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SPAG1 Gene

protein-coding   GIFtS: 55
GCID: GC08P101170

Sperm Associated Antigen 1

  See SPAG1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sperm Associated Antigen 11 2     SP752
Infertility-Related Sperm Protein Spag-12 3     TPIS2
HSD-3.82 3     Sperm-Associated Antigen 12
CILD282 5     Tetratricopeptide Repeat-Containing Protein2
CT1402     TPR-Containing Protein Involved In Spermatogenesis2

External Ids:    HGNC: 112121   Entrez Gene: 66742   Ensembl: ENSG000001044507   OMIM: 6033955   UniProtKB: Q076173   

Export aliases for SPAG1 gene to outside databases

Previous GC identifers: GC08P100176 GC08P101240 GC08P100839 GC08P101126 GC08P101239 GC08P096373


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SPAG1 Gene:
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these
antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as
identification of proteins for targeted contraception, are dependent on the identification and characterization
of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating
antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein
reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the
post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase
activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and
fertilization. Two transcript variants of this gene encode the same protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for SPAG1 Gene:
SPAG1 (sperm associated antigen 1) is a protein-coding gene. Diseases associated with SPAG1 include ciliary dyskinesia, primary, 28, and myofascial pain syndrome. GO annotations related to this gene include hydrolase activity and GTP binding. An important paralog of this gene is TOMM70A.

UniProtKB/Swiss-Prot: SPAG1_HUMAN, Q07617
Function: Plays a role in fertilization. Binds GTP and has GTPase activity

Gene Wiki entry for SPAG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPAG1 gene promoter:
         SRY   GATA-3   CUTL1   GATA-2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPAG1 promoter sequence
   Search Chromatin IP Primers for SPAG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPAG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.2   Ensembl cytogenetic band:  8q22.2   HGNC cytogenetic band: 8q22

SPAG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPAG1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P101170:  view genomic region     (about GC identifiers)

Start:
101,170,134 bp from pter      End:
101,271,506 bp from pter
Size:
101,373 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SPAG1_HUMAN, Q07617 (See protein sequence)
Recommended Name: Sperm-associated antigen 1  
Size: 926 amino acids; 103639 Da
Miscellaneous: Antibodies against SPAG1 interfere with fertilization (By similarity)
Sequence caution: Sequence=AAH55091.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
Secondary accessions: A6NP70 Q7Z5G1

Explore the universe of human proteins at neXtProt for SPAG1: NX_Q07617

Explore proteomics data for SPAG1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SPAG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_003105.2  NP_757367.1  

    ENSEMBL proteins: 
     ENSP00000427716   ENSP00000428070   ENSP00000373450   ENSP00000251809  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TTC: Tetratricopeptide (TTC) repeat domain containing

    5 InterPro protein domains:
     IPR001440 TPR_1
     IPR011990 TPR-like_helical
     IPR025986 RPAP3-like_C
     IPR013026 TPR-contain_dom
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry Q07617

    ProtoNet protein and cluster: Q07617

    UniProtKB/Swiss-Prot: SPAG1_HUMAN, Q07617
    Similarity: Contains 9 TPR repeats


    Find genes that share domains with SPAG1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPAG1_HUMAN, Q07617
    Function: Plays a role in fertilization. Binds GTP and has GTPase activity

         Genatlas biochemistry entry for SPAG1:
    sperm associated antigen 1,75kDa

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005525GTP binding IEA--
    GO:0016787hydrolase activity IEA--
         
    Find genes that share ontologies with SPAG1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SPAG1:
     G0/1 arrest  Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPAG1
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    Block miRNA regulation of human, mouse, rat SPAG1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate SPAG1:
    hsa-miR-569 hsa-miR-182 hsa-miR-103b hsa-miR-2116 hsa-miR-34b hsa-miR-3674 hsa-miR-628-3p
    SwitchGear 3'UTR luciferase reporter plasmidSPAG1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPAG1_HUMAN, Q07617: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton3
    cytosol3
    nucleus3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0015630microtubule cytoskeleton IDA--

    Find genes that share ontologies with SPAG1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPAG1
    Interactions:

        GeneGlobe Interaction Network for SPAG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for SPAG1 (Q076173 ENSP000002518094) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKCAP172523, ENSP000002843844I2D: score=1 STRING: ENSP00000284384
    PCNAP120043I2D: score=1 
    RUVBL1ENSP000003182974STRING: ENSP00000318297
    RUVBL2ENSP000002214134STRING: ENSP00000221413
    DNAAF2ENSP000002982924STRING: ENSP00000298292
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007338single fertilization IEA--
    GO:0070286axonemal dynein complex assembly ISS--

    Find genes that share ontologies with SPAG1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPAG1

    1 HMDB Compound for SPAG1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SPAG1 gene (2 alternative transcripts): 
    NM_003114.4  NM_172218.2  

    Unigene Cluster for SPAG1:

    Sperm associated antigen 1
    Hs.591866  [show with all ESTs]
    Unigene Representative Sequence: NM_003114
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000520643(uc003yjg.1) ENST00000520508 ENST00000388798(uc003yji.2)
    ENST00000523302 ENST00000519424 ENST00000519409 ENST00000251809(uc003yjh.2)

    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate SPAG1:
    hsa-miR-569 hsa-miR-182 hsa-miR-103b hsa-miR-2116 hsa-miR-34b hsa-miR-3674 hsa-miR-628-3p
    SwitchGear 3'UTR luciferase reporter plasmidSPAG1 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat SPAG1

    Additional mRNA sequence: 

    AF311312.1 AK057482.1 BC055091.1 

    9 DOTS entries:

    DT.409321  DT.100754381  DT.75104704  DT.121481029  DT.75173562  DT.91965403  DT.101969872  DT.100667507 
    DT.100783746 

    Selected AceView cDNA sequences (see all 51):

    CB161106 BF739945 AK057482 BM981630 NM_003114 AI167655 CB321799 AI452902 
    BX117722 BM557203 NM_172218 AA400424 AW589648 AI624411 AL079394 AI559507 
    CD357612 CA423307 AW592742 BM479815 AW854258 AF311312 AL079393 AI239514 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SPAG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGAAAGCTC
    SPAG1 Expression
    About this image

    SPAG1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPAG1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591866

    UniProtKB/Swiss-Prot: SPAG1_HUMAN, Q07617
    Tissue specificity: Detected in sperm and testis, in particular in pachytene primary spermatocytes

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SPAG1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spag11 , 5 sperm associated antigen 11, 5 77.03(n)1
    71.94(a)1
      15 (14.46 cM)5
    269421  NM_012031.31  NP_036161.21 
     361795305 
    chicken
    (Gallus gallus)
    Aves SPAG11 sperm associated antigen 1 64.69(n)
    56.03(a)
      420249  XM_418360.4  XP_418360.4 
    lizard
    (Anolis carolinensis)
    Reptilia SPAG16
    sperm associated antigen 1
    51(a)
    1 ↔ 1
    GL343394.1(256005-295486)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.44272 Xenopus laevis transcribed sequence with weak similarity more 71.18(n)    CA973487.1 
    zebrafish
    (Danio rerio)
    Actinopterygii spag1a1 sperm associated antigen 1a 62.77(n)
    58.76(a)
      564953  NM_001089406.2  NP_001082875.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG184721 CG18472 48.88(n)
    38.02(a)
      43239  NM_143257.2  NP_651514.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TOM716
    TOM706
    Mitochondrial outer membrane protein with similari...
    Component of the TOM (translocase of outer membran...
    16(a)
    16(a)
    many ↔ many
    many ↔ many
    VIII(342349-344268) YHR117W
    XIV(398684-400537) YNL121C


    ENSEMBL Gene Tree for SPAG1 (if available)
    TreeFam Gene Tree for SPAG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SPAG1 gene
    TOMM70A2  TTC12  TOMM342  UNC45A2  UNC45B2  
    1 SIMAP similar gene for SPAG1 using alignment to 2 protein entries:     SPAG1_HUMAN (see all proteins):
    TOMM34

    Find genes that share paralogs with SPAG1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SPAG1 (see all 1551)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs31334071,2
    H--96371062(+) ATAAGC/GTTTGT 1 -- us2k14Minor allele frequency- G:0.00NS EA 414
    rs31041971,2
    C,F,O,A,H--96371086(+) GTGGCA/GTGGTT 1 -- us2k122Minor allele frequency- N:0.00NS EA NA WA CSA 1426
    rs1881893641,2
    --101168304(+) ATTACC/TGAAAC 1 -- us2k10--------
    rs1448740651,2
    C--101168309(+) GAAAC-/AGAGAAA 1 -- us2k10--------
    rs1460518781,2
    --101168587(+) AGACCA/GTCTGT 2 -- us2k10--------
    rs1998443941,2
    C--101168645(-) ACTTCC/TCACCA 2 -- us2k10--------
    rs732790031,2
    C,F--101168765(+) CCTGGC/GTAAGT 2 -- us2k12Minor allele frequency- G:0.05WA 120
    rs736961571,2
    C--101168855(+) AAAAAT/ATTTTT 2 -- us2k11Minor allele frequency- A:0.50WA 2
    rs744338681,2
    C--101168856(+) AAAAAA/TTTTTT 2 -- us2k10--------
    rs1135506931,2
    C,F--101168864(+) TTTTTT/CTATTT 2 -- us2k12Minor allele frequency- C:0.05WA 120

    HapMap Linkage Disequilibrium report for SPAG1 (101170134 - 101271506 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SPAG1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6329CNV Loss18451855

    Human Gene Mutation Database (HGMD): SPAG1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SPAG1
    DNA2.0 Custom Variant and Variant Library Synthesis for SPAG1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603395   
    OMIM disorders: 615505  
    4 diseases for SPAG1:    
    About MalaCards
    ciliary dyskinesia, primary, 28    myofascial pain syndrome    infertility    ciliary dyskinesia, primary, 19

    1 disease from the University of Copenhagen DISEASES database for SPAG1:
    Myofascial pain syndrome

    Find genes that share disorders with SPAG1           About GenesLikeMe

    Genetic Association Database (GAD): SPAG1

    Export disorders for SPAG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPAG1 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with SPAG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A sperm component, HSD-3.8 (SPAG1), interacts with G-protein beta 1 subunit and activates extracellular signal-regulated kinases (ERK). (PubMed id 16368546)1, 3 Liu N....Wang L. (Front. Biosci. 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Expression and function of the HSD-3.8 gene encoding a testis- specific protein. (PubMed id 11517287)1, 2 Lin W....Koide S.S. (Mol. Hum. Reprod. 2001)
    4. Isolation and sequencing of the cDNA encoding the 75-kD human sperm protein related to infertility. (PubMed id 1299558)1, 2 Zhang M.L.... Koide S.S. (Chin. Med. J. 1992)
    5. Sperm-associated antigen 1 is expressed early in pancreatic tumorigenesis and promotes motility of cancer cells. (PubMed id 16983343)1, 9 Neesse A....Crnogorac-Jurcevic T. (Oncogene 2007)
    6. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (EMBO J. 2013)
    7. Mutations in SPAG1 cause primary ciliary dyskinesia associated with defective outer and inner dynein arms. (PubMed id 24055112)1 Knowles M.R....Zariwala M.A. (Am. J. Hum. Genet. 2013)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. Proliferating cell nuclear antigen in the cytoplasm interacts with components of glycolysis and cancer. (PubMed id 20849852)1 Naryzhny S.N. and Lee H. (FEBS Lett. 2010)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6674 HGNC: 11212 AceView: SPAG1 Ensembl:ENSG00000104450 euGenes: HUgn6674
    ECgene: SPAG1 H-InvDB: SPAG1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SPAG1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SPAG1 gene:
    Search GeneIP for patents involving SPAG1

    GeneCards and IP:
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