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SPAG9 Gene

protein-coding   GIFtS: 61
GCID: GC17M049039

Sperm Associated Antigen 9

  See SPAG9-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sperm Associated Antigen 91 2     JLP2 3
Cancer/Testis Antigen 891 2 3     PHET2 3
Sperm Surface Protein1 2 3     KIAA05163 5
JNK-Associated Leucine-Zipper Protein1 3     SYD13 5
C-Jun NH2-Terminal Kinase-Associated Leucine Zipper Protein1 2     HLC-4 Protein1
JNK Interacting Protein1 2     Sperm Specific Protein1
JNK/SAPK-Associated Protein1 2     HLC42
Lung Cancer Oncogene 41 2     JIP42
Max-Binding Protein1 2     PIG62
Proliferation-Inducing Gene 61 2     C-Jun-Amino-Terminal Kinase-Interacting Protein 42
Human Lung Cancer Oncogene 6 Protein2 3     HSS3
Mitogen-Activated Protein Kinase 8-Interacting Protein 42 3     MAPK8IP43
Protein Highly Expressed In Testis2 3     JNK-Interacting Protein 43
Sunday Driver 12 3     Proliferation-Inducing Protein 63
CT892 3     Sperm-Associated Antigen 93
HLC-62 3     Sperm-Specific Protein3
JIP-42 3     

External Ids:    HGNC: 145241   Entrez Gene: 90432   Ensembl: ENSG000000082947   OMIM: 6054305   UniProtKB: O602713   

Export aliases for SPAG9 gene to outside databases

Previous GC identifers: GC17M048755 GC17M051523 GC17M049383 GC17M049515 GC17M046397 GC17M044409


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SPAG9 Gene:
This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold
protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase
signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This
protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript
variants. (provided by RefSeq, Oct 2011)

GeneCards Summary for SPAG9 Gene:
SPAG9 (sperm associated antigen 9) is a protein-coding gene. Diseases associated with SPAG9 include dengue disease, and lung cancer. GO annotations related to this gene include mitogen-activated protein kinase p38 binding and kinesin binding. An important paralog of this gene is ARHGEF10.

UniProtKB/Swiss-Prot: JIP4_HUMAN, O60271
Function: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by
aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play
a role in spermatozoa-egg-interaction

Gene Wiki entry for SPAG9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPAG9 gene promoter:
         ATF-2   Lmo2   Olf-1   XBP-1   NF-kappaB   c-Jun   ZIC2/Zic2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SPAG9 promoter sequence
   Search Chromatin IP Primers for SPAG9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPAG9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.33   Ensembl cytogenetic band:  17q21.33   HGNC cytogenetic band: 17q21.33

SPAG9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPAG9 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M049039:  view genomic region     (about GC identifiers)

Start:
49,039,535 bp from pter      End:
49,198,226 bp from pter
Size:
158,692 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: JIP4_HUMAN, O60271 (See protein sequence)
Recommended Name: C-Jun-amino-terminal kinase-interacting protein 4  
Size: 1321 amino acids; 146205 Da
Subunit: Homodimer. The homodimer interacts with ARF6, forming a heterotetramer. Homooligomer. Interacts with MAX,
MAPK8, MAPK9, MAPK10, MAPK14, MAP3K3, MYC, KNS2 and MAP2K4. Interaction with KNS2 is important in the formation
of ternary complex with MAPK8. Interacts with NFKB1
Sequence caution: Sequence=AAH07524.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Sequence=AAH59946.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact; Sequence=AAI06049.1;
Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part;
Sequence=AAO66462.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA25442.3;
Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAB14812.1; Type=Miscellaneous
discrepancy; Note=Unlikely isoform. Aberrant splicing; Sequence=CAA62987.1; Type=Erroneous initiation;
Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for SPAG9:
2W83 (3D)    
Secondary accessions: A6H8U5 A8MSX0 B4DHH2 O60905 Q3KQU8 Q3MKM7 Q86WC7 Q86WC8 Q8IZX7 Q96II0
Q9H811
Alternative splicing: 6 isoforms:  O60271-1   O60271-2   O60271-3   O60271-4   O60271-5   O60271-9   (No experimental confirmation available. Ref.5 (BAG58134) sequence is in conflict in position: 9:F->S)

Explore the universe of human proteins at neXtProt for SPAG9: NX_O60271

Explore proteomics data for SPAG9 at MOPED

Post-translational modifications: 

  • Phosphorylated by MAPK8 and MAPK14 (By similarity)1
  • Ubiquitination2 at Lys233, Lys653, Lys1227
  • Modification sites at PhosphoSitePlus

  • See SPAG9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001123999.1  NP_001124000.1  NP_001238900.1  NP_003962.3  

    ENSEMBL proteins: 
     ENSP00000262013   ENSP00000423165   ENSP00000426900   ENSP00000349636   ENSP00000423346  
     ENSP00000430205   ENSP00000429343   ENSP00000426061  
    Reactome Protein details: O60271

    SPAG9 Human Recombinant Protein Products:

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    Novus Biologicals SPAG9 Protein
    Novus Biologicals SPAG9 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SPAG9

     
    Search eBioscience for Proteins for SPAG9 

    SPAG9 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Search eBioscience for ELISAs for SPAG9 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR019143 JNK/Rab-associated_protein-1_N
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry O60271

    ProtoNet protein and cluster: O60271

    UniProtKB/Swiss-Prot: JIP4_HUMAN, O60271
    Similarity: Belongs to the JIP scaffold family


    Find genes that share domains with SPAG9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: JIP4_HUMAN, O60271
    Function: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by
    aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play
    a role in spermatozoa-egg-interaction
    Induction: Isoform 3 is increased in systemic sclerosis fibroblasts

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19644450
    GO:0008432JUN kinase binding IEA--
    GO:0019894kinesin binding IEA--
    GO:0048273mitogen-activated protein kinase p38 binding IEA--
         
    Find genes that share ontologies with SPAG9           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SPAG9:
     Decreased viability of wild-ty 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Spag9):
     integument  pigmentation  reproductive system 

    Find genes that share phenotypes with SPAG9           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Spag9tm1Ysok for SPAG9

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPAG9
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SPAG9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPAG9
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPAG9

    miRNA
    Products:
        
    miRTarBase miRNAs that target SPAG9:
    hsa-mir-375 (MIRT019876), hsa-mir-484 (MIRT041911), hsa-mir-215-5p (MIRT024300), hsa-mir-9-5p (MIRT021369), hsa-mir-122-5p (MIRT023290), hsa-mir-335-5p (MIRT017842), hsa-mir-192-5p (MIRT026494), hsa-mir-877-3p (MIRT036882), hsa-mir-193b-3p (MIRT041411), hsa-let-7e-5p (MIRT051618), hsa-mir-27b-3p (MIRT046181)

    Block miRNA regulation of human, mouse, rat SPAG9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SPAG9 (see all 101):
    hsa-miR-548j hsa-miR-607 hsa-miR-376b hsa-miR-200a hsa-miR-3653 hsa-miR-30d hsa-miR-371-5p hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmidSPAG9 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SPAG9
    Predesigned siRNA for gene silencing in human, mouse, rat SPAG9

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for SPAG9 (see all 14)
    OriGene ORF clones in mouse, rat for SPAG9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SPAG9 (NM_003971)
    Sino Biological Human cDNA Clone for SPAG9
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPAG9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPAG9

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPAG9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    JIP4_HUMAN, O60271: Cytoplasm. Cytoplasm, perinuclear region. Note=Perinuclear distribution in response to
    stress signals such as UV radiation
    JIP4_HUMAN, O60271: Isoform 5: Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Associated with the plasma
    membrane of the acrosomal compartment and also localizes in the acrosome matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    plasma membrane2
    cytoskeleton1
    endoplasmic reticulum1
    endosome1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0016021integral component of membrane TAS9480848
    GO:0048471perinuclear region of cytoplasm IEA--

    Find genes that share ontologies with SPAG9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SPAG9 About    
    See pathways by source

    SuperPathContained pathways About
    1CDO in myogenesis
    CDO in myogenesis1.00
    Myogenesis1.00
    2L1CAM interactions
    Developmental Biology0.63
    3Akt Signaling
    p38 Signaling0.60
    4MAPK targets/ Nuclear events mediated by MAP kinases
    MAP Kinase Signaling0.31
    5Arf6 trafficking events
    Arf6 trafficking events


    Find genes that share SuperPaths with SPAG9           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SPAG9
        p38 Signaling

    1 Cell Signaling Technology (CST) Pathway for SPAG9
        MAP Kinase Signaling

    1 BioSystems Pathway for SPAG9
        Arf6 trafficking events


    1 Reactome Pathway for SPAG9
        CDO in myogenesis


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPAG9
    Interactions:

        GeneGlobe Interaction Network for SPAG9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SPAG9 (O602711, 2, 3 ENSP000002620134) via UniProtKB, MINT, STRING, and/or I2D (see all 53)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARF6P623301, 2, 3, ENSP000002983164EBI-1023301,EBI-638181 MINT-7922449 MINT-7922407 MINT-7922481 MINT-7922462 MINT-7922423 MINT-7922498 MINT-7915283 MINT-7922515 I2D: score=3 STRING: ENSP00000298316
    ARF1P840771, 2, 3, ENSP000002721024EBI-1023301,EBI-447171 MINT-7922576 MINT-7922541 MINT-7922558 I2D: score=1 STRING: ENSP00000272102
    NFKB1P198382, 3, ENSP000002265744MINT-48540 MINT-47889 MINT-48560 I2D: score=4 STRING: ENSP00000226574
    PNRC2Q9NPJ42, 3, ENSP000003348404MINT-8267030 I2D: score=2 STRING: ENSP00000334840
    MAP1LC3BQ9GZQ82, 3, ENSP000002686074MINT-8259778 I2D: score=2 STRING: ENSP00000268607
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity ----
    GO:0007257activation of JUN kinase activity IEA--
    GO:0007283spermatogenesis TAS9480848
    GO:0030335positive regulation of cell migration IMP18826971
    GO:0042147retrograde transport, endosome to Golgi IDA19056739

    Find genes that share ontologies with SPAG9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPAG9 (JIP4)

    6 Novoseek inferred chemical compound relationships for SPAG9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sp(1-7) 88.6 5 9780359 (1), 7525387 (1), 12530914 (1), 7578682 (1) (see all 5)
    leucine 32.2 11 15693750 (2), 18826971 (2), 16077255 (1), 12391307 (1)
    phosphotyrosine 25.8 3 12390886 (2), 9047024 (1)
    biotin 20.6 2 1426351 (1), 9047024 (1)
    calcium 13.7 4 12390886 (2), 12566158 (1), 15579586 (1)
    tyrosine 0 3 16219692 (1), 15223846 (1)



    Find genes that share compounds with SPAG9           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SPAG9 gene (5 alternative transcripts): 
    NM_001130527.2  NM_001130528.2  NM_001251971.1  NM_003971.5  NM_172345.1  

    Unigene Cluster for SPAG9:

    Sperm associated antigen 9
    Hs.463439  [show with all ESTs]
    Unigene Representative Sequence: NM_001130528
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000262013(uc002ita.3 uc002itc.3 uc002itd.3 uc002itb.3)
    ENST00000509724 ENST00000510283 ENST00000505279 ENST00000357122 ENST00000506500
    ENST00000513746 ENST00000511312 ENST00000513906 ENST00000514613(uc002ite.3 uc002itf.3)
    ENST00000505173 ENST00000514205 ENST00000506483 ENST00000513827 ENST00000515685
    ENST00000513547 ENST00000511795 ENST00000576492
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SPAG9 (see all 101):
    hsa-miR-548j hsa-miR-607 hsa-miR-376b hsa-miR-200a hsa-miR-3653 hsa-miR-30d hsa-miR-371-5p hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmidSPAG9 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector (see all 2): SPAG9 (NM_003971)
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat SPAG9

    Additional mRNA sequence: 

    AB011088.3 AF327452.1 AF542172.1 AK023512.1 AK091921.1 AK129652.1 AK295098.1 AK299553.1 
    AK302789.1 AK307793.1 AK309214.1 AY219897.1 AY219898.1 AY236487.1 AY850123.1 BC007524.1 
    BC059946.1 BC146755.1 BC153878.1 X91879.1 

    23 DOTS entries:

    DT.100796546  DT.95378814  DT.212964  DT.445501  DT.101956305  DT.75107274  DT.97843947  DT.97812510 
    DT.97844752  DT.120918771  DT.91763028  DT.406687  DT.100796538  DT.120918714  DT.120918762  DT.120918761 
    DT.120918765  DT.120918691  DT.120918693  DT.120918726  DT.97843946  DT.120918737  DT.91826864 

    Selected AceView cDNA sequences (see all 380):

    N78519 CB178609 BQ342602 AI758541 BQ425325 AI189714 AA569357 BM832541 
    AA724020 AW873711 AB011088 BI712371 BM786329 BX109710 AI110819 AA586494 
    AA719651 BQ221357 AA224285 AA249265 BG255460 AW136793 CD366899 BG290577 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SPAG9 (see all 14)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a ·
    SP1:                          -     -     -                 -                                                                                         -     -   
    SP2:                          -     -     -           -     -                                                                                         -     -   
    SP3:                          -     -     -           -     -                                                                                         -     -   
    SP4:                          -     -     -                 -                                                                                         -     -   
    SP5:                                                                                                                                                  -     -   

    ExUns: 17b ^ 18 ^ 19a · 19b ^ 20a · 20b · 20c ^ 21 ^ 22a · 22b · 22c · 22d ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28a · 28b ^ 29 ^ 30a · 30b ^ 31 ^ 32a · 32b ·
    SP1:                          -           -     -                 -     -                                               -     -     -                           
    SP2:                          -           -     -                 -     -                                               -     -     -                           
    SP3:                          -           -     -                                                                                                               
    SP4:                          -           -     -                                                                                                               
    SP5:                          -           -     -                 -     -                                               -           -                           

    ExUns: 32c · 32d
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for SPAG9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SPAG9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGCAGACA
    SPAG9 Expression
    About this image


    SPAG9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Eye (Sensory Organs)
             Retina
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Thyroid (Endocrine System)
     
     Testis (Reproductive System)
    SPAG9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPAG9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.463439

    UniProtKB/Swiss-Prot: JIP4_HUMAN, O60271
    Tissue specificity: Isoform 5 is expressed only in testis on the round spermatids of stage I, II and II. Isoform 5
    is absent in spermatogonia and spermatocyte. Isoform 3 is expressed in testis. Isoform 4 is expressed in testis
    and in acute myeloid leukemia (AML) patients

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SPAG9 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spag91 , 5 sperm associated antigen 91, 5 90.67(n)1
    96.63(a)1
      11 (58.90 cM)5
    708341  NM_001199204.11  NP_001186133.11 
     939960915 
    chicken
    (Gallus gallus)
    Aves SPAG91 sperm associated antigen 9 82.13(n)
    89(a)
      422095  XM_004946306.1  XP_004946363.1 
    lizard
    (Anolis carolinensis)
    Reptilia SPAG96
    sperm associated antigen 9
    83(a)
    1 ↔ 1
    2(117637416-117739729)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.17192 Transcribed sequence with moderate similarity to protein more 75.33(n)    AL852414.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003337611 c-Jun-amino-terminal kinase-interacting protein 4-like 65.76(n)
    71.24(a)
      100333761  XM_002663870.4  XP_002663916.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta syd1 sunday driver 52.03(n)
    49.61(a)
      43905  NM_079913.3  NP_524652.1 
    worm
    (Caenorhabditis elegans)
    Secernentea unc-161 unc-16 53.91(n)
    49.71(a)
      176349  NM_001129276.1  NP_001122748.1 


    ENSEMBL Gene Tree for SPAG9 (if available)
    TreeFam Gene Tree for SPAG9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SPAG9 gene
    ARHGEF102  ARHGEF172  ARHGEF10L2  MAPK8IP32  
    2 SIMAP similar genes for SPAG9 using alignment to 5 protein entries:     JIP4_HUMAN (see all proteins):
    HLC4    MAPK8IP3

    Find genes that share paralogs with SPAG9           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SPAG9 (see all 3032)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1381304041,2
    C--44418457(+) CTAAA-/AAAC  
            
    AAACA
    4 -- int10--------
    rs713536901,2
    C,F--44418485(+) CAAAC-/AAAC/AA
    ACAAACAAAC
    AAAAC
    8 -- int1 cds12NA CSA 4
    rs1498234121,2
    C--44447880(+) AAATG-/AATGAAT
    AAATAAATA
    AATAA
    4 -- int10--------
    rs2015539281,2
    C--44447884(+) GAATG-/AATA  
            
    AATAA
    4 -- int10--------
    rs675832541,2
    C--44461011(+) CACAT-/ACACACA 4 -- int10--------
    rs728264141,2
    --44471140(+) ACGCCC/TGAAAT 4 -- int10--------
    rs748428761,2
    C--44500892(+) ACAGAC/GTGAGA 3 -- int10--------
    rs2013341371,2
    C--49042289(+) TTTTT-/TGGTAG 4 -- ut310--------
    rs1127803951,2
    C,F--49058902(+) AGAAAG/TAAAGA 4 -- int11Minor allele frequency- T:0.50WA 2
    rs1133636061,2
    C,F--49070411(+) GAGACG/AGTGCC 4 -- int11Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for SPAG9 (49039535 - 49198226 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SPAG9:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2178597CNV Deletion18987734
    esv2672135CNV Deletion23128226
    esv2667230CNV Deletion23128226
    esv2716042CNV Deletion23290073
    nsv908610CNV Loss21882294
    nsv833480CNV Loss17160897
    nsv525470CNV Loss19592680
    nsv457825CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for SPAG9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605430    OMIM disorders: --

    2 diseases for SPAG9:    
    About MalaCards
    dengue disease    lung cancer

    1 disease from the University of Copenhagen DISEASES database for SPAG9:
    Dengue disease

    Find genes that share disorders with SPAG9           About GenesLikeMe

    2 Novoseek inferred disease relationships for SPAG9 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    infertility 56.2 5 1550425 (1), 2383616 (1), 10336018 (1), 18980760 (1) (see all 5)
    autoimmunity 4.58 1 1514025 (1)

    Genetic Association Database (GAD): SPAG9

    Export disorders for SPAG9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPAG9 gene, integrated from 10 sources (see all 127):
    (articles sorted by number of sources associating them with SPAG9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a novel human testis mRNA specifically expressed in testicular haploid germ cells, having unique palindromic sequences and encoding a leucine zipper dimerization motif. (PubMed id 9480848)1, 2, 3, 9 Shankar S.... Suri A. (Biochem. Biophys. Res. Commun. 1998)
    2. Characterization of a novel human sperm-associated antigen 9 (SPAG9) having structural homology with c-Jun N-terminal kinase-interacting protein. (PubMed id 15693750)1, 2, 9 Jagadish N.... Suri A. (Biochem. J. 2005)
    3. A novel protein highly expressed in testis is overexpressed in systemic sclerosis fibroblasts and targeted by autoantibodies. (PubMed id 14662895)1, 2, 9 Yasuoka H.... Kuwana M. (J. Immunol. 2003)
    4. JLP: a scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors. (PubMed id 12391307)1, 2, 9 Lee C.M.... Reddy E.P. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. The structural basis of Arf effector specificity: the crystal structure of ARF6 in a complex with JIP4. (PubMed id 19644450)1, 2 Isabet T....MAcnActrey J. (EMBO J. 2009)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia. (PubMed id 16112646)1, 2 Guinn B.-A.... Mufti G.J. (Biochem. Biophys. Res. Commun. 2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)
    10. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. (PubMed id 14743216)1, 2 Bouwmeester T....Superti-Furga G. (Nat. Cell Biol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9043 HGNC: 14524 AceView: SPAG9 Ensembl:ENSG00000008294 euGenes: HUgn9043
    ECgene: SPAG9 H-InvDB: SPAG9

    (According to HUGE)
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    HUGE: KIAA0516

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SPAG9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SPAG9 gene:
    Search GeneIP for patents involving SPAG9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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