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SPAM1 Gene

protein-coding   GIFtS: 58
GCID: GC07P123565

Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida
Binding)1 2
     PH-202
Hyaluronoglucosaminidase PH-202 3     SPAG152
Sperm Surface Protein PH-202 3     Epididymis Secretory Sperm Binding Protein Li 96n2
HYAL32 3     hyal-PH202
PH202 3     Hyaluronidase PH-202
HEL-S-96n2     EC 3.2.1.353
HYA12     Hyal-PH203
HYAL12     Sperm Adhesion Molecule 13
HYAL52     

External Ids:    HGNC: 112171   Entrez Gene: 66772   Ensembl: ENSG000001063047   OMIM: 6009305   UniProtKB: P385673   

Export aliases for SPAM1 gene to outside databases

Previous GC identifers: GC07P122043 GC07P123106 GC07P123119 GC07P123159 GC07P123352 GC07P117928


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SPAM1 Gene:
Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and
basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on
chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned
the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes
a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional
protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer
surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor
that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this
protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Mar 2010)

GeneCards Summary for SPAM1 Gene:
SPAM1 (sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)) is a protein-coding gene. Diseases associated with SPAM1 include mucopolysaccharidosis ix, and breast adenocarcinoma. GO annotations related to this gene include hyalurononglucosaminidase activity. An important paralog of this gene is HYAL3.

UniProtKB/Swiss-Prot: HYALP_HUMAN, P38567
Function: Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells
that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing
hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells
by digesting hyaluronic acid

Gene Wiki entry for SPAM1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPAM1 gene promoter:
         AML1a   p53   NF-YA   NF-YB   CBF-A   CBF-B   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SPAM1 promoter sequence
   Search Chromatin IP Primers for SPAM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPAM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.3   Ensembl cytogenetic band:  7q31.32   HGNC cytogenetic band: 7q31

SPAM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPAM1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P123565:  view genomic region     (about GC identifiers)

Start:
123,565,286 bp from pter      End:
123,611,468 bp from pter
Size:
46,183 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 122,953,904-123,000,093     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HYALP_HUMAN, P38567 (See protein sequence)
Recommended Name: Hyaluronidase PH-20 precursor  
Size: 509 amino acids; 57848 Da
Secondary accessions: Q8TC30
Alternative splicing: 2 isoforms:  P38567-1   P38567-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SPAM1: NX_P38567

Explore proteomics data for SPAM1 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Glycosylation2 at Asn82, Asn166, Asn235, Asn254, Asn368, Asn393
  • Modification sites at PhosphoSitePlus

  • See SPAM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001167515.1  NP_001167516.1  NP_001167517.1  NP_003108.2  NP_694859.1  

    ENSEMBL proteins: 
     ENSP00000391491   ENSP00000417934   ENSP00000345849   ENSP00000402123   ENSP00000386028  
     ENSP00000223028  
    Reactome Protein details: P38567

    SPAM1 Human Recombinant Protein Products:

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    LSBio Antibodies in human, mouse, rat for SPAM1

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    Cloud-Clone Corp. CLIAs for SPAM1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR013785 Aldolase_TIM
     IPR018155 Hyaluronidase
     IPR017853 Glycoside_hydrolase_SF
     IPR001439 Hyaluronidase_PH20

    Graphical View of Domain Structure for InterPro Entry P38567

    ProtoNet protein and cluster: P38567

    2 Blocks protein domains:
    IPB001439 Sperm surface protein PH20 (hyaluronidase) signature
    IPB001968 Glycosyl hydrolase family 56 signature


    UniProtKB/Swiss-Prot: HYALP_HUMAN, P38567
    Similarity: Belongs to the glycosyl hydrolase 56 family


    SPAM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HYALP_HUMAN, P38567
    Function: Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells
    that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing
    hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells
    by digesting hyaluronic acid
    Catalytic activity: Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate
    residues in hyaluronate

         Genatlas biochemistry entry for SPAM1:
    sperm adhesion molecule,possessing hyaluronidase activity,involved in sperm-egg interaction,homologous to guinea
    pig PH-20,paralog to HYAL1

         Enzyme Number (IUBMB): EC 3.2.1.351

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004415hyalurononglucosaminidase activity IEA--
         
    SPAM1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Spam1):
     reproductive system 

    SPAM1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Spam1tm1Tba for SPAM1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPAM1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SPAM1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPAM1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPAM1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SPAM1:
    hsa-mir-16-5p (MIRT031666)

    Block miRNA regulation of human, mouse, rat SPAM1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate SPAM1:
    hsa-miR-640 hsa-miR-876-5p hsa-miR-3167
    SwitchGear 3'UTR luciferase reporter plasmidSPAM1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SPAM1
    Predesigned siRNA for gene silencing in human, mouse, rat SPAM1

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    GenScript: all cDNA clones in your preferred vector (see all 5): SPAM1 (NM_153189)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPAM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPAM1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPAM1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HYALP_HUMAN, P38567: Cell membrane; Lipid-anchor, GPI-anchor
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0031225anchored component of membrane IEA--

    SPAM1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SPAM1 About    
    See pathways by source

    SuperPathContained pathways About
    1Glycosaminoglycan degradation
    Glycosaminoglycan degradation
    Interaction With Cumulus Cells0.00
    2Reproduction
    Reproduction1.00
    Fertilization1.00
    3Metabolism
    Metabolic pathways0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SPAM1
        Interaction With Cumulus Cells


    2 Kegg Pathways  (Kegg details for SPAM1):
        Glycosaminoglycan degradation
    Metabolic pathways


    SPAM1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPAM1
    Interactions:

        Search GeneGlobe Interaction Network for SPAM1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for SPAM1 (ENSP000003458494) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARSBENSP000002649144STRING: ENSP00000264914
    IDUAENSP000002479334STRING: ENSP00000247933
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process IEA--
    GO:0007155cell adhesion IEA--
    GO:0007338single fertilization TAS--
    GO:0007339binding of sperm to zona pellucida TAS8195297
    GO:0007342fusion of sperm to egg plasma membrane IEA--

    SPAM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPAM1 (HYALP)

    3 HMDB Compounds for SPAM1    About this table
    CompoundSynonyms CAS #PubMed Ids
    N-Acetylgalactosamine2-Acetamido-2-desoxy-b-D-talofuranose (see all 113)1811-31-0--
    N-Acetylgalactosamine 4-sulphateN-Acetyl-D-galactosamine 4-sulfate (see all 7)45233-43-0--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    7 Novoseek inferred chemical compound relationships for SPAM1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyaluronic acid 76.4 62 11371930 (7), 15305383 (7), 11278412 (5), 12750291 (5) (see all 12)
    glycosaminoglycan 61.7 1 16203124 (1)
    biotin 23.7 1 9590538 (1)
    lipid 0 1 16831275 (1)
    calcium 0 2 9590538 (1), 9770775 (1)
    progesterone 0 2 15457544 (1)
    lactate 0 1 10582172 (1)



    SPAM1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SPAM1 gene (5 alternative transcripts): 
    NM_001174044.1  NM_001174045.1  NM_001174046.1  NM_003117.4  NM_153189.2  

    Unigene Cluster for SPAM1:

    Sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
    Hs.121494  [show with all ESTs]
    Unigene Representative Sequence: NM_003117
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000413927 ENST00000460182(uc003vld.3 uc022aks.1) ENST00000340011(uc003vle.3 uc011koa.1)
    ENST00000439500(uc003vlf.4 uc010lku.3) ENST00000402183 ENST00000223028

    miRNA
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    Block miRNA regulation of human, mouse, rat SPAM1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate SPAM1:
    hsa-miR-640 hsa-miR-876-5p hsa-miR-3167
    SwitchGear 3'UTR luciferase reporter plasmidSPAM1 3' UTR sequence
    Inhib. RNA
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SPAM1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPAM1
      QuantiTect SYBR Green Assays in human, mouse, rat SPAM1
      QuantiFast Probe-based Assays in human, mouse, rat SPAM1

    Additional mRNA sequence: 

    AK292229.1 AY920278.1 AY920279.1 AY920280.1 AY920281.1 BC026163.1 L13781.1 S67798.1 
    X84347.1 

    5 DOTS entries:

    DT.121120875  DT.308861  DT.100735391  DT.121120879  DT.121120881 

    21 AceView cDNA sequences:

    BX100330 BE503684 NM_153189 NM_003117 AW236602 S67798 X84347 L13781 
    BC026163 L13779 BG773088 AA953414 BC041947 BI832432 BI830390 BI831525 
    BI826995 AI473374 AI873430 BI597922 AI203061 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SPAM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGACAGAAG
    SPAM1 Expression
    About this image


    SPAM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Heart (Cardiovascular System)
             Atrioventricular Node
     
     Testis (Reproductive System)
    SPAM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPAM1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.121494

    UniProtKB/Swiss-Prot: HYALP_HUMAN, P38567
    Tissue specificity: Testis

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SPAM1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spam15
    Hyal51
    sperm adhesion molecule 15
    hyaluronoglucosaminidase 51
    72.88(n)1
    63.6(a)1
      6 (11.28 cM)5
    744681  NM_028957.21  NP_083233.11 
     247958245 
    chicken
    (Gallus gallus)
    Aves SPAM11 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona more 64.42(n)
    54.48(a)
      417749  XM_004937519.1  XP_004937576.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Hyaluronidase
    41(a)
    many ↔ many
    5(67342535-67343522)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3982852 hyaluronidase 73.78(n)    AF134981.1 
    zebrafish
    (Danio rerio)
    Actinopterygii spam11 sperm adhesion molecule 1 49.87(n)
    43.26(a)
      791203  NM_001080685.1  NP_001074154.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T22C8.23 hyaluronidase 33(a)   II(8614552-8617147)   --


    ENSEMBL Gene Tree for SPAM1 (if available)
    TreeFam Gene Tree for SPAM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SPAM1 gene
    HYAL32  HYAL22  HYAL12  HYAL42  
    4 SIMAP similar genes for SPAM1 using alignment to 3 protein entries:     HYALP_HUMAN (see all proteins):
    HYAL4    HYAL2    HYAL1    HYAL3

    SPAM1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SPAM1 (see all 840)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1420677851,2
    --123563306(+) GATCAC/GAATGA 3 -- us2k10--------
    rs1457244861,2
    --123563312(+) AATGAA/GAATAA 3 -- us2k10--------
    rs1887353891,2
    --123563358(+) CATATC/TCCATT 3 -- us2k10--------
    rs1807576491,2
    --123563399(+) AGTCTA/TATCAA 3 -- us2k10--------
    rs1837812841,2
    --123563429(+) TTATGA/GAGAAT 3 -- us2k10--------
    rs1477748191,2
    --123563489(+) TGATTC/GACAAA 3 -- us2k10--------
    rs795959471,2
    C,F--123563517(+) AACCAC/AACAAG 3 -- us2k13Minor allele frequency- A:0.10WA NA EA 358
    rs1159156361,2
    C,F--123563658(+) TTGTAG/AAAGCA 3 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1414058321,2
    --123563773(+) TTTATA/GTACAA 3 -- us2k10--------
    rs1892997941,2
    --123563800(+) GCCTAA/TTCAGG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for SPAM1 (123565286 - 123611468 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SPAM1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SPAM1
    DNA2.0 Custom Variant and Variant Library Synthesis for SPAM1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600930    OMIM disorders: --

    13 diseases for SPAM1:    
    About MalaCards
    mucopolysaccharidosis ix    breast adenocarcinoma    mucopolysaccharidosis    laryngeal carcinoma
    epididymitis    laryngitis    periodontitis    infertility
    prostate cancer    prostatitis    breast cancer    adenocarcinoma
    lung cancer


    SPAM1 for disorders           About GeneDecksing

    7 Novoseek inferred disease relationships for SPAM1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bladder tumors 40 2 11371930 (2)
    prostate cancer 23.1 8 11802201 (3), 15305383 (1), 12750291 (1), 12084718 (1)
    bladder cancer 22.8 5 11371930 (2), 15781637 (1)
    tumors 16 35 11371930 (6), 11802201 (4), 11922735 (2), 11163112 (2) (see all 11)
    metastasis 11.1 5 11278412 (1), 11922735 (1), 11802201 (1)
    breast cancer 3.79 10 11953163 (4), 11922735 (2), 16831275 (2), 11802201 (1)
    cancer 0 5 16713680 (1), 11922735 (1), 17227790 (1), 18725949 (1)

    Genetic Association Database (GAD): SPAM1
    Human Genome Epidemiology (HuGE) Navigator: SPAM1 (1 document)

    Export disorders for SPAM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPAM1 gene, integrated from 10 sources (see all 77):
    (articles sorted by number of sources associating them with SPAM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression analysis, genomic structure, and mapping to 7q31 of the human sperm adhesion molecule gene SPAM1. (PubMed id 8575780)1, 2, 3, 9 Jones M.H.... Affara N.A. (Genomics 1995)
    2. The human sperm protein PH-20 has hyaluronidase activity. (PubMed id 8282124)1, 2, 3, 9 Gmachl M.... Kreil G. (FEBS Lett. 1993)
    3. Molecular cloning of the human and monkey sperm surface protein PH- 20. (PubMed id 8234258)1, 2, 9 Lin Y.... Primakoff P. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    4. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    5. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    6. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    7. The dual functions of GPI-anchored PH-20: hyaluronidase and intracellular signaling. (PubMed id 11731269)1, 9 Cherr G.N....Overstreet J.W. (Matrix Biol. 2001)
    8. cDNA cloning reveals the molecular structure of a sperm surface protein, PH-20, involved in sperm-egg adhesion and the wide distribution of its gene among mammals. (PubMed id 2269661)1, 9 Lathrop W.F....Primakoff P. (J. Cell Biol. 1990)
    9. Transcription of the human and rodent SPAM1 / PH-20 genes initiates within an ancient endogenous retrovirus. (PubMed id 15804358)1, 9 Dunn C.A. and Mager D.L. (BMC Genomics 2005)
    10. A hyaluronidase activity of the sperm plasma membrane protein PH-20 enables sperm to penetrate the cumulus cell layer surrounding the egg. (PubMed id 8195297)1, 9 Lin Y....Primakoff P. (J. Cell Biol. 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6677 HGNC: 11217 AceView: SPAM1 Ensembl:ENSG00000106304 euGenes: HUgn6677
    ECgene: SPAM1 Kegg: 6677 H-InvDB: SPAM1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SPAM1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SPAM1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SPAM1 gene:
    Search GeneIP for patents involving SPAM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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