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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SPACA5 Gene

protein-coding GIFtS: 38
GCID: GC0XP047864

sperm acrosome associated 5

Search for SPACA5
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sperm Acrosome Associated 5¹ ²		Sperm-Specific Lysozyme-Like Protein X² ³
LYZL5¹ ² ³		SLLP-X² ³
LYC5¹ ²		Sperm Acrosome-Associated Protein 5²
PNPK6288¹ ²		Sperm Lysozyme-Like Protein 2²
SLLP2¹ ²		EC 3.2.1.17³
UNQ6288¹ ²		SPACA5A³
DJ54B20.3¹		LOC389852⁵
Lysozyme-Like Protein 5² ³

External Ids:	HGNC: 31353¹	Entrez Gene: 389852²	Ensembl: ENSG00000171489⁷	OMIM: 300593⁵	UniProtKB: Q96QH8³

Export aliases for SPACA5 gene to outside databases

Previous GC identifers: GC00U916482 GC0XP047750 GC0XP045698

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_079573.4

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SPACA5 gene promoter:
Nkx3-1 ISGF-3 Nkx3-1 v4 AML1a Nkx3-1 v1 Evi-1 Nkx3-1 v2 HFH-1 Nkx3-1 v3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SPACA5 promoter sequence

Search SABiosciences Chromatin IP Primers for SPACA5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPACA5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.3

SPACA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPACA5 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP047864: view genomic region (about GC identifiers)

Start:	47,863,734 bp from pter	End:	47,869,130 bp from pter
Size:	5,397 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
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About This Section

UniProtKB/Swiss-Prot: LYZL5_HUMAN, Q96QH8 (See protein sequence)

Recommended Name: Sperm acrosome-associated protein 5 precursor

Size: 159 amino acids; 17896 Da

Subcellular location: Secreted (Probable)

Secondary accessions: Q6UWD1

Explore the universe of human proteins at neXtProt for SPACA5: NX_Q96QH8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96QH8

SPACA5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_995328.2

ENSEMBL proteins:

ENSP00000366139 ENSP00000305847

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	--	--

SPACA5 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SPACA5 for domains About GeneDecksing

3 InterPro domains/families:

IPR000974 Glyco_hydro_22_lys

IPR023346 Lysozyme-like_dom

IPR001916 Glyco_hydro_22

Graphical View of Domain Structure for InterPro Entry Q96QH8

ProtoNet protein and cluster: Q96QH8

1 Blocks protein family: IPB000974 Lysozyme signature

UniProtKB/Swiss-Prot: LYZL5_HUMAN, Q96QH8

Similarity: Belongs to the glycosyl hydrolase 22 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: LYZL5_HUMAN, Q96QH8

Catalytic activity: Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues

in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins

Enzyme Number (IUBMB): EC 3.2.1.17¹

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003796	lysozyme activity	--	--

SPACA5 for ontologies About GeneDecksing

Animal Models:

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SPACA5

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016998	cell wall macromolecule catabolic process	--	--

SPACA5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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1 HMDB Compound for SPACA5 About this table

Compound	Synonyms	CAS #	PubMed Ids
N-Acetyl-D-glucosamine	2-(acetylamino)-2-deoxyhexose (see all 9)	7512-17-6	--

Search CenterWatch for drugs/clinical trials and news about SPACA5 / LYZL5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for SPACA5 gene:

NM_205856.2

Unigene Cluster for SPACA5:

Sperm acrosome associated 5

Hs.319319 [show with all ESTs]

Unigene Representative Sequence: NM_205856

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000376940 ENST00000304355(uc004diu.3)

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Additional cDNA sequence: AY358844.1

2 DOTS entries:

DT.91712996 DT.121322762

2 AceView cDNA sequences:

NM_205856 AY358844

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SPACA5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

SPACA5 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Spermatid

Germ Cells, Male Gametocytes

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SPACA5 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.319319

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SPACA5 gene from 3/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	-- --	--	42(a) 35(a)	many ↔ many many ↔ many	GL343252.1(66835-75936) 2(69254027-69263483)
zebrafish (Danio rerio)	Actinopterygii	lyz⁶	lysozyme	36(a)	1 → many	24(24643811-24646748)
fruit fly (Drosophila melanogaster)	Insecta	CG8492⁶ LysP⁶ (see all 13)	Lysozyme P (see all 13)	4(a) 32(a) (see all 13)	many ↔ many many ↔ many (see all 13)	3L(7720904-7725087) 3L(1218082-1218696)

ENSEMBL Gene Tree for SPACA5 (if available)
TreeFam Gene Tree for SPACA5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SPACA5 gene

SPACA5B¹ ² LYZL4² LALBA² LYZL6² LYZ² SPACA3² LYZL2² LYZL1²

7 SIMAP similar genes for SPACA5 using alignment to 1 protein entry: LYZL5_HUMAN:

LYZ SPACA3 LYZL6 LYZL1 LYZL2 LYZL4

LALBA

SPACA5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs191232860^1,2		--	47866010(+)	`GAGTGC/TGCATG`	1	--	int¹		0	--	--	--	--
rs200854051^1,2	--	--	47867739(+)	`GCTCTA/GTACCT`	1	--	int¹		0	--	--	--	--
rs137973576^1,2	--	--	47868346(+)	`TGGTGG/TTGTTG`	1	--	int¹		0	--	--	--	--
rs150352211^1,2	--	--	47866962(+)	`GAATGC/TGTGCC`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SPACA5 (47863734 - 47869130 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 22 variations for SPACA5
15/21 CNVs (see all 21): 31547 83493 34416 4149 67975 0822 7789 2277 8304 37578 8306 67974 96641 37638 34577
1 Inversion: 59879

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SPACA5 for disorders About MalaCards

SPACA5 for disorders About GeneDecksing

OMIM gene information: 300593 OMIM disorders: --

Export disorders for SPACA5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SPACA5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SPACA5)

Utopia: connect your pdf to the dynamic
world of online information

Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome. (PubMed id 16382448)^{1, 2, 3} Chen Y.T....Jongeneel C.V. (2006)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
The DNA sequence of the human X chromosome. (PubMed id 15772651)² Ross M.T.... Bentley D.R. (2005)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 389852	HGNC: 31353	AceView: LOC389852	Ensembl:ENSG00000171489	euGenes: HUgn389852
ECgene: SPACA5	H-InvDB: SPACA5

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SPACA5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SPACA5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SPACA5 gene:
Search GeneIP for patents involving SPACA5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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	Antibodies for SPACA5
	See all of Abcam's Antibodies, Kits and Proteins for SPACA5
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SPACA5 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for SPACA5

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPACA5

	Browse SwitchGear 3'UTR luciferase reporter plasmids for SPACA5
	SwitchGear Promoter luciferase reporter plasmids for SPACA5

Search ThermoFisher Antibodies for SPACA5

Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SPACA5

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SPACA5

Sirion Biotech Customized:

	stable knockdown cell line services for SPACA5
	inducible knockdown cell line services for SPACA5
	design and validation of potent shRNA sequences against SPACA5
	adenovirus for potent knockdown of SPACA5
	adenovirus for overexpression of SPACA5
	stable overexpressing cell line services for SPACA5
	inducible overexpressing cell line services for SPACA5

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SPACA5 gene at Home site.

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SPACA5 Gene

sperm acrosome associated 5

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SPACA5 Gene

sperm acrosome associated 5

Aliasesfor SPACA5 gene

Summariesfor SPACA5 gene

Genomic Viewsfor SPACA5 gene

Proteinsfor SPACA5 gene

Protein Domains /Familiesfor SPACA5 gene

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Genome Databases showing SPACA5 gene

Other Databases showing SPACA5 gene

Specialized Databases showing SPACA5 gene

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for SPACA5 gene

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for SPACA5 gene

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for SPACA5 gene

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for SPACA5 gene

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for SPACA5 gene

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for SPACA5 gene

Pathways & Interactions
for SPACA5 gene

Drugs & Compounds
for SPACA5 gene

Transcripts
for SPACA5 gene

Expression
for SPACA5 gene

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for SPACA5 gene

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for SPACA5 gene

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for SPACA5 gene

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for SPACA5 gene

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for SPACA5 gene

Intellectual Property
for SPACA5 gene

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for SPACA5 gene