Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPAG9 Gene

protein-coding   GIFtS: 60
GCID: GC17M049039

Sperm Associated Antigen 9

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sperm Associated Antigen 91 2     JLP2 3
Cancer/Testis Antigen 891 2 3     PHET2 3
Sperm Surface Protein1 2 3     KIAA05163 5
JNK-Associated Leucine-Zipper Protein1 3     SYD13 5
C-Jun NH2-Terminal Kinase-Associated Leucine Zipper Protein1 2     HLC-4 Protein1
JNK Interacting Protein1 2     Sperm Specific Protein1
JNK/SAPK-Associated Protein1 2     HLC42
Lung Cancer Oncogene 41 2     JIP42
Max-Binding Protein1 2     PIG62
Proliferation-Inducing Gene 61 2     C-Jun-Amino-Terminal Kinase-Interacting Protein 42
Human Lung Cancer Oncogene 6 Protein2 3     HSS3
Mitogen-Activated Protein Kinase 8-Interacting Protein 42 3     MAPK8IP43
Protein Highly Expressed In Testis2 3     JNK-Interacting Protein 43
Sunday Driver 12 3     Proliferation-Inducing Protein 63
CT892 3     Sperm-Associated Antigen 93
HLC-62 3     Sperm-Specific Protein3
JIP-42 3     

External Ids:    HGNC: 145241   Entrez Gene: 90432   Ensembl: ENSG000000082947   OMIM: 6054305   UniProtKB: O602713   

Export aliases for SPAG9 gene to outside databases

Previous GC identifers: GC17M048755 GC17M051523 GC17M049383 GC17M049515 GC17M046397 GC17M044409


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SPAG9 Gene:
This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold
protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase
signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This
protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript
variants. (provided by RefSeq, Oct 2011)

GeneCards Summary for SPAG9 Gene: 
SPAG9 (sperm associated antigen 9) is a protein-coding gene. Diseases associated with SPAG9 include lung cancer, and dengue disease, and among its related super-pathways are Myogenesis and Axon guidance. GO annotations related to this gene include mitogen-activated protein kinase p38 binding and kinesin binding. An important paralog of this gene is ARHGEF10.

UniProtKB/Swiss-Prot: JIP4_HUMAN, O60271
Function: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by
aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play
a role in spermatozoa-egg-interaction

Gene Wiki entry for SPAG9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPAG9 gene promoter:
         ATF-2   Lmo2   Olf-1   XBP-1   NF-kappaB   c-Jun   ZIC2/Zic2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SPAG9 promoter sequence
   Search SABiosciences Chromatin IP Primers for SPAG9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPAG9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.33   Ensembl cytogenetic band:  17q21.33   HGNC cytogenetic band: 17q21.33

SPAG9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPAG9 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M049039:  view genomic region     (about GC identifiers)

Start:
49,039,535 bp from pter      End:
49,198,226 bp from pter
Size:
158,692 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: JIP4_HUMAN, O60271 (See protein sequence)
Recommended Name: C-Jun-amino-terminal kinase-interacting protein 4  
Size: 1321 amino acids; 146205 Da
Subunit: Homooligomer. Interacts with MAX, MAPK8, MAPK9, MAPK10, MAPK14, MAP3K3, MYC, KNS2 and MAP2K4. Interaction
with KNS2 is important in the formation of ternary complex with MAPK8. Interacts with NFKB1
Subcellular location: Cytoplasm. Cytoplasm, perinuclear region. Note=Perinuclear distribution in response to
stress signals such as UV radiation
Subcellular location: Isoform 5: Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Associated with the plasma
membrane of the acrosomal compartment and also localizes in the acrosome matrix
Sequence caution: Sequence=AAH07524.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Sequence=AAH59946.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact; Sequence=AAI06049.1;
Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part;
Sequence=AAO66462.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA25442.3;
Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAB14812.1; Type=Miscellaneous
discrepancy; Note=Unlikely isoform. Aberrant splicing; Sequence=CAA62987.1; Type=Erroneous initiation;
Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for SPAG9:
2W83 (3D)    
Secondary accessions: A6H8U5 A8MSX0 B4DHH2 O60905 Q3KQU8 Q3MKM7 Q86WC7 Q86WC8 Q8IZX7 Q96II0
Q9H811
Alternative splicing: 6 isoforms:  O60271-1   O60271-2   O60271-3   O60271-4   O60271-5   O60271-9   (No experimental confirmation available. Ref.5 (BAG58134) sequence is in conflict in position: 9:F->S)

Explore the universe of human proteins at neXtProt for SPAG9: NX_O60271

Explore proteomics data for SPAG9 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by MAPK8 and MAPK14 (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O60271

  • SPAG9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SPAG9 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001123999.1  NP_001124000.1  NP_001238900.1  NP_003962.3  

    ENSEMBL proteins: 
     ENSP00000262013   ENSP00000423165   ENSP00000426900   ENSP00000349636   ENSP00000423346  
     ENSP00000430205   ENSP00000429343   ENSP00000426061  
    Reactome Protein details: O60271
    Human Recombinant Protein Products for SPAG9: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SPAG9
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SPAG9
    GenScript Custom Purified and Recombinant Proteins Services for SPAG9
    Novus Biologicals SPAG9 Protein
    Novus Biologicals SPAG9 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SPAG9 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0016021integral to membrane TAS9480848
    GO:0048471perinuclear region of cytoplasm IEA--

    SPAG9 for ontologies           About GeneDecksing



    SPAG9 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for SPAG9  (JIP4)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SPAG9
    GenScript Custom Superior Antibodies Services for SPAG9
    Novus Biologicals SPAG9 Antibodies
    Abcam antibodies for SPAG9
    Cloud-Clone Corp. Antibodies for SPAG9 
    ThermoFisher Antibodies for SPAG9
    LSBio Antibodies in human, mouse, rat for SPAG9 

    Assay Products for SPAG9: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SPAG9
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SPAG9
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SPAG9 
    Cloud-Clone Corp. CLIAs for SPAG9


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR019143 JNK/Rab-associated_protein-1_N
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry O60271

    ProtoNet protein and cluster: O60271

    UniProtKB/Swiss-Prot: JIP4_HUMAN, O60271
    Similarity: Belongs to the JIP scaffold family


    SPAG9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: JIP4_HUMAN, O60271
    Function: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by
    aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play
    a role in spermatozoa-egg-interaction
    Induction: Isoform 3 is increased in systemic sclerosis fibroblasts

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19644450
    GO:0008432JUN kinase binding IEA--
    GO:0019894kinesin binding IEA--
    GO:0048273mitogen-activated protein kinase p38 binding IEA--
         
    SPAG9 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SPAG9:
     Decreased viability of wild-ty 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Spag9):
     integument  pigmentation  reproductive system 

    SPAG9 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Spag9tm1Ysok for SPAG9

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SPAG9 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SPAG9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPAG9 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPAG9 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPAG9
    8/101 QIAGEN miScript miRNA Assays for microRNAs that regulate SPAG9 (see all 101):
    hsa-miR-548j hsa-miR-607 hsa-miR-376b hsa-miR-200a hsa-miR-3653 hsa-miR-30d hsa-miR-371-5p hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmidSPAG9 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SPAG9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPAG9

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SPAG9
    Sirion Biotech Customized adenovirus for overexpression of SPAG9

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SPAG9 (see all 11)
    OriGene ORF clones in mouse, rat for SPAG9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SPAG9 (NM_003971)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPAG9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPAG9
    Sirion Biotech Customized lentivirus for stable overexpression of SPAG9 
                         Customized lentivirus expression plasmids for stable overexpression of SPAG9 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SPAG9
    Search LifeMap BioReagents cell lines for SPAG9
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPAG9


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SPAG9 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1CDO in myogenesis
    CDO in myogenesis1.00
    Myogenesis1.00
    2Axon guidance
    Developmental Biology0.69
    3Akt Signaling
    p38 Signaling0.60
    4MAP Kinase Signaling
    MAP Kinase Signaling
    5Arf6 trafficking events
    Arf6 trafficking events

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SPAG9
        p38 Signaling

    1 Cell Signaling Technology (CST) Pathway for SPAG9
        MAP Kinase Signaling

    1 BioSystems Pathway for SPAG9
        Arf6 trafficking events

    3        Reactome Pathways for SPAG9
        Developmental Biology
    Myogenesis
    CDO in myogenesis



    SPAG9 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SPAG9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/47 Interacting proteins for SPAG9 (O602712, 3 ENSP000002620134) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARF6P623302, 3, ENSP000002983164MINT-7922449 MINT-7922407 MINT-7922481 MINT-7922423 MINT-7922462 MINT-7922498 MINT-7915283 MINT-7922515 I2D: score=3 STRING: ENSP00000298316
    NFKB1P198382, 3, ENSP000002265744MINT-48540 MINT-47889 MINT-48560 I2D: score=4 STRING: ENSP00000226574
    ARF1P840772, 3, ENSP000002721024MINT-7922576 MINT-7922541 MINT-7922558 I2D: score=1 STRING: ENSP00000272102
    PNRC2Q9NPJ42, 3, ENSP000003348404MINT-8267030 I2D: score=2 STRING: ENSP00000334840
    MAP1LC3BQ9GZQ82, 3MINT-8259778 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity ----
    GO:0007257activation of JUN kinase activity IEA--
    GO:0007283spermatogenesis TAS9480848
    GO:0030335positive regulation of cell migration IMP18826971
    GO:0042147retrograde transport, endosome to Golgi IDA19056739

    SPAG9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SPAG9 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPAG9 (JIP4)

    6 Novoseek inferred chemical compound relationships for SPAG9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sp(1-7) 88.6 5 9780359 (1), 7525387 (1), 12530914 (1), 7578682 (1) (see all 5)
    leucine 32.2 11 15693750 (2), 18826971 (2), 16077255 (1), 12391307 (1)
    phosphotyrosine 25.8 3 12390886 (2), 9047024 (1)
    biotin 20.6 2 1426351 (1), 9047024 (1)
    calcium 13.7 4 12390886 (2), 12566158 (1), 15579586 (1)
    tyrosine 0 3 16219692 (1), 15223846 (1)

    Search CenterWatch for drugs/clinical trials and news about SPAG9 / JIP4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SPAG9 gene (5 alternative transcripts): 
    NM_001130527.2  NM_001130528.2  NM_001251971.1  NM_003971.5  NM_172345.1  

    Unigene Cluster for SPAG9:

    Sperm associated antigen 9
    Hs.463439  [show with all ESTs]
    Unigene Representative Sequence: NM_001130528
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000262013(uc002ita.3 uc002itc.3 uc002itd.3 uc002itb.3)
    ENST00000509724 ENST00000510283 ENST00000505279 ENST00000357122 ENST00000506500
    ENST00000513746 ENST00000511312 ENST00000513906 ENST00000514613(uc002ite.3 uc002itf.3)
    ENST00000505173 ENST00000514205 ENST00000506483 ENST00000513827 ENST00000515685
    ENST00000513547 ENST00000511795 ENST00000576492

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPAG9
    8/101 QIAGEN miScript miRNA Assays for microRNAs that regulate SPAG9 (see all 101):
    hsa-miR-548j hsa-miR-607 hsa-miR-376b hsa-miR-200a hsa-miR-3653 hsa-miR-30d hsa-miR-371-5p hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmidSPAG9 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SPAG9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPAG9
    Clone
    Products:
         
    OriGene clones in human, mouse for SPAG9 (see all 11)
    OriGene ORF clones in mouse, rat for SPAG9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SPAG9 (NM_003971)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPAG9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPAG9
    Sirion Biotech Customized lentivirus for stable overexpression of SPAG9 
                         Customized lentivirus expression plasmids for stable overexpression of SPAG9 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SPAG9
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPAG9
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPAG9
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPAG9

    Additional mRNA sequence: 

    AB011088.3 AF327452.1 AF542172.1 AK023512.1 AK091921.1 AK129652.1 AK295098.1 AK299553.1 
    AK302789.1 AK307793.1 AK309214.1 AY219897.1 AY219898.1 AY236487.1 AY850123.1 BC007524.1 
    BC059946.1 BC146755.1 BC153878.1 X91879.1 

    23 DOTS entries:

    DT.100796546  DT.95378814  DT.212964  DT.445501  DT.101956305  DT.75107274  DT.97843947  DT.97812510 
    DT.97844752  DT.120918771  DT.91763028  DT.406687  DT.100796538  DT.120918714  DT.120918762  DT.120918761 
    DT.120918765  DT.120918691  DT.120918693  DT.120918726  DT.97843946  DT.120918737  DT.91826864 

    24/380 AceView cDNA sequences (see all 380):

    BQ431712 BG290577 Z39128 AA742970 BF941791 AW589699 BQ774865 BX953815 
    CB178609 AL698121 BQ342602 NM_003971 H94730 AU143722 AA227712 AI189714 
    Z41139 AA131494 AI754470 AI561319 AW007173 AW958121 AW611776 CB113111 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for SPAG9 (see all 14)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a ·
    SP1:                          -     -     -                 -                                                                                         -     -   
    SP2:                          -     -     -           -     -                                                                                         -     -   
    SP3:                          -     -     -           -     -                                                                                         -     -   
    SP4:                          -     -     -                 -                                                                                         -     -   
    SP5:                                                                                                                                                  -     -   

    ExUns: 17b ^ 18 ^ 19a · 19b ^ 20a · 20b · 20c ^ 21 ^ 22a · 22b · 22c · 22d ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28a · 28b ^ 29 ^ 30a · 30b ^ 31 ^ 32a · 32b ·
    SP1:                          -           -     -                 -     -                                               -     -     -                           
    SP2:                          -           -     -                 -     -                                               -     -     -                           
    SP3:                          -           -     -                                                                                                               
    SP4:                          -           -     -                                                                                                               
    SP5:                          -           -     -                 -     -                                               -           -                           

    ExUns: 32c · 32d
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for SPAG9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPAG9 expression in normal human tissues (normalized intensities)      SPAG9 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGCAGACA
    SPAG9 Expression
    About this image


    SPAG9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 5 entries
             neutrophils   
     
     Breast (Uncategorized)
             breast stroma   
     
     Umbilical Cord (Extraembryonic Tissues)
             stem cells (umbilical cord cd34+)   
     
     Cartilage (Muscoskeletal System)
             fetal cartilage   
     
     Eye (Sensory Organs)
             Retina

    See SPAG9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPAG9

    SOURCE GeneReport for Unigene cluster: Hs.463439

    UniProtKB/Swiss-Prot: JIP4_HUMAN, O60271
    Tissue specificity: Isoform 5 is expressed only in testis on the round spermatids of stage I, II and II. Isoform 5
    is absent in spermatogonia and spermatocyte. Isoform 3 is expressed in testis. Isoform 4 is expressed in testis
    and in acute myeloid leukemia (AML) patients

        SABiosciences Custom PCR Arrays for SPAG9
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SPAG9
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPAG9
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPAG9
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPAG9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPAG9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SPAG9 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spag91 , 5 sperm associated antigen 91, 5 90.67(n)1
    96.63(a)1
      11 (58.90 cM)5
    708341  NM_001199204.11  NP_001186133.11 
     939960915 
    chicken
    (Gallus gallus)
    Aves SPAG91 sperm associated antigen 9 82.1(n)
    89(a)
      422095  XM_420098.3  XP_420098.3 
    lizard
    (Anolis carolinensis)
    Reptilia SPAG96
    --
    --
    83(a)
    36(a)
    1 ↔ 1
    possible ortholog
    2(117637416-117739729)
    GL343279.1(1183989-1209191)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.17192 Transcribed sequence with moderate similarity to protein more 75.33(n)    AL852414.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003337611 c-Jun-amino-terminal kinase-interacting protein 4-like 65.77(n)
    71(a)
      100333761  XM_002663870.3  XP_002663916.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta syd1 sunday driver 52.18(n)
    49.96(a)
      43905  NM_079913.2  NP_524652.1 
    worm
    (Caenorhabditis elegans)
    Secernentea unc-161 Protein UNC-16 48.53(n)
    40.61(a)
      176349  NM_171221.3  NP_741263.3 


    ENSEMBL Gene Tree for SPAG9 (if available)
    TreeFam Gene Tree for SPAG9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPAG9 gene
    ARHGEF102  ARHGEF172  ARHGEF10L2  MAPK8IP32  
    2 SIMAP similar genes for SPAG9 using alignment to 5 protein entries:     JIP4_HUMAN (see all proteins):
    HLC4    MAPK8IP3

    SPAG9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3032 SNPs in SPAG9 are shown (see all 3032)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1381304041,2
    C--44418457(+) CTAAA-/AAAC  
            
    AAACA
    4 -- int10--------
    rs713536901,2
    C,F--44418485(+) CAAAC-/AAAC/AA
    ACAAACAAAC
    AAAAC
    8 -- int1 cds12NA CSA 4
    rs1498234121,2
    C--44447880(+) AAATG-/AATGAAT
    AAATAAATA
    AATAA
    4 -- int10--------
    rs2015539281,2
    C--44447884(+) GAATG-/AATA  
            
    AATAA
    4 -- int10--------
    rs675832541,2
    C--44461011(+) CACAT-/ACACACA 4 -- int10--------
    rs728264141,2
    --44471140(+) ACGCCC/TGAAAT 4 -- int10--------
    rs748428761,2
    C--44500892(+) ACAGAC/GTGAGA 3 -- int10--------
    rs2013341371,2
    C--49042289(+) TTTTT-/TGGTAG 4 -- ut310--------
    rs1127803951,2
    C,F--49058902(+) AGAAAG/TAAAGA 4 -- int11Minor allele frequency- T:0.50WA 2
    rs1133636061,2
    C,F--49070411(+) GAGACG/AGTGCC 4 -- int11Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for SPAG9 (49039535 - 49198226 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SPAG9:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2178597CNV Deletion18987734
    esv2672135CNV Deletion23128226
    esv2667230CNV Deletion23128226
    esv2716042CNV Deletion23290073
    nsv908610CNV Loss21882294
    nsv833480CNV Loss17160897
    nsv525470CNV Loss19592680
    nsv457825CNV Gain19166990

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SPAG9
    DNA2.0 Custom Variant and Variant Library Synthesis for SPAG9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605430    OMIM disorders: --

    16 diseases for SPAG9:    About MalaCards
    lung cancer    dengue disease    epididymitis    infertility
    chronic myeloid leukemia    myeloid leukemia    thyroid cancer    endometrial carcinoma
    nasopharyngitis    acute myeloid leukemia    ovarian cancer    renal cell carcinoma
    thyroiditis    leukemia    alzheimer's disease    neuronitis

    1 disease from the University of Copenhagen DISEASES database for SPAG9:
    Dengue disease

    SPAG9 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for SPAG9 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    infertility 56.2 5 1550425 (1), 2383616 (1), 10336018 (1), 18980760 (1) (see all 5)
    autoimmunity 4.58 1 1514025 (1)

    Genetic Association Database (GAD): SPAG9

    Export disorders for SPAG9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPAG9 gene, integrated from 9 sources (see all 124):
    (articles sorted by number of sources associating them with SPAG9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a novel human testis mRNA specifically expressed in testicular haploid germ cells, having unique palindromic sequences and encoding a leucine zipper dimerization motif. (PubMed id 9480848)1, 2, 3, 9 Shankar S.... Suri A. (1998)
    2. Characterization of a novel human sperm-associated antigen 9 (SPAG9) having structural homology with c-Jun N-terminal kinase-interacting protein. (PubMed id 15693750)1, 2, 9 Jagadish N.... Suri A. (2005)
    3. A novel protein highly expressed in testis is overexpressed in systemic sclerosis fibroblasts and targeted by autoantibodies. (PubMed id 14662895)1, 2, 9 Yasuoka H.... Kuwana M. (2003)
    4. JLP: a scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors. (PubMed id 12391307)1, 2, 9 Lee C.M.... Reddy E.P. (2002)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    6. Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia. (PubMed id 16112646)1, 2 Guinn B.-A.... Mufti G.J. (2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)
    9. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. (PubMed id 14743216)1, 2 Bouwmeester T....Superti-Furga G. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9043 HGNC: 14524 AceView: SPAG9 Ensembl:ENSG00000008294 euGenes: HUgn9043
    ECgene: SPAG9 H-InvDB: SPAG9

    (According to HUGE)
    About This Section
    HUGE: KIAA0516

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPAG9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SPAG9 gene:
    Search GeneIP for patents involving SPAG9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SPAG9  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SPAG9  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SPAG9  
     OriGene qSTAR qPCR primer pairs in human, mouse for SPAG9   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SPAG9   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SPAG9   OriGene Custom Protein Services for SPAG9  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPAG9
     QIAGEN SeqTarget long-range PCR primers for resequencing SPAG9
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPAG9
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPAG9
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPAG9
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPAG9
     GenScript Custom Purified and Recombinant Proteins Services for SPAG9 GenScript cDNA clones with any tag delivered in your preferred vector for SPAG9
     GenScript Custom Assay Services for SPAG9 GenScript Custom Superior Antibodies Services for SPAG9
     GenScript Custom overexpressing Cell Line Services for SPAG9 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for SPAG9  (JIP4)

     Regulatory tfbs in SPAG9 promoter
     Search Chromatin IP Primers for SPAG9
     RT2 qPCR Primer Assay in human, mouse, rat SPAG9
     GNC Network for SPAG9
     SABiosciences PCR Arrays including human, mouse, rat SPAG9
     Search Tocris compounds for SPAG9 (JIP4)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SPAG9 antibodies
     SPAG9 proteins
     SPAG9 lysates
     Antibodies for SPAG9
     See all of Abcam's Antibodies, Kits and Proteins for SPAG9
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SPAG9
     Antibodies for SPAG9
     ELISAs for SPAG9
     CLIAs for SPAG9
     Search LifeMap BioReagents cell lines for SPAG9
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPAG9
     SwitchGear 3'UTR luciferase reporter plasmids for SPAG9
     SwitchGear Promoter luciferase reporter plasmids for SPAG9
     ThermoFisher Antibodies for SPAG9
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPAG9
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SPAG9
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SPAG9
    Customized:
     lentivirus for stable overexpression of SPAG9
     lentivirus expression plasmids for stable overexpression of SPAG9
     adenovirus for overexpression of SPAG9
     LSBio Antibodies in human, mouse, rat for SPAG9
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SPAG9 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4