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Aliases for SPACA5 Gene

Aliases for SPACA5 Gene

  • Sperm Acrosome Associated 5 2 3 5
  • Sperm-Specific Lysozyme-Like Protein X 3 4
  • Sperm Lysozyme-Like Protein 2 2 3
  • Lysozyme-Like Protein 5 3 4
  • SLLP-X 3 4
  • LYZL5 3 4
  • Sperm Acrosome-Associated Protein 5 3
  • Testicular Tissue Protein Li 113 3
  • EC 4
  • PNPK6288 3
  • UNQ6288 3
  • SPACA5A 4
  • SLLP2 3
  • LYC5 3

External Ids for SPACA5 Gene

Previous GeneCards Identifiers for SPACA5 Gene

  • GC00U916482
  • GC0XP047750
  • GC0XP047864
  • GC0XP045698

Summaries for SPACA5 Gene

GeneCards Summary for SPACA5 Gene

SPACA5 (Sperm Acrosome Associated 5) is a Protein Coding gene. GO annotations related to this gene include lysozyme activity. An important paralog of this gene is SPACA5B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPACA5 Gene

Genomics for SPACA5 Gene

Regulatory Elements for SPACA5 Gene

Enhancers for SPACA5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF047523 1.3 FANTOM5 Ensembl ENCODE 1.2 -480.6 -480636 1.4 ATF1 CBX3 ARID4B ZNF2 RAD21 ZNF366 RCOR1 ZNF391 CREM KLF13 ZNF41 LINC01560 CDK16 USP11 ELK1 CFP SYN1 SPACA5 NUS1P1 ARAF
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SPACA5 on UCSC Golden Path with GeneCards custom track

Promoters for SPACA5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000478330 -736 2400 ATF1 ZNF133 ARID4B FEZF1 BRCA1 ZNF2 YY1 GLIS2 SP3 REST

Genomic Location for SPACA5 Gene

48,004,336 bp from pter
48,010,162 bp from pter
5,827 bases
Plus strand

Genomic View for SPACA5 Gene

Genes around SPACA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPACA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPACA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPACA5 Gene

Proteins for SPACA5 Gene

  • Protein details for SPACA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sperm acrosome-associated protein 5
    Protein Accession:
    Secondary Accessions:
    • Q6UWD1

    Protein attributes for SPACA5 Gene

    159 amino acids
    Molecular mass:
    17896 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPACA5 Gene

Post-translational modifications for SPACA5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPACA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPACA5 Gene

Domains & Families for SPACA5 Gene

Gene Families for SPACA5 Gene

Protein Domains for SPACA5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 22 family.
  • Belongs to the glycosyl hydrolase 22 family.
genes like me logo Genes that share domains with SPACA5: view

No data available for Suggested Antigen Peptide Sequences for SPACA5 Gene

Function for SPACA5 Gene

Molecular function for SPACA5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Enzyme Numbers (IUBMB) for SPACA5 Gene

Gene Ontology (GO) - Molecular Function for SPACA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003796 lysozyme activity IBA --
GO:0016787 hydrolase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
genes like me logo Genes that share ontologies with SPACA5: view

Phenotypes for SPACA5 Gene

genes like me logo Genes that share phenotypes with SPACA5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SPACA5

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPACA5 Gene

Localization for SPACA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPACA5 Gene

Gene Ontology (GO) - Cellular Components for SPACA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with SPACA5: view

No data available for Subcellular locations from COMPARTMENTS for SPACA5 Gene

Pathways & Interactions for SPACA5 Gene

SuperPathways for SPACA5 Gene

No Data Available

Interacting Proteins for SPACA5 Gene

Selected Interacting proteins: Q96QH8-LYZL5_HUMAN for SPACA5 Gene via IID

Gene Ontology (GO) - Biological Process for SPACA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0016998 cell wall macromolecule catabolic process IBA --
GO:0050829 defense response to Gram-negative bacterium IBA --
GO:0050830 defense response to Gram-positive bacterium IBA --
genes like me logo Genes that share ontologies with SPACA5: view

No data available for Pathways by source and SIGNOR curated interactions for SPACA5 Gene

Drugs & Compounds for SPACA5 Gene

(1) Drugs for SPACA5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
N-Acetyl-D-glucosamine Approved Nutra 0
genes like me logo Genes that share compounds with SPACA5: view

Transcripts for SPACA5 Gene

mRNA/cDNA for SPACA5 Gene

(2) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPACA5 Gene

No ASD Table

Relevant External Links for SPACA5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPACA5 Gene

mRNA expression in normal human tissues for SPACA5 Gene

mRNA differential expression in normal tissues according to GTEx for SPACA5 Gene

This gene is overexpressed in Testis (x25.9).

Protein differential expression in normal tissues from HIPED for SPACA5 Gene

This gene is overexpressed in Ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPACA5 Gene

Protein tissue co-expression partners for SPACA5 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPACA5 Gene:

genes like me logo Genes that share expression patterns with SPACA5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SPACA5 Gene

Orthologs for SPACA5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPACA5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 35
  • 100 (a)
  • 99.79 (n)
(Canis familiaris)
Mammalia SPACA5 34
  • 83.97 (n)
-- 35
  • 75 (a)
(Bos Taurus)
Mammalia SPACA5 34 35
  • 82.47 (n)
(Rattus norvegicus)
Mammalia Spaca5 34
  • 82.03 (n)
(Mus musculus)
Mammalia Spaca5 34 35
  • 80.22 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 51 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 43 (a)
fruit fly
(Drosophila melanogaster)
Insecta LysP 35
  • 34 (a)
CG7798 35
  • 33 (a)
LysB 35
  • 33 (a)
LysE 35
  • 33 (a)
LysS 35
  • 33 (a)
CG11159 35
  • 32 (a)
LysC 35
  • 32 (a)
LysD 35
  • 32 (a)
LysX 35
  • 32 (a)
CG16756 35
  • 28 (a)
CG16799 35
  • 26 (a)
CG30062 35
  • 24 (a)
CG8492 35
  • 4 (a)
Species where no ortholog for SPACA5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPACA5 Gene

Gene Tree for SPACA5 (if available)
Gene Tree for SPACA5 (if available)

Paralogs for SPACA5 Gene

Paralogs for SPACA5 Gene

(7) SIMAP similar genes for SPACA5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPACA5: view

Variants for SPACA5 Gene

Sequence variations from dbSNP and Humsavar for SPACA5 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs112023987 -- 48,003,439(+) TCCCA(C/G)GCCCC intron-variant, upstream-variant-2KB
rs113913823 -- 48,009,365(+) CCTCA(A/G)ACCTG splice-acceptor-variant
rs142706674 -- 48,002,574(+) AATGA(A/G)GAAAC intron-variant, upstream-variant-2KB
rs151019067 -- 48,004,295(+) AGGAA(A/G)AGATT upstream-variant-2KB
rs181120675 -- 48,002,453(+) TCTAA(A/T)TTGGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SPACA5 Gene

Variant ID Type Subtype PubMed ID
dgv17n29 CNV gain+loss 16826518
dgv2286e212 CNV gain 25503493
dgv2287e212 CNV loss 25503493
dgv37n14 CNV gain 18776910
dgv4586e59 CNV duplication 20981092
dgv4587e59 CNV duplication 20981092
esv25781 CNV gain 19812545
esv2752324 CNV gain 17911159
esv2758866 CNV gain+loss 17122850
esv32909 CNV gain+loss 17666407
esv34308 CNV gain 17911159
esv8782 OTHER inversion 19470904
nsv1119336 CNV duplication 24896259
nsv1145804 CNV duplication 26484159
nsv471601 CNV gain 15918152
nsv515198 CNV gain 21397061
nsv515200 CNV gain+loss 21397061
nsv517350 CNV gain+loss 19592680
nsv519165 CNV loss 19592680
nsv521227 CNV gain 19592680
nsv522886 CNV gain 19592680
nsv6890 CNV deletion 18451855
nsv6892 CNV insertion 18451855
nsv9938 CNV gain 18304495

Relevant External Links for SPACA5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SPACA5 Gene

Disorders for SPACA5 Gene

Relevant External Links for SPACA5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SPACA5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPACA5 Gene

Publications for SPACA5 Gene

  1. Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome. (PMID: 16382448) Chen Y.-T. … Jongeneel C.V. (Genes Chromosomes Cancer 2006) 2 3 4 64
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 4 64

Products for SPACA5 Gene

Sources for SPACA5 Gene

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