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Aliases for SPACA7 Gene

Aliases for SPACA7 Gene

  • Sperm Acrosome Associated 7 2 3 5
  • C13orf28 3 4
  • Chromosome 13 Open Reading Frame 28 2
  • Protein SPACA7 3

External Ids for SPACA7 Gene

Previous HGNC Symbols for SPACA7 Gene

  • C13orf28

Previous GeneCards Identifiers for SPACA7 Gene

  • GC13P113031

Summaries for SPACA7 Gene

GeneCards Summary for SPACA7 Gene

SPACA7 (Sperm Acrosome Associated 7) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SPACA7 Gene

  • Involved in fertilization. Seems not to play a direct role in sperm-egg binding or gamete fusion.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPACA7 Gene

Genomics for SPACA7 Gene

Genomic Location for SPACA7 Gene

Chromosome:
13
Start:
112,375,881 bp from pter
End:
112,434,695 bp from pter
Size:
58,815 bases
Orientation:
Plus strand

Genomic View for SPACA7 Gene

Genes around SPACA7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPACA7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPACA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPACA7 Gene

No data available for Regulatory Elements for SPACA7 Gene

Proteins for SPACA7 Gene

  • Protein details for SPACA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KW9-SPAC7_HUMAN
    Recommended name:
    Sperm acrosome-associated protein 7
    Protein Accession:
    Q96KW9
    Secondary Accessions:
    • Q5T8L1

    Protein attributes for SPACA7 Gene

    Size:
    195 amino acids
    Molecular mass:
    21466 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPACA7 Gene

Proteomics data for SPACA7 Gene at MOPED

Post-translational modifications for SPACA7 Gene

  • Glycosylation at Asn 62 and Asn 159
  • Modification sites at PhosphoSitePlus

Other Protein References for SPACA7 Gene

No data available for DME Specific Peptides for SPACA7 Gene

Domains & Families for SPACA7 Gene

Protein Domains for SPACA7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPACA7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPACA7: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SPACA7 Gene

Function for SPACA7 Gene

Molecular function for SPACA7 Gene

UniProtKB/Swiss-Prot Function:
Involved in fertilization. Seems not to play a direct role in sperm-egg binding or gamete fusion.

Phenotypes for SPACA7 Gene

genes like me logo Genes that share phenotypes with SPACA7: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPACA7 Gene

Localization for SPACA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPACA7 Gene

Secreted. Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasmic vesicle, secretory vesicle, acrosome lumen. Note=Localized in perinuclear pro-acrosomal granules in round spermatides. Localized between the inner and outer acrosomal membranes (matrix or lumen) in spermatozoa. Secreted during acrosome exocytosis. {ECO:0000250 UniProtKB:Q9D2S4}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPACA7 Gene COMPARTMENTS Subcellular localization image for SPACA7 gene
Compartment Confidence
extracellular 4
lysosome 3
vacuole 3
cytosol 1
golgi apparatus 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for SPACA7 Gene

Pathways & Interactions for SPACA7 Gene

SuperPathways for SPACA7 Gene

No Data Available

Interacting Proteins for SPACA7 Gene

Gene Ontology (GO) - Biological Process for SPACA7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPACA7 Gene

Drugs & Compounds for SPACA7 Gene

No Compound Related Data Available

Transcripts for SPACA7 Gene

Unigene Clusters for SPACA7 Gene

Sperm acrosome associated 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPACA7 Gene

No ASD Table

Relevant External Links for SPACA7 Gene

GeneLoc Exon Structure for
SPACA7
ECgene alternative splicing isoforms for
SPACA7

Expression for SPACA7 Gene

mRNA expression in normal human tissues for SPACA7 Gene

mRNA differential expression in normal tissues according to GTEx for SPACA7 Gene

This gene is overexpressed in Testis (x52.8).

SOURCE GeneReport for Unigene cluster for SPACA7 Gene Hs.97592

mRNA Expression by UniProt/SwissProt for SPACA7 Gene

Q96KW9-SPAC7_HUMAN
Tissue specificity: Expressed in spermatozoa (at protein level) (PubMed:22495889).
genes like me logo Genes that share expression patterns with SPACA7: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SPACA7 Gene

Orthologs for SPACA7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPACA7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SPACA7 35
  • 60.91 (n)
  • 38.1 (a)
dog
(Canis familiaris)
Mammalia SPACA7 35
  • 72.11 (n)
  • 47.71 (a)
mouse
(Mus musculus)
Mammalia Spaca7 35
  • 64.3 (n)
  • 44.97 (a)
Spaca7 16
Spaca7 36
  • 41 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SPACA7 35
  • 97.95 (n)
  • 95.38 (a)
SPACA7 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spaca7 35
  • 64.16 (n)
  • 47.26 (a)
Species with no ortholog for SPACA7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPACA7 Gene

ENSEMBL:
Gene Tree for SPACA7 (if available)
TreeFam:
Gene Tree for SPACA7 (if available)

Paralogs for SPACA7 Gene

Pseudogenes.org Pseudogenes for SPACA7 Gene

genes like me logo Genes that share paralogs with SPACA7: view

No data available for Paralogs for SPACA7 Gene

Variants for SPACA7 Gene

Sequence variations from dbSNP and Humsavar for SPACA7 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
VAR_030260 -
VAR_035675 A colorectal cancer sample

Structural Variations from Database of Genomic Variants (DGV) for SPACA7 Gene

Variant ID Type Subtype PubMed ID
nsv901038 CNV Loss 21882294

Variation tolerance for SPACA7 Gene

Residual Variation Intolerance Score: 67.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPACA7 Gene

HapMap Linkage Disequilibrium report
SPACA7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPACA7 Gene

Disorders for SPACA7 Gene

Relevant External Links for SPACA7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPACA7

No disorders were found for SPACA7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPACA7 Gene

Publications for SPACA7 Gene

  1. Identification of a new mouse sperm acrosome-associated protein. (PMID: 22495889) Korfanty J. … Widlak W. (Reproduction 2012) 2 3 4 67
  2. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  4. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. (PMID: 19490893) Luo J. … Elledge S.J. (Cell 2009) 3
  5. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3

Products for SPACA7 Gene

Sources for SPACA7 Gene

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