SPANXA1 Gene
protein-coding GIFtS: 41
GCID: GC0XM140671
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sperm protein associated with the nucleus, X-linked, family...(Previous names: sperm protein associated with the nucleus, X chromosome,...)
(Previous symbol: SPANX)
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Aliases
for SPANXA1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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| Aliases |
|---|
| Sperm Protein Associated With The Nucleus, X-Linked, Family Member A11 2 | | Nuclear-Associated Protein SPAN-Xa2 3 | | CT11.11 2 3 | | SPAN-X2 3 | | SPANX1 2 5 | | SPANX-A2 3 | | NAP-X1 2 | | SPANX Family Member A2 3 | | SPAN-Xa1 2 | | Cancer/Testis Antigen Family 11, Member 12 | | SPAN-Xb1 2 | | SPANX Family, Member A12 | | Sperm Protein Associated With The Nucleus, X Chromosome, Family Member A11 2 | | Sperm Protein Associated With The Nucleus On The X Chromosome A2 | | Cancer/Testis Antigen 11.12 3 | | SPANXA3 |
Export aliases for SPANXA1 gene to outside databasesPrevious GC identifers: GC0XP135207 GC0XM137529 GC0XM138604 GC0XM139365 GC0XP139371 GC0XM140398 GC0XM140499 |
Summaries
for SPANXA1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SPANXA1:
Temporally regulated transcription and translation of several testis-specific genes is required to initiate the seriesof molecular and morphological changes in the male germ cell lineage necessary for the formation of maturespermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in acluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize tovarious subcellular compartments. This particular gene maps to chromosome X in a head-to-head orientation with SPANXfamily member A2, which appears to be a duplication of the A1 locus. The protein encoded by this gene targets to thenucleus where it associates with nuclear vacuoles and the redundant nuclear envelope. Based on its association withthese poorly characterized regions of the sperm nucleus, this protein provides a biochemical marker to study uniquestructures in spermatazoa while attempting to further define its role in spermatogenesis. (provided by RefSeq, Jul2008)
Gene Wiki entry for SPANXA1 (Sperm protein associated with the nucleus, X-linked, family member A1)
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Genomic Views
for SPANXA1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011786.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPANXA1 gene promoter:
STAT5B Max1 STAT4 STAT6 STAT5A STAT2 STAT3 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPANXA1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPANXA1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq27.1 Ensembl cytogenetic band: Xq27.2 HGNC cytogenetic band: Xq27.2SPANXA1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM140671: view genomic region
(about GC identifiers)
Start:
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140,671,796 bp from pter |
End:
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140,673,133 bp from pter |
Size:
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1,338 bases |
Orientation:
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minus strand |
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Proteins
for SPANXA1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPNXA_HUMAN, Q9NS26 (See
protein sequence)Recommended Name: Sperm protein associated with the nucleus on the X chromosome A Size: 97 amino acids; 11038 Da
Subcellular location: Cytoplasm. Nucleus. Note=Associated with nuclear craters
Developmental stage: Detected in round and elongating spermatids
Secondary accessions: Q5JWI0Explore the universe of human proteins at neXtProt for SPANXA1: NX_Q9NS26
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NS26
SPANXA1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_038481.2
ENSEMBL proteins: ENSP00000359550
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SPANXA1 for ontologies About GeneDecksing
SPANXA1 Antibody Products:
Assay Products for SPANXA1: |
Protein
Domains /
Families
for SPANXA1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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SPANXA1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NS26ProtoNet protein and cluster: Q9NS26 UniProtKB/Swiss-Prot: SPNXA_HUMAN, Q9NS26Similarity: Belongs to the SPAN-X family |
Function
for SPANXA1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXA1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXA1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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|
Pathways & Interactions
for SPANXA1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPANXA1
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0007283 | spermatogenesis |
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SPANXA1 for ontologies About GeneDecksing
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Drugs & Compounds
for SPANXA1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPANXA1
Search CenterWatch for drugs/clinical trials and news about SPANXA1 / SPNXA
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Transcripts
for SPANXA1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPANXA1 gene: NM_013453.2 Unigene Cluster for SPANXA1: Sperm protein associated with the nucleus, X-linked, family member A1 Hs.334464 [show with all ESTs]Unigene Representative Sequence: BF2121771 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000370519(uc004fbn.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXA1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPANXA1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPANXA1 (NM_013453) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPANXA1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPANXA1 |
3 DOTS entries: DT.121307159 DT.100036177 DT.101961078 24/27 AceView cDNA sequences (see all 27): NM_013453 CB115288 CB110020 CB121332 CB107410 BX280141 AF098306 CB113891 CB122914 BC069816 BV206967 NM_145662 BV199311 BC069393 AI208372 CB122922 AW444776 CB114159 BV199565 CB121392 BF056463 AI962751 BC062672 CB108555
GeneLoc Exon Structure
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Expression
for SPANXA1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPANXA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SPANXA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPANXA1
SOURCE GeneReport for Unigene cluster: Hs.334464
UniProtKB/Swiss-Prot: SPNXA_HUMAN, Q9NS26Tissue specificity: Detected in testis and sperm
SABiosciences Custom PCR Arrays for SPANXA1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPANXA1
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat SPANXA1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPANXA1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPANXA1 |
Orthologs
for SPANXA1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
ENSEMBL Gene Tree for SPANXA1 (if available)
TreeFam Gene Tree for SPANXA1 (if available) |
Paralogs
for SPANXA1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SPANXA1 gene
- SPANXA21 2 SPANXC1 2 SPANXD1 2 SPANXB21 2 SPANXB11 2 SPANXN22 SPANXN12 SPANXN52
- SPANXN32 SPANXN42
11 SIMAP similar genes for SPANXA1 using alignment to 1 protein entry: SPNXA_HUMAN:SPANXA2 SPANXD SPANXC SPANXE SPANXB1 SPANXB2
SPANXF1 SPANXN5 SPANXN1 SPANXN2 SPANXN3
SPANXA1 for paralogs About GeneDecksing
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Genomic Variants
for SPANXA1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SPANXA1 (140671796 - 140673133 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 16 variations for SPANXA1
14 CNVs: 74066 52941 83797 4175 97029 83796 3257 74065 8312 0827 2282 74064 31567 34509
2 Inversions: 37352 37353 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPANXA1 |
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Disorders
/ Diseases
for SPANXA1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SPANXA1 for disorders About GeneDecksing
OMIM gene information: 300305
OMIM disorders: --
7  diseases for SPANXA1: About MalaCardsmale germ cell tumor germ cell tumor down syndrome prostate cancer
infertility melanoma prostatitis
3 Novoseek disease relationships for SPANXA1 gene About this table
Human Genome Epidemiology (HuGE) Navigator: SPANXA1 (1 document)
Export disorders for SPANXA1 gene to outside databases
|
Publications
for SPANXA1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPANXA1 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with SPANXA1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Spermatid-specific expression of the novel X-linked gene product SPAN-X localized to the nucleus of human spermatozoa. (PubMed id 10906052)1, 2, 3, 9 Westbrook V.A.... Herr J.C. (2000)
- The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines. (PubMed id 12758128)1, 2, 9 Zendman A.J.... van Muijen G.N.P. (2003)
- Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27. (PubMed id 16251457)1, 2, 9 Kouprina N.... Larionov V. (2005)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Differential nuclear localization of the cancer/testis-associated protein, SPAN-X/CTp11, in transfected cells and in 50% of human spermatozoa. (PubMed id 11133693)1, 9 Westbrook V.A....Herr J.C. (2001)
- SPANX gene variation in fertile and infertile males. (PubMed id 20073942)1 Hansen S....Carrell D. (2010)
- Expression of SpanX proteins in normal testes and in testicular germ cell tumours. (PubMed id 16390498)1 Salemi M....Vicari E. (2006)
- Genomic organization, incidence, and localization of the SPAN-x family of cancer-testis antigens in melanoma tumors and cell lines. (PubMed id 14734458)1 Westbrook V.A....Herr J.C. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for SPANXA1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SPANXA1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPANXA1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPANXA1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
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About This Section
| Patent Information for SPANXA1 gene:
Search GeneIP for patents involving SPANXA1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPANXA1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | SPANXA1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for SPANXA1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPANXA1 |
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