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Aliases for SPACA7 Gene

Aliases for SPACA7 Gene

  • Sperm Acrosome Associated 7 2 3 5
  • C13orf28 3 4
  • Chromosome 13 Open Reading Frame 28 2
  • Sperm Acrosome-Associated Protein 7 3
  • Protein SPACA7 3

External Ids for SPACA7 Gene

Previous HGNC Symbols for SPACA7 Gene

  • C13orf28

Previous GeneCards Identifiers for SPACA7 Gene

  • GC13P113031

Summaries for SPACA7 Gene

GeneCards Summary for SPACA7 Gene

SPACA7 (Sperm Acrosome Associated 7) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SPACA7 Gene

  • Involved in fertilization. Seems not to play a direct role in sperm-egg binding or gamete fusion.

Additional gene information for SPACA7 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPACA7 Gene

Genomics for SPACA7 Gene

Regulatory Elements for SPACA7 Gene

Enhancers for SPACA7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13H112346 1 ENCODE 17.5 -29.5 -29480 0.2 PKNOX1 FEZF1 ZNF2 ZNF121 GLIS2 KLF7 TSHZ1 ZNF488 ZNF623 ZNF518A SPACA7 LOC102724489 LINC02337 LINC01043 LINC01044 LDHBP1
GH13H113206 1.4 ENCODE dbSUPER 10.9 +833.0 832961 5 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC TUBGCP3 PCID2 PROZ GAS6-AS1 GAS6 LINC01043 DCUN1D2-AS SPACA7 LDHBP1 LINC01044
GH13H113296 1.2 ENCODE 10.9 +921.8 921842 2.5 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZNF610 GLIS1 CDC16 PCID2 TUBGCP3 GAS6-AS2 GAS6 LINC01043 CUL4A SPACA7 LDHBP1 GAS6-AS1
GH13H112586 1.1 ENCODE 11 +212.0 211957 2.8 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 ZNF207 TUBGCP3 PCID2 LOC102724489 LINC02337 CUL4A LINC01043 SPACA7 LINC01044 LDHBP1 DCUN1D2-AS
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPACA7 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SPACA7 Gene

Genomic Locations for SPACA7 Gene
58,815 bases
Plus strand

Genomic View for SPACA7 Gene

Genes around SPACA7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPACA7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPACA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPACA7 Gene

Proteins for SPACA7 Gene

  • Protein details for SPACA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sperm acrosome-associated protein 7
    Protein Accession:
    Secondary Accessions:
    • Q5T8L1

    Protein attributes for SPACA7 Gene

    195 amino acids
    Molecular mass:
    21466 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPACA7 Gene

Post-translational modifications for SPACA7 Gene

  • Glycosylation at Asn62 and Asn159
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SPACA7 Gene

Domains & Families for SPACA7 Gene

Gene Families for SPACA7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for SPACA7 Gene


Suggested Antigen Peptide Sequences for SPACA7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPACA7: view

No data available for UniProtKB/Swiss-Prot for SPACA7 Gene

Function for SPACA7 Gene

Molecular function for SPACA7 Gene

UniProtKB/Swiss-Prot Function:
Involved in fertilization. Seems not to play a direct role in sperm-egg binding or gamete fusion.

Phenotypes From GWAS Catalog for SPACA7 Gene

Gene Ontology (GO) - Molecular Function for SPACA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003796 lysozyme activity IBA --
genes like me logo Genes that share ontologies with SPACA7: view

Phenotypes for SPACA7 Gene

genes like me logo Genes that share phenotypes with SPACA7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPACA7 Gene

Localization for SPACA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPACA7 Gene

Secreted. Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasmic vesicle, secretory vesicle, acrosome lumen. Note=Localized in perinuclear pro-acrosomal granules in round spermatides. Localized between the inner and outer acrosomal membranes (matrix or lumen) in spermatozoa. Secreted during acrosome exocytosis. {ECO:0000250 UniProtKB:Q9D2S4}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPACA7 gene
Compartment Confidence
extracellular 4
lysosome 3
nucleus 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SPACA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IDA 22495889
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
GO:0031410 cytoplasmic vesicle IEA --
GO:0043160 acrosomal lumen IEA --
genes like me logo Genes that share ontologies with SPACA7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SPACA7 Gene

Pathways & Interactions for SPACA7 Gene

SuperPathways for SPACA7 Gene

No Data Available

Interacting Proteins for SPACA7 Gene

Selected Interacting proteins: Q96KW9-SPAC7_HUMAN for SPACA7 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for SPACA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007162 negative regulation of cell adhesion IEA --
GO:0007338 single fertilization IEA --
GO:0016998 cell wall macromolecule catabolic process IBA --
GO:0050829 defense response to Gram-negative bacterium IBA --
GO:0050830 defense response to Gram-positive bacterium IBA --
genes like me logo Genes that share ontologies with SPACA7: view

No data available for Pathways by source and SIGNOR curated interactions for SPACA7 Gene

Drugs & Compounds for SPACA7 Gene

No Compound Related Data Available

Transcripts for SPACA7 Gene

Unigene Clusters for SPACA7 Gene

Sperm acrosome associated 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPACA7 Gene

No ASD Table

Relevant External Links for SPACA7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPACA7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPACA7 Gene

mRNA differential expression in normal tissues according to GTEx for SPACA7 Gene

This gene is overexpressed in Testis (x52.8).

NURSA nuclear receptor signaling pathways regulating expression of SPACA7 Gene:


SOURCE GeneReport for Unigene cluster for SPACA7 Gene:


mRNA Expression by UniProt/SwissProt for SPACA7 Gene:

Tissue specificity: Expressed in spermatozoa (at protein level) (PubMed:22495889).
genes like me logo Genes that share expression patterns with SPACA7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPACA7 Gene

Orthologs for SPACA7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPACA7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPACA7 33 34
  • 97.95 (n)
(Canis familiaris)
Mammalia SPACA7 33
  • 72.11 (n)
(Mus musculus)
Mammalia Spaca7 33 16 34
  • 64.3 (n)
(Rattus norvegicus)
Mammalia Spaca7 33
  • 64.16 (n)
(Bos Taurus)
Mammalia SPACA7 33
  • 60.91 (n)
Species where no ortholog for SPACA7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPACA7 Gene

Gene Tree for SPACA7 (if available)
Gene Tree for SPACA7 (if available)

Paralogs for SPACA7 Gene Pseudogenes for SPACA7 Gene

genes like me logo Genes that share paralogs with SPACA7: view

No data available for Paralogs for SPACA7 Gene

Variants for SPACA7 Gene

Sequence variations from dbSNP and Humsavar for SPACA7 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs376712879 A colorectal cancer sample 112,376,458(+) AGCTC(C/T)GGCCG upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs1000026196 -- 112,391,167(+) GAGTT(C/T)AGTCC intron-variant
rs1000066880 -- 112,431,913(+) TGAAC(A/T)GATTA intron-variant
rs1000157949 -- 112,405,033(+) GCAGG(A/C)GTGCA intron-variant
rs1000195009 -- 112,434,722(+) GTTAA(A/G)CCAAA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SPACA7 Gene

Variant ID Type Subtype PubMed ID
esv3633580 CNV gain 21293372
nsv1050682 CNV gain 25217958
nsv1053676 CNV gain 25217958
nsv983620 CNV duplication 23825009
esv3633578 CNV gain 21293372
esv3633577 CNV gain 21293372

Variation tolerance for SPACA7 Gene

Residual Variation Intolerance Score: 67.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPACA7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPACA7 Gene

Disorders for SPACA7 Gene

Relevant External Links for SPACA7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SPACA7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPACA7 Gene

Publications for SPACA7 Gene

  1. Identification of a new mouse sperm acrosome-associated protein. (PMID: 22495889) Korfanty J … Widlak W (Reproduction (Cambridge, England) 2012) 2 3 4 60
  2. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M … Rocchi P (Molecular & cellular proteomics : MCP 2014) 3 60
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 60

Products for SPACA7 Gene

Sources for SPACA7 Gene

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