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Aliases for SPAG7 Gene

Aliases for SPAG7 Gene

  • Sperm Associated Antigen 7 2 3 5
  • Sperm-Associated Antigen 7 3
  • FSA-1 3
  • ACRP 3

External Ids for SPAG7 Gene

Previous GeneCards Identifiers for SPAG7 Gene

  • GC17M005281
  • GC17M004807
  • GC17M005064
  • GC17M005065
  • GC17M004803
  • GC17M004862

Summaries for SPAG7 Gene

GeneCards Summary for SPAG7 Gene

SPAG7 (Sperm Associated Antigen 7) is a Protein Coding gene. Diseases associated with SPAG7 include Chronic Intestinal Vascular Insufficiency and Pharyngitis. GO annotations related to this gene include nucleic acid binding.

Gene Wiki entry for SPAG7 Gene

Additional gene information for SPAG7 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPAG7 Gene

Genomics for SPAG7 Gene

Regulatory Elements for SPAG7 Gene

Enhancers for SPAG7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H004965 1.4 ENCODE dbSUPER 36.9 -0.7 -745 5 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 SPAG7 ZNF232 NUP88 INCA1 CHRNE KIF1C MIS12 CAMTA2 RNF167 SLC25A11
GH17H004937 1.4 ENCODE dbSUPER 30.5 +22.9 22855 14 MLX FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC SSRP1 ZNF610 ZNF585B SPAG7 CHRNE LOC100130950 CAMTA2 RPAIN ZNF232 ENO3 ANKFY1 ZNF594 LOC105371506
GH17H005030 1.2 Ensembl ENCODE 32.1 -63.7 -63712 1 HDGF RB1 RAD21 ZEB1 ZNF121 GLIS2 EGR1 ZNF143 IKZF2 CREM SPAG7 CHRNE CAMTA2 KIF1C LOC105371502 LOC105371501
GH17H005041 1 Ensembl ENCODE 37.5 -74.6 -74598 1 HDAC1 IRF2 SOX6 TAL1 ZBTB11 ZEB2 ZBTB40 GABPA FOSL1 TCF12 SPAG7 ENO3 ENSG00000234203 INCA1 KIF1C CAMTA2 ZFP3 PFN1 SLC52A1 LOC105371502
GH17H004972 0.7 Ensembl ENCODE 36.8 -5.3 -5348 1 PAF1 POLR2A SPAG7 CHRNE ENSG00000234203 ENSG00000262678
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPAG7 on UCSC Golden Path with GeneCards custom track

Promoters for SPAG7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000090567 372 2201 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1

Genomic Location for SPAG7 Gene

Chromosome:
17
Start:
4,959,226 bp from pter
End:
4,967,872 bp from pter
Size:
8,647 bases
Orientation:
Minus strand

Genomic View for SPAG7 Gene

Genes around SPAG7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPAG7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPAG7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPAG7 Gene

Proteins for SPAG7 Gene

  • Protein details for SPAG7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75391-SPAG7_HUMAN
    Recommended name:
    Sperm-associated antigen 7
    Protein Accession:
    O75391
    Secondary Accessions:
    • Q96EU5

    Protein attributes for SPAG7 Gene

    Size:
    227 amino acids
    Molecular mass:
    26034 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC39888.1; Type=Frameshift; Positions=227; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SPAG7 Gene

neXtProt entry for SPAG7 Gene

Post-translational modifications for SPAG7 Gene

  • Ubiquitination at Lys173
  • Modification sites at PhosphoSitePlus

Other Protein References for SPAG7 Gene

No data available for DME Specific Peptides for SPAG7 Gene

Domains & Families for SPAG7 Gene

Gene Families for SPAG7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPAG7 Gene

Suggested Antigen Peptide Sequences for SPAG7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPAG7: view

No data available for UniProtKB/Swiss-Prot for SPAG7 Gene

Function for SPAG7 Gene

Phenotypes From GWAS Catalog for SPAG7 Gene

Gene Ontology (GO) - Molecular Function for SPAG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with SPAG7: view
genes like me logo Genes that share phenotypes with SPAG7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SPAG7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPAG7 Gene

Localization for SPAG7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPAG7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPAG7 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SPAG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SPAG7: view

Pathways & Interactions for SPAG7 Gene

SuperPathways for SPAG7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPAG7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPAG7 Gene

Drugs & Compounds for SPAG7 Gene

No Compound Related Data Available

Transcripts for SPAG7 Gene

Unigene Clusters for SPAG7 Gene

Sperm associated antigen 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SPAG7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SPAG7 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - - - -
SP8:
SP9: - - -

Relevant External Links for SPAG7 Gene

GeneLoc Exon Structure for
SPAG7
ECgene alternative splicing isoforms for
SPAG7

Expression for SPAG7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPAG7 Gene

Protein differential expression in normal tissues from HIPED for SPAG7 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.2), CD8 Tcells (8.8), and Pancreas (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SPAG7 Gene



Protein tissue co-expression partners for SPAG7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SPAG7 Gene:

SPAG7

SOURCE GeneReport for Unigene cluster for SPAG7 Gene:

Hs.90436

mRNA Expression by UniProt/SwissProt for SPAG7 Gene:

O75391-SPAG7_HUMAN
Tissue specificity: Detected in fetal brain.

Evidence on tissue expression from TISSUES for SPAG7 Gene

  • Blood(4.2)
  • Nervous system(3.2)
  • Muscle(3.1)
  • Stomach(2.8)
  • Intestine(2.6)
  • Heart(2.2)
  • Liver(2.2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with SPAG7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPAG7 Gene

Orthologs for SPAG7 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPAG7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPAG7 33 34
  • 97.17 (n)
oppossum
(Monodelphis domestica)
Mammalia SPAG7 34
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPAG7 33 34
  • 92.95 (n)
rat
(Rattus norvegicus)
Mammalia Spag7 33
  • 91.92 (n)
mouse
(Mus musculus)
Mammalia Spag7 33 16 34
  • 91.78 (n)
dog
(Canis familiaris)
Mammalia SPAG7 33 34
  • 90.6 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7128 33
zebrafish
(Danio rerio)
Actinopterygii spag7 33 34
  • 70.57 (n)
zgc66397 33
fruit fly
(Drosophila melanogaster)
Insecta CG2608 33 34
  • 53.21 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012500 33
  • 47.31 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
OneToOne
Species where no ortholog for SPAG7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPAG7 Gene

ENSEMBL:
Gene Tree for SPAG7 (if available)
TreeFam:
Gene Tree for SPAG7 (if available)

Paralogs for SPAG7 Gene

No data available for Paralogs for SPAG7 Gene

Variants for SPAG7 Gene

Sequence variations from dbSNP and Humsavar for SPAG7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000105806 -- 4,967,406(+) AATGC(A/G)GCAGG intron-variant, utr-variant-5-prime
rs1000414575 -- 4,964,668(+) ATCCT(C/T)TACAT intron-variant
rs1000456742 -- 4,967,579(+) CAGCA(A/G)CCCTT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1000749234 -- 4,966,304(+) GTTTT(C/T)GAGTC intron-variant
rs1000999789 -- 4,963,119(+) TGAGC(A/G)TGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPAG7 Gene

Variant ID Type Subtype PubMed ID
nsv574273 CNV gain 21841781
nsv833349 CNV loss 17160897
nsv833350 CNV loss 17160897

Variation tolerance for SPAG7 Gene

Residual Variation Intolerance Score: 35.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.43; 54.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPAG7 Gene

Human Gene Mutation Database (HGMD)
SPAG7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPAG7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPAG7 Gene

Disorders for SPAG7 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SPAG7 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
chronic intestinal vascular insufficiency
  • chronic mesenteric ischemia
pharyngitis
  • acute sore throat
aphthous stomatitis
  • aphtha
functional gastric disease
- elite association - COSMIC cancer census association via MalaCards
Search SPAG7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SPAG7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPAG7
genes like me logo Genes that share disorders with SPAG7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPAG7 Gene

Publications for SPAG7 Gene

  1. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. (PMID: 9653160) Mao M … Chen Z (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Cloning and characterization of a fox sperm protein FSA-1. (PMID: 7624517) Beaton S … Bradley MP (Reproduction, fertility, and development 1994) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2016) 3 60

Products for SPAG7 Gene

Sources for SPAG7 Gene

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