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Aliases for SPACA9 Gene

Aliases for SPACA9 Gene

  • Sperm Acrosome Associated 9 2 3 5
  • C9orf9 3 4
  • Sperm Acrosome-Associated Protein 9 3
  • Chromosome 9 Open Reading Frame 9 2
  • Rsb66 Homolog 3
  • Mast 3

External Ids for SPACA9 Gene

Previous HGNC Symbols for SPACA9 Gene

  • C9orf9

Summaries for SPACA9 Gene

GeneCards Summary for SPACA9 Gene

SPACA9 (Sperm Acrosome Associated 9) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPACA9 Gene

Genomics for SPACA9 Gene

Regulatory Elements for SPACA9 Gene

Enhancers for SPACA9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F132901 0.6 ENCODE 11.8 +23.8 23840 0.8 ATF1 TBL1XR1 WRNIP1 ARID4B ZNF2 RAD21 RFX5 ZNF143 RCOR1 CREM SPACA9 AK8 TSC1 PIR193201 PIR60978
GH09F132903 0.5 ENCODE 11.8 +25.8 25845 0.5 ZNF316 MAFG EMSY MAFK AK8 SPACA9 PIR193201 PIR60978
GH09F132908 0.2 ENCODE 11.7 +30.8 30792 0.1 ZNF362 AK8 SPACA9 TSC1 GFI1B RNU7-21P RPL39P24 PIR193201 PIR60978
GH09F132937 0.2 Ensembl 11.2 +59.8 59774 0.4 BCOR SMARCE1 NR2F1 ZMYM3 DPF2 ARID1B ATF3 SMARCA4 FOS TRIM24 RPL39P24 RNU7-21P SPACA9 AK8 GFI1B PIR193201
GH09F132806 0.2 ENCODE 11 -70.8 -70761 0.8 GATA3 PKNOX1 CTBP1 TEAD4 ZIC2 PRDM1 EGR2 SPACA9 AK8 GFI1B PIR47443
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SPACA9 on UCSC Golden Path with GeneCards custom track

Promoters for SPACA9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001316651 573 2001 ATF1 CREB3L1 ARID4B SIN3A YBX1 ZNF48 BRCA1 ZNF121 GLIS2 ELK1

Genomic Location for SPACA9 Gene

Chromosome:
9
Start:
132,878,027 bp from pter
End:
132,890,201 bp from pter
Size:
12,175 bases
Orientation:
Plus strand

Genomic View for SPACA9 Gene

Genes around SPACA9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPACA9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPACA9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPACA9 Gene

Proteins for SPACA9 Gene

  • Protein details for SPACA9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96E40-SACA9_HUMAN
    Recommended name:
    Sperm acrosome-associated protein 9
    Protein Accession:
    Q96E40
    Secondary Accessions:
    • Q9UGQ0

    Protein attributes for SPACA9 Gene

    Size:
    222 amino acids
    Molecular mass:
    25166 Da
    Quaternary structure:
    • Interacts with CABP1 AND CALR.

    Alternative splice isoforms for SPACA9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPACA9 Gene

Post-translational modifications for SPACA9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPACA9 Gene

No data available for DME Specific Peptides for SPACA9 Gene

Domains & Families for SPACA9 Gene

Protein Domains for SPACA9 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPACA9: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SPACA9 Gene

Function for SPACA9 Gene

Gene Ontology (GO) - Molecular Function for SPACA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0048306 calcium-dependent protein binding IEA --
genes like me logo Genes that share ontologies with SPACA9: view
genes like me logo Genes that share phenotypes with SPACA9: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPACA9 Gene

Localization for SPACA9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPACA9 Gene

Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=In caudal sperms localizes onto sperm head. Is also present on midpiece and principle piece of sperm tails. Acrosome and sperm tail localization is regulated by Y-chromosome. {ECO:0000250 UniProtKB:Q7TPM5}.

Gene Ontology (GO) - Cellular Components for SPACA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005737 cytoplasm IEA --
GO:0005881 cytoplasmic microtubule IDA 23264731
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with SPACA9: view

No data available for Subcellular locations from COMPARTMENTS for SPACA9 Gene

Pathways & Interactions for SPACA9 Gene

SuperPathways for SPACA9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPACA9 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPACA9 Gene

Transcripts for SPACA9 Gene

mRNA/cDNA for SPACA9 Gene

(5) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPACA9 Gene

Chromosome 9 open reading frame 9:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPACA9 Gene

No ASD Table

Relevant External Links for SPACA9 Gene

GeneLoc Exon Structure for
SPACA9
ECgene alternative splicing isoforms for
SPACA9

Expression for SPACA9 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPACA9 Gene:

SPACA9

SOURCE GeneReport for Unigene cluster for SPACA9 Gene:

Hs.62595
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SPACA9 Gene

Orthologs for SPACA9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPACA9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C9orf9 35
  • 99 (a)
OneToOne
C9H9orf9 34
  • 97.36 (n)
dog
(Canis familiaris)
Mammalia C9H9orf9 34
  • 89.48 (n)
C9ORF9 35
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rsb66 34
  • 88.49 (n)
cow
(Bos Taurus)
Mammalia C11H9orf9 34
  • 88.41 (n)
C11H9ORF9 35
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700026L06Rik 34 35
  • 86.9 (n)
Spaca9 16
oppossum
(Monodelphis domestica)
Mammalia C9orf9 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C9orf9 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves C9ORF9 34 35
  • 69.94 (n)
lizard
(Anolis carolinensis)
Reptilia C9orf9 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c9orf9 34
  • 63.69 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:153740 34
  • 55.63 (n)
C5H9orf9 35
  • 36 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10159 35
  • 17 (a)
OneToMany
-- 35
  • 14 (a)
OneToMany
Species where no ortholog for SPACA9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPACA9 Gene

ENSEMBL:
Gene Tree for SPACA9 (if available)
TreeFam:
Gene Tree for SPACA9 (if available)

Paralogs for SPACA9 Gene

No data available for Paralogs for SPACA9 Gene

Variants for SPACA9 Gene

Sequence variations from dbSNP and Humsavar for SPACA9 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1062218 -- 132,888,694(+) TACCC(A/G)TGGAC intron-variant, nc-transcript-variant, utr-variant-3-prime
rs10901218 -- 132,876,472(+) AGTAG(C/T)GGTTA intron-variant, upstream-variant-2KB
rs111227014 -- 132,888,789(+) TTGAG(A/G)CGGAG intron-variant, nc-transcript-variant, utr-variant-3-prime
rs111237224 -- 132,887,181(+) TCCAT(C/G)TATAG intron-variant
rs111332020 -- 132,890,035(+) CTCTC(C/T)GCCTG intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SPACA9 Gene

Variant ID Type Subtype PubMed ID
esv2671227 CNV deletion 23128226
esv2739138 CNV deletion 23290073
esv2739146 CNV deletion 23290073
esv3397210 CNV duplication 20981092
esv3545558 CNV deletion 23714750
esv3621925 CNV loss 21293372
esv3621926 CNV loss 21293372
esv3621927 CNV gain 21293372
nsv831743 CNV loss 17160897

Variation tolerance for SPACA9 Gene

Residual Variation Intolerance Score: 65.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPACA9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPACA9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPACA9 Gene

Disorders for SPACA9 Gene

Relevant External Links for SPACA9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPACA9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPACA9

No disorders were found for SPACA9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPACA9 Gene

Publications for SPACA9 Gene

  1. A mouse protein that localizes to acrosome and sperm tail is regulated by Y-chromosome. (PMID: 24256100) Bhattacharya R. … Jesudasan R.A. (BMC Cell Biol. 2013) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for SPACA9 Gene

Sources for SPACA9 Gene

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