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Aliases for SPAG11A Gene

Aliases for SPAG11A Gene

  • Sperm Associated Antigen 11A 2 3 5
  • Human Epididymis-Specific Protein 2 3 4
  • Epididymal Protein 2A 2 3
  • Sperm Antigen HE2 3 4
  • HE2 3 4
  • Sperm-Associated Antigen 11A 3
  • Protein EP2 4
  • EDDM2A 3
  • EP2 4

External Ids for SPAG11A Gene

Previous GeneCards Identifiers for SPAG11A Gene

  • GC08P007745
  • GC08P007705

Summaries for SPAG11A Gene

GeneCards Summary for SPAG11A Gene

SPAG11A (Sperm Associated Antigen 11A) is a Protein Coding gene. An important paralog of this gene is SPAG11B.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPAG11A Gene

Genomics for SPAG11A Gene

Regulatory Elements for SPAG11A Gene


Genomic Location for SPAG11A Gene

Chromosome:
8
Start:
7,847,864 bp from pter
End:
7,868,867 bp from pter
Size:
21,004 bases
Orientation:
Plus strand

Genomic View for SPAG11A Gene

Genes around SPAG11A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPAG11A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPAG11A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPAG11A Gene

Proteins for SPAG11A Gene

  • Protein details for SPAG11A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PDA7-SG11A_HUMAN
    Recommended name:
    Sperm-associated antigen 11A
    Protein Accession:
    Q6PDA7
    Secondary Accessions:
    • A6NIY0
    • E9PAK7

    Protein attributes for SPAG11A Gene

    Size:
    123 amino acids
    Molecular mass:
    13842 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AC130365; Type=Erroneous termination; Positions=104; Note=Translated as Glu.; Evidence={ECO:0000305};

    Alternative splice isoforms for SPAG11A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPAG11A Gene

Post-translational modifications for SPAG11A Gene

No data available for DME Specific Peptides for SPAG11A Gene

Domains & Families for SPAG11A Gene

Protein Domains for SPAG11A Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPAG11A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PDA7

UniProtKB/Swiss-Prot:

SG11A_HUMAN :
  • Belongs to the SPAG11 family.
Family:
  • Belongs to the SPAG11 family.
genes like me logo Genes that share domains with SPAG11A: view

No data available for Gene Families for SPAG11A Gene

Function for SPAG11A Gene

Phenotypes for SPAG11A Gene

GenomeRNAi human phenotypes for SPAG11A:
genes like me logo Genes that share phenotypes with SPAG11A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SPAG11A

CRISPR Products

miRNA for SPAG11A Gene

miRTarBase miRNAs that target SPAG11A

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPAG11A Gene

Localization for SPAG11A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPAG11A Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPAG11A gene
Compartment Confidence
extracellular 5
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SPAG11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with SPAG11A: view

Pathways & Interactions for SPAG11A Gene

SuperPathways for SPAG11A Gene

No Data Available

Interacting Proteins for SPAG11A Gene

Gene Ontology (GO) - Biological Process for SPAG11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response IEA --
genes like me logo Genes that share ontologies with SPAG11A: view

No data available for Pathways by source and SIGNOR curated interactions for SPAG11A Gene

Drugs & Compounds for SPAG11A Gene

No Compound Related Data Available

Transcripts for SPAG11A Gene

mRNA/cDNA for SPAG11A Gene

(6) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPAG11A Gene

Sperm associated antigen 11A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPAG11A Gene

No ASD Table

Relevant External Links for SPAG11A Gene

GeneLoc Exon Structure for
SPAG11A
ECgene alternative splicing isoforms for
SPAG11A

Expression for SPAG11A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPAG11A Gene

Protein differential expression in normal tissues from HIPED for SPAG11A Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPAG11A Gene



Protein tissue co-expression partners for SPAG11A Gene

NURSA nuclear receptor signaling pathways regulating expression of SPAG11A Gene:

SPAG11A

SOURCE GeneReport for Unigene cluster for SPAG11A Gene:

Hs.559506
genes like me logo Genes that share expression patterns with SPAG11A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPAG11A Gene

Orthologs for SPAG11A Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPAG11A Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Spag11b 35
  • 38 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SPAG11 35
  • 37 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SPAG11 35
  • 27 (a)
OneToMany
Species where no ortholog for SPAG11A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPAG11A Gene

ENSEMBL:
Gene Tree for SPAG11A (if available)
TreeFam:
Gene Tree for SPAG11A (if available)

Paralogs for SPAG11A Gene

Paralogs for SPAG11A Gene

genes like me logo Genes that share paralogs with SPAG11A: view

Variants for SPAG11A Gene

Sequence variations from dbSNP and Humsavar for SPAG11A Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1001447241 -- 7,857,231(+) AGTCA(A/T)CTTAG intron-variant, upstream-variant-2KB
rs1001814961 -- 7,852,468(+) AGCTG(A/G)GATTA intron-variant
rs1002414627 -- 7,863,618(+) AGAGG(C/T)CAGGA utr-variant-3-prime
rs1005286935 -- 7,860,856(+) GGCAG(A/G)GATGT intron-variant, downstream-variant-500B
rs1005729495 -- 7,861,656(+) GAATT(G/T)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPAG11A Gene

Variant ID Type Subtype PubMed ID
dgv1170n67 CNV loss 20364138
dgv11911n54 CNV loss 21841781
dgv11913n54 CNV gain 21841781
dgv11914n54 CNV gain 21841781
dgv11928n54 CNV gain 21841781
dgv11929n54 CNV loss 21841781
dgv11930n54 CNV gain 21841781
dgv11931n54 CNV loss 21841781
dgv11932n54 CNV loss 21841781
dgv11933n54 CNV loss 21841781
dgv11934n54 CNV loss 21841781
dgv11935n54 CNV gain 21841781
dgv11936n54 CNV loss 21841781
dgv2035e212 CNV gain 25503493
dgv26n31 CNV gain 19718026
dgv6882n100 CNV gain 25217958
dgv6887n100 CNV loss 25217958
dgv6890n100 CNV gain 25217958
dgv6895n100 CNV loss 25217958
dgv6896n100 CNV gain+loss 25217958
dgv6909n100 CNV gain 25217958
dgv6910n100 CNV gain+loss 25217958
dgv6911n100 CNV loss 25217958
dgv6912n100 CNV loss 25217958
dgv6915n100 CNV gain 25217958
dgv6935n100 CNV gain 25217958
dgv6936n100 CNV gain+loss 25217958
dgv6940n100 CNV loss 25217958
dgv6948n100 CNV gain+loss 25217958
dgv6949n100 CNV gain 25217958
dgv6950n100 CNV loss 25217958
dgv6955n100 CNV gain 25217958
dgv6958n100 CNV gain+loss 25217958
dgv6959n100 CNV loss 25217958
dgv6960n100 CNV loss 25217958
dgv6961n100 CNV gain+loss 25217958
dgv6962n100 CNV gain 25217958
dgv6963n100 CNV loss 25217958
dgv6964n100 CNV gain 25217958
dgv6965n100 CNV gain+loss 25217958
dgv6966n100 CNV loss 25217958
esv25631 CNV gain+loss 19812545
esv2752265 CNV gain 17911159
esv2752266 CNV loss 17911159
esv2759589 CNV gain+loss 17122850
esv2761169 CNV gain+loss 21179565
esv2764098 CNV gain+loss 21179565
esv33606 CNV gain+loss 17666407
esv3584574 CNV gain 24956385
esv3584577 CNV gain 24956385
esv3891318 CNV gain 25118596
esv3891321 CNV gain+loss 25118596
esv3891323 CNV gain+loss 25118596
esv992071 CNV gain 20482838
nsv1017081 CNV gain 25217958
nsv1030619 CNV loss 25217958
nsv1031577 CNV gain 25217958
nsv1032072 CNV gain 25217958
nsv1139926 CNV duplication 24896259
nsv428194 CNV gain+loss 18775914
nsv433398 CNV gain 18776910
nsv442397 CNV gain 18776908
nsv471458 CNV gain 19718026
nsv471650 CNV gain+loss 15918152
nsv482120 CNV gain 20164927
nsv508496 CNV deletion 20534489
nsv510977 OTHER complex 20534489
nsv515968 CNV gain+loss 19592680
nsv610102 CNV gain+loss 21841781
nsv610113 CNV loss 21841781
nsv610116 CNV loss 21841781
nsv610119 CNV gain+loss 21841781
nsv610129 CNV loss 21841781
nsv610131 CNV gain+loss 21841781
nsv610134 CNV loss 21841781
nsv610135 CNV loss 21841781
nsv610136 CNV gain 21841781
nsv610137 CNV loss 21841781
nsv821656 CNV gain 15273396
nsv824524 CNV gain+loss 20364138
nsv8281 CNV gain+loss 18304495
nsv951093 CNV deletion 24416366
nsv967558 CNV duplication 23825009

Relevant External Links for SPAG11A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPAG11A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SPAG11A Gene

Disorders for SPAG11A Gene

Relevant External Links for SPAG11A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPAG11A

No disorders were found for SPAG11A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPAG11A Gene

Publications for SPAG11A Gene

  1. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 3 4 64
  2. Organization of the human gene encoding the epididymis-specific EP2 protein variants and its relationship to defensin genes. (PMID: 11259252) Frohlich O. … Young L.G. (Biol. Reprod. 2001) 3 4 64
  3. HE2 beta and HE2 gamma, new members of an epididymis-specific family of androgen-regulated proteins in the human. (PMID: 10698202) Hamil K.G. … Hall S.H. (Endocrinology 2000) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for SPAG11A Gene

Sources for SPAG11A Gene

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