SPACA7 Gene
protein-coding GIFtS: 36
GCID: GC13P113031
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sperm acrosome associated 7(Previous name: chromosome 13 open reading frame 28 )
(Previous symbol: C13orf28)
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Aliases
for SPACA7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sperm Acrosome Associated 71 2 | | C13orf281 2 3 | | Sperm Acrosome-Associated Protein 72 3 | | Chromosome 13 Open Reading Frame 281 | | Protein SPACA72 |
Export aliases for SPACA7 gene to outside databases |
Summaries
for SPACA7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SPACA7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_027140.6
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for SPACA7
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPACA7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPACA7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q34 Ensembl cytogenetic band: 13q34 HGNC cytogenetic band: 13q34SPACA7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13P113031: view genomic region
(about GC identifiers)
Start:
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113,030,633 bp from pter |
End:
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113,089,009 bp from pter |
Size:
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58,377 bases |
Orientation:
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plus strand |
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Proteins
for SPACA7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPAC7_HUMAN, Q96KW9 (See
protein sequence)Recommended Name: Protein SPACA7 precursor Size: 195 amino acids; 21466 Da
Subcellular location: Secreted (Potential)
Secondary accessions: Q5T8L1Explore the universe of human proteins at neXtProt for SPACA7: NX_Q96KW9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96KW9
SPACA7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_660291.2
ENSEMBL proteins: ENSP00000283550 ENSP00000416096 ENSP00000406733 ENSP00000364851
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001669 | acrosomal vesicle |
IDA | -- | | GO:0005576 | extracellular region |
IEA | -- |
SPACA7 for ontologies About GeneDecksing
SPACA7 Antibody Products:
Assay Products for SPACA7: |
Protein
Domains /
Families
for SPACA7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q96KW9 |
Function
for SPACA7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPACA7 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPACA7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SPACA7 (NM_145248) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPACA7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPACA7 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPACA7 |
1 GenomeRNAi human phenotype for SPACA7:
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Pathways & Interactions
for SPACA7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPACA7
|
Drugs & Compounds
for SPACA7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPACA7
Search CenterWatch for drugs/clinical trials and news about SPACA7 / SPAC7
|
Transcripts
for SPACA7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPACA7 gene: NM_145248.4 Unigene Cluster for SPACA7: Sperm acrosome associated 7 Hs.97592 [show with all ESTs]Unigene Representative Sequence: BM9081244 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000283550(uc001vsd.2) ENST00000414180 ENST00000443541 ENST00000375699
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPACA7 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPACA7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPACA7 (NM_145248) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPACA7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPACA7 |
Additional cDNA sequence: AK130866.1 BC016750.2 2 DOTS entries: DT.109770 DT.91914851 24/26 AceView cDNA sequences (see all 26): AA399394 AI207157 CR594241 NM_145248 AK130866 BC016750 AA398222 AA417031 BP369564 BM908124 AW629296 BP370514 BF979983 BG720974 BG771679 BX379455 BX379456 AI219896 AI004132 AA417153 BG037176 AW629288 AA844666 AI003920
GeneLoc Exon Structure
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Expression
for SPACA7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPACA7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCGATCCTTC
About this image
See SPACA7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPACA7
SOURCE GeneReport for Unigene cluster: Hs.97592
SABiosciences Custom PCR Arrays for SPACA7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPACA7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPACA7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPACA7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPACA7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPACA7 |
Orthologs
for SPACA7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for SPACA7 gene from 1/3 species (see all 3) About this table
ENSEMBL Gene Tree for SPACA7 (if available)
TreeFam Gene Tree for SPACA7 (if available) |
Paralogs
for SPACA7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SPACA7 gene
SPACA7 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SPACA7
PGOHUM00000248493
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Genomic Variants
for SPACA7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SPACA7 (113030633 - 113089009 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SPACA7: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPACA7 |
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Disorders
/ Diseases
for SPACA7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for SPACA7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPACA7 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SPACA7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
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External Searches for SPACA7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SPACA7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing SPACA7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPACA7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPACA7 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SPACA7 gene:
Search GeneIP for patents involving SPACA7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPACA7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPACA7 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPACA7 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPACA7 | | | OriGene Protein Over-expression Lysate for SPACA7 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPACA7 | | OriGene 3'-UTR Clone for SPACA7 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPACA7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPACA7 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SPACA7 | | OriGene Custom Protein Services for SPACA7 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPACA7 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPACA7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPACA7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPACA7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPACA7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPACA7 |
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 |  |  |  | |
| | | | Search Tocris compounds for SPACA7 |
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 | | | SPACA7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPACA7 |
|  |  |  | | | | Search ThermoFisher Antibodies for SPACA7 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPACA7 |
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