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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPACA5 Gene

protein-coding   GIFtS: 35
GCID: GC0XP047864

Sperm Acrosome Associated 5

  Search for SPACA5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sperm Acrosome Associated 51 2     PNPK62882
Sperm Lysozyme-Like Protein 21 2     SLLP22
Lysozyme-Like Protein 52 3     UNQ62882
Sperm-Specific Lysozyme-Like Protein X2 3     Sperm Acrosome-Associated Protein 52
LYZL52 3     EC 3.2.1.173
SLLP-X2 3     SPACA5A3
LYC52     LOC3898525

External Ids:    HGNC: 313531   Entrez Gene: 3898522   Ensembl: ENSG000001714897   OMIM: 3005935   UniProtKB: Q96QH83   

Export aliases for SPACA5 gene to outside databases

Previous GC identifers: GC00U916482 GC0XP047750 GC0XP045698


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SPACA5 Gene: 
SPACA5 (sperm acrosome associated 5) is a protein-coding gene. An important paralog of this gene is LYZL6.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPACA5 gene promoter:
         Nkx3-1   ISGF-3   Nkx3-1 v4   AML1a   Nkx3-1 v1   Evi-1   Nkx3-1 v2   HFH-1   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SPACA5 promoter sequence
   Search SABiosciences Chromatin IP Primers for SPACA5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPACA5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.3

SPACA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPACA5 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP047864:  view genomic region     (about GC identifiers)

Start:
47,863,734 bp from pter      End:
47,869,130 bp from pter
Size:
5,397 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LYZL5_HUMAN, Q96QH8 (See protein sequence)
Recommended Name: Sperm acrosome-associated protein 5 precursor  
Size: 159 amino acids; 17896 Da
Subcellular location: Secreted (Probable)
Secondary accessions: Q6UWD1

Explore the universe of human proteins at neXtProt for SPACA5: NX_Q96QH8

Explore proteomics data for SPACA5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96QH8

  • SPACA5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SPACA5 Protein Expression
    REFSEQ proteins: NP_995328.2  
    ENSEMBL proteins: 
     ENSP00000366139   ENSP00000305847  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----

    SPACA5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR000974 Glyco_hydro_22_lys
     IPR023346 Lysozyme-like_dom
     IPR001916 Glyco_hydro_22

    Graphical View of Domain Structure for InterPro Entry Q96QH8

    ProtoNet protein and cluster: Q96QH8

    1 Blocks protein domain: IPB000974 Lysozyme signature

    UniProtKB/Swiss-Prot: LYZL5_HUMAN, Q96QH8
    Similarity: Belongs to the glycosyl hydrolase 22 family


    SPACA5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LYZL5_HUMAN, Q96QH8
    Catalytic activity: Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine
    residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins

         Enzyme Number (IUBMB): EC 3.2.1.171

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003796lysozyme activity ----
         
    SPACA5 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPACA5

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016998cell wall macromolecule catabolic process ----

    SPACA5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPACA5 (LYZL5)

    1 HMDB Compound for SPACA5    About this table
    CompoundSynonyms CAS #PubMed Ids
    N-Acetyl-D-glucosamine2-(acetylamino)-2-deoxyhexose (see all 9)7512-17-6--

    Search CenterWatch for drugs/clinical trials and news about SPACA5 / LYZL5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for SPACA5 gene: 
    NM_205856.3  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376940 ENST00000304355(uc004diu.3)
    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPACA5

    2 AceView cDNA sequences:

    AY358844 NM_205856 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPACA5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SPACA5 Expression
    About this image


    See SPACA5 Protein Expression from SPIRE MOPED and PaxDB    SABiosciences Custom PCR Arrays for SPACA5
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPACA5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SPACA5 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spaca51 , 5 sperm acrosome associated 51, 5 80.3(n)1
    72.73(a)1
      X (16.59 cM)5
    2782031  NM_001085393.11  NP_001078862.11 
     210684065 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    43(a)
    1 → many
    GL343252.1(52487-76084)


    ENSEMBL Gene Tree for SPACA5 (if available)
    TreeFam Gene Tree for SPACA5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPACA5 gene
    SPACA5B1 2  LYZL62  LYZL42  LYZ2  SPACA32  LALBA2  LYZL22  LYZL12  
    7 SIMAP similar genes for SPACA5 using alignment to 1 protein entry:     LYZL5_HUMAN:
    LYZ    SPACA3    LYZL6    LYZL1    LYZL2    LYZL4
    LALBA

    SPACA5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    7 SNPs in SPACA5 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1912328601,2
    --47866010(+) GAGTGC/TGCATG 1 -- int10--------
    rs3772109621,2
    ----47866011(+) AGTGCA/GCATGA 1 -- int10--------
    rs3729853091,2
    ----47866187(+) CACAGC/TGTGAC 1 -- int10--------
    rs2008540511,2
    ----47867739(+) GCTCTA/GTACCT 1 -- int10--------
    rs1379735761,2
    ----47868346(+) TGGTGG/TTGTTG 1 -- int10--------
    rs1503522111,2
    ----47866962(+) GAATGC/TGTGCC 1 -- int10--------
    rs3749785091,2
    ----47868052(+) GGAGAA/GAAGTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for SPACA5 (47863734 - 47869130 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/20 variations for SPACA5 (see all 20):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv6892CNV Insertion18451855
    nsv519165CNV Loss19592680
    nsv6890CNV Loss18451855
    nsv521227CNV Gain19592680
    nsv522886CNV Gain19592680
    dgv37n14CNV Gain18776910
    nsv515198CNV Gain21397061
    nsv471601CNV Gain15918152
    esv2752324CNV Gain17911159
    nsv9938CNV Gain18304495

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SPACA5 for disorders           About MalaCards
    OMIM gene information: 300593    OMIM disorders: --


    SPACA5 for disorders           About GeneDecksing


    Export disorders for SPACA5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPACA5 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SPACA5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome. (PubMed id 16382448)1, 2, 3 Chen Y.T....Jongeneel C.V. (2006)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
    4. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 389852 HGNC: 31353 AceView: LOC389852 Ensembl:ENSG00000171489 euGenes: HUgn389852
    ECgene: SPACA5 H-InvDB: SPACA5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPACA5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SPACA5 gene:
    Search GeneIP for patents involving SPACA5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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     inGenious Targeting Laboratory - Custom generated mouse model solutions for SPACA5
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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