Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SPAG7 Gene

Aliases for SPAG7 Gene

  • Sperm Associated Antigen 7 2 3
  • Sperm-Associated Antigen 7 3
  • FSA-1 3
  • ACRP 3

External Ids for SPAG7 Gene

Previous GeneCards Identifiers for SPAG7 Gene

  • GC17M005281
  • GC17M004807
  • GC17M005064
  • GC17M005065
  • GC17M004803
  • GC17M004862

Summaries for SPAG7 Gene

GeneCards Summary for SPAG7 Gene

SPAG7 (Sperm Associated Antigen 7) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding.

Gene Wiki entry for SPAG7 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPAG7 Gene

Genomics for SPAG7 Gene

Regulatory Elements for SPAG7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SPAG7 Gene

Start:
4,959,226 bp from pter
End:
4,967,872 bp from pter
Size:
8,647 bases
Orientation:
Minus strand

Genomic View for SPAG7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPAG7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPAG7 Gene

Proteins for SPAG7 Gene

  • Protein details for SPAG7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75391-SPAG7_HUMAN
    Recommended name:
    Sperm-associated antigen 7
    Protein Accession:
    O75391
    Secondary Accessions:
    • Q96EU5

    Protein attributes for SPAG7 Gene

    Size:
    227 amino acids
    Molecular mass:
    26034 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC39888.1; Type=Frameshift; Positions=227; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SPAG7 Gene

neXtProt entry for SPAG7 Gene

Proteomics data for SPAG7 Gene at MOPED

Post-translational modifications for SPAG7 Gene

  • Ubiquitination at Lys173
  • Modification sites at PhosphoSitePlus

Other Protein References for SPAG7 Gene

Antibody Products

No data available for DME Specific Peptides for SPAG7 Gene

Domains for SPAG7 Gene

Protein Domains for SPAG7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPAG7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75391

UniProtKB/Swiss-Prot:

SPAG7_HUMAN :
  • O75391
Domain:
  • Contains 1 R3H domain.
genes like me logo Genes that share domains with SPAG7: view

No data available for Gene Families for SPAG7 Gene

Function for SPAG7 Gene

Gene Ontology (GO) - Molecular Function for SPAG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with SPAG7: view

Animal Model Products

miRNA for SPAG7 Gene

miRTarBase miRNAs that target SPAG7

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SPAG7 Gene

Localization for SPAG7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPAG7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPAG7 Gene COMPARTMENTS Subcellular localization image for SPAG7 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for SPAG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SPAG7: view

Pathways for SPAG7 Gene

SuperPathways for SPAG7 Gene

No Data Available

Interacting Proteins for SPAG7 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000206020%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000379282%0d%0a
Selected Interacting proteins: O75391-SPAG7_HUMAN ENSP00000206020 for SPAG7 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for SPAG7 Gene

None

No data available for Pathways by source for SPAG7 Gene

Transcripts for SPAG7 Gene

Unigene Clusters for SPAG7 Gene

Sperm associated antigen 7:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPAG7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPAG7 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - - - -
SP8:
SP9: - - -

Relevant External Links for SPAG7 Gene

GeneLoc Exon Structure for
SPAG7
ECgene alternative splicing isoforms for
SPAG7

Expression for SPAG7 Gene

mRNA expression in normal human tissues for SPAG7 Gene

Protein differential expression in normal tissues for SPAG7 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.2), CD8 Tcells (8.8), and Pancreas (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPAG7 Gene

SOURCE GeneReport for Unigene cluster for SPAG7 Gene Hs.90436

mRNA Expression by UniProt/SwissProt for SPAG7 Gene

O75391-SPAG7_HUMAN
Tissue specificity: Detected in fetal brain.
genes like me logo Genes that share expressions with SPAG7: view

Expression partners for SPAG7 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SPAG7 Gene

Orthologs for SPAG7 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPAG7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SPAG7 35
  • 92.95 (n)
  • 98.24 (a)
SPAG7 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPAG7 35
  • 90.6 (n)
  • 98.24 (a)
SPAG7 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spag7 35
  • 91.78 (n)
  • 96.92 (a)
Spag7 16
Spag7 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SPAG7 35
  • 97.17 (n)
  • 97.17 (a)
SPAG7 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spag7 35
  • 91.92 (n)
  • 96.04 (a)
oppossum
(Monodelphis domestica)
Mammalia SPAG7 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7128 35
zebrafish
(Danio rerio)
Actinopterygii spag7 35
  • 70.57 (n)
  • 75.23 (a)
zgc66397 35
spag7 36
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012500 35
  • 47.31 (n)
  • 38.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2608 35
  • 53.21 (n)
  • 40.85 (a)
CG2608 36
  • 33 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToOne
Species with no ortholog for SPAG7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPAG7 Gene

ENSEMBL:
Gene Tree for SPAG7 (if available)
TreeFam:
Gene Tree for SPAG7 (if available)

Paralogs for SPAG7 Gene

No data available for Paralogs for SPAG7 Gene

Variants for SPAG7 Gene

Sequence variations from dbSNP and Humsavar for SPAG7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs238224 -- 4,960,115(+) TCCTG(A/G)AGAAG intron-variant
rs2005724 -- 4,958,909(+) CTAAA(C/T)GTACA downstream-variant-500B
rs2240288 -- 4,967,163(+) ACGGA(C/T)GGGAA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs4790716 -- 4,962,633(+) aggat(A/G)gtAtt intron-variant
rs7220443 -- 4,958,748(+) ccCGA(C/T)TGCAC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SPAG7 Gene

Variant ID Type Subtype PubMed ID
nsv833349 CNV Loss 17160897
nsv907619 CNV Loss 21882294
nsv907620 CNV Loss 21882294
nsv833350 CNV Loss 17160897

Relevant External Links for SPAG7 Gene

HapMap Linkage Disequilibrium report
SPAG7
Human Gene Mutation Database (HGMD)
SPAG7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPAG7 Gene

Disorders for SPAG7 Gene

(2) University of Copenhagen DISEASES for SPAG7 Gene

genes like me logo Genes that share disorders with SPAG7: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for SPAG7 Gene

Publications for SPAG7 Gene

  1. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PMID: 9653160) Mao M. … Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4
  2. Cloning and characterization of a fox sperm protein FSA-1. (PMID: 7624517) Beaton S. … Bradley M.P. (Reprod. Fertil. Dev. 1994) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for SPAG7 Gene

Sources for SPAG7 Gene

Back to Top

Content