SPAG7 Gene
protein-coding GIFtS: 47
GCID: GC17M004862
|
|
sperm associated antigen 7
| |
Aliases
for SPAG7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sperm Associated Antigen 71 2 | | ACRP1 2 | | FSA-11 2 | | MGC201341 | | Sperm-Associated Antigen 72 |
Export aliases for SPAG7 gene to outside databasesPrevious GC identifers: GC17M005281 GC17M004807 GC17M005064 GC17M005065 GC17M004803 |
Summaries
for SPAG7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for SPAG7
|
Genomic Views
for SPAG7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPAG7 gene promoter:
E2F-4 E2F-3a E2F-5 E2F-2 Nkx2-5 c-Ets-1 E47 E2F-1 E2F
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPAG7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPAG7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13.2 Ensembl cytogenetic band: 17p13.2 HGNC cytogenetic band: 17p13.2SPAG7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M004862: view genomic region
(about GC identifiers)
Start:
|
4,862,521 bp from pter |
End:
|
4,871,167 bp from pter |
Size:
|
8,647 bases |
Orientation:
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minus strand |
|
Proteins
for SPAG7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPAG7_HUMAN, O75391 (See
protein sequence)Recommended Name: Sperm-associated antigen 7 Size: 227 amino acids; 26034 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=AAC39888.1; Type=Frameshift; Positions=227;
1 PDB 3D structure from  and Proteopedia  for SPAG7:2CPM (3D)
Secondary accessions: Q96EU5Explore the universe of human proteins at neXtProt for SPAG7: NX_O75391
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75391
SPAG7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004881.2
ENSEMBL proteins: ENSP00000461145 ENSP00000206020 ENSP00000458405 ENSP00000458264
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
SPAG7 for ontologies About GeneDecksing
SPAG7 Antibody Products:
Assay Products for SPAG7: |
Protein
Domains /
Families
for SPAG7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPAG7 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O75391ProtoNet protein and cluster: O75391 UniProtKB/Swiss-Prot: SPAG7_HUMAN, O75391Similarity: Contains 1 R3H domain |
Function
for SPAG7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPAG7 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPAG7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SPAG7 (NM_004890) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPAG7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPAG7 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPAG7 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
IEA | -- |
SPAG7 for ontologies About GeneDecksing
|
Pathways & Interactions
for SPAG7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPAG7
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/6 Interacting proteins for SPAG7 (O753912, 3 ENSP000002060204) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
|
Drugs & Compounds
for SPAG7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPAG7
Search CenterWatch for drugs/clinical trials and news about SPAG7
|
Transcripts
for SPAG7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPAG7 gene: NM_004890.2 Unigene Cluster for SPAG7: Sperm associated antigen 7 Hs.90436 [show with all ESTs]Unigene Representative Sequence: AK1230658 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000575142(uc002gaf.3) ENST00000206020(uc002gae.3) ENST00000573366
ENST00000575784 ENST00000572148 ENST00000573805 ENST00000571023 ENST00000570341
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPAG7 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPAG7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPAG7 (NM_004890) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPAG7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPAG7 |
Additional cDNA sequence: AF047437.1 AK123065.1 AK312174.1 BC007819.2 BC011934.2 14 DOTS entries: DT.455275 DT.100793908 DT.65288760 DT.100793910 DT.121003011 DT.95142015 DT.97822216 DT.121002958 DT.40314292 DT.91822995 DT.91919206 DT.92433472 DT.92436079 DT.95142016 24/201 AceView cDNA sequences (see all 201): BG491414 BM807898 BM708592 BC007819 AI378846 CD742666 BU580900 AW960452 BG740955 BM743958 AI367842 BQ686758 CR598182 BQ679058 BG114380 BU554186 BE746271 BG680902 AA352749 AW610502 BC011934 AI651466 BG292237 BE739198
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SPAG7 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c |
|---|
|
| SP1: | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SPAG7
|
Expression
for SPAG7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPAG7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SPAG7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPAG7
SOURCE GeneReport for Unigene cluster: Hs.90436
UniProtKB/Swiss-Prot: SPAG7_HUMAN, O75391Tissue specificity: Detected in fetal brain
SABiosciences Custom PCR Arrays for SPAG7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPAG7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPAG7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPAG7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPAG7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPAG7 |
Orthologs
for SPAG7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SPAG7 gene from 4/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Spag71 , 5 |
sperm associated antigen 71, 5 |
91.78(n)1
96.92(a)1 |
|
11 (43.21 cM)5
2168731 NM_172561.31 NP_766149.21
706637715 |
African clawed frog
(Xenopus laevis) |
Amphibia |
CA982745.12 |
-- |
78.28(n) |
|
CA982745.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc663972 |
similar to sperm associated antigen 7 |
79.02(n) |
|
394100 BC054697.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG26081 |
CG2608 |
52.91(n)
39.91(a) |
|
35323 NM_136198.3 NP_610042.1 |
ENSEMBL Gene Tree for SPAG7 (if available)
TreeFam Gene Tree for SPAG7 (if available) |
Paralogs
for SPAG7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SPAG7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SPAG7 (4862521 - 4871167 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SPAG7
1 CNV: 4987 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPAG7 |
|
Disorders
/ Diseases
for SPAG7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SPAG7 for disorders About GeneDecksing
OMIM gene information: 610056
OMIM disorders: --
3  diseases for SPAG7: About MalaCardsgastric outlet obstruction gastroparesis dyspepsia
2 diseases from the University of Copenhagen DISEASES database for SPAG7:Gastroparesis Dyspepsia Export disorders for SPAG7 gene to outside databases
|
Publications
for SPAG7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPAG7 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with SPAG7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PubMed id 9653160)1, 2, 3 Mao M.... Chen Z. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Cloning and characterization of a fox sperm protein FSA-1. (PubMed id 7624517)1, 2 Beaton S.... Bradley M.P. (1994)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
|
External Searches for SPAG7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SPAG7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPAG7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPAG7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPAG7 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SPAG7 gene:
Search GeneIP for patents involving SPAG7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPAG7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPAG7 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPAG7 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPAG7 | | | OriGene Protein Over-expression Lysate for SPAG7 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPAG7 | | OriGene 3'-UTR Clone for SPAG7 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPAG7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPAG7 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SPAG7 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SPAG7 | | OriGene Custom Protein Services for SPAG7 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPAG7 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPAG7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPAG7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPAG7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPAG7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPAG7 |
| |
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| |  |  |  |  | | | | |
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 | | | SPAG7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPAG7 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPAG7 |
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