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Aliases for SPACA5 Gene

Aliases for SPACA5 Gene

  • Sperm Acrosome Associated 5 2 3 5
  • Sperm-Specific Lysozyme-Like Protein X 3 4
  • Sperm Lysozyme-Like Protein 2 2 3
  • Lysozyme-Like Protein 5 3 4
  • SLLP-X 3 4
  • LYZL5 3 4
  • Testicular Tissue Protein Li 113 3
  • SPACA5 SPACA5B 4
  • EC 3.2.1.17 4
  • PNPK6288 3
  • UNQ6288 3
  • SPACA5A 4
  • SLLP2 3
  • LYC5 3

External Ids for SPACA5 Gene

Previous GeneCards Identifiers for SPACA5 Gene

  • GC00U916482
  • GC0XP047750
  • GC0XP047864
  • GC0XP045698

Summaries for SPACA5 Gene

GeneCards Summary for SPACA5 Gene

SPACA5 (Sperm Acrosome Associated 5) is a Protein Coding gene. GO annotations related to this gene include lysozyme activity. An important paralog of this gene is SPACA5B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPACA5 Gene

Genomics for SPACA5 Gene

Regulatory Elements for SPACA5 Gene

Promoters for SPACA5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SPACA5 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPACA5 Gene

Chromosome:
X
Start:
48,004,336 bp from pter
End:
48,010,162 bp from pter
Size:
5,827 bases
Orientation:
Plus strand

Genomic View for SPACA5 Gene

Genes around SPACA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPACA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPACA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPACA5 Gene

Proteins for SPACA5 Gene

  • Protein details for SPACA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QH8-LYZL5_HUMAN
    Recommended name:
    Sperm acrosome-associated protein 5
    Protein Accession:
    Q96QH8
    Secondary Accessions:
    • Q6UWD1

    Protein attributes for SPACA5 Gene

    Size:
    159 amino acids
    Molecular mass:
    17896 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPACA5 Gene

Proteomics data for SPACA5 Gene at MOPED

Post-translational modifications for SPACA5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPACA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPACA5 Gene

Domains & Families for SPACA5 Gene

Gene Families for SPACA5 Gene

Protein Domains for SPACA5 Gene

Graphical View of Domain Structure for InterPro Entry

Q96QH8

UniProtKB/Swiss-Prot:

LYZL5_HUMAN :
  • Belongs to the glycosyl hydrolase 22 family.
Family:
  • Belongs to the glycosyl hydrolase 22 family.
genes like me logo Genes that share domains with SPACA5: view

No data available for Suggested Antigen Peptide Sequences for SPACA5 Gene

Function for SPACA5 Gene

Molecular function for SPACA5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Enzyme Numbers (IUBMB) for SPACA5 Gene

Phenotypes for SPACA5 Gene

genes like me logo Genes that share phenotypes with SPACA5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SPACA5

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPACA5 Gene

Localization for SPACA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPACA5 Gene

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SPACA5 Gene

Pathways & Interactions for SPACA5 Gene

SuperPathways for SPACA5 Gene

No Data Available

Interacting Proteins for SPACA5 Gene

Gene Ontology (GO) - Biological Process for SPACA5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPACA5 Gene

Drugs & Compounds for SPACA5 Gene

(1) Drugs for SPACA5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
N-Acetyl-D-glucosamine Approved Nutra 0
genes like me logo Genes that share compounds with SPACA5: view

Transcripts for SPACA5 Gene

mRNA/cDNA for SPACA5 Gene

(2) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SPACA5 Gene

No ASD Table

Relevant External Links for SPACA5 Gene

GeneLoc Exon Structure for
SPACA5
ECgene alternative splicing isoforms for
SPACA5

Expression for SPACA5 Gene

mRNA expression in normal human tissues for SPACA5 Gene

mRNA differential expression in normal tissues according to GTEx for SPACA5 Gene

This gene is overexpressed in Testis (x25.9).

Protein differential expression in normal tissues from HIPED for SPACA5 Gene

This gene is overexpressed in Ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPACA5 Gene



genes like me logo Genes that share expression patterns with SPACA5: view

Protein tissue co-expression partners for SPACA5 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SPACA5 Gene

Orthologs for SPACA5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPACA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPACA5B 35
  • 99.79 (n)
  • 100 (a)
-- 36
  • 100 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SPACA5 35
  • 82.47 (n)
  • 73.38 (a)
SPACA5 36
  • 72 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 75 (a)
OneToMany
SPACA5 35
  • 83.97 (n)
  • 78.21 (a)
mouse
(Mus musculus)
Mammalia Spaca5 36
  • 70 (a)
OneToMany
Spaca5 35
  • 80.22 (n)
  • 72.26 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 51 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Spaca5 35
  • 82.03 (n)
  • 77.92 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 43 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11159 36
  • 32 (a)
ManyToMany
CG16756 36
  • 28 (a)
ManyToMany
CG16799 36
  • 26 (a)
ManyToMany
CG30062 36
  • 24 (a)
ManyToMany
CG7798 36
  • 33 (a)
ManyToMany
CG8492 36
  • 4 (a)
ManyToMany
LysB 36
  • 33 (a)
ManyToMany
LysC 36
  • 32 (a)
ManyToMany
LysD 36
  • 32 (a)
ManyToMany
LysE 36
  • 33 (a)
ManyToMany
LysP 36
  • 34 (a)
ManyToMany
LysS 36
  • 33 (a)
ManyToMany
LysX 36
  • 32 (a)
ManyToMany
Species with no ortholog for SPACA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPACA5 Gene

ENSEMBL:
Gene Tree for SPACA5 (if available)
TreeFam:
Gene Tree for SPACA5 (if available)

Paralogs for SPACA5 Gene

Paralogs for SPACA5 Gene

(7) SIMAP similar genes for SPACA5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPACA5: view

Variants for SPACA5 Gene

Sequence variations from dbSNP and Humsavar for SPACA5 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs372985309 -- 48,006,789(+) CACAG(C/T)GTGAC intron-variant
rs782001555 -- 48,007,010(+) TAAGT(A/G)TATGT intron-variant
rs782059308 -- 48,007,376(+) CAGTG(C/T)AAGTG intron-variant
rs782093236 -- 48,006,640(+) GCAGA(A/G)TGAGA intron-variant
rs782702568 -- 48,008,339(+) AAGCT(C/G)TATAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPACA5 Gene

Variant ID Type Subtype PubMed ID
dgv2442e1 CNV Complex 17122850
esv8782 OTHER Inversion 19470904
dgv2443e1 CNV Complex 17122850
nsv6890 CNV Loss 18451855
dgv14n29 CNV Complex 16826518
nsv471601 CNV Gain 15918152
nsv522886 CNV Gain 19592680
dgv2444e1 CNV Complex 17122850
esv2752324 CNV Gain 17911159
esv25781 CNV Gain 19812545
esv32909 CNV Gain+Loss 17666407
nsv515198 CNV Gain 21397061
nsv9938 CNV Gain 18304495
dgv37n14 CNV Gain 18776910
nsv517350 CNV Gain+Loss 19592680
nsv519165 CNV Loss 19592680
esv34308 CNV Gain 17911159
nsv521227 CNV Gain 19592680
nsv6892 CNV Insertion 18451855
nsv515200 CNV Complex 21397061

Relevant External Links for SPACA5 Gene

HapMap Linkage Disequilibrium report
SPACA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SPACA5 Gene

Disorders for SPACA5 Gene

Relevant External Links for SPACA5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPACA5

No disorders were found for SPACA5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPACA5 Gene

Publications for SPACA5 Gene

  1. Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome. (PMID: 16382448) Chen Y.-T. … Jongeneel C.V. (Genes Chromosomes Cancer 2006) 2 3 4 67
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3

Products for SPACA5 Gene

Sources for SPACA5 Gene

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