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Aliases for SPACA7 Gene

Aliases for SPACA7 Gene

  • Sperm Acrosome Associated 7 2 3 5
  • C13orf28 3 4
  • Chromosome 13 Open Reading Frame 28 2
  • Sperm Acrosome-Associated Protein 7 3
  • Protein SPACA7 3

External Ids for SPACA7 Gene

Previous HGNC Symbols for SPACA7 Gene

  • C13orf28

Previous GeneCards Identifiers for SPACA7 Gene

  • GC13P113031

Summaries for SPACA7 Gene

GeneCards Summary for SPACA7 Gene

SPACA7 (Sperm Acrosome Associated 7) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SPACA7 Gene

  • Involved in fertilization. Seems not to play a direct role in sperm-egg binding or gamete fusion.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPACA7 Gene

Genomics for SPACA7 Gene

Regulatory Elements for SPACA7 Gene

Enhancers for SPACA7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F113214 1.4 FANTOM5 Ensembl ENCODE 12.4 +840.1 840131 2.8 HDAC1 ATF1 PKNOX1 ARID4B THRB RFX5 ZNF366 SCRT2 CREM ZBTB2 PROZ LINC01043 SPACA7 LINC01044 LINC00454 LDHBP1 GRTP1 ADPRHL1 PCID2 MCF2L
GH13F112346 0.9 ENCODE 19 -29.5 -29480 0.2 PKNOX1 ZNF76 KLF17 FEZF1 ZNF2 ZEB1 ZNF121 GLIS2 ZNF366 SCRT2 SPACA7 LOC102724489 LOC105370369 LINC01043 LINC01044 LDHBP1
GH13F113296 1.2 ENCODE 12.4 +921.8 921842 2.5 CREB3L1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZNF610 TUBGCP3 LINC01043 GAS6-AS1 SPACA7 GAS6-AS2 LINC01044 LAMP1 LINC00454 LDHBP1 DCUN1D2-AS
GH13F113206 1.2 ENCODE 12.4 +833.0 832961 5.0 PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TUBGCP3 PROZ TMEM255B F10 LINC01043 SPACA7 LINC01044 LINC00454 LDHBP1 GAS6-AS1
GH13F112586 1.1 ENCODE 12.5 +212.0 211957 2.8 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 TUBGCP3 LOC102724489 LOC105370369 LINC01043 F10 SPACA7 LINC01044 LDHBP1 DCUN1D2-AS GC13P112588
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPACA7 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPACA7 Gene

Chromosome:
13
Start:
112,375,881 bp from pter
End:
112,434,695 bp from pter
Size:
58,815 bases
Orientation:
Plus strand

Genomic View for SPACA7 Gene

Genes around SPACA7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPACA7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPACA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPACA7 Gene

Proteins for SPACA7 Gene

  • Protein details for SPACA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KW9-SPAC7_HUMAN
    Recommended name:
    Sperm acrosome-associated protein 7
    Protein Accession:
    Q96KW9
    Secondary Accessions:
    • Q5T8L1

    Protein attributes for SPACA7 Gene

    Size:
    195 amino acids
    Molecular mass:
    21466 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPACA7 Gene

Post-translational modifications for SPACA7 Gene

  • Glycosylation at Asn 62 and Asn 159
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SPACA7 Gene

Domains & Families for SPACA7 Gene

Protein Domains for SPACA7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPACA7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPACA7: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SPACA7 Gene

Function for SPACA7 Gene

Molecular function for SPACA7 Gene

UniProtKB/Swiss-Prot Function:
Involved in fertilization. Seems not to play a direct role in sperm-egg binding or gamete fusion.

Phenotypes for SPACA7 Gene

genes like me logo Genes that share phenotypes with SPACA7: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPACA7 Gene

Localization for SPACA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPACA7 Gene

Secreted. Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasmic vesicle, secretory vesicle, acrosome lumen. Note=Localized in perinuclear pro-acrosomal granules in round spermatides. Localized between the inner and outer acrosomal membranes (matrix or lumen) in spermatozoa. Secreted during acrosome exocytosis. {ECO:0000250 UniProtKB:Q9D2S4}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPACA7 gene
Compartment Confidence
extracellular 4
lysosome 3
nucleus 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SPACA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IDA 22495889
GO:0005576 extracellular region IEA --
GO:0031410 cytoplasmic vesicle IEA --
GO:0043160 acrosomal lumen IEA --
genes like me logo Genes that share ontologies with SPACA7: view

Pathways & Interactions for SPACA7 Gene

SuperPathways for SPACA7 Gene

No Data Available

Interacting Proteins for SPACA7 Gene

Selected Interacting proteins: Q96KW9-SPAC7_HUMAN for SPACA7 Gene via IID

Symbol External ID(s) Details
HSPB1

Gene Ontology (GO) - Biological Process for SPACA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007162 negative regulation of cell adhesion IEA --
GO:0007338 single fertilization IEA,IBA --
genes like me logo Genes that share ontologies with SPACA7: view

No data available for Pathways by source and SIGNOR curated interactions for SPACA7 Gene

Transcripts for SPACA7 Gene

Unigene Clusters for SPACA7 Gene

Sperm acrosome associated 7:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPACA7 Gene

No ASD Table

Relevant External Links for SPACA7 Gene

GeneLoc Exon Structure for
SPACA7
ECgene alternative splicing isoforms for
SPACA7

Expression for SPACA7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPACA7 Gene

mRNA differential expression in normal tissues according to GTEx for SPACA7 Gene

This gene is overexpressed in Testis (x52.8).

NURSA nuclear receptor signaling pathways regulating expression of SPACA7 Gene:

SPACA7

SOURCE GeneReport for Unigene cluster for SPACA7 Gene:

Hs.97592

mRNA Expression by UniProt/SwissProt for SPACA7 Gene:

Q96KW9-SPAC7_HUMAN
Tissue specificity: Expressed in spermatozoa (at protein level) (PubMed:22495889).
genes like me logo Genes that share expression patterns with SPACA7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SPACA7 Gene

Orthologs for SPACA7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPACA7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPACA7 34 35
  • 97.95 (n)
dog
(Canis familiaris)
Mammalia SPACA7 34
  • 72.11 (n)
mouse
(Mus musculus)
Mammalia Spaca7 34 16 35
  • 64.3 (n)
rat
(Rattus norvegicus)
Mammalia Spaca7 34
  • 64.16 (n)
cow
(Bos Taurus)
Mammalia SPACA7 34
  • 60.91 (n)
Species where no ortholog for SPACA7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPACA7 Gene

ENSEMBL:
Gene Tree for SPACA7 (if available)
TreeFam:
Gene Tree for SPACA7 (if available)

Paralogs for SPACA7 Gene

Pseudogenes.org Pseudogenes for SPACA7 Gene

genes like me logo Genes that share paralogs with SPACA7: view

No data available for Paralogs for SPACA7 Gene

Variants for SPACA7 Gene

Sequence variations from dbSNP and Humsavar for SPACA7 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs376712879 A colorectal cancer sample 112,376,458(+) AGCTC(C/T)GGCCG upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs10161904 -- 112,399,869(+) AGAAG(A/T)CCCTA intron-variant
rs1034049 -- 112,411,071(+) gactg(A/G)taatt intron-variant
rs10467699 -- 112,434,850(+) GAGCT(A/C)ATAAA intron-variant, downstream-variant-500B
rs10467700 -- 112,435,158(+) TACAC(A/G)CATAC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SPACA7 Gene

Variant ID Type Subtype PubMed ID
nsv983620 CNV duplication 23825009
nsv1053676 CNV gain 25217958
nsv1050682 CNV gain 25217958
esv3633580 CNV gain 21293372
esv3633578 CNV gain 21293372
esv3633577 CNV gain 21293372

Variation tolerance for SPACA7 Gene

Residual Variation Intolerance Score: 67.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPACA7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPACA7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPACA7 Gene

Disorders for SPACA7 Gene

Relevant External Links for SPACA7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPACA7

No disorders were found for SPACA7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPACA7 Gene

Publications for SPACA7 Gene

  1. Identification of a new mouse sperm acrosome-associated protein. (PMID: 22495889) Korfanty J. … Widlak W. (Reproduction 2012) 2 3 4 64
  2. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 3 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 64

Products for SPACA7 Gene

Sources for SPACA7 Gene

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