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Aliases for SPACA6 Gene

Aliases for SPACA6 Gene

  • Sperm Acrosome Associated 6 2 2 3 5
  • Long Intergenic Non-Protein Coding RNA 85 2 3
  • Sperm Acrosome Associated 6, Pseudogene 2 3
  • BACHELOR-Like Protein 3 4
  • Let-7e Host 2 3
  • SPACA6P 3 4
  • Sperm Acrosome Membrane-Associated Protein 6 3
  • Non-Protein Coding RNA 85 2
  • NCRNA00085 3
  • LINC00085 3
  • LET7EH 3

External Ids for SPACA6 Gene

Previous HGNC Symbols for SPACA6 Gene

  • NCRNA00085
  • LINC00085
  • SPACA6P

Previous GeneCards Identifiers for SPACA6 Gene

  • GC19P051703
  • GC19P051706
  • GC19P051710

Summaries for SPACA6 Gene

GeneCards Summary for SPACA6 Gene

SPACA6 (Sperm Acrosome Associated 6) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SPACA6 Gene

  • Sperm protein potentially involved sperm-egg fusion.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPACA6 Gene

Genomics for SPACA6 Gene

Regulatory Elements for SPACA6 Gene

Enhancers for SPACA6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G051687 1.8 FANTOM5 ENCODE dbSUPER 21 -2.9 -2850 6.9 CREB3L1 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D ZNF610 ZNF808 ZNF836 ZNF616 ZNF841 ZNF137P ENSG00000268970 ZNF766 ENSG00000269825 ZNF528 ZNF175
GH19G051545 2 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -143.6 -143567 8.0 MLX CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 NFYC MEF2D NBN ZNF175 SIGLEC6 SIGLEC14 SIGLEC8 CEACAM18 SIGLEC12 RPL7P51 SIGLEC5 MIR125A MIR99B
GH19G051393 1.5 FANTOM5 ENCODE 13.5 -298.3 -298293 2.8 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ZFP64 ARID4B SIN3A YY1 ZNF143 ZNF766 ZNF577 SPACA6P-AS ZNF836 C19orf84 ZNF432 ZNF616 ZNF880 ENSG00000268015 ZNF175
GH19G051016 1.2 Ensembl ENCODE 13.4 -676.0 -675964 1.5 PKNOX1 ATF1 SIN3A GLI4 ZNF121 GLIS2 ZNF143 KLF7 SP3 REST ZNF175 ZNF615 KLK10 ZNF577 LRRC4B SPACA6 KLK13 KLK6 ZNF649 KLK14
GH19G051766 1.1 FANTOM5 13.6 +73.3 73285 0.4 ATF1 CREB3L1 MLX E2F7 ARID4B SIN3A DMAP1 ZNF48 YY1 ELK1 FPR1 FPR2 ZNF615 ZNF175 ZNF528 SPACA6 LOC100419835 SPACA6P-AS SIGLEC10 ZNF528-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPACA6 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPACA6 Gene

Chromosome:
19
Start:
51,693,340 bp from pter
End:
51,712,387 bp from pter
Size:
19,048 bases
Orientation:
Plus strand

Genomic View for SPACA6 Gene

Genes around SPACA6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPACA6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPACA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPACA6 Gene

Proteins for SPACA6 Gene

  • Protein details for SPACA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    W5XKT8-SACA6_HUMAN
    Recommended name:
    Sperm acrosome membrane-associated protein 6
    Protein Accession:
    W5XKT8
    Secondary Accessions:
    • C0H5Y6
    • Q6UWG3

    Protein attributes for SPACA6 Gene

    Size:
    324 amino acids
    Molecular mass:
    36333 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPACA6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPACA6 Gene

Post-translational modifications for SPACA6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPACA6 Gene

No data available for DME Specific Peptides for SPACA6 Gene

Domains & Families for SPACA6 Gene

Protein Domains for SPACA6 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPACA6: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SPACA6 Gene

Function for SPACA6 Gene

Molecular function for SPACA6 Gene

UniProtKB/Swiss-Prot Function:
Sperm protein potentially involved sperm-egg fusion.

Gene Ontology (GO) - Molecular Function for SPACA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SPACA6: view

Phenotypes for SPACA6 Gene

GenomeRNAi human phenotypes for SPACA6:
genes like me logo Genes that share phenotypes with SPACA6: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPACA6 Gene

Localization for SPACA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPACA6 Gene

Membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for SPACA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SPACA6: view

No data available for Subcellular locations from COMPARTMENTS for SPACA6 Gene

Pathways & Interactions for SPACA6 Gene

SuperPathways for SPACA6 Gene

No Data Available

Interacting Proteins for SPACA6 Gene

Selected Interacting proteins: W5XKT8-SACA6_HUMAN for SPACA6 Gene via UniProtKB

Symbol External ID(s) Details
BANP

Gene Ontology (GO) - Biological Process for SPACA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007342 fusion of sperm to egg plasma membrane IEA --
genes like me logo Genes that share ontologies with SPACA6: view

No data available for Pathways by source and SIGNOR curated interactions for SPACA6 Gene

Drugs & Compounds for SPACA6 Gene

No Compound Related Data Available

Transcripts for SPACA6 Gene

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPACA6 Gene

No ASD Table

Relevant External Links for SPACA6 Gene

GeneLoc Exon Structure for
SPACA6
ECgene alternative splicing isoforms for
SPACA6

Expression for SPACA6 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPACA6 Gene:

SPACA6

mRNA Expression by UniProt/SwissProt for SPACA6 Gene:

W5XKT8-SACA6_HUMAN
Tissue specificity: Expressed in testis.

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPACA6 Gene

Orthologs for SPACA6 Gene

Evolution for SPACA6 Gene

ENSEMBL:
Gene Tree for SPACA6 (if available)
TreeFam:
Gene Tree for SPACA6 (if available)

No data available for Orthologs for SPACA6 Gene

Paralogs for SPACA6 Gene

No data available for Paralogs for SPACA6 Gene

Variants for SPACA6 Gene

Sequence variations from dbSNP and Humsavar for SPACA6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000008875 -- 51,707,601(+) CAGTT(C/T)TCCAA intron-variant
rs1000024807 -- 51,701,726(+) AAGAA(A/G)GTAAA nc-transcript-variant, reference, missense
rs1000035470 -- 51,705,721(+) AGGCA(C/T)CATCT intron-variant
rs1000093001 -- 51,690,919(+) GGGGG(-/A)CGGGG intron-variant, upstream-variant-2KB
rs1000157128 -- 51,687,100(+) CTACA(C/G)AATAC nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SPACA6 Gene

Variant ID Type Subtype PubMed ID
esv2758767 CNV gain+loss 17122850
esv3644679 CNV loss 21293372
nsv1140251 OTHER inversion 24896259
nsv953608 CNV deletion 24416366
nsv9742 CNV gain+loss 18304495

Relevant External Links for SPACA6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPACA6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SPACA6 Gene

Disorders for SPACA6 Gene

Relevant External Links for SPACA6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPACA6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPACA6

No disorders were found for SPACA6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPACA6 Gene

Publications for SPACA6 Gene

  1. A transgenic insertion on mouse chromosome 17 inactivates a novel immunoglobulin superfamily gene potentially involved in sperm-egg fusion. (PMID: 24275887) Lorenzetti D. … Bishop C.E. (Mamm. Genome 2014) 2 3 4 64
  2. Pinstripe: a suite of programs for integrating transcriptomic and proteomic datasets identifies novel proteins and improves differentiation of protein-coding and non-coding genes. (PMID: 23044541) Gascoigne D.K. … Mattick J.S. (Bioinformatics 2012) 2 3 64
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64

Products for SPACA6 Gene

Sources for SPACA6 Gene

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