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SPACA7 Gene

protein-coding   GIFtS: 36
GCID: GC13P113031

Sperm Acrosome Associated 7

(Previous name: chromosome 13 open reading frame 28)
(Previous symbol: C13orf28)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sperm Acrosome Associated 71 2
C13orf281 2 3
Sperm Acrosome-Associated Protein 72 3
Chromosome 13 Open Reading Frame 281
Protein SPACA72

External Ids:    HGNC: 295751   Entrez Gene: 1222582   Ensembl: ENSG000001534987   UniProtKB: Q96KW93   

Export aliases for SPACA7 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SPACA7 Gene:
SPACA7 (sperm acrosome associated 7) is a protein-coding gene. Diseases associated with SPACA7 include breast and colorectal cancer, and colorectal cancer.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NT_027140.7  NT_187592.1  NC_018924.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SPACA7
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SPACA7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPACA7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

SPACA7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPACA7 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P113031:  view genomic region     (about GC identifiers)

Start:
113,030,633 bp from pter      End:
113,089,009 bp from pter
Size:
58,377 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SPAC7_HUMAN, Q96KW9 (See protein sequence)
Recommended Name: Protein SPACA7 precursor  
Size: 195 amino acids; 21466 Da
Secondary accessions: Q5T8L1

Explore the universe of human proteins at neXtProt for SPACA7: NX_Q96KW9

Explore proteomics data for SPACA7 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn62, Asn159

  • See SPACA7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_660291.2  
    ENSEMBL proteins: 
     ENSP00000283550   ENSP00000416096   ENSP00000406733   ENSP00000364851  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q96KW9


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for SPACA7:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPACA7
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPAC7_HUMAN, Q96KW9: Secreted (Potential)

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IDA--
    GO:0005576extracellular region IEA--

    SPACA7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPACA7
    Interactions:

        Search GeneGlobe Interaction Network for SPACA7

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPACA7 (SPAC7)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SPACA7 gene: 
    NM_145248.4  

    Unigene Cluster for SPACA7:

    Sperm acrosome associated 7
    Hs.97592  [show with all ESTs]
    Unigene Representative Sequence: BM908124
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000283550(uc001vsd.2) ENST00000414180 ENST00000443541 ENST00000375699

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    Additional mRNA sequence: 

    AK130866.1 BC016750.2 

    2 DOTS entries:

    DT.109770  DT.91914851 

    Selected AceView cDNA sequences (see all 26):

    AI207157 AA399394 CR594241 AA417031 AK130866 BP369564 AW629296 AA398222 
    BP370514 BM908124 NM_145248 BG720974 BF979983 BC016750 AW629288 AI219896 
    BX379456 BG771679 BG037176 AI004132 BX379455 AA417153 AI003920 AA844666 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SPACA7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGATCCTTC
    SPACA7 Expression
    About this image

    SPACA7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPACA7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.97592
        Custom PCR Arrays for SPACA7
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for SPACA7 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spaca71 , 5 sperm acrosome associated 71, 5 64.3(n)1
    44.97(a)1
      8 (5.73 cM)5
    786341  NM_024279.21  NP_077241.11 
     125730495 


    ENSEMBL Gene Tree for SPACA7 (if available)
    TreeFam Gene Tree for SPACA7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SPACA7 gene

    SPACA7 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SPACA7
    PGOHUM00000248493


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SPACA7 (see all 1455)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356754
    A colorectal cancer sample4--see VAR_0356752 R W mis40--------
    rs1500566701,2
    --113028677(+) GCCTCA/GGACAT 1 -- us2k10--------
    rs79851921,2
    C,F,A,H--113028741(+) AAGCAA/GTCACA 1 -- us2k127Minor allele frequency- G:0.17NS EA NA WA 2948
    rs1454273091,2
    --113028774(+) AGCTTC/TGGGCA 1 -- us2k10--------
    rs1425313851,2
    C--113028820(+) GAGGCC/TCCTCT 1 -- us2k10--------
    rs12780181,2
    C,A--113028850(-) GGGGGC/TGAGGC 1 -- us2k14Minor allele frequency- T:0.24NA WA 242
    rs93242931,2
    C,F,H--113028913(+) CCTTAG/CCCAGA 1 -- us2k1 tfbs39Minor allele frequency- C:0.08NS EA NA WA CSA 545
    rs1821215441,2
    --113028930(+) TCCTTA/GGTGCA 1 -- us2k10--------
    rs1177715981,2
    C,F--113028944(+) GGTGTC/TGTTCG 1 -- us2k11Minor allele frequency- T:0.06NA 120
    rs767893341,2
    --113029091(+) TCTCAC/TTTGGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SPACA7 (113030633 - 113089009 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SPACA7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv901038CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SPACA7
    DNA2.0 Custom Variant and Variant Library Synthesis for SPACA7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for SPACA7:    
    About MalaCards
    breast and colorectal cancer    colorectal cancer


    SPACA7 for disorders           About GeneDecksing


    Export disorders for SPACA7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPACA7 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SPACA7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a new mouse sperm acrosome-associated protein. (PubMed id 22495889)1, 3 Korfanty J....Widlak W. (Reproduction 2012)
    2. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 122258 HGNC: 29575 AceView: LOC122258 Ensembl:ENSG00000153498 euGenes: HUgn122258
    ECgene: SPACA7 H-InvDB: SPACA7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SPACA7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SPACA7 gene:
    Search GeneIP for patents involving SPACA7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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