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Aliases for SPAM1 Gene

Aliases for SPAM1 Gene

  • Sperm Adhesion Molecule 1 2 3 4
  • Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) 2 3 5
  • Hyaluronoglucosaminidase PH-20 3 4
  • Sperm Surface Protein PH-20 3 4
  • PH-20 Hyaluronidase 2 3
  • Hyal-PH20 3 4
  • HYAL3 3 4
  • PH20 3 4
  • Epididymis Secretory Sperm Binding Protein Li 96n 3
  • EC 3.2.1.35 4
  • HEL-S-96n 3
  • SPAG15 3
  • HYAL1 3
  • HYAL5 3
  • PH-20 3
  • HYA1 3

External Ids for SPAM1 Gene

Previous GeneCards Identifiers for SPAM1 Gene

  • GC07P122043
  • GC07P123106
  • GC07P123119
  • GC07P123159
  • GC07P123352
  • GC07P123565
  • GC07P117928

Summaries for SPAM1 Gene

Entrez Gene Summary for SPAM1 Gene

  • Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

GeneCards Summary for SPAM1 Gene

SPAM1 (Sperm Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with SPAM1 include mucopolysaccharidosis type ix and breast adenocarcinoma. Among its related pathways are Glycosaminoglycan degradation and Metabolism. GO annotations related to this gene include hyalurononglucosaminidase activity. An important paralog of this gene is HYAL3.

UniProtKB/Swiss-Prot for SPAM1 Gene

  • Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid.

Gene Wiki entry for SPAM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPAM1 Gene

Genomics for SPAM1 Gene

Regulatory Elements for SPAM1 Gene

Enhancers for SPAM1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SPAM1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPAM1 Gene

Chromosome:
7
Start:
123,925,232 bp from pter
End:
123,971,414 bp from pter
Size:
46,183 bases
Orientation:
Plus strand

Genomic View for SPAM1 Gene

Genes around SPAM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPAM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPAM1 Gene

Proteins for SPAM1 Gene

  • Protein details for SPAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P38567-HYALP_HUMAN
    Recommended name:
    Hyaluronidase PH-20
    Protein Accession:
    P38567
    Secondary Accessions:
    • Q8TC30

    Protein attributes for SPAM1 Gene

    Size:
    509 amino acids
    Molecular mass:
    57848 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPAM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPAM1 Gene

Proteomics data for SPAM1 Gene at MOPED

Post-translational modifications for SPAM1 Gene

Antibody Products

No data available for DME Specific Peptides for SPAM1 Gene

Domains & Families for SPAM1 Gene

Graphical View of Domain Structure for InterPro Entry

P38567

UniProtKB/Swiss-Prot:

HYALP_HUMAN :
  • Belongs to the glycosyl hydrolase 56 family.
Family:
  • Belongs to the glycosyl hydrolase 56 family.
genes like me logo Genes that share domains with SPAM1: view

No data available for Gene Families for SPAM1 Gene

Function for SPAM1 Gene

Molecular function for SPAM1 Gene

GENATLAS Biochemistry:
sperm adhesion molecule,possessing hyaluronidase activity,involved in sperm-egg interaction,homologous to guinea pig PH-20,paralog to HYAL1
UniProtKB/Swiss-Prot CatalyticActivity:
Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.
UniProtKB/Swiss-Prot Function:
Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid.

Enzyme Numbers (IUBMB) for SPAM1 Gene

genes like me logo Genes that share phenotypes with SPAM1: view

Animal Models for SPAM1 Gene

MGI Knock Outs for SPAM1:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPAM1 Gene

Localization for SPAM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPAM1 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPAM1 Gene COMPARTMENTS Subcellular localization image for SPAM1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
vacuole 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for SPAM1 Gene

Pathways & Interactions for SPAM1 Gene

genes like me logo Genes that share pathways with SPAM1: view

Pathways by source for SPAM1 Gene

3 Reactome pathways for SPAM1 Gene
2 KEGG pathways for SPAM1 Gene

Interacting Proteins for SPAM1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000345849%0d%0a9606.ENSP00000247933%0d%0a9606.ENSP00000264914%0d%0a
Selected Interacting proteins: ENSP00000345849 for SPAM1 Gene via STRING

Gene Ontology (GO) - Biological Process for SPAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007338 single fertilization TAS --
GO:0035036 sperm-egg recognition TAS --
genes like me logo Genes that share ontologies with SPAM1: view

No data available for SIGNOR curated interactions for SPAM1 Gene

Drugs & Compounds for SPAM1 Gene

(4) Drugs for SPAM1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for SPAM1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N-Acetylgalactosamine
  • 2-Acetamido-2-deoxy-a-D-allopyranose
  • 2-Acetamido-2-deoxy-a-D-glucopyranose
  • 2-Acetamido-2-deoxy-alpha-D-allopyranose
  • 2-Acetamido-2-deoxy-alpha-D-glucopyranose
  • 2-Acetamido-2-deoxy-alpha-delta-allopyranose
1811-31-0
N-Acetylgalactosamine 4-sulphate
  • 2-(Acetylamino)-2-deoxy-D-Galactose 4-(hydrogen sulfate)
  • 2-(Acetylamino)-2-deoxy-D-Galactose 4-(hydrogen sulphate)
  • GalNAc4S
  • N-Acetyl-D-galactosamine 4-sulfate
  • N-Acetyl-D-galactosamine 4-sulphate
45233-43-0
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with SPAM1: view

Transcripts for SPAM1 Gene

Unigene Clusters for SPAM1 Gene

Sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPAM1 Gene

No ASD Table

Relevant External Links for SPAM1 Gene

GeneLoc Exon Structure for
SPAM1
ECgene alternative splicing isoforms for
SPAM1

Expression for SPAM1 Gene

mRNA expression in normal human tissues for SPAM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPAM1 Gene

This gene is overexpressed in Testis (x49.9).

Protein differential expression in normal tissues from HIPED for SPAM1 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPAM1 Gene



SOURCE GeneReport for Unigene cluster for SPAM1 Gene Hs.121494

mRNA Expression by UniProt/SwissProt for SPAM1 Gene

P38567-HYALP_HUMAN
Tissue specificity: Testis.
genes like me logo Genes that share expression patterns with SPAM1: view

Protein tissue co-expression partners for SPAM1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SPAM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPAM1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC509761 35
  • 78.18 (n)
  • 66.52 (a)
-- 36
  • 56 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SPAM1 35
  • 76.21 (n)
  • 63.68 (a)
SPAM1 36
  • 55 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hyal5 35
  • 72.88 (n)
  • 63.6 (a)
Hyal5 16
Hyal5 36
  • 58 (a)
OneToMany
Spam1 36
  • 54 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia SPAM1 35
  • 99.54 (n)
  • 99.02 (a)
SPAM1 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hyal5 35
  • 71.81 (n)
  • 62.1 (a)
oppossum
(Monodelphis domestica)
Mammalia SPAM1 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPAM1 36
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPAM1 35
  • 64.42 (n)
  • 54.48 (a)
SPAM1 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 41 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486024 35
  • 58.11 (n)
  • 47.81 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398285 35
zebrafish
(Danio rerio)
Actinopterygii spam1 35
  • 49.87 (n)
  • 43.26 (a)
spam1 36
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T22C8.2 37
  • 33 (a)
chhy-1 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for SPAM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPAM1 Gene

ENSEMBL:
Gene Tree for SPAM1 (if available)
TreeFam:
Gene Tree for SPAM1 (if available)

Paralogs for SPAM1 Gene

Paralogs for SPAM1 Gene

(4) SIMAP similar genes for SPAM1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SPAM1: view

Variants for SPAM1 Gene

Sequence variations from dbSNP and Humsavar for SPAM1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs34633019 - 123,953,710(+) AAATG(C/T)GCCTT reference, missense
VAR_064756 -
rs960356 -- 123,968,398(+) attgc(C/T)tttgg intron-variant
rs989926 -- 123,941,175(-) tttac(A/G)GAATC intron-variant
rs1014439 -- 123,942,274(-) ACTTA(C/T)AGTTT intron-variant

Variation tolerance for SPAM1 Gene

Residual Variation Intolerance Score: 60.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.73; 32.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPAM1 Gene

HapMap Linkage Disequilibrium report
SPAM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SPAM1 Gene

Disorders for SPAM1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SPAM1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
mucopolysaccharidosis type ix
  • mucopolysaccharidosis ix
breast adenocarcinoma
  • adenocarcinoma of breast
- elite association - COSMIC cancer census association via MalaCards
Search SPAM1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SPAM1

Genetic Association Database (GAD)
SPAM1
Human Genome Epidemiology (HuGE) Navigator
SPAM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPAM1
genes like me logo Genes that share disorders with SPAM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPAM1 Gene

Publications for SPAM1 Gene

  1. Expression analysis, genomic structure, and mapping to 7q31 of the human sperm adhesion molecule gene SPAM1. (PMID: 8575780) Jones M.H. … Affara N.A. (Genomics 1995) 2 3 4 23 67
  2. The human sperm protein PH-20 has hyaluronidase activity. (PMID: 8282124) Gmachl M. … Kreil G. (FEBS Lett. 1993) 2 3 23
  3. Transcription of the human and rodent SPAM1 / PH-20 genes initiates within an ancient endogenous retrovirus. (PMID: 15804358) Dunn C.A. … Mager D.L. (BMC Genomics 2005) 3 23
  4. The six hyaluronidase-like genes in the human and mouse genomes. (PMID: 11731267) Csoka A.B. … Stern R. (Matrix Biol. 2001) 3 23
  5. The dual functions of GPI-anchored PH-20: hyaluronidase and intracellular signaling. (PMID: 11731269) Cherr G.N. … Overstreet J.W. (Matrix Biol. 2001) 3 23

Products for SPAM1 Gene

Sources for SPAM1 Gene

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