052
genes like me logo Genes that share ontologies with SPANXA1: view

No data available for Pathways by source and SIGNOR curated interactions for SPANXA1 Gene

Drugs & Compounds for SPANXA1 Gene

No Compound Related Data Available

Transcripts for SPANXA1 Gene

mRNA/cDNA for SPANXA1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(27) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPANXA1 Gene

Sperm protein associated with the nucleus, X-linked, family member A1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPANXA1 Gene

No ASD Table

Relevant External Links for SPANXA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPANXA1 Gene

mRNA expression in normal human tissues for SPANXA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPANXA1 Gene

This gene is overexpressed in Testis (x53.0).

Protein differential expression in normal tissues from HIPED for SPANXA1 Gene

This gene is overexpressed in Bone (49.5) and Breast (19.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPANXA1 Gene

Protein tissue co-expression partners for SPANXA1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPANXA1 Gene:


SOURCE GeneReport for Unigene cluster for SPANXA1 Gene:


mRNA Expression by UniProt/SwissProt for SPANXA1 Gene:

Tissue specificity: Detected in testis and sperm.
genes like me logo Genes that share expression patterns with SPANXA1: view

Primer Products

Orthologs for SPANXA1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SPANXA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 35
  • 57 (a)
Species where no ortholog for SPANXA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPANXA1 Gene

Gene Tree for SPANXA1 (if available)
Gene Tree for SPANXA1 (if available)

Paralogs for SPANXA1 Gene

Paralogs for SPANXA1 Gene

(11) SIMAP similar genes for SPANXA1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPANXA1: view

Variants for SPANXA1 Gene

Structural Variations from Database of Genomic Variants (DGV) for SPANXA1 Gene

Variant ID Type Subtype PubMed ID
dgv2500e212 CNV gain 25503493
dgv2501e212 CNV loss 25503493
dgv2502e212 CNV gain 25503493
esv26320 CNV gain+loss 19812545
esv2752315 CNV gain 17911159
esv2758896 CNV gain+loss 17122850
esv3574870 CNV loss 25503493
esv3574874 CNV loss 25503493
esv3574877 CNV loss 25503493
esv3577446 CNV gain 25503493
nsv469528 CNV loss 16826518
nsv470367 CNV loss 18288195
nsv470369 CNV gain 18288195
nsv471606 CNV gain 15918152
nsv515177 CNV gain 21397061
nsv516880 CNV gain+loss 19592680
nsv7462 OTHER inversion 18451855
nsv9983 CNV gain 18304495

Relevant External Links for SPANXA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for SPANXA1 Gene

Disorders for SPANXA1 Gene

Relevant External Links for SPANXA1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SPANXA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPANXA1 Gene

Publications for SPANXA1 Gene

  1. Spermatid-specific expression of the novel X-linked gene product SPAN-X localized to the nucleus of human spermatozoa. (PMID: 10906052) Westbrook V.A. … Herr J.C. (Biol. Reprod. 2000) 2 3 4 22 65
  2. Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27. (PMID: 16251457) Kouprina N. … Larionov V. (Genome Res. 2005) 3 4 22 65
  3. The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines. (PMID: 12758128) Zendman A.J. … van Muijen G.N.P. (Gene 2003) 3 4 22 65
  4. SPANX gene variation in fertile and infertile males. (PMID: 20073942) Hansen S. … Carrell D. (Syst Biol Reprod Med 2010) 3 46 65
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 65

Products for SPANXA1 Gene

Sources for SPANXA1 Gene

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