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Aliases for SPAG11A Gene

Aliases for SPAG11A Gene

  • Sperm Associated Antigen 11A 2 3
  • Human Epididymis-Specific Protein 2 3 4
  • Epididymal Protein 2A 2 3
  • Sperm Antigen HE2 3 4
  • HE2 3 4
  • Sperm-Associated Antigen 11A 3
  • Protein EP2 4
  • EDDM2A 3
  • EP2 4

External Ids for SPAG11A Gene

Previous GeneCards Identifiers for SPAG11A Gene

  • GC08P007745
  • GC08P007705

Summaries for SPAG11A Gene

GeneCards Summary for SPAG11A Gene

SPAG11A (Sperm Associated Antigen 11A) is a Protein Coding gene. Diseases associated with SPAG11A include choroid plexus carcinoma. An important paralog of this gene is SPAG11B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPAG11A Gene

Genomics for SPAG11A Gene

Regulatory Elements for SPAG11A Gene

Genomic Location for SPAG11A Gene

7,847,688 bp from pter
7,868,867 bp from pter
21,180 bases
Plus strand

Genomic View for SPAG11A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPAG11A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPAG11A Gene

Proteins for SPAG11A Gene

  • Protein details for SPAG11A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sperm-associated antigen 11A
    Protein Accession:
    Secondary Accessions:
    • A6NIY0
    • E9PAK7

    Protein attributes for SPAG11A Gene

    123 amino acids
    Molecular mass:
    13842 Da
    Quaternary structure:
    No Data Available
    • Sequence=AC130365; Type=Erroneous termination; Positions=104; Note=Translated as Glu.; Evidence={ECO:0000305};

    Alternative splice isoforms for SPAG11A Gene


neXtProt entry for SPAG11A Gene

Proteomics data for SPAG11A Gene at MOPED

Post-translational modifications for SPAG11A Gene

No data available for DME Specific Peptides for SPAG11A Gene

Domains for SPAG11A Gene

Protein Domains for SPAG11A Gene


Suggested Antigen Peptide Sequences for SPAG11A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPAG11 family.
  • Belongs to the SPAG11 family.
genes like me logo Genes that share domains with SPAG11A: view

No data available for Gene Families for SPAG11A Gene

Function for SPAG11A Gene

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPAG11A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPAG11A Gene

Localization for SPAG11A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPAG11A Gene


Subcellular locations from

Jensen Localization Image for SPAG11A Gene COMPARTMENTS Subcellular localization image for SPAG11A gene
Compartment Confidence
extracellular 5
cytosol 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SPAG11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with SPAG11A: view

Pathways for SPAG11A Gene

SuperPathways for SPAG11A Gene

No Data Available

Interacting Proteins for SPAG11A Gene

Gene Ontology (GO) - Biological Process for SPAG11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response --
genes like me logo Genes that share ontologies with SPAG11A: view

No data available for Pathways by source for SPAG11A Gene

Transcripts for SPAG11A Gene

mRNA/cDNA for SPAG11A Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPAG11A Gene

Sperm associated antigen 11A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPAG11A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPAG11A Gene

No ASD Table

Relevant External Links for SPAG11A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPAG11A Gene

mRNA expression in normal human tissues for SPAG11A Gene

Protein differential expression in normal tissues for SPAG11A Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SPAG11A Gene

SOURCE GeneReport for Unigene cluster for SPAG11A Gene Hs.559506

genes like me logo Genes that share expressions with SPAG11A: view

Expression partners for SPAG11A Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPAG11A Gene

Orthologs for SPAG11A Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPAG11A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SPAG11 36
  • 27 (a)
(Canis familiaris)
Mammalia SPAG11 36
  • 37 (a)
(Mus musculus)
Mammalia Spag11b 36
  • 38 (a)
Species with no ortholog for SPAG11A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPAG11A Gene

Gene Tree for SPAG11A (if available)
Gene Tree for SPAG11A (if available)

Paralogs for SPAG11A Gene

Paralogs for SPAG11A Gene

genes like me logo Genes that share paralogs with SPAG11A: view

Variants for SPAG11A Gene

Sequence variations from dbSNP and Humsavar for SPAG11A Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1071601 -- 7,860,393(+) ATCTG(A/C/T)GTGGG intron-variant, stop-gained, reference, synonymous-codon
rs1071602 -- 7,860,658(+) TCCAC(A/C/T)GGGAA missense, reference, synonymous-codon
rs1126901 -- 7,860,386(+) ATTTA(A/G)GATCT intron-variant, reference, missense
rs1126907 -- 7,860,398(+) CGTGG(A/G)CTTTT intron-variant, missense, reference
rs2737559 -- 7,860,539(-) AAGTA(C/T)TTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPAG11A Gene

Variant ID Type Subtype PubMed ID
nsv428194 CNV Gain+Loss 18775914
dgv2191e1 CNV Complex 17122850
nsv515968 CNV Gain+Loss 19592680
nsv821656 CNV Gain 15273396
dgv2192e1 CNV Complex 17122850
nsv510977 CNV Complex 20534489
dgv7659n71 CNV Gain 21882294
esv33606 CNV Gain+Loss 17666407
dgv7662n71 CNV Gain 21882294
nsv8281 CNV Gain+Loss 18304495
dgv7664n71 CNV Loss 21882294
nsv471650 CNV Gain+Loss 15918152
dgv2195e1 CNV Complex 17122850
dgv7669n71 CNV Gain 21882294
dgv7670n71 CNV Loss 21882294
dgv7673n71 CNV Gain+Loss 21882294
esv2752265 CNV Gain 17911159
nsv442397 CNV CNV 18776908
dgv7679n71 CNV Gain 21882294
esv2752266 CNV Loss 17911159
nsv508496 CNV Loss 20534489
dgv7682n71 CNV Gain 21882294
esv25631 CNV Gain+Loss 19812545
nsv890256 CNV Gain+Loss 21882294
dgv7683n71 CNV Gain+Loss 21882294
dgv7684n71 CNV Loss 21882294
dgv7685n71 CNV Gain 21882294
nsv890270 CNV Loss 21882294
dgv7686n71 CNV Gain 21882294
dgv7687n71 CNV Gain 21882294
esv992071 CNV Gain 20482838
dgv7688n71 CNV Gain 21882294
dgv7689n71 CNV Gain 21882294
nsv433398 CNV Gain 18776910
dgv7690n71 CNV Gain+Loss 21882294
dgv7691n71 CNV Gain 21882294
dgv26n31 CNV Duplication 19718026
dgv1170n67 CNV Loss 20364138
nsv824524 CNV Gain+Loss 20364138
dgv7692n71 CNV Gain 21882294
dgv7693n71 CNV Gain+Loss 21882294
dgv7694n71 CNV Loss 21882294
dgv7695n71 CNV Gain 21882294
nsv890300 CNV Loss 21882294
dgv7696n71 CNV Gain 21882294
nsv471458 CNV Duplication 19718026
nsv482120 CNV Gain 20164927
nsv890317 CNV Gain+Loss 21882294
dgv7697n71 CNV Gain 21882294

Relevant External Links for SPAG11A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPAG11A Gene

Disorders for SPAG11A Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SPAG11A Gene in MalaCards »

(1) Disease for SPAG11A Gene

(1) University of Copenhagen DISEASES for SPAG11A Gene

genes like me logo Genes that share disorders with SPAG11A: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for SPAG11A Gene

Publications for SPAG11A Gene

  1. Organization of the human gene encoding the epididymis-specific EP2 protein variants and its relationship to defensin genes. (PMID: 11259252) Frohlich O. … Young L.G. (Biol. Reprod. 2001) 3 4
  2. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 3 4
  3. HE2 beta and HE2 gamma, new members of an epididymis-specific family of androgen-regulated proteins in the human. (PMID: 10698202) Hamil K.G. … Hall S.H. (Endocrinology 2000) 3 4
  4. Molecular cloning and characterization of a novel human sperm antigen (HE2) specifically expressed in the proximal epididymis. (PMID: 8167223) Osterhoff C. … Ivell R. (Biol. Reprod. 1994) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for SPAG11A Gene

Sources for SPAG11A Gene

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