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Aliases for SPACA5B Gene

Aliases for SPACA5B Gene

  • Sperm Acrosome Associated 5B 2 3
  • Sperm-Specific Lysozyme-Like Protein X 3 4
  • Lysozyme-Like Protein 5 3 4
  • SLLP-X 3 4
  • EC 4
  • SPACA5A 4
  • LYZL5 4

External Ids for SPACA5B Gene

Previous GeneCards Identifiers for SPACA5B Gene

  • GC0XP047873
  • GC0XP047986

Summaries for SPACA5B Gene

GeneCards Summary for SPACA5B Gene

SPACA5B (Sperm Acrosome Associated 5B) is a Protein Coding gene. GO annotations related to this gene include lysozyme activity. An important paralog of this gene is LYZ.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPACA5B Gene

Genomics for SPACA5B Gene

Regulatory Elements for SPACA5B Gene

Genomic Location for SPACA5B Gene

48,130,657 bp from pter
48,132,613 bp from pter
1,957 bases
Plus strand

Genomic View for SPACA5B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPACA5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPACA5B Gene

Proteins for SPACA5B Gene

  • Protein details for SPACA5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sperm acrosome-associated protein 5
    Protein Accession:
    Secondary Accessions:
    • Q6UWD1

    Protein attributes for SPACA5B Gene

    159 amino acids
    Molecular mass:
    17896 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPACA5B Gene

Proteomics data for SPACA5B Gene at MOPED

Post-translational modifications for SPACA5B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPACA5B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPACA5B Gene

Domains & Families for SPACA5B Gene

Gene Families for SPACA5B Gene

Protein Domains for SPACA5B Gene

Suggested Antigen Peptide Sequences for SPACA5B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 22 family.
  • Belongs to the glycosyl hydrolase 22 family.
genes like me logo Genes that share domains with SPACA5B: view

Function for SPACA5B Gene

Molecular function for SPACA5B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins

Enzyme Numbers (IUBMB) for SPACA5B Gene

Gene Ontology (GO) - Molecular Function for SPACA5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003796 lysozyme activity IEA --
genes like me logo Genes that share ontologies with SPACA5B: view

Animal Model Products

CRISPR Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPACA5B Gene

Localization for SPACA5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPACA5B Gene

Subcellular locations from

Jensen Localization Image for SPACA5B Gene COMPARTMENTS Subcellular localization image for SPACA5B gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for SPACA5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with SPACA5B: view

Pathways & Interactions for SPACA5B Gene

SuperPathways for SPACA5B Gene

No Data Available

Interacting Proteins for SPACA5B Gene

Gene Ontology (GO) - Biological Process for SPACA5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with SPACA5B: view

No data available for Pathways by source and SIGNOR curated interactions for SPACA5B Gene

Drugs & Compounds for SPACA5B Gene

No Compound Related Data Available

Transcripts for SPACA5B Gene

mRNA/cDNA for SPACA5B Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPACA5B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPACA5B Gene

No ASD Table

Relevant External Links for SPACA5B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPACA5B Gene

mRNA expression in normal human tissues for SPACA5B Gene

Protein differential expression in normal tissues from HIPED for SPACA5B Gene

This gene is overexpressed in Ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPACA5B Gene

SOURCE GeneReport for Unigene cluster for SPACA5B Gene Hs.319319

genes like me logo Genes that share expression patterns with SPACA5B: view

Protein tissue co-expression partners for SPACA5B Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPACA5B Gene

Orthologs for SPACA5B Gene

This gene was present in the common ancestor of animals.

Orthologs for SPACA5B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SPACA5 35
  • 82.47 (n)
  • 73.38 (a)
  • 72 (a)
(Canis familiaris)
Mammalia SPACA5 35
  • 83.97 (n)
  • 78.21 (a)
-- 36
  • 75 (a)
(Mus musculus)
Mammalia Spaca5 35
  • 80.22 (n)
  • 72.26 (a)
Spaca5 36
  • 70 (a)
(Pan troglodytes)
Mammalia SPACA5B 35
  • 99.79 (n)
  • 100 (a)
-- 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Spaca5 35
  • 82.03 (n)
  • 77.92 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 51 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11159 36
  • 32 (a)
CG16756 36
  • 28 (a)
CG16799 36
  • 26 (a)
CG30062 36
  • 24 (a)
CG7798 36
  • 33 (a)
CG8492 36
  • 4 (a)
LysB 36
  • 33 (a)
LysC 36
  • 32 (a)
LysD 36
  • 32 (a)
LysE 36
  • 33 (a)
LysP 36
  • 34 (a)
LysS 36
  • 33 (a)
LysX 36
  • 32 (a)
Species with no ortholog for SPACA5B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPACA5B Gene

Gene Tree for SPACA5B (if available)
Gene Tree for SPACA5B (if available)

Paralogs for SPACA5B Gene

Paralogs for SPACA5B Gene

(7) SIMAP similar genes for SPACA5B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPACA5B: view

Variants for SPACA5B Gene

Sequence variations from dbSNP and Humsavar for SPACA5B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs571692 -- 48,131,539(-) AACTT(C/T)TCTCC intron-variant
rs145718944 -- 48,129,674(+) CACAG(C/T)GTGAC upstream-variant-2KB
rs146576176 -- 48,131,833(+) TGGTG(G/T)TGTTG intron-variant
rs147564853 -- 48,128,862(+) AGGAG(A/G)TACAT upstream-variant-2KB
rs148504381 -- 48,130,203(+) CTGTG(A/G)GGAAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SPACA5B Gene

Variant ID Type Subtype PubMed ID
dgv2442e1 CNV Complex 17122850
esv8782 OTHER Inversion 19470904
dgv2443e1 CNV Complex 17122850
nsv6890 CNV Loss 18451855
dgv14n29 CNV Complex 16826518
nsv471601 CNV Gain 15918152
nsv522886 CNV Gain 19592680
dgv2444e1 CNV Complex 17122850
esv2752324 CNV Gain 17911159
esv25781 CNV Gain 19812545
esv32909 CNV Gain+Loss 17666407
nsv515198 CNV Gain 21397061
nsv9938 CNV Gain 18304495
dgv37n14 CNV Gain 18776910
nsv517350 CNV Gain+Loss 19592680
nsv519165 CNV Loss 19592680
esv34308 CNV Gain 17911159
nsv521227 CNV Gain 19592680
nsv6892 CNV Insertion 18451855
nsv515200 CNV Complex 21397061

Relevant External Links for SPACA5B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SPACA5B Gene

Disorders for SPACA5B Gene

Relevant External Links for SPACA5B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SPACA5B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPACA5B Gene

Publications for SPACA5B Gene

  1. Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome. (PMID: 16382448) Chen Y.-T. … Jongeneel C.V. (Genes Chromosomes Cancer 2006) 2 67
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 67
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 67

Products for SPACA5B Gene

Sources for SPACA5B Gene

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