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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SPAG1 Gene

protein-coding GIFtS: 51
GCID: GC08P101170

sperm associated antigen 1

Explore 6 diseases affiliated with
SPAG1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sperm Associated Antigen 1¹ ²		FLJ32920¹
HSD-3.8¹ ² ³		Sperm-Associated Antigen 1²
SP75¹ ²		Tetratricopeptide Repeat-Containing Protein²
TPIS¹ ²		TPR-Containing Protein Involved In Spermatogenesis²
Infertility-Related Sperm Protein Spag-1² ³

External Ids:	HGNC: 11212¹	Entrez Gene: 6674²	Ensembl: ENSG00000104450⁷	OMIM: 603395⁵	UniProtKB: Q07617³

Export aliases for SPAG1 gene to outside databases

Previous GC identifers: GC08P100176 GC08P101240 GC08P100839 GC08P101126 GC08P101239 GC08P096373

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SPAG1:

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies

in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of

proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm

antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile

woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein

localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature

spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP

signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene

encode the same protein. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SPAG1_HUMAN, Q07617

Function: Plays a role in fertilization. Binds GTP and has GTPase activity

Gene Wiki entry for SPAG1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_008046.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SPAG1 gene promoter:
SRY GATA-3 CUTL1 GATA-2 GATA-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SPAG1 promoter sequence

Search SABiosciences Chromatin IP Primers for SPAG1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPAG1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.2 Ensembl cytogenetic band: 8q22.2 HGNC cytogenetic band: 8q22

SPAG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPAG1 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P101170: view genomic region (about GC identifiers)

Start:	101,170,134 bp from pter	End:	101,271,506 bp from pter
Size:	101,373 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SPAG1_HUMAN, Q07617 (See protein sequence)

Recommended Name: Sperm-associated antigen 1

Size: 926 amino acids; 103639 Da

Subcellular location: Cytoplasm

Miscellaneous: Antibodies against SPAG1 interfere with fertilization (By similarity)

Sequence caution: Sequence=AAH55091.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A

sequence;

Secondary accessions: A6NP70 Q7Z5G1

Explore the universe of human proteins at neXtProt for SPAG1: NX_Q07617

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q07617

SPAG1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_003105.2 NP_757367.1

ENSEMBL proteins:

ENSP00000427716 ENSP00000428070 ENSP00000373450 ENSP00000251809

Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SPAG1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--

SPAG1 for ontologies About GeneDecksing

SPAG1 Antibody Products:

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	ThermoFisher Antibodies for SPAG1

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	Uscn ELISAs and CLIAs for SPAG1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SPAG1 for domains About GeneDecksing

5 InterPro domains/families:

IPR001440 TPR-1

IPR011990 TPR-like_helical

IPR025986 RPAP3-like_C

IPR013026 TPR-contain_dom

IPR019734 TPR_repeat

Graphical View of Domain Structure for InterPro Entry Q07617

ProtoNet protein and cluster: Q07617

UniProtKB/Swiss-Prot: SPAG1_HUMAN, Q07617

Similarity: Contains 9 TPR repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SPAG1_HUMAN, Q07617

Function: Plays a role in fertilization. Binds GTP and has GTPase activity

Genatlas biochemistry entry for SPAG1:

sperm associated antigen 1,75kDa

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SPAG1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPAG1
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate SPAG1:
		hsa-miR-569 hsa-miR-182 hsa-miR-103b hsa-miR-2116 hsa-miR-34b hsa-miR-3674 hsa-miR-628-3p
		SwitchGear 3'UTR luciferase reporter plasmid: SPAG1 3' UTR sequence

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPAG1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005525	GTP binding	IEA	--
GO:0016787	hydrolase activity	IEA	--

SPAG1 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for SPAG1:

G0/1 arrest

Increased S DNA content

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SPAG1

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for SPAG1 (Q07617³ ENSP00000251809⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PRKCA	P17252³, ENSP00000284384⁴	I2D: score=1 STRING: ENSP00000284384
PCNA	P12004³	I2D: score=1

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007338	single fertilization	IEA	--

SPAG1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SPAG1

1 HMDB Compound for SPAG1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about SPAG1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SPAG1 gene (2 alternative transcripts):

NM_003114.4 NM_172218.2

Unigene Cluster for SPAG1:

Sperm associated antigen 1

Hs.591866 [show with all ESTs]

Unigene Representative Sequence: NM_003114

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000520643(uc003yjg.1) ENST00000520508 ENST00000388798(uc003yji.2)

ENST00000523302 ENST00000519424 ENST00000519409 ENST00000251809(uc003yjh.2)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SPAG1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPAG1
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate SPAG1:
		hsa-miR-569 hsa-miR-182 hsa-miR-103b hsa-miR-2116 hsa-miR-34b hsa-miR-3674 hsa-miR-628-3p
		SwitchGear 3'UTR luciferase reporter plasmid: SPAG1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPAG1 (see all 7) OriGene shRNA RFP: SPAG1 OriGene siRNA: SPAG1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPAG1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPAG1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPAG1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPAG1

Additional cDNA sequence:

AF311312.1 AK057482.1 BC055091.1

9 DOTS entries:

DT.409321 DT.100754381 DT.75104704 DT.121481029 DT.75173562 DT.91965403 DT.101969872 DT.100667507

DT.100783746

24/51 AceView cDNA sequences (see all 51):

BF739945 AK057482 AI452902 CB321799 BM557203 NM_003114 NM_172218 BX117722

AI167655 BM981630 CB161106 BC055091 AW173216 BU567487 BU674622 AW854258

AI239514 CA423307 AI624411 BX456239 AW592742 AL079393 CD357612 CN478700

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SPAG1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGAAAGCTC

About this image

SPAG1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SPAG1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPAG1

SOURCE GeneReport for Unigene cluster: Hs.591866

UniProtKB/Swiss-Prot: SPAG1_HUMAN, Q07617

Tissue specificity: Detected in sperm and testis, in particular in pachytene primary spermatocytes

SABiosciences Custom PCR Arrays for SPAG1

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPAG1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPAG1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SPAG1 gene from 6/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SPAG1¹	sperm associated antigen 1	66.43(n) 57.92(a)		420249 XM_418360.3 XP_418360.3
lizard (Anolis carolinensis)	Reptilia	SPAG1⁶	--	52(a)	1 ↔ 1	GL343394.1(260659-292825)
African clawed frog (Xenopus laevis)	Amphibia	Xl.4427²	Xenopus laevis transcribed sequence with weak similarity more	71.18(n)		CA973487.1
zebrafish (Danio rerio)	Actinopterygii	spag1b¹	sperm associated antigen 1b	46.12(n) 35.53(a)		768178 NM_001077321.1 NP_001070789.1
fruit fly (Drosophila melanogaster)	Insecta	CG18472¹	CG18472	47.48(n) 37.14(a)		43239 NM_143257.2 NP_651514.1
rice (Oryza sativa)	Liliopsida	-- -- (see all 3)	heat shock protein STI, putative, expressed U-box domain containing heat shock protein, putati... (see all 3)	9(a) 13(a) (see all 3)	possible ortholog possible ortholog (see all 3)	6(3034392-3038391) 6(3050105-3054710)

ENSEMBL Gene Tree for SPAG1 (if available)
TreeFam Gene Tree for SPAG1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SPAG1 gene

RPAP3² TOMM34² STIP1² TTC1²

1 SIMAP similar gene for SPAG1 using alignment to 2 protein entries: SPAG1_HUMAN (see all proteins):

TOMM34

SPAG1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188189364^1,2		--	101168304(+)	`ATTACC/TGAAAC`	1	--	us2k¹		0	--	--	--	--
rs144874065^1,2	C,	--	101168309(+)	`GAAAC-/AGAGAAA`	1	--	us2k¹		0	--	--	--	--
rs146051878^1,2		--	101168587(+)	`AGACCA/GTCTGT`	2	--	us2k¹		0	--	--	--	--
rs199844394^1,2	C	--	101168645(-)	`ACTTCC/TCACCA`	2	--	us2k¹		0	--	--	--	--
rs73279003^1,2	C,	--	101168765(+)	`CCTGGC/GTAAGT`	2	--	us2k¹		2		WA	120
rs73696157^1,2	C,	--	101168855(+)	`AAAAAT/ATTTTT`	2	--	us2k¹		1		WA	2
rs74433868^1,2	C,	--	101168856(+)	`AAAAAA/TTTTTT`	2	--	us2k¹		0	--	--	--	--
rs113550693^1,2	C,	--	101168864(+)	`TTTTTT/CTATTT`	2	--	us2k¹		2		WA	120
rs2453644^1,2	C,F,H,	--	101168989(+)	`CTGCCG/AAGCAT`	2	--	us2k¹		15		NS EA NA WA CSA	793
rs140189505^1,2		--	101169098(+)	`TGTAAA/GTTAAC`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SPAG1 (101170134 - 101271506 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SPAG1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPAG1

DNA2.0 Custom Variant and Variant Library Synthesis for SPAG1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SPAG1 for disorders           About GeneDecksing

OMIM gene information: 603395    OMIM disorders: --

6 diseases for SPAG1:    About MalaCards

infertility myofascial pain syndrome theileriasis paine syndrome

pancreatitis malaria

1 disease from the University of Copenhagen DISEASES database for SPAG1:

Myofascial pain syndrome

Export disorders for SPAG1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SPAG1 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with SPAG1)

Utopia: connect your pdf to the dynamic
world of online information

A sperm component, HSD-3.8 (SPAG1), interacts with G-protein beta 1 subunit and activates extracellular signal-regulated kinases (ERK). (PubMed id 16368546)^{1, 3} Liu N....Wang L. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Expression and function of the HSD-3.8 gene encoding a testis- specific protein. (PubMed id 11517287)^{1, 2} Lin W....Koide S.S. (2001)
Isolation and sequencing of the cDNA encoding the 75-kD human sperm protein related to infertility. (PubMed id 1299558)^{1, 2} Zhang M.L.... Koide S.S. (1992)
Sperm-associated antigen 1 is expressed early in pancreatic tumorigenesis and promotes motility of cancer cells. (PubMed id 16983343)^{1, 9} Neesse A....Crnogorac-Jurcevic T. (2007)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Proliferating cell nuclear antigen in the cytoplasm i nteracts with components of glycolysis and cancer. (PubMed id 20849852)¹ Naryzhny S.N. and Lee H. (2010)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)² Dephoure N.... Gygi S.P. (2008)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)² Nusbaum C....Lander E.S. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6674	HGNC: 11212	AceView: SPAG1	Ensembl:ENSG00000104450	euGenes: HUgn6674
ECgene: SPAG1	H-InvDB: SPAG1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SPAG1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SPAG1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SPAG1 gene:
Search GeneIP for patents involving SPAG1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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	Browse OriGene Antibodies		OriGene shRNA RFP for SPAG1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPAG1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPAG1
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPAG1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPAG1
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	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPAG1
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	GenScript Custom Purified and Recombinant Proteins Services for SPAG1		GenScript cDNA clones with any tag delivered in your preferred vector for SPAG1
	GenScript Custom Assay Services for SPAG1		GenScript Custom Superior Antibodies Services for SPAG1
	GenScript Custom overexpressing Cell Line Services for SPAG1		CloneReady with Over 120,000 Genes
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	Regulatory tfbs in SPAG1 promoter
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPAG1

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ThermoFisher Antibodies for SPAG1

Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SPAG1

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SPAG1 gene at Home site.

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SPAG1 Gene

sperm associated antigen 1

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SPAG1 Gene

sperm associated antigen 1

Aliasesfor SPAG1 gene

Summariesfor SPAG1 gene

Genomic Viewsfor SPAG1 gene

Proteinsfor SPAG1 gene

Protein Domains /Familiesfor SPAG1 gene

Functionfor SPAG1 gene

Pathways & Interactionsfor SPAG1 gene

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