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Aliases for SPAG9 Gene

Aliases for SPAG9 Gene

  • Sperm Associated Antigen 9 2 3
  • Cancer/Testis Antigen 89 2 3 4
  • Sperm Surface Protein 2 3 4
  • C-Jun NH2-Terminal Kinase-Associated Leucine Zipper Protein 2 3
  • Mitogen-Activated Protein Kinase 8-Interacting Protein 4 3 4
  • JNK-Associated Leucine-Zipper Protein 2 4
  • Human Lung Cancer Oncogene 6 Protein 3 4
  • Protein Highly Expressed In Testis 3 4
  • Proliferation-Inducing Gene 6 2 3
  • JNK/SAPK-Associated Protein 2 3
  • JNK Interacting Protein 2 3
  • Lung Cancer Oncogene 4 2 3
  • Sunday Driver 1 3 4
  • KIAA0516 4 6
  • HLC-6 3 4
  • JIP-4 3 4
  • CT89 3 4
  • PHET 3 4
  • SYD1 4 6
  • JLP 3 4
  • C-Jun-Amino-Terminal Kinase-Interacting Protein 4 3
  • Sperm Associated Antigen 9 Variant 5 3
  • Proliferation-Inducing Protein 6 4
  • Sperm-Associated Antigen 9 4
  • JNK-Interacting Protein 4 4
  • Sperm Specific Protein 2
  • Sperm-Specific Protein 4
  • MAX-Binding Protein 3
  • Max-Binding Protein 2
  • HLC-4 Protein 2
  • MAPK8IP4 4
  • PIG6 3
  • HLC4 3
  • HLC6 3
  • JIP4 3
  • HSS 4

External Ids for SPAG9 Gene

Previous GeneCards Identifiers for SPAG9 Gene

  • GC17M048755
  • GC17M051523
  • GC17M049383
  • GC17M049515
  • GC17M046397
  • GC17M049039
  • GC17M044409

Summaries for SPAG9 Gene

Entrez Gene Summary for SPAG9 Gene

  • This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]

GeneCards Summary for SPAG9 Gene

SPAG9 (Sperm Associated Antigen 9) is a Protein Coding gene. Diseases associated with SPAG9 include dengue disease and lung cancer. Among its related pathways are L1CAM interactions and Akt Signaling. GO annotations related to this gene include kinesin binding and mitogen-activated protein kinase p38 binding. An important paralog of this gene is ARHGEF10L.

UniProtKB/Swiss-Prot for SPAG9 Gene

  • The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg-interaction.

Gene Wiki entry for SPAG9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPAG9 Gene

Genomics for SPAG9 Gene

Regulatory Elements for SPAG9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SPAG9 Gene

Start:
50,962,174 bp from pter
End:
51,120,865 bp from pter
Size:
158,692 bases
Orientation:
Minus strand

Genomic View for SPAG9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPAG9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPAG9 Gene

Proteins for SPAG9 Gene

  • Protein details for SPAG9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60271-JIP4_HUMAN
    Recommended name:
    C-Jun-amino-terminal kinase-interacting protein 4
    Protein Accession:
    O60271
    Secondary Accessions:
    • A6H8U5
    • A8MSX0
    • B4DHH2
    • O60905
    • Q3KQU8
    • Q3MKM7
    • Q86WC7
    • Q86WC8
    • Q8IZX7
    • Q96II0
    • Q9H811

    Protein attributes for SPAG9 Gene

    Size:
    1321 amino acids
    Molecular mass:
    146205 Da
    Quaternary structure:
    • Homodimer. The homodimer interacts with ARF6, forming a heterotetramer. Homooligomer. Interacts with MAX, MAPK8, MAPK9, MAPK10, MAPK14, MAP3K3, MYC, KNS2 and MAP2K4. Interaction with KNS2 is important in the formation of ternary complex with MAPK8. Interacts with NFKB1.
    SequenceCaution:
    • Sequence=AAH07524.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=AAH59946.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=AAI06049.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305}; Sequence=AAO66462.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA25442.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB14812.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splicing.; Evidence={ECO:0000305}; Sequence=CAA62987.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SPAG9 Gene

    Alternative splice isoforms for SPAG9 Gene

neXtProt entry for SPAG9 Gene

Proteomics data for SPAG9 Gene at MOPED

Post-translational modifications for SPAG9 Gene

No data available for DME Specific Peptides for SPAG9 Gene

Domains for SPAG9 Gene

Protein Domains for SPAG9 Gene

Suggested Antigen Peptide Sequences for SPAG9 Gene

Graphical View of Domain Structure for InterPro Entry

O60271

UniProtKB/Swiss-Prot:

JIP4_HUMAN :
  • O60271
Family:
  • Belongs to the JIP scaffold family.
genes like me logo Genes that share domains with SPAG9: view

No data available for Gene Families for SPAG9 Gene

Function for SPAG9 Gene

Molecular function for SPAG9 Gene

UniProtKB/Swiss-Prot Function: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg-interaction.
UniProtKB/Swiss-Prot Induction: Isoform 3 is increased in systemic sclerosis fibroblasts.

Gene Ontology (GO) - Molecular Function for SPAG9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005078 MAP-kinase scaffold activity IBA --
GO:0005515 protein binding IPI 19644450
GO:0008432 JUN kinase binding IBA --
GO:0019894 kinesin binding IBA --
GO:0030159 receptor signaling complex scaffold activity IBA --
genes like me logo Genes that share ontologies with SPAG9: view
genes like me logo Genes that share phenotypes with SPAG9: view

Animal Models for SPAG9 Gene

MGI Knock Outs for SPAG9:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPAG9

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SPAG9 Gene

Localization for SPAG9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPAG9 Gene

Cytoplasm. Cytoplasm, perinuclear region. Note=Perinuclear distribution in response to stress signals such as UV radiation.
Isoform 5: Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Associated with the plasma membrane of the acrosomal compartment and also localizes in the acrosome matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPAG9 Gene COMPARTMENTS Subcellular localization image for SPAG9 gene
Compartment Confidence
cytosol 4
plasma membrane 2
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SPAG9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0016021 integral component of membrane TAS 9480848
GO:0031410 cytoplasmic vesicle --
genes like me logo Genes that share ontologies with SPAG9: view

Pathways for SPAG9 Gene

genes like me logo Genes that share pathways with SPAG9: view

Pathways by source for SPAG9 Gene

1 Qiagen pathway for SPAG9 Gene
1 Cell Signaling Technology pathway for SPAG9 Gene
1 BioSystems pathway for SPAG9 Gene
3 Reactome pathways for SPAG9 Gene

Gene Ontology (GO) - Biological Process for SPAG9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity --
GO:0007257 activation of JUN kinase activity IBA --
GO:0007283 spermatogenesis TAS 9480848
GO:0030335 positive regulation of cell migration IMP 18826971
GO:0042147 retrograde transport, endosome to Golgi IDA 19056739
genes like me logo Genes that share ontologies with SPAG9: view

Compounds for SPAG9 Gene

(6) Novoseek inferred chemical compound relationships for SPAG9 Gene

Compound -log(P) Hits PubMed IDs
sp(1-7) 88.6 5
leucine 32.2 6
phosphotyrosine 25.8 3
biotin 20.6 2
calcium 13.7 4
genes like me logo Genes that share compounds with SPAG9: view

Transcripts for SPAG9 Gene

Unigene Clusters for SPAG9 Gene

Sperm associated antigen 9:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPAG9

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SPAG9

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPAG9 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - -
SP6: - - - - - - - - - - - -
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

ExUns: 17b ^ 18 ^ 19a · 19b ^ 20a · 20b · 20c ^ 21 ^ 22a · 22b · 22c · 22d ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28a · 28b ^ 29 ^ 30a · 30b ^ 31 ^ 32a · 32b ·
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - -
SP4: - - -
SP5: - - - - - - -
SP6: - - - - -
SP7: - - - - - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

ExUns: 32c · 32d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for SPAG9 Gene

GeneLoc Exon Structure for
SPAG9
ECgene alternative splicing isoforms for
SPAG9

Expression for SPAG9 Gene

mRNA expression in normal human tissues for SPAG9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPAG9 Gene

SOURCE GeneReport for Unigene cluster for SPAG9 Gene Hs.463439

mRNA Expression by UniProt/SwissProt for SPAG9 Gene

O60271-JIP4_HUMAN
Tissue specificity: Isoform 5 is expressed only in testis on the round spermatids of stage I, II and II. Isoform 5 is absent in spermatogonia and spermatocyte. Isoform 3 is expressed in testis. Isoform 4 is expressed in testis and in acute myeloid leukemia (AML) patients.
genes like me logo Genes that share expressions with SPAG9: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SPAG9 Gene

Orthologs for SPAG9 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPAG9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPAG9 35
  • 99.72 (n)
  • 99.85 (a)
SPAG9 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPAG9 35
  • 92.48 (n)
  • 95.68 (a)
SPAG9 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPAG9 35
  • 94 (n)
  • 97.78 (a)
SPAG9 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spag9 35
  • 90.67 (n)
  • 96.63 (a)
Spag9 16
Spag9 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPAG9 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPAG9 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spag9 35
  • 89.7 (n)
  • 96.1 (a)
chicken
(Gallus gallus)
Aves SPAG9 35
  • 82.13 (n)
  • 89 (a)
SPAG9 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPAG9 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spag9 35
  • 67.98 (n)
  • 74.75 (a)
Str.1719 35
zebrafish
(Danio rerio)
Actinopterygii CABZ01073118.1 36
  • 65 (a)
OneToOne
LOC100333761 35
  • 65.76 (n)
  • 71.24 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005042 35
  • 52.76 (n)
  • 51.46 (a)
fruit fly
(Drosophila melanogaster)
Insecta syd 35
  • 52.03 (n)
  • 49.61 (a)
worm
(Caenorhabditis elegans)
Secernentea unc-16 35
  • 53.91 (n)
  • 49.71 (a)
Species with no ortholog for SPAG9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPAG9 Gene

ENSEMBL:
Gene Tree for SPAG9 (if available)
TreeFam:
Gene Tree for SPAG9 (if available)

Paralogs for SPAG9 Gene

Paralogs for SPAG9 Gene

Selected SIMAP similar genes for SPAG9 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SPAG9: view

Variants for SPAG9 Gene

Sequence variations from dbSNP and Humsavar for SPAG9 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs8125 -- 50,965,987(-) ATGTG(A/G)TTTAC utr-variant-3-prime
rs14474 -- 50,962,329(+) CAAGT(G/T)GGACA utr-variant-3-prime
rs1001474 -- 51,119,524(-) ACCTG(C/G)GCGCC intron-variant
rs1001475 -- 51,119,509(-) CCTCG(A/G)CTCTG intron-variant
rs1004501 -- 50,962,164(+) ACACA(C/T)TAGAC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SPAG9 Gene

Variant ID Type Subtype PubMed ID
nsv457825 CNV Gain 19166990
nsv833480 CNV Loss 17160897
esv2667230 CNV Deletion 23128226
nsv525470 CNV Loss 19592680
nsv908610 CNV Loss 21882294
esv2716042 CNV Deletion 23290073
esv2178597 CNV Deletion 18987734
esv2672135 CNV Deletion 23128226

Relevant External Links for SPAG9 Gene

HapMap Linkage Disequilibrium report
SPAG9
Human Gene Mutation Database (HGMD)
SPAG9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPAG9 Gene

Disorders for SPAG9 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for SPAG9 Gene including...

Search for SPAG9 Gene in MalaCards »

(1) University of Copenhagen DISEASES for SPAG9 Gene

(2) Novoseek inferred disease relationships for SPAG9 Gene

Disease -log(P) Hits PubMed IDs
infertility 56.2 5
autoimmunity 4.58 1

Relevant External Links for SPAG9

Genetic Association Database (GAD)
SPAG9
genes like me logo Genes that share disorders with SPAG9: view

No data available for UniProtKB/Swiss-Prot for SPAG9 Gene

Publications for SPAG9 Gene

  1. Cloning of a novel human testis mRNA specifically expressed in testicular haploid germ cells, having unique palindromic sequences and encoding a leucine zipper dimerization motif. (PMID: 9480848) Shankar S. … Suri A. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 23
  2. JLP: a scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors. (PMID: 12391307) Lee C.M. … Reddy E.P. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4 23
  3. A novel protein highly expressed in testis is overexpressed in systemic sclerosis fibroblasts and targeted by autoantibodies. (PMID: 14662895) Yasuoka H. … Kuwana M. (J. Immunol. 2003) 3 4 23
  4. Characterization of a novel human sperm-associated antigen 9 (SPAG9) having structural homology with c-Jun N-terminal kinase-interacting protein. (PMID: 15693750) Jagadish N. … Suri A. (Biochem. J. 2005) 3 4 23
  5. Sperm associated antigen 9 (SPAG9): a new member of c-Jun NH2 -terminal kinase (JNK) interacting protein exclusively expressed in testis. (PMID: 16077255) Jagadish N. … Suri A. (Keio J Med 2005) 3 23

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