Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SPAG7 Gene

Aliases for SPAG7 Gene

  • Sperm Associated Antigen 7 2 3 5
  • Sperm-Associated Antigen 7 3
  • FSA-1 3
  • ACRP 3

External Ids for SPAG7 Gene

Previous GeneCards Identifiers for SPAG7 Gene

  • GC17M005281
  • GC17M004807
  • GC17M005064
  • GC17M005065
  • GC17M004803
  • GC17M004862

Summaries for SPAG7 Gene

GeneCards Summary for SPAG7 Gene

SPAG7 (Sperm Associated Antigen 7) is a Protein Coding gene. Diseases associated with SPAG7 include Chronic Intestinal Vascular Insufficiency and Pharyngitis. GO annotations related to this gene include nucleic acid binding.

Gene Wiki entry for SPAG7 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPAG7 Gene

Genomics for SPAG7 Gene

Regulatory Elements for SPAG7 Gene

Enhancers for SPAG7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SPAG7 on UCSC Golden Path with GeneCards custom track

Promoters for SPAG7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SPAG7 Gene

4,959,226 bp from pter
4,967,872 bp from pter
8,647 bases
Minus strand

Genomic View for SPAG7 Gene

Genes around SPAG7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPAG7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPAG7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPAG7 Gene

Proteins for SPAG7 Gene

  • Protein details for SPAG7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sperm-associated antigen 7
    Protein Accession:
    Secondary Accessions:
    • Q96EU5

    Protein attributes for SPAG7 Gene

    227 amino acids
    Molecular mass:
    26034 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC39888.1; Type=Frameshift; Positions=227; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SPAG7 Gene

neXtProt entry for SPAG7 Gene

Post-translational modifications for SPAG7 Gene

  • Ubiquitination at Lys 173
  • Modification sites at PhosphoSitePlus

Other Protein References for SPAG7 Gene

No data available for DME Specific Peptides for SPAG7 Gene

Domains & Families for SPAG7 Gene

Protein Domains for SPAG7 Gene


Suggested Antigen Peptide Sequences for SPAG7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 R3H domain.
  • Contains 1 R3H domain.
genes like me logo Genes that share domains with SPAG7: view

No data available for Gene Families for SPAG7 Gene

Function for SPAG7 Gene

Gene Ontology (GO) - Molecular Function for SPAG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with SPAG7: view
genes like me logo Genes that share phenotypes with SPAG7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPAG7 Gene

Localization for SPAG7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPAG7 Gene

Subcellular locations from

Jensen Localization Image for SPAG7 Gene COMPARTMENTS Subcellular localization image for SPAG7 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for SPAG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SPAG7: view

Pathways & Interactions for SPAG7 Gene

SuperPathways for SPAG7 Gene

No Data Available

Interacting Proteins for SPAG7 Gene

Gene Ontology (GO) - Biological Process for SPAG7 Gene


No data available for Pathways by source and SIGNOR curated interactions for SPAG7 Gene

Drugs & Compounds for SPAG7 Gene

No Compound Related Data Available

Transcripts for SPAG7 Gene

Unigene Clusters for SPAG7 Gene

Sperm associated antigen 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPAG7 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - - - -
SP9: - - -

Relevant External Links for SPAG7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPAG7 Gene

mRNA expression in normal human tissues for SPAG7 Gene

Protein differential expression in normal tissues from HIPED for SPAG7 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.2), CD8 Tcells (8.8), and Pancreas (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SPAG7 Gene

Protein tissue co-expression partners for SPAG7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SPAG7 Gene:


SOURCE GeneReport for Unigene cluster for SPAG7 Gene:


mRNA Expression by UniProt/SwissProt for SPAG7 Gene:

Tissue specificity: Detected in fetal brain.
genes like me logo Genes that share expression patterns with SPAG7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SPAG7 Gene

Orthologs for SPAG7 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPAG7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SPAG7 34
  • 92.95 (n)
  • 98.24 (a)
SPAG7 35
  • 99 (a)
(Canis familiaris)
Mammalia SPAG7 34
  • 90.6 (n)
  • 98.24 (a)
SPAG7 35
  • 98 (a)
(Mus musculus)
Mammalia Spag7 34
  • 91.78 (n)
  • 96.92 (a)
Spag7 16
Spag7 35
  • 97 (a)
(Pan troglodytes)
Mammalia SPAG7 34
  • 97.17 (n)
  • 97.17 (a)
SPAG7 35
  • 99 (a)
(Rattus norvegicus)
Mammalia Spag7 34
  • 91.92 (n)
  • 96.04 (a)
(Monodelphis domestica)
Mammalia SPAG7 35
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7128 34
(Danio rerio)
Actinopterygii spag7 34
  • 70.57 (n)
  • 75.23 (a)
zgc66397 34
spag7 35
  • 73 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012500 34
  • 47.31 (n)
  • 38.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2608 34
  • 53.21 (n)
  • 40.85 (a)
CG2608 35
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 47 (a)
Species where no ortholog for SPAG7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPAG7 Gene

Gene Tree for SPAG7 (if available)
Gene Tree for SPAG7 (if available)

Paralogs for SPAG7 Gene

No data available for Paralogs for SPAG7 Gene

Variants for SPAG7 Gene

Sequence variations from dbSNP and Humsavar for SPAG7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs238224 -- 4,960,115(+) TCCTG(A/G)AGAAG intron-variant
rs2240288 -- 4,967,163(+) ACGGA(C/T)GGGAA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs2005724 -- 4,958,909(+) CTAAA(C/T)GTACA downstream-variant-500B
rs4790716 -- 4,962,633(+) aggat(A/G)gtAtt intron-variant
rs7220443 -- 4,958,748(+) ccCGA(C/T)TGCAC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SPAG7 Gene

Variant ID Type Subtype PubMed ID
nsv574273 CNV gain 21841781
nsv833349 CNV loss 17160897
nsv833350 CNV loss 17160897

Variation tolerance for SPAG7 Gene

Residual Variation Intolerance Score: 35.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.43; 54.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPAG7 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPAG7 Gene

Disorders for SPAG7 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SPAG7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
chronic intestinal vascular insufficiency
  • chronic mesenteric ischemia
  • acute sore throat
aphthous stomatitis
  • aphtha
functional gastric disease
- elite association - COSMIC cancer census association via MalaCards
Search SPAG7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SPAG7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SPAG7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPAG7 Gene

Publications for SPAG7 Gene

  1. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PMID: 9653160) Mao M. … Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. Cloning and characterization of a fox sperm protein FSA-1. (PMID: 7624517) Beaton S. … Bradley M.P. (Reprod. Fertil. Dev. 1994) 3 4 65
  4. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 65
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65

Products for SPAG7 Gene

Sources for SPAG7 Gene

Loading form....