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Aliases for SPACA9 Gene

Aliases for SPACA9 Gene

  • Sperm Acrosome Associated 9 2 3
  • C9orf9 3 4 5
  • Chromosome 9 Open Reading Frame 9 2 5
  • Rsb66 Homolog 3
  • Mast 3

External Ids for SPACA9 Gene

Previous HGNC Symbols for SPACA9 Gene

  • C9orf9

Summaries for SPACA9 Gene

GeneCards Summary for SPACA9 Gene

SPACA9 (Sperm Acrosome Associated 9) is a Protein Coding gene. Diseases associated with SPACA9 include mast syndrome.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPACA9 Gene

Genomics for SPACA9 Gene

Regulatory Elements for SPACA9 Gene

Enhancers for SPACA9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SPACA9 on UCSC Golden Path with GeneCards custom track

Promoters for SPACA9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SPACA9 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPACA9 Gene

Chromosome:
9
Start:
132,878,027 bp from pter
End:
132,890,201 bp from pter
Size:
12,175 bases
Orientation:
Plus strand

Genomic View for SPACA9 Gene

Genes around SPACA9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPACA9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPACA9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPACA9 Gene

Proteins for SPACA9 Gene

  • Protein details for SPACA9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96E40-CI009_HUMAN
    Recommended name:
    Uncharacterized protein C9orf9
    Protein Accession:
    Q96E40
    Secondary Accessions:
    • Q9UGQ0

    Protein attributes for SPACA9 Gene

    Size:
    222 amino acids
    Molecular mass:
    25166 Da
    Quaternary structure:
    • Interacts with CABP1 AND CALR.

    Alternative splice isoforms for SPACA9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPACA9 Gene

Proteomics data for SPACA9 Gene at MOPED

Post-translational modifications for SPACA9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPACA9 Gene

No data available for DME Specific Peptides for SPACA9 Gene

Domains & Families for SPACA9 Gene

Protein Domains for SPACA9 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPACA9: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SPACA9 Gene

Function for SPACA9 Gene

Gene Ontology (GO) - Molecular Function for SPACA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048306 calcium-dependent protein binding IEA --
genes like me logo Genes that share ontologies with SPACA9: view
genes like me logo Genes that share phenotypes with SPACA9: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPACA9 Gene

Localization for SPACA9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPACA9 Gene

Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=In caudal sperms localizes onto sperm head. Is also present on midpiece and principle piece of sperm tails. Acrosome and sperm tail localization is regulated by Y-chromosome. {ECO:0000250 UniProtKB:Q7TPM5}.

Gene Ontology (GO) - Cellular Components for SPACA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SPACA9: view

No data available for Subcellular locations from COMPARTMENTS for SPACA9 Gene

Pathways & Interactions for SPACA9 Gene

SuperPathways for SPACA9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPACA9 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPACA9 Gene

Drugs & Compounds for SPACA9 Gene

No Compound Related Data Available

Transcripts for SPACA9 Gene

mRNA/cDNA for SPACA9 Gene

(5) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPACA9 Gene

Chromosome 9 open reading frame 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPACA9 Gene

No ASD Table

Relevant External Links for SPACA9 Gene

GeneLoc Exon Structure for
SPACA9
ECgene alternative splicing isoforms for
SPACA9

Expression for SPACA9 Gene

SOURCE GeneReport for Unigene cluster for SPACA9 Gene Hs.62595

No Expression Related Data Available

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SPACA9 Gene

Orthologs for SPACA9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPACA9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C11H9orf9 35
  • 88.41 (n)
  • 90.85 (a)
C11H9ORF9 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C9H9orf9 35
  • 89.48 (n)
  • 91.67 (a)
C9ORF9 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700026L06Rik 35
  • 86.9 (n)
  • 91.07 (a)
Spaca9 16
1700026L06Rik 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C9H9orf9 35
  • 97.36 (n)
  • 96.34 (a)
C9orf9 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rsb66 35
  • 88.49 (n)
  • 93.45 (a)
oppossum
(Monodelphis domestica)
Mammalia C9orf9 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C9orf9 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves C9ORF9 35
  • 69.94 (n)
  • 65.64 (a)
C9ORF9 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C9orf9 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c9orf9 35
  • 63.69 (n)
  • 56.69 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:153740 35
  • 55.63 (n)
  • 50.96 (a)
C5H9orf9 36
  • 36 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 14 (a)
OneToMany
CSA.10159 36
  • 17 (a)
OneToMany
Species with no ortholog for SPACA9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPACA9 Gene

ENSEMBL:
Gene Tree for SPACA9 (if available)
TreeFam:
Gene Tree for SPACA9 (if available)

Paralogs for SPACA9 Gene

No data available for Paralogs for SPACA9 Gene

Variants for SPACA9 Gene

Sequence variations from dbSNP and Humsavar for SPACA9 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1062218 -- 132,888,694(+) TACCC(A/G)TGGAC intron-variant, utr-variant-3-prime
rs7849589 -- 132,886,891(+) actgc(A/G)gcctc intron-variant
rs7855759 -- 132,885,091(+) ctggg(C/T)gacag intron-variant
rs112978122 -- 132,890,252(+) TAGTT(-/A)AGAGA downstream-variant-500B
rs113091953 -- 132,881,167(+) ATGCT(C/T)CTAAT intron-variant

Variation tolerance for SPACA9 Gene

Residual Variation Intolerance Score: 65.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPACA9 Gene

HapMap Linkage Disequilibrium report
SPACA9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SPACA9 Gene

Disorders for SPACA9 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SPACA9 Gene - From: OMIM

Disorder Aliases PubMed IDs
mast syndrome
  • autosomal recessive spastic paraplegia 21
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SPACA9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPACA9
genes like me logo Genes that share disorders with SPACA9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPACA9 Gene

Publications for SPACA9 Gene

  1. A mouse protein that localizes to acrosome and sperm tail is regulated by Y-chromosome. (PMID: 24256100) Bhattacharya R. … Jesudasan R.A. (BMC Cell Biol. 2013) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis. (PMID: 23264731) Fong K.W. … Chen J. (J. Cell Sci. 2013) 3
  5. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. (PMID: 21048031) Casabonne D. … de Sanjose S. (Haematologica 2011) 3

Products for SPACA9 Gene

Sources for SPACA9 Gene

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