SPAM1 Gene
protein-coding GIFtS: 55
GCID: GC07P123565
|
|
sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida...
| |
Aliases
for SPAM1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding)1 2 | | HYA12 | | HYAL51 2 | | HYAL12 | | PH-201 2 | | Hyal-PH203 | | SPAG151 2 | | Hyaluronidase PH-202 | | Hyaluronoglucosaminidase PH-202 3 | | EC 3.2.1.353 | | Sperm Surface Protein PH-202 3 | | Hyal-PH203 | | HYAL32 3 | | Sperm Adhesion Molecule 13 | | PH202 3 | | |
Export aliases for SPAM1 gene to outside databasesPrevious GC identifers: GC07P122043 GC07P123106 GC07P123119 GC07P123159 GC07P123352 GC07P117928 |
Summaries
for SPAM1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SPAM1:
Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basementmembranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbolSPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzymelocated on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase thatenables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor thatplays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucidaadhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranesleading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found forthis gene. (provided by RefSeq, Mar 2010)
UniProtKB/Swiss-Prot: HYALP_HUMAN, P38567Function: Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells thatsurrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronicacid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digestinghyaluronic acid
Gene Wiki entry for SPAM1
|
Genomic Views
for SPAM1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPAM1 gene promoter:
AML1a p53 NF-YA NF-YB CBF-A CBF-B CP1A NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPAM1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPAM1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q31.3 Ensembl cytogenetic band: 7q31.32 HGNC cytogenetic band: 7q31SPAM1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P123565: view genomic region
(about GC identifiers)
Start:
|
123,565,286 bp from pter |
End:
|
123,611,468 bp from pter |
Size:
|
46,183 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 122,953,904-123,000,093 |
|
Proteins
for SPAM1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HYALP_HUMAN, P38567 (See
protein sequence)Recommended Name: Hyaluronidase PH-20 precursor Size: 509 amino acids; 57848 Da
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor
Secondary accessions: Q8TC30Alternative splicing: 2 isoforms: P38567-1 P38567-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SPAM1: NX_P38567
Post-translational modifications:
N-glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P38567
SPAM1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001167515.1 NP_001167516.1 NP_001167517.1 NP_003108.2 NP_694859.1
ENSEMBL proteins: ENSP00000391491 ENSP00000417934 ENSP00000345849 ENSP00000402123 ENSP00000386028 ENSP00000223028
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0031225 | anchored to membrane |
IEA | -- |
SPAM1 for ontologies About GeneDecksing
SPAM1 Antibody Products:
Assay Products for SPAM1: |
Protein
Domains /
Families
for SPAM1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPAM1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P38567ProtoNet protein and cluster: P38567 2 Blocks protein families: IPB001439 Sperm surface protein PH20 (hyaluronidase) signature IPB001968 Glycosyl hydrolase family 56 signature
UniProtKB/Swiss-Prot: HYALP_HUMAN, P38567Similarity: Belongs to the glycosyl hydrolase 56 family |
Function
for SPAM1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: HYALP_HUMAN, P38567Function: Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells thatsurrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronicacid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digestinghyaluronic acidCatalytic activity: Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residuesin hyaluronate Genatlas biochemistry entry for SPAM1:sperm adhesion molecule,possessing hyaluronidase activity,involved in sperm-egg interaction,homologous to guinea pigPH-20,paralog to HYAL1
Enzyme Number (IUBMB): EC 3.2.1.351
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPAM1 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPAM1 (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPAM1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004415 | hyalurononglucosaminidase activity |
IEA | -- |
SPAM1 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Spam1tm1Tba for SPAM1
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Spam1):
SPAM1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SPAM1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Glycosaminoglycan degradation | | | 2 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Kegg Pathways (Kegg details for SPAM1):
SPAM1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPAM1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for SPAM1 (ENSP000003458494) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
SPAM1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SPAM1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SPAM1 for compounds About GeneDecksing
 Browse Tocris compounds for SPAM1
3 HMDB Compounds for SPAM1 About this table
7 Novoseek chemical compound relationships for SPAM1 gene About this table
Search CenterWatch for drugs/clinical trials and news about SPAM1 / HYALP
|
Transcripts
for SPAM1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPAM1 gene (5 alternative transcripts): NM_001174044.1 NM_001174045.1 NM_001174046.1 NM_003117.4 NM_153189.2 Unigene Cluster for SPAM1: Sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) Hs.121494 [show with all ESTs]Unigene Representative Sequence: NM_0031176 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000413927 ENST00000460182(uc003vld.3 uc022aks.1) ENST00000340011(uc003vle.3 uc011koa.1)
ENST00000439500(uc003vlf.4 uc010lku.3) ENST00000402183 ENST00000223028
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPAM1 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPAM1 (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 5): SPAM1 (NM_153189) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPAM1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPAM1 |
Additional cDNA sequence: AK292229.1 AY920278.1 AY920279.1 AY920280.1 AY920281.1 BC026163.1 L13781.1 S67798.1 X84347.1 5 DOTS entries: DT.121120875 DT.308861 DT.100735391 DT.121120879 DT.121120881 21 AceView cDNA sequences: BX100330 NM_153189 BE503684 AW236602 NM_003117 BG773088 BI830390 X84347 BI832432 L13779 BC041947 AA953414 S67798 L13781 BI831525 BC026163 BI826995 AI473374 BI597922 AI873430 AI203061
GeneLoc Exon Structure
|
Expression
for SPAM1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPAM1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGACAGAAG
About this image
See SPAM1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPAM1
SOURCE GeneReport for Unigene cluster: Hs.121494
UniProtKB/Swiss-Prot: HYALP_HUMAN, P38567Tissue specificity: Testis
SABiosciences Custom PCR Arrays for SPAM1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPAM1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPAM1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPAM1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPAM1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPAM1 |
Orthologs
for SPAM1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SPAM1 gene from 5/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SPAM11 |
sperm adhesion molecule 1 (PH-20 hyaluronidase, zona more |
64.56(n)
54.63(a) |
|
417749 XM_001233400.2 XP_001233401.2 |
African clawed frog
(Xenopus laevis) |
Amphibia |
LOC3982852 |
hyaluronidase |
73.78(n) |
|
AF134981.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
spam11 |
sperm adhesion molecule 1 |
49.87(n)
43.26(a) |
|
791203 NM_001080685.1 NP_001074154.1 |
honey bee
(Apis mellifera) |
Insecta |
-- |
-- |
25(a) |
1 → many |
Group14.3(803059-805153) |
worm
(Caenorhabditis elegans) |
Secernentea |
T22C8.23 |
hyaluronidase |
33(a) |
|
II(8614552-8617147) -- |
ENSEMBL Gene Tree for SPAM1 (if available)
TreeFam Gene Tree for SPAM1 (if available) |
Paralogs
for SPAM1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SPAM1 gene
- HYAL32 HYAL22 HYAL12 HYAL42
4 SIMAP similar genes for SPAM1 using alignment to 3 protein entries: HYALP_HUMAN (see all proteins):HYAL4 HYAL2 HYAL1 HYAL3
SPAM1 for paralogs About GeneDecksing
|
Genomic Variants
for SPAM1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SPAM1 (123565286 - 123611468 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SPAM1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPAM1 |
|
Disorders
/ Diseases
for SPAM1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SPAM1 for disorders About GeneDecksing
OMIM gene information: 600930
OMIM disorders: --
14  diseases for SPAM1: About MalaCardsmucopolysaccharidosis type ix mucopolysaccharidosis laryngitis laryngeal carcinoma
epididymitis laryngeal cancer prostate cancer breast cancer
breast adenocarcinoma periodontitis lung cancer adenocarcinoma
prostatitis carcinoma
1 disease from the University of Copenhagen DISEASES database for SPAM1:Infertility 7 Novoseek disease relationships for SPAM1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| bladder tumors |
40 |
2 |
11371930 (2) |
| prostate cancer |
23.1 |
8 |
11802201 (3), 15305383 (1), 12750291 (1), 12084718 (1) |
| bladder cancer |
22.8 |
5 |
11371930 (2), 15781637 (1) |
| tumors |
16 |
35 |
11371930 (6), 11802201 (4), 11922735 (2), 11163112 (2) (see all 11) |
| metastasis |
11.1 |
5 |
11278412 (1), 11922735 (1), 11802201 (1) |
| breast cancer |
3.79 |
10 |
11953163 (4), 11922735 (2), 16831275 (2), 11802201 (1) |
| cancer |
0 |
5 |
16713680 (1), 11922735 (1), 17227790 (1), 18725949 (1) |
Human Genome Epidemiology (HuGE) Navigator: SPAM1 (1 document)
Export disorders for SPAM1 gene to outside databases
|
Publications
for SPAM1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPAM1 gene, integrated from 9 sources (see all 74):
(articles sorted by number of sources associating them with SPAM1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Expression analysis, genomic structure, and mapping to 7q31 of the human sperm adhesion molecule gene SPAM1. (PubMed id 8575780)1, 2, 3, 9 Jones M.H.... Affara N.A. (1995)
- The human sperm protein PH-20 has hyaluronidase activity. (PubMed id 8282124)1, 2, 3, 9 Gmachl M.... Kreil G. (1993)
- Molecular cloning of the human and monkey sperm surface protein PH- 20. (PubMed id 8234258)1, 2, 9 Lin Y.... Primakoff P. (1993)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- The dual functions of GPI-anchored PH-20: hyaluronidase and intracellular signaling. (PubMed id 11731269)1, 9 Cherr G.N....Overstreet J.W. (2001)
- cDNA cloning reveals the molecular structure of a sperm surface protein, PH-20, involved in sperm-egg adhesion and the wide distribution of its gene among mammals. (PubMed id 2269661)1, 9 Lathrop W.F....Primakoff P. (1990)
- Transcription of the human and rodent SPAM1 / PH-20 genes initiates within an ancient endogenous retrovirus. (PubMed id 15804358)1, 9 Dunn C.A. and Mager D.L. (2005)
- A hyaluronidase activity of the sperm plasma membrane protein PH-20 enables sperm to penetrate the cumulus cell layer surrounding the egg. (PubMed id 8195297)1, 9 Lin Y....Primakoff P. (1994)
- The six hyaluronidase-like genes in the human and mouse genomes. (PubMed id 11731267)1, 9 Csoka A.B....Stern R. (2001)
|
External Searches for SPAM1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SPAM1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPAM1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPAM1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SPAM1 gene:
Search GeneIP for patents involving SPAM1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPAM1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPAM1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPAM1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPAM1 | | | OriGene Protein Over-expression Lysate for SPAM1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPAM1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPAM1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPAM1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SPAM1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SPAM1 | | OriGene Custom Protein Services for SPAM1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPAM1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPAM1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPAM1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPAM1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPAM1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPAM1 |
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| | | | Search Tocris compounds for SPAM1 |
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 | | | SPAM1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPAM1 |
|  |  |  | | | | Search ThermoFisher Antibodies for SPAM1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPAM1 |
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