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Aliases for SPANXA1 Gene

Aliases for SPANXA1 Gene

  • Sperm Protein Associated With The Nucleus, X-Linked, Family Member A1 2 3
  • Sperm Protein Associated With The Nucleus, X Chromosome, Family Member A1 2 3
  • Nuclear-Associated Protein SPAN-Xa 3 4
  • Cancer/Testis Antigen 11.1 3 4
  • SPANX Family Member A 3 4
  • SPANX-A 3 4
  • CT11.1 3 4
  • SPAN-X 3 4
  • SPANX 3 6
  • Sperm Protein Associated With The Nucleus On The X Chromosome A 3
  • Cancer/Testis Antigen Family 11, Member 1 3
  • Cancer/Testis Antigen Family 11 2
  • SPANX Family, Member A1 3
  • Member 1 2
  • SPAN-Xa 3
  • SPAN-Xb 3
  • SPANXA 4
  • NAP-X 3

External Ids for SPANXA1 Gene

Previous Symbols for SPANXA1 Gene


Summaries for SPANXA1 Gene

Entrez Gene Summary for SPANXA1 Gene

  • Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-head orientation with SPANX family member A2, which appears to be a duplication of the A1 locus. The protein encoded by this gene targets to the nucleus where it associates with nuclear vacuoles and the redundant nuclear envelope. Based on its association with these poorly characterized regions of the sperm nucleus, this protein provides a biochemical marker to study unique structures in spermatazoa while attempting to further define its role in spermatogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for SPANXA1 Gene

SPANXA1 (Sperm Protein Associated With The Nucleus, X-Linked, Family Member A1) is a Protein Coding gene. An important paralog of this gene is SPANXD.

Gene Wiki entry for SPANXA1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPANXA1 Gene

Genomics for SPANXA1 Gene

Genomic Location for SPANXA1 Gene

141,583,674 bp from pter
141,698,444 bp from pter
114,771 bases
Minus strand

Genomic View for SPANXA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPANXA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPANXA1 Gene

Regulatory Elements for SPANXA1 Gene

Proteins for SPANXA1 Gene

  • Protein details for SPANXA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sperm protein associated with the nucleus on the X chromosome A
    Protein Accession:
    Secondary Accessions:
    • Q5JWI0

    Protein attributes for SPANXA1 Gene

    97 amino acids
    Molecular mass:
    11038 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPANXA1 Gene

Proteomics data for SPANXA1 Gene at MOPED

Post-translational modifications for SPANXA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPANXA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPANXA1 Gene

Domains for SPANXA1 Gene

Protein Domains for SPANXA1 Gene



  • Belongs to the SPAN-X family.:
    • Q9NS26
genes like me logo Genes that share domains with SPANXA1: view

No data available for Gene Families for SPANXA1 Gene

Function for SPANXA1 Gene

Gene Ontology (GO) - Molecular Function for SPANXA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SPANXA1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SPANXA1 Gene

Localization for SPANXA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPANXA1 Gene

Cytoplasm. Nucleus. Note=Associated with nuclear craters.

Subcellular locations from

Jensen Localization Image for SPANXA1 Gene COMPARTMENTS Subcellular localization image for SPANXA1 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for SPANXA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SPANXA1: view

Pathways for SPANXA1 Gene

SuperPathways for SPANXA1 Gene

No Data Available

Interacting Proteins for SPANXA1 Gene

Selected Interacting proteins: Q9NS26-SPNXA_HUMAN for SPANXA1 Gene via UniProtKB

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for SPANXA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis TAS 10906052
genes like me logo Genes that share ontologies with SPANXA1: view

No data available for Pathways by source for SPANXA1 Gene

Transcripts for SPANXA1 Gene

mRNA/cDNA for SPANXA1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(27) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPANXA1 Gene

Sperm protein associated with the nucleus, X-linked, family member A1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPANXA1 Gene

No ASD Table

Relevant External Links for SPANXA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPANXA1 Gene

mRNA expression in normal human tissues for SPANXA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPANXA1 Gene

This gene is overexpressed in Testis (53.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SPANXA1 Gene

SOURCE GeneReport for Unigene cluster for SPANXA1 Gene Hs.334464

mRNA Expression by UniProt/SwissProt for SPANXA1 Gene

Tissue specificity: Detected in testis and sperm.
genes like me logo Genes that share expressions with SPANXA1: view

Orthologs for SPANXA1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SPANXA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 37
  • 57 (a)
Species with no ortholog for SPANXA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPANXA1 Gene

Gene Tree for SPANXA1 (if available)
Gene Tree for SPANXA1 (if available)

Paralogs for SPANXA1 Gene

Paralogs for SPANXA1 Gene

Selected SIMAP similar genes for SPANXA1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPANXA1: view

Variants for SPANXA1 Gene

Structural Variations from Database of Genomic Variants (DGV) for SPANXA1 Gene

Variant ID Type Subtype PubMed ID
dgv2483e1 CNV Complex 17122850
nsv7462 OTHER Inversion 18451855
nsv470367 CNV Loss 18288195
nsv516880 CNV Gain+Loss 19592680
dgv2485e1 CNV Complex 17122850
nsv470369 CNV Gain 18288195
esv2752315 CNV Gain 17911159
dgv2486e1 CNV Complex 17122850
essv9625 CNV CNV 17122850
nsv471606 CNV Gain 15918152
nsv469528 CNV Loss 16826518
nsv9983 CNV Gain 18304495
esv26320 CNV Gain+Loss 19812545
nsv515177 CNV Complex 21397061

Relevant External Links for SPANXA1 Gene

HapMap Linkage Disequilibrium report

No data available for Sequence variations from dbSNP and Humsavar for SPANXA1 Gene

Disorders for SPANXA1 Gene

(3) Novoseek inferred disease relationships for SPANXA1 Gene

Disease -log(P) Hits PubMed IDs
melanoma 47.4 4
cancer 26.8 1
tumors 9.27 5

Relevant External Links for SPANXA1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SPANXA1: view

No data available for UniProtKB/Swiss-Prot for SPANXA1 Gene

Publications for SPANXA1 Gene

  1. Spermatid-specific expression of the novel X-linked gene product SPAN-X localized to the nucleus of human spermatozoa. (PMID: 10906052) Westbrook V.A. … Herr J.C. (Biol. Reprod. 2000) 2 3 4 23
  2. The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines. (PMID: 12758128) Zendman A.J. … van Muijen G.N.P. (Gene 2003) 3 4 23
  3. Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27. (PMID: 16251457) Kouprina N. … Larionov V. (Genome Res. 2005) 3 4 23
  4. Differential nuclear localization of the cancer/testis-associated protein, SPAN-X/CTp11, in transfected cells and in 50% of human spermatozoa. (PMID: 11133693) Westbrook V.A. … Herr J.C. (Biol. Reprod. 2001) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SPANXA1 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate SPANXA1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for SPANXA1
    • Block miRNA regulation of SPANXA1 using miScript Target Protectors

    Sources for SPANXA1 Gene

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