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Aliases for SPACA5 Gene

Aliases for SPACA5 Gene

  • Sperm Acrosome Associated 5 2 3
  • Sperm-Specific Lysozyme-Like Protein X 3 4
  • Sperm Lysozyme-Like Protein 2 2 3
  • Lysozyme-Like Protein 5 3 4
  • SLLP-X 3 4
  • LYZL5 3 4
  • Sperm Acrosome-Associated Protein 5 3
  • EC 4
  • LOC389852 6
  • PNPK6288 3
  • UNQ6288 3
  • SPACA5A 4
  • SLLP2 3
  • LYC5 3

External Ids for SPACA5 Gene

Previous GeneCards Identifiers for SPACA5 Gene

  • GC00U916482
  • GC0XP047750
  • GC0XP047864
  • GC0XP045698

Summaries for SPACA5 Gene

GeneCards Summary for SPACA5 Gene

SPACA5 (Sperm Acrosome Associated 5) is a Protein Coding gene. An important paralog of this gene is SPACA5B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPACA5 Gene

Genomics for SPACA5 Gene

Regulatory Elements for SPACA5 Gene

Genomic Location for SPACA5 Gene

48,004,336 bp from pter
48,009,824 bp from pter
5,489 bases
Plus strand

Genomic View for SPACA5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPACA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPACA5 Gene

Proteins for SPACA5 Gene

  • Protein details for SPACA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sperm acrosome-associated protein 5
    Protein Accession:
    Secondary Accessions:
    • Q6UWD1

    Protein attributes for SPACA5 Gene

    159 amino acids
    Molecular mass:
    17896 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPACA5 Gene

Proteomics data for SPACA5 Gene at MOPED

Post-translational modifications for SPACA5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPACA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPACA5 Gene

Domains for SPACA5 Gene

Protein Domains for SPACA5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q96QH8
  • Belongs to the glycosyl hydrolase 22 family.
genes like me logo Genes that share domains with SPACA5: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for SPACA5 Gene

Function for SPACA5 Gene

Molecular function for SPACA5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins

Enzyme Numbers (IUBMB) for SPACA5 Gene

Gene Ontology (GO) - Molecular Function for SPACA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003796 lysozyme activity IEA --
genes like me logo Genes that share ontologies with SPACA5: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPACA5

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SPACA5 Gene

Localization for SPACA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPACA5 Gene


Subcellular locations from

Jensen Localization Image for SPACA5 Gene COMPARTMENTS Subcellular localization image for SPACA5 gene
Compartment Confidence
extracellular 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SPACA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with SPACA5: view

Pathways for SPACA5 Gene

SuperPathways for SPACA5 Gene

No Data Available

Interacting Proteins for SPACA5 Gene

Gene Ontology (GO) - Biological Process for SPACA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0016998 cell wall macromolecule catabolic process --
genes like me logo Genes that share ontologies with SPACA5: view

No data available for Pathways by source for SPACA5 Gene

Compounds for SPACA5 Gene

(1) HMDB Compounds for SPACA5 Gene

Compound Synonyms Cas Number PubMed IDs
  • 2-(acetylamino)-2-deoxyhexose
genes like me logo Genes that share compounds with SPACA5: view

Transcripts for SPACA5 Gene

mRNA/cDNA for SPACA5 Gene

(2) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPACA5

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPACA5 Gene

No ASD Table

Relevant External Links for SPACA5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPACA5 Gene

mRNA expression in normal human tissues for SPACA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPACA5 Gene

This gene is overexpressed in Testis (25.9).

Protein differential expression in normal tissues for SPACA5 Gene

This gene is overexpressed in Ovary (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SPACA5 Gene

genes like me logo Genes that share expressions with SPACA5: view

Expression partners for SPACA5 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SPACA5 Gene

Orthologs for SPACA5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPACA5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SPACA5 35
  • 82.47 (n)
  • 73.38 (a)
  • 72 (a)
(Canis familiaris)
Mammalia SPACA5 35
  • 83.97 (n)
  • 78.21 (a)
-- 36
  • 75 (a)
(Mus musculus)
Mammalia Spaca5 35
  • 80.22 (n)
  • 72.26 (a)
Spaca5 16
Spaca5 36
  • 70 (a)
(Pan troglodytes)
Mammalia SPACA5B 35
  • 99.79 (n)
  • 100 (a)
-- 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Spaca5 35
  • 82.03 (n)
  • 77.92 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 51 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11159 36
  • 32 (a)
CG16756 36
  • 28 (a)
CG16799 36
  • 26 (a)
CG30062 36
  • 24 (a)
CG7798 36
  • 33 (a)
CG8492 36
  • 4 (a)
LysB 36
  • 33 (a)
LysC 36
  • 32 (a)
LysD 36
  • 32 (a)
LysE 36
  • 33 (a)
LysP 36
  • 34 (a)
LysS 36
  • 33 (a)
LysX 36
  • 32 (a)
Species with no ortholog for SPACA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPACA5 Gene

Gene Tree for SPACA5 (if available)
Gene Tree for SPACA5 (if available)

Paralogs for SPACA5 Gene

Paralogs for SPACA5 Gene

Selected SIMAP similar genes for SPACA5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPACA5: view

Variants for SPACA5 Gene

Sequence variations from dbSNP and Humsavar for SPACA5 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs113913823 -- 48,009,365(+) CCTCA(A/G)ACCTG splice-acceptor-variant
rs137973576 -- 48,008,949(+) TGGTG(G/T)TGTTG intron-variant
rs150352211 -- 48,007,564(+) GAATG(C/T)GTGCC intron-variant, upstream-variant-2KB
rs191232860 -- 48,006,612(+) GAGTG(C/T)GCATG intron-variant, upstream-variant-2KB
rs200854051 -- 48,008,341(+) GCTCT(A/G)TACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPACA5 Gene

Variant ID Type Subtype PubMed ID
dgv2442e1 CNV Complex 17122850
esv8782 OTHER Inversion 19470904
dgv2443e1 CNV Complex 17122850
nsv6890 CNV Loss 18451855
dgv14n29 CNV Complex 16826518
nsv471601 CNV Gain 15918152
nsv522886 CNV Gain 19592680
dgv2444e1 CNV Complex 17122850
esv2752324 CNV Gain 17911159
esv25781 CNV Gain 19812545
esv32909 CNV Gain+Loss 17666407
nsv515198 CNV Gain 21397061
nsv9938 CNV Gain 18304495
dgv37n14 CNV Gain 18776910
nsv517350 CNV Gain+Loss 19592680
nsv519165 CNV Loss 19592680
esv34308 CNV Gain 17911159
nsv521227 CNV Gain 19592680
nsv6892 CNV Insertion 18451855
nsv515200 CNV Complex 21397061

Relevant External Links for SPACA5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPACA5 Gene

Disorders for SPACA5 Gene

No disorders were found for SPACA5 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for SPACA5 Gene

Publications for SPACA5 Gene

  1. Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome. (PMID: 16382448) Chen Y.-T. … Jongeneel C.V. (Genes Chromosomes Cancer 2006) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 4

Products for SPACA5 Gene

Sources for SPACA5 Gene

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