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Aliases for SPAG11B Gene

Aliases for SPAG11B Gene

  • Sperm Associated Antigen 11B 2 3 5
  • Human Epididymis-Specific Protein 2 3 4
  • Epididymal Protein 2B 2 3
  • Sperm Antigen HE2 3 4
  • EP2 3 4
  • HE2 3 4
  • Protein EP2 4
  • EDDM2B 3
  • SPAG11 3
  • EP2C 3
  • EP2D 3
  • HE2C 3

External Ids for SPAG11B Gene

Previous GeneCards Identifiers for SPAG11B Gene

  • GC08M007294

Summaries for SPAG11B Gene

Entrez Gene Summary for SPAG11B Gene

  • This gene encodes several androgen-dependent, epididymis-specific secretory proteins. The specific functions of these proteins have not been determined, but they are thought to be involved in sperm maturation. Some of the isoforms contain regions of similarity to beta-defensins, a family of antimicrobial peptides. The gene is located on chromosome 8p23 near the defensin gene cluster. Alternative splicing of this gene results in seven transcript variants encoding different isoforms. Two different N-terminal and five different C-terminal protein sequences are encoded by the splice variants. Two additional variants have been described, but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for SPAG11B Gene

SPAG11B (Sperm Associated Antigen 11B) is a Protein Coding gene. An important paralog of this gene is SPAG11A.

Gene Wiki entry for SPAG11B Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPAG11B Gene

Genomics for SPAG11B Gene

Regulatory Elements for SPAG11B Gene

Enhancers for SPAG11B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SPAG11B on UCSC Golden Path with GeneCards custom track

Genomic Location for SPAG11B Gene

7,442,684 bp from pter
7,463,674 bp from pter
20,991 bases
Minus strand

Genomic View for SPAG11B Gene

Genes around SPAG11B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPAG11B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPAG11B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPAG11B Gene

Proteins for SPAG11B Gene

  • Protein details for SPAG11B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sperm-associated antigen 11B
    Protein Accession:
    Secondary Accessions:
    • E9PFH0
    • Q546A0
    • Q6ZYB2
    • Q9H4P8
    • Q9H4P9
    • Q9H4Q0
    • Q9H4Q1
    • Q9H4Q2
    • Q9NRT3
    • Q9NRV4
    • Q9NRV5
    • Q9NRV6
    • Q9NRV7
    • Q9NRV8

    Protein attributes for SPAG11B Gene

    103 amino acids
    Molecular mass:
    11431 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPAG11B Gene

neXtProt entry for SPAG11B Gene

Proteomics data for SPAG11B Gene at MOPED

Post-translational modifications for SPAG11B Gene

No data available for DME Specific Peptides for SPAG11B Gene

Domains & Families for SPAG11B Gene

Protein Domains for SPAG11B Gene


Suggested Antigen Peptide Sequences for SPAG11B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPAG11 family.
  • Belongs to the SPAG11 family.
genes like me logo Genes that share domains with SPAG11B: view

No data available for Gene Families for SPAG11B Gene

Function for SPAG11B Gene

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPAG11B Gene

Localization for SPAG11B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPAG11B Gene


Subcellular locations from

Jensen Localization Image for SPAG11B Gene COMPARTMENTS Subcellular localization image for SPAG11B gene
Compartment Confidence
extracellular 5
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for SPAG11B Gene

Pathways & Interactions for SPAG11B Gene

SuperPathways for SPAG11B Gene

No Data Available

Interacting Proteins for SPAG11B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000381480 for SPAG11B Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for SPAG11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response IEA --
genes like me logo Genes that share ontologies with SPAG11B: view

No data available for Pathways by source and SIGNOR curated interactions for SPAG11B Gene

Drugs & Compounds for SPAG11B Gene

(1) Additional Compounds for SPAG11B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SPAG11B: view

Transcripts for SPAG11B Gene

Unigene Clusters for SPAG11B Gene

Sperm associated antigen 11B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPAG11B Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: -
SP2: - -
SP3: - - - -
SP5: - - -

Relevant External Links for SPAG11B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPAG11B Gene

mRNA expression in normal human tissues for SPAG11B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for SPAG11B Gene Hs.2717

mRNA Expression by UniProt/SwissProt for SPAG11B Gene

Tissue specificity: Specifically expressed in caput and proximal corpus of epididymis. Present in the epididymal epithelium and on the sperm surface, with a subacrosomal equatorial distribution on the sperm head.
genes like me logo Genes that share expression patterns with SPAG11B: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SPAG11B Gene

Orthologs for SPAG11B Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPAG11B Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia SPAG11B 35
  • 76.28 (n)
  • 64.86 (a)
SPAG11 36
  • 41 (a)
(Mus musculus)
Mammalia Spag11b 35
  • 71.77 (n)
  • 61.26 (a)
Spag11b 16
Spag11b 36
  • 42 (a)
(Pan troglodytes)
Mammalia SPAG11B 35
  • 99.41 (n)
  • 98.23 (a)
SPAG11 36
  • 98 (a)
(Rattus norvegicus)
Mammalia LOC100362580 35
  • 71.17 (n)
  • 63.06 (a)
(Bos Taurus)
Mammalia SPAG11 36
  • 32 (a)
Species with no ortholog for SPAG11B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPAG11B Gene

Gene Tree for SPAG11B (if available)
Gene Tree for SPAG11B (if available)

Paralogs for SPAG11B Gene

Paralogs for SPAG11B Gene

genes like me logo Genes that share paralogs with SPAG11B: view

Variants for SPAG11B Gene

Sequence variations from dbSNP and Humsavar for SPAG11B Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2853658 - 7,451,184(-) TCACC(A/G)GGAGG intron-variant, reference, missense
rs2738035 - 7,451,148(-) TGTGG(A/G)CTTTT intron-variant, reference, missense
rs2251705 -- 7,463,011(-) ACAAA(C/T)GTGCA intron-variant
rs2256100 -- 7,450,888(-) TCCAC(C/G/T)GGGAA intron-variant, reference, synonymous-codon, missense
rs2294141 -- 7,451,207(-) TGTTT(C/G)CTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPAG11B Gene

Variant ID Type Subtype PubMed ID
nsv428194 CNV Gain+Loss 18775914
dgv2191e1 CNV Complex 17122850
nsv515968 CNV Gain+Loss 19592680
nsv821656 CNV Gain 15273396
dgv2192e1 CNV Complex 17122850
esv2736558 CNV Deletion 23290073
nsv510977 CNV Complex 20534489
dgv2193e1 CNV Complex 17122850
dgv7659n71 CNV Gain 21882294
esv21583 CNV Gain+Loss 19812545
nsv890078 CNV Gain 21882294
esv33606 CNV Gain+Loss 17666407
dgv7661n71 CNV Gain 21882294
dgv7662n71 CNV Gain 21882294
nsv8281 CNV Gain+Loss 18304495
dgv7663n71 CNV Loss 21882294
dgv7664n71 CNV Loss 21882294
dgv2194e1 CNV Complex 17122850
nsv471650 CNV Gain+Loss 15918152
dgv2195e1 CNV Complex 17122850
dgv7666n71 CNV Gain 21882294
dgv7667n71 CNV Gain+Loss 21882294
dgv7668n71 CNV Gain 21882294
dgv7669n71 CNV Gain 21882294
dgv7670n71 CNV Loss 21882294
dgv7672n71 CNV Gain+Loss 21882294
dgv7673n71 CNV Gain+Loss 21882294
esv996398 CNV Gain 20482838
nsv890110 CNV Gain 21882294
esv2752265 CNV Gain 17911159
nsv824519 CNV Loss 20364138
nsv824521 CNV Gain 20364138
nsv515100 CNV Complex 21397061
dgv31n14 CNV Loss 18776910
dgv7675n71 CNV Loss 21882294
nsv890153 CNV Loss 21882294
nsv442397 CNV CNV 18776908
nsv469521 CNV Complex 16826518
dgv7677n71 CNV Gain+Loss 21882294
dgv7678n71 CNV Gain 21882294
dgv7679n71 CNV Gain 21882294
dgv25n31 CNV Duplication 19718026
dgv7680n71 CNV Loss 21882294
dgv7681n71 CNV Gain 21882294
esv2752266 CNV Loss 17911159
nsv508496 CNV Loss 20534489
dgv7682n71 CNV Gain 21882294
esv25631 CNV Gain+Loss 19812545
nsv890256 CNV Gain+Loss 21882294
dgv7683n71 CNV Gain+Loss 21882294
dgv7684n71 CNV Loss 21882294
dgv7685n71 CNV Gain 21882294
nsv890270 CNV Loss 21882294
dgv7686n71 CNV Gain 21882294
dgv7687n71 CNV Gain 21882294
esv992071 CNV Gain 20482838
dgv7688n71 CNV Gain 21882294
dgv7689n71 CNV Gain 21882294
nsv433398 CNV Gain 18776910
dgv7690n71 CNV Gain+Loss 21882294
dgv7691n71 CNV Gain 21882294
dgv26n31 CNV Duplication 19718026
dgv1170n67 CNV Loss 20364138
nsv824524 CNV Gain+Loss 20364138
dgv7692n71 CNV Gain 21882294
dgv7693n71 CNV Gain+Loss 21882294
dgv7694n71 CNV Loss 21882294
dgv7695n71 CNV Gain 21882294
nsv890300 CNV Loss 21882294
dgv7696n71 CNV Gain 21882294
nsv471458 CNV Duplication 19718026
nsv482120 CNV Gain 20164927

Variation tolerance for SPAG11B Gene

Residual Variation Intolerance Score: 89.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.42; 9.30% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SPAG11B Gene

Disorders for SPAG11B Gene

Relevant External Links for SPAG11B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SPAG11B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPAG11B Gene

Publications for SPAG11B Gene

  1. Molecular cloning and characterization of a novel human sperm antigen (HE2) specifically expressed in the proximal epididymis. (PMID: 8167223) Osterhoff C. … Ivell R. (Biol. Reprod. 1994) 2 3 4 23 67
  2. Novel partners of SPAG11B isoform D in the human male reproductive tract. (PMID: 19535787) Radhakrishnan Y. … French F.S. (Biol. Reprod. 2009) 3 23
  3. Antimicrobial actions of human and macaque sperm associated antigen (SPAG) 11 isoforms: influence of the N-terminal peptide. (PMID: 16411022) Yenugu S. … Hall S.H. (Mol. Cell. Biochem. 2006) 3 23
  4. Differential expression and antibacterial activity of epididymis protein 2 isoforms in the male reproductive tract of human and rhesus monkey (Macaca mulatta). (PMID: 15229135) Avellar M.C. … Hall S.H. (Biol. Reprod. 2004) 3 23
  5. Novel antimicrobial peptide of human epididymal duct origin. (PMID: 12193388) von Horsten H.H. … Kirchhoff C. (Biol. Reprod. 2002) 3 23

Products for SPAG11B Gene

Sources for SPAG11B Gene