Aliases for SPAG16 Gene
External Ids for SPAG16 Gene
Previous GeneCards Identifiers for SPAG16 Gene
Cilia and flagella are comprised of a microtubular backbone, the axoneme, which is organized by the basal body and surrounded by plasma membrane. SPAG16 encodes 2 major proteins that associate with the axoneme of sperm tail and the nucleus of postmeiotic germ cells, respectively (Zhang et al., 2007 [PubMed 17699735]).[supplied by OMIM, Jul 2008]
GeneCards Summary for SPAG16 Gene
SPAG16 (Sperm Associated Antigen 16) is a Protein Coding gene. Diseases associated with SPAG16 include gonococcal synovitis. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is PRPF4.
UniProtKB/Swiss-Prot for SPAG16 Gene
Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia (By similarity).